Failed Experiment ReportMedicine
Guinard P, Pécaut J, Le-Goff A et al. · 2026 · Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
In order to mitigate superoxide-induced damage, cells rely on superoxide dismutases (SODs), a family of metalloenzymes that catalyze the dismutation of superoxide. These enzymes display a positively-charged substrate entrance channel for…
View details →DOI: 10.1007/s00775-026-02150-3 Negative / Null Result ReportMedicine
Vogel MJ, Hacker K, Herting J et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society
Background Electrical cardioversion (ECV) is an effective treatment for restoring sinus rhythm in supraventricular tachycardias such as atrial fibrillation (AFib) and atrial flutter (AFlu). In clinical practice, serum potassium is often…
View details →DOI: 10.1007/s00392-026-02944-0 Negative / Null Result ReportOpen accessMedicine
Treat T, Jones D, Lorenzano N et al. · 2026 · Journal of periodontology
Background Evidence for whether and how non-surgical periodontal treatment (NSPT) improves systemic outcomes remains equivocal. Inconclusive findings may in part be due to design variations of randomized controlled trials (RCTs) in this…
View details →DOI: 10.1002/jper.24-0847 Negative / Null Result ReportMedicine
Abapolnikova M, Coyne AE, Glushka L et al. · 2026 · Psychotherapy research : journal of the Society for Psychotherapy Research
Objective Although interpersonal psychotherapy (IPT) and cognitive behavioral therapy (CBT) for depression are comparably efficacious, less is known about the respective patient-level processes that help transmit their beneficial effect.…
View details →DOI: 10.1080/10503307.2026.2656698 Negative / Null Result ReportMedicine
Ersoy O, Kizilay G · 2026 · Biotechnic & histochemistry : official publication of the Biological Stain Commission
Clinical and experimental studies have shown that sitagliptin regulates blood glucose levels. This study was designed because it is thought that sitagliptin may reduce diabetes-induced apoptosis in testes by affecting blood glucose levels…
View details →DOI: 10.1080/10520295.2025.2583963 Negative / Null Result ReportOpen accessMedicine
Sosnówka-Czajka E, Skomorucha I, Wojtysiak D et al. · 2026 · Animals : an open access journal from MDPI
The growing greenhouse gas emissions from agricultural production are increasing the pressure on poultry producers to use practices that reduce the environmental impact of farms, mainly by reducing ammonia emissions. The study evaluated…
View details →DOI: 10.3390/ani16060911 Negative / Null Result ReportOpen accessMedicine
Adeva-Andany MM · 2025 · World journal of nephrology
Sodium-glucose cotransporter-2 (SGLT2) inhibitors suppress glucose reabsorption in the kidney proximal tubule through the SGLT2 protein, leading to glucosuria and osmotic diuresis. Randomized placebo-controlled clinical trials show that…
View details →DOI: 10.5527/wjn.v14.i4.110990 Negative / Null Result ReportMedicine
Kobayashi Y, Hosoda C, Kohda M et al. · 2026 · Journal of ethology
Parental care has a direct and beneficial effect on parental fitness. An important question regarding the evolution of parental care is why parental roles and the amount of care invested are characterized by sexual bias. In species that…
Negative / Null Result ReportMedicine
Bourgeois J, Domange C, Celie B · 2026 · International journal of environmental research and public health
Sleep is a fundamental aspect of physiological and psychological functioning, and the beneficial effect of exercise on sleep quality and quantity, depending on training modality, remains underexplored. This study compared the effects of…
View details →DOI: 10.3390/ijerph23020202 Replication Failure
Lan T, Ming J, Liu J et al. · 2026 · Preprint
Objective: Evidence on the stress–fecundability relationship is mixed, and both the population heterogeneity and the effects of moderate stress remain understudied. We aimed to investigate the association of stress with fecundability in…
View details →DOI: 10.22541/au.177095736.68250416/v1 Failed Experiment ReportOpen accessMedicine
Okon-Rocha E, Taylor D · 2026 · Therapeutic advances in psychopharmacology
Cariprazine is effective in a number of conditions and has shown efficacy in the treatment of negative symptoms. Data on its use as an adjunct to other antipsychotics is growing. To evaluate the effectiveness of add-on cariprazine in…
View details →DOI: 10.1177/20451253261456389 Negative / Null Result ReportMedicine
Kolli RD, Kasireddy B, Iuspa MA et al. · 2026 · British poultry science
1. This 42 d study further examined the physiological mechanisms underlying responses to a precision biotic (PB) on growth performance and ileal amino acid digestibility. It focussed on fermentation profile, caecal soluble protein levels,…
View details →DOI: 10.1080/00071668.2026.2630726 Negative / Null Result ReportOpen accessMedicine
Fransisca S, Sitepu BRE, Delfi · 2026 · Frontiers in medicine
Background Visual disturbances are a common and often debilitating complication following stroke, significantly impairing patients' functional independence and quality of life. Among various neuroprotective agents, Citicoline…
