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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 574 of 725

Negative / Null Result ReportMedicine

Biomechanical Comparison of Different Fixation Methods for Treating Jones Fracture of the Fifth Metatarsal.

Shih CM, Yen YC, Wang CH et al. · 2026 · Bioengineering (Basel, Switzerland)

Jones fractures are Zone 2 fractures of the fifth metatarsal. Biomechanical comparisons of fixation strategies for Jones fractures remain limited by the lack of standardized, head-to-head evaluations across major fixation methods. The…

View details →DOI: 10.3390/bioengineering13020135
Negative / Null Result ReportMedicine

Impact of eravacycline on fibrinogen.

Stevenson E, Ponder M, Daniels L et al. · 2026 · The Journal of antimicrobial chemotherapy

Objectives While tigecycline has been associated with hypofibrinogenaemia, limited data with eravacycline suggest this may also occur with this agent. However, the incidence and clinical significance of this finding are not well defined.…

View details →DOI: 10.1093/jac/dkag030
Negative / Null Result ReportMedicine

There Is No Clinical and Radiological Difference between Suspensory and Cortical Button Fixation at the Treatment of Medial Meniscus Posterior Root Tear.

Sarikaya G, Paksoy AE, Karaşahin Ö et al. · 2026 · Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Purpose of the study The purpose of this prospective study was to compare the two surgical techniques; (Transosseous Fixation with the Suspensory Fixation System technique and Pull Out Suture Repair) for clinical and radiologic scores and…

View details →DOI: 10.55095/achot2026/001
Negative / Null Result ReportMedicine

Vasopressors or Fluids in Early Septic Shock.

Peake SL, Macdonald SPJ, Howe BD et al. · 2026 · The New England journal of medicine

Background The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy along with smaller…

View details →DOI: 10.1056/nejmoa2516225
Negative / Null Result Report

Safety and Pharmacokinetics of Intravitreally Repeatedly Injected Panitumumab in Non-Human Primates - A Study Performed Under Good Laboratory Practice

Wang YX, Holz FG, Coenen M et al. · 2026 · Preprint

Abstract Background Epidermal growth factor (EGF) has been suggested to play a role in myopic axial elongation, and EGF receptor blockade may be of potential therapeutic benefit. Here we examined the ocular and systemic toxicity of…

View details →DOI: 10.21203/rs.3.rs-8501876/v1
Negative / Null Result ReportMedicine

Transforming extracted cashew nut shell into biochar and its application as soil amender for jute mallow (Corchorus olitorius L.) cultivation.

Alaka MO, Ogunjobi JK, Omoruyi OE et al. · 2026 · Scientific reports

This study addresses the environmental challenges posed by the waste generated during the extraction of cashew nut shell (CNS) liquid by proposing a sustainable repurposing method. Extracted CNS (waste) was pyrolyzed at varying…

View details →DOI: 10.1038/s41598-026-35559-6
Negative / Null Result ReportMedicine

The influence of verbalization versus imagery on trauma memory.

Rupietta AE, Meyer T, Margraf J et al. · 2026 · Journal of behavior therapy and experimental psychiatry

Background Cognitive theories on trauma memory postulate that trauma-related intrusions are associated with more data-driven and less contextual processing. However, contextualisation can be enhanced via verbalization, suggesting that…

View details →DOI: 10.1016/j.jbtep.2026.102088
Negative / Null Result ReportMedicine

Response of juvenile Chinook salmon (Oncorhynchis tshawytscha) to the aquatic herbicide florpyrauxifen-benzyl.

Grue C, Getsinger KD, Heilman MA et al. · 2026 · Environmental toxicology and chemistry

Florpyrauxifen-benzyl (aquatic tradename ProcellaCOR) is an aquatic herbicide commonly used to control Eurasian watermilfoil (Myriophyllum spicatum) and other invasive aquatic plants. Previous studies have demonstrated effective Eurasian…

View details →DOI: 10.1093/etojnl/vgaf273
Negative / Null Result ReportMedicine

Safety, Immunogenicity of Co-Administered Vaccines, and Lot-to-Lot Consistency of a 14-Valent Pneumococcal Conjugate Vaccine (PNEUBEVAX 14<sup>®</sup>) Administered at 6-10-14 Weeks in Healthy Infants: A Multicenter, Phase IV Trial.

