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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21350 results · page 574 of 712

Negative / Null Result ReportOpen accessMedicine

Naturalistic investigation of cannabis strains varying in THC and CBD ratios and verbal recognition memory.

Paulich KN, Place C, Giordano G et al. · 2025 · Frontiers in psychology

Introduction Cannabis, which contains cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), has become the third-most-commonly used psychoactive substance in the United States. The legal market has grown alongside the…

View details →DOI: 10.3389/fpsyg.2025.1685412
Negative / Null Result ReportOpen accessMedicine

No Association Between Hypnotizability and Basal Ganglia Morphometry.

Picerni E, Piras F, Laricchiuta D et al. · 2026 · Brain sciences

Background: Hypnotizability is a psychophysiological trait measured by standardized scales whose scores indicate the proneness to modify perception, memory, and behavior according to specific suggestions, and to experience the hypnotic…

View details →DOI: 10.3390/brainsci16030287
Negative / Null Result ReportOpen accessMedicine

How robust are egocentric and altercentric interference effects in social cognition? a test with explicit and implicit versions of a continuous false belief task.

Haskaraca FN, Proft M, Liszkowski U et al. · 2023 · Frontiers in psychology

It has been long assumed that meta-representational theory of mind (ToM) -our ability to ascribe mental states to ourselves and other people- emerges around age four as indicated in performance on explicit verbal false belief tasks. In…

View details →DOI: 10.3389/fpsyg.2023.1142302
Negative / Null Result ReportOpen accessMedicine

Administration of ketogenic intervention as a potential treatment during post-traumatic brain injury recovery: a scoping review.

Quddus DY, Aydin S, Waheed AA et al. · 2026 · Frontiers in nutrition

Background Traumatic brain injury (TBI) affects 69 million individuals annually and represents a major global health burden. Ketogenic interventions have emerged as a potential therapy to address deficits following TBI. This scoping review…

View details →DOI: 10.3389/fnut.2026.1848682
Negative / Null Result ReportOpen accessMedicine

The impact of cardiac rehabilitation on rehospitalization and mortality rates in heart failure with preserved ejection fraction.

Liu F, Wang Q, Han S et al. · 2026 · Frontiers in cardiovascular medicine

Introduction Heart failure with preserved ejection fraction (HFpEF) is associated with substantial functional limitation and recurrent hospitalization, while effective pharmacological options remain limited. Exercise-based cardiac…

View details →DOI: 10.3389/fcvm.2026.1799035
Negative / Null Result ReportMedicine

Effects of the Visual Fidelity of Virtual Environments on Presence, Context-dependent Forgetting, and Source-monitoring Error.

Mizuho T, Narumi T, Kuzuoka H · 2023 · IEEE transactions on visualization and computer graphics

Advances in virtual reality technology have enabled the creation of virtual environments (VEs) with significantly high visual fidelity when compared to real environments (REs). In this study, we use a high-fidelity VE to examine two…

View details →DOI: 10.1109/tvcg.2023.3247063
Negative / Null Result ReportMedicine

Socio-emotional well-being is associated with cognitive function and informant-rated cognitive decline: Results from the Harmonized Cognitive Assessment Protocol in Europe.

Luchetti M, Terracciano A, Karakose S et al. · 2026 · Journal of the International Neuropsychological Society : JINS

Objective This study examines how multiple dimensions of socio-emotional well-being relate to cognitive functioning in older adults, and whether the associations vary by cognitive status, depression, and socio-demographic factors. Methods…

View details →DOI: 10.1017/s1355617726101933
Negative / Null Result ReportOpen accessMedicine

No immediate attentional bias towards or choice bias for male secondary sexual characteristics in Bornean orang-utans (Pongo pygmaeus).