View details →DOI: 10.3389/fmed.2026.1769632 Negative / Null Result ReportMedicine
Omae K, Luo Y, Sahker E et al. · 2026 · World journal of urology
PURPOSE: The smallest worthwhile difference (SWD) represents the minimal beneficial effect of an intervention that patients consider valuable when weighed against its burdens, including potential harms, costs, and inconveniences. We aimed…
View details →DOI: 10.1007/s00345-026-06274-8 Negative / Null Result ReportMedicine
Zhiping N, Yuanyuan Y, Qichun Z et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
With the acceleration of China's aging society, how to enhance the subjective well-being of older adults has become a core issue of concern. This study aims to explore the influence mechanisms of socioeconomic status, health, recreation,…
View details →DOI: 10.1177/07334648251409958 Methods Dead-EndMedicine
Khatib M, Robinson D, Lavon E et al. · 2026 · Journal of clinical medicine
Background/Objectives : Chronic lower limb ulcers represent a significant clinical challenge, with conventional therapies achieving healing in only 30-40% of complex cases. This study evaluated the comparative effectiveness of autologous…
View details →DOI: 10.3390/jcm15051902 Negative / Null Result Report
Cohen L, Laferrère A · 2025 · Preprint
Palliative care (PC) is a multidimensional approach to end-of-life care aimed at alleviating suffering and enhancing the quality of life for individuals and their families. A key aspect of PC is managing symptoms such as pain, dyspnea, and…
View details →DOI: 10.20944/preprints202510.1534.v1 Negative / Null Result ReportOpen accessMedicine
Feola M, Landra F, Greco CA et al. · 2026 · Journal of clinical medicine
Cardiac arrest is a way of demise of patients who are affected by heart failure (HF), being more frequent in those with HF with a reduced left ventricular ejection fraction (HFrEF), and is, as such, responsible for 30-50% of cardiac death.…
View details →DOI: 10.3390/jcm15083041 Negative / Null Result ReportMedicine
Noël A, Picard L · 2025 · Emotion (Washington, D.C.)
Numerous studies have highlighted the beneficial effect of humor on memory in younger adults. While older adults are known to preferentially process positive information and appreciate humor, no study has investigated whether the effect of…
View details →DOI: 10.1037/emo0001519 Negative / Null Result Report
Kolb B, Witt-Lajeunesse A, Cioe J · 2025 · Preprint
This experiment compared the effects of a structured rehabilitation regime (skilled reaching for 5 mo) and more varied training (complex environment for 5 mo) with and without postlesion infusion of FGF-2 for 7 days in rats having…
View details →DOI: 10.1101/2025.10.02.680152 Negative / Null Result ReportMedicine
Wei Y, Meade ML, Soderstrom NC · 2025 · Memory (Hove, England)
The present study replicated and extended prior research by comparing the effects of reviewing notes in groups vs. reviewing notes individually on individual final test performance. We also examined the potential interaction between…
View details →DOI: 10.1080/09658211.2025.2573272 Negative / Null Result ReportMedicine
Silva AT, Ferreira NM, Vaz F et al. · 2025 · Journal of biomechanical engineering
Pelvic organ prolapse (POP) is a common pelvic floor disorder resulting from weakened supportive muscles and ligaments. Although the demand for surgeries involving surgical meshes is expected to increase, current options remain limited. In…
View details →DOI: 10.1115/1.4069708 Negative / Null Result ReportMedicine
Wang C, Ren J, Cui Y et al. · 2025 · Journal of Applied Ecology.
Grassland carbon storage depends on microbial‐mediated interactions between grazing and nitrogen (N) addition, which regulates the balance between soil organic carbon (SOC) retention and priming effects. However, uncertainties regarding…
Negative / Null Result ReportOpen accessMedicine
Panopoulos S, Poulia V, Vlachogiannis N et al. · 2026 · Rheumatology international
Randomized trials have demonstrated that nintedanib is beneficial for Systemic Sclerosis-associated interstitial lung disease (SSc-ILD) with an acceptable safety profile. We evaluated the long-term safety and efficacy of nintedanib in a…
View details →DOI: 10.1007/s00296-026-06173-6 Negative / Null Result ReportMedicine
Cai Y, Ren X, Ding C · 2026 · Intensive & critical care nursing
Objectives To assess the effects of various non-pharmacological interventions on long-term outcomes associated with Post-Intensive Care Syndrome (PICS) in intensive care unit (ICU) survivors, based on existing systematic reviews and…
View details →DOI: 10.1016/j.iccn.2025.104326 Negative / Null Result ReportOpen accessMedicine
Pietersen LC, Broekman N, Broekman N et al. · 2025 · Clinical transplantation
Acute kidney injury (AKI) is a common complication following liver transplantation (LT), with multifactorial etiology. It is believed that perioperative hemodynamic instability could lead to AKI. A temporary portocaval shunt (TPCS) could…
View details →DOI