Thuluva S, Gunneri S, Ningaiah S et al. · 2026 · Vaccines

Background: Pneumococcal conjugate vaccines (PCVs) have substantially reduced pneumococcal disease in children; however, serotype distribution varies geographically, and residual disease due to non-PCV13 serotypes persists. Biological E's…

View details →DOI: 10.3390/vaccines14060464
Negative / Null Result ReportMedicine

DNA recovery from 3D printed firearms.

Oltrogger FT, Howe G, McNevin D et al. · 2026 · Science & justice : journal of the Forensic Science Society

Over the last few years, additive manufacturing, by means of fused deposition modelling 3D printing, has become increasingly popular and accessible due to the relative low costs, flexibility, and continually lowering barriers for entry.…

View details →DOI: 10.1016/j.scijus.2026.101409
Negative / Null Result ReportMedicine

Beyond Gram-Negative and Gram-Positive Bacteria: Virulence as a Determinant of Clinical Outcome in Periprosthetic Joint Infections.

Achatz V, Sebastian S, Mitterer JA et al. · 2026 · The Journal of arthroplasty

Background Gram-negative (GN) periprosthetic joint infections (PJIs) are still less frequent than gram-positive (GP) PJIs. There is only little data available on a direct comparison of GP- and GN-associated PJIs. Therefore, we investigated…

View details →DOI: 10.1016/j.arth.2026.02.031
Negative / Null Result ReportMedicine

Natural versus GnRHa-HRT cycle for FET in tubal infertility with prior failed natural cycles: a propensity score-matched retrospective cohort study.

Li L, Gao S, Zhu H et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Introduction Frozen embryo transfer offers improved cumulative pregnancy rates and reduces complications compared to fresh cycles. Successful outcomes depend on both embryonic potential and endometrial receptivity, necessitating…

View details →DOI: 10.1016/j.ejogrb.2026.115194
Negative / Null Result ReportMedicine

The Effect of Contrast Media Formulations with Different Iodine Preparation Concentrations at a Constant Iodine Delivery Rate in Low-kV CT Angiography: An Experimental Animal Study.

Holtkamp M, Jost G, Salhöfer L et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

Purpose The effect of iodine preparation concentration on vascular attenuation during computed tomography angiography (CTA) is a topic of controversy. Iodine-based contrast media (CM) formulations are used in different iodine preparation…

View details →DOI: 10.1055/a-2818-5244
Negative / Null Result ReportMedicine

Light at the End of the Tunnel! Effects of 405 nm Visible Light Disinfection on Surgical Site Infection: A Prospective Randomized Cohort Study.

Bauerle WB, Allsbrook A, Green A et al. · 2026 · Surgical infections

Introduction Surgical site infections (SSIs) are a substantial contributor to morbidity and mortality rates. 405 nm visible light disinfection (VLD) has been shown to reduce bacterial burden in operating rooms (ORs); however, its effect on…

View details →DOI: 10.1177/10962964251410006
Negative / Null Result ReportMedicine

Ultra-long-term EEG recordings indicate no effect of vagus nerve stimulation on sleep in epilepsy patients.

van Norden SJ, Kho KH, Meppelink AM et al. · 2026 · Epilepsy & behavior : E&B

Objective Vagus nerve stimulation (VNS) is a therapeutic option for pharmacoresistant epilepsy patients who are not eligible for surgery. While its primary aim is seizure reduction, the effects of VNS on sleep remain unclear, with previous…

View details →DOI: 10.1016/j.yebeh.2026.111004
Negative / Null Result ReportMedicine

The Cost-Utility of a Workplace Mental Health Program for Employees with Common Mental Disorders (FRIAA Project).

Mulfinger N, Waldmann T, Herold R et al. · 2026 · The journal of mental health policy and economics

Background Common mental disorders (CMDs) are a leading cause of sickness absence and early retirement due to health problems. Early identification and treatment of CMDs may have a positive impact on prognosis and associated economic…

Negative / Null Result ReportMedicine

Contribution of oilseed waste on the development of the edible insect species Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae): From trash to cash.

Baliota GV, Rumbos CI, Athanassiou CG · 2026 · The Science of the total environment

The lesser mealworm, Alphitobius diaperinus (Panzer) (Coleoptera: Tenebrionidae), has attracted considerable commercial interest as an authorized insect species for use as food and feed, thanks to many important features that enable its…

View details →DOI: 10.1016/j.scitotenv.2025.181157
Negative / Null Result ReportMedicine

Metabolic biomarkers add little to diagnostic performance of FIB-4 in MASLD.