Roth TS, Samara I, Perea-Garcia JO et al. · 2024 · Scientific reports

Primate faces provide information about a range of variant and invariant traits, including some that are relevant for mate choice. For example, faces of males may convey information about their health or genetic quality through symmetry or…

View details →DOI: 10.1038/s41598-024-62187-9
Negative / Null Result ReportOpen accessMedicine

Effects of one avocado a day for six months on cognitive performance in overweight adults: A randomized controlled trial.

Lee GJ, Morrell HER, Adams M et al. · 2026 · The journal of nutrition, health & aging

Background With the rising incidence of neurodegenerative diseases and aging of the global population, it is important to investigate foods that may preserve cognitive function with advancing years. Avocados are rich in fiber, carotenoids,…

View details →DOI: 10.1016/j.jnha.2026.100847
Negative / Null Result ReportOpen accessMedicine

Dietary supplement for mood symptoms in early postpartum: a double-blind randomized placebo controlled trial.

Meyer JH, Wang Z, Santhirakumar A et al. · 2024 · EClinicalMedicine

Background Postpartum blues (PPB) is a frequent syndrome of sad mood, crying spells, anxiety, restlessness, reduced appetite, and irritability, typically peaking day 5 postpartum. When severe, it greatly increases risk for later postpartum…

View details →DOI: 10.1016/j.eclinm.2024.102593
Negative / Null Result ReportOpen accessMedicine

Immunotherapy for Peritoneal Metastases from Gastric Cancer: Rationale, Current Practice and Ongoing Trials.

Ruiz Hispán E, Pedregal M, Cristobal I et al. · 2021 · Journal of clinical medicine

Peritoneal metastases from gastric cancer play a key role in the fatal prognosis of the disease. The lack of efficacy of actual therapeutic approaches together with the outcomes achieved with checkpoint inhibitors in gastric cancer compel…

View details →DOI: 10.3390/jcm10204649
Negative / Null Result ReportOpen accessMedicine

Stride Velocity 95th Centile Detects Decline in Ambulatory Function Over Shorter Intervals than the 6-Minute Walk Test or North Star Ambulatory Assessment in Duchenne Muscular Dystrophy.

Rabbia M, Guridi Ormazabal M, Staunton H et al. · 2024 · Journal of neuromuscular diseases

Background Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne…

View details →DOI: 10.3233/jnd-230188
Negative / Null Result ReportOpen accessMedicine

Patient-reported outcomes of a randomized phase III clinical trial of adjuvant radiation versus chemoradiation in intermediate risk, stage I/IIA cervical cancer patients treated with initial radical hysterectomy and pelvic lymphadenectomy (NRG/GOG-0263).

Chase DM, Huang HQ, Deng W et al. · 2025 · Gynecologic oncology

Objective To prospectively evaluate the impact of adjuvant chemoradiation (RT + CIS) versus radiation (RT) on quality of life (QOL) and patient-reported outcomes (PROs) among patients with intermediate-risk, stage I-IIA cervical cancer…

View details →DOI: 10.1016/j.ygyno.2025.09.014
Negative / Null Result ReportOpen accessMedicine

A pediatric near-infrared spectroscopy brain-computer interface based on the detection of emotional valence.

Floreani ED, Orlandi S, Chau T · 2022 · Frontiers in human neuroscience

Brain-computer interfaces (BCIs) are being investigated as an access pathway to communication for individuals with physical disabilities, as the technology obviates the need for voluntary motor control. However, to date, minimal research…

View details →DOI: 10.3389/fnhum.2022.938708
Negative / Null Result ReportOpen accessMedicine

Associations between ambient pollen exposure and measures of cognitive performance.

Corpening B, Bürgler A, Tamási B et al. · 2025 · Environmental epidemiology (Philadelphia, Pa.)

Background Prior research suggests pollen allergies may be associated with cognitive function, although the effect sizes and specific cognitive outcomes varied across studies. With pollen seasons starting earlier and intensifying due to…

View details →DOI: 10.1097/ee9.0000000000000374
Negative / Null Result ReportOpen accessMedicine

The role of long-term hair steroids as diagnostic and intervention-related biomarkers in a multimorbid inpatient sample with posttraumatic stress disorder.

Shkreli L, Woud ML, Bergunde L et al. · 2025 · European journal of psychotraumatology

Background: Steroid hormone dysregulations have frequently been implicated in posttraumatic stress disorder (PTSD) pathogenesis. However, the translation into naturalistic clinical settings as markers of symptomatology and treatment…

View details →DOI: 10.1080/20008066.2025.2457295
Negative / Null Result ReportOpen accessMedicine

Long-term effects of cooking with liquefied petroleum gas or biomass on linear growth trajectories from birth to the pre-school years in Puno, Peru: a prospective cohort study.

Nicolaou L, Reuland CJ, Yang M et al. · 2026 · Lancet regional health. Americas

Background Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent. Methods We followed children born…

View details →DOI: 10.1016/j.lana.2026.101382
Negative / Null Result ReportOpen accessMedicine

No gene by stressful life events interaction on individual differences in adults' self-control.

Willems YE, Raffington L, Ligthart L et al. · 2024 · Frontiers in psychiatry

Background Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding,…

View details →DOI: 10.3389/fpsyt.2024.1388264
Negative / Null Result ReportOpen accessMedicine

Air Pollution and Blood Pressure: Evidence From Indonesia.

Madrigano J, Yan D, Liu T et al. · 2024 · GeoHealth

Indonesia faces significant air quality issues due to multiple emissions sources, including rapid urbanization and peatland fires associated with agricultural land management. Limited prior research has estimated the episodic shock of…

View details →DOI: 10.1029/2024gh001014
Negative / Null Result ReportOpen accessMedicine

Women With Ovulatory Cycles Have Longer Sleep, but Phases of Their Menstrual Cycles Do Not Differ in Sleep Characteristics.

Wachowicz A, Galbarczyk A, Marcinkowska UM et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Duration and quality of sleep are influenced by many factors, including hormonal changes. The aim of this study was to investigate the differences between the phases of the menstrual cycle in total sleep duration and sleep stage…

View details →DOI: 10.1002/ajhb.70247
Negative / Null Result ReportOpen accessMedicine

The role of household composition in social isolation and anxiety: evidence from adults in South Africa during the COVID-19 pandemic.

Jennings EA, Roberts-Toler C, Harriman NW et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives Social isolation is a concern among aging populations, and household composition may play an important role in its impact on mental health. We use data from an aging cohort in rural South Africa to investigate the moderating…

View details →DOI: 10.1093/geronb/gbag076
Negative / Null Result ReportOpen accessMedicine

Reward-Related Brain Function as an Endophenotype in the Mood-Psychosis Spectrum.

Barendse MEA, Bilder RM, Snijders AL et al. · 2026 · Biological psychiatry global open science

Background Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an endophenotype of these…

View details →DOI: 10.1016/j.bpsgos.2026.100692
Negative / Null Result Report

Null Results for the Steal-Framing Effect on Out-Group Aggression

Mifune N · 2021 · Preprint

Whether intergroup conflict is a necessary condition for the evolution of human prosociality has been a matter of debate. At the center of the debate is the coevolutionary model of parochial altruism—that human cooperation with in-group…

View details →DOI: 10.21203/rs.3.rs-936427/v1
Negative / Null Result ReportOpen accessMedicine

The Effect of 5G Mobile Phone Electromagnetic Exposure on Corticospinal and Intracortical Excitability in Healthy Adults: A Randomized Controlled Pilot Study.

Torkan A, Zoghi M, Foroughimehr N et al. · 2025 · Brain sciences

Background Research on the impact of 5G mobile phone electromagnetic exposure on corticospinal excitability and intracortical mechanisms is still poorly understood. Objective This randomized controlled pilot study explored the effects of…

View details →DOI: 10.3390/brainsci15111134