Ullman S, Hegmar H, Vessby J et al. · 2026 · Scandinavian journal of gastroenterology

Background Advanced fibrosis is the main risk factor for liver-related complications in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The first line-test for evaluating presence of advanced fibrosis,…

View details →DOI: 10.1080/00365521.2026.2615408
Negative / Null Result ReportMedicine

Simulation of lung volume and SPECT count errors due to mismatch between SPECT and CT during free-breathing in lung perfusion scintigraphy.

Nojima Y, Yamazaki Y · 2026 · Biomedical physics & engineering express

Respiratory phase mismatch between single-photon emission computed tomography (SPECT) and computed tomography (CT) acquisition phases presents a challenge in lung perfusion scintigraphy using SPECT/CT. This study simulated lung volume and…

View details →DOI: 10.1088/2057-1976/ae2ebb
Negative / Null Result ReportMedicine

Joint line elevation after TKA is higher in patients with metaphyseal deformity: a prospective study.

Albayrak S, Demirkale İ, Özer M et al. · 2025 · Archives of orthopaedic and trauma surgery

Introduction Joint level restoration is crucial for the success of total knee arthroplasty. The aim of this study was to evaluate joint line estimation methods between two patient groups with mild to moderate or advanced varus deformities.…

View details →DOI: 10.1007/s00402-025-06054-w
Negative / Null Result ReportMedicine

Effects of wood ash, nitrogen, and biosolids fertilisation on the growth and soil properties of Scots pine and Norway spruce stands

Mäkinen H, Ilvesniemi H, Lindroos AJ et al. · 2025 · Forest Ecology and Management.

The recycling of wood ash back to forests has the potential to restore nutrients that are removed during the harvesting of wood chips for bioenergy. Biosolids are nutrient-rich organic residual materials derived from biowaste and sewage…

Negative / Null Result ReportMedicine

Exploitation of Saccharomyces cerevisiae as an alternative microencapsulation strategy of thymol via β-glucan based matrix for the development of multilayer LDPE active packaging films – comparison with zeolite- and activated carbon-based carriers

Giotopoulou I, Stamatis H, Barkoula NM · 2025 · International Journal of Biological Macromolecules

In the current study Saccharomyces cerevisiae (S. cerevisiae) was exploited as an alternative carrier of thymol with the aim of developing multilayer low-density polyethylene (LDPE) films with advanced bioactivity over time. The results…

Negative / Null Result ReportMedicine

A network-based team situation awareness enhanced training strategy and experimental validation in simulated maritime collaboration.

Min Y, Wanyan X, Liu S et al. · 2025 · Ergonomics

This study proposes a network-based training strategy to improve the team situation awareness (TSA) of crews in complex socio-technical systems. Eighty-four participants were recruited and divided into twenty-one teams to receive different…

View details →DOI: 10.1080/00140139.2025.2538703
Negative / Null Result ReportOpen accessMedicine

Dimensional Stability of SLA 3D-Printed Surgical Guide Resin After Steam Sterilization (121 °C and 134 °C) and Isopropyl Alcohol Disinfection: An In Vitro Study.

Sîrbu I, Custura A, Radu A et al. · 2026 · Dentistry journal

Background : Additively manufactured surgical guides require post-processing and subsequent decontamination prior to intraoral use. Steam sterilization and chemical disinfection protocols may influence the dimensional stability of…

View details →DOI: 10.3390/dj14040204
Negative / Null Result Report

The influence of verbalization versus imagery on trauma memory

Rupietta AE, Meyer T, Margraf J et al. · 2025 · Preprint

Background: Cognitive theories on trauma memory postulate that trauma-related intrusions are associated with more data-driven and less contextual processing. However, contextualisation can be enhanced via verbalization, suggesting that…

View details →DOI: 10.31234/osf.io/tcsre_v2
Negative / Null Result ReportMedicine

Effects of hypocaloric wholegrain rye vs refined wheat diets on weight loss, cardiometabolic risk factors and gut microbiota: A 12-week randomized controlled trial.

Åberg S, Nordin E, Iversen KN et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background and aims Wholegrain rye foods have shown promising effects on metabolic regulation and weight-loss, which may be mediated via gut microbiota and derived metabolites. This study aimed to investigate effects of hypocaloric diets…

View details →DOI: 10.1016/j.clnu.2026.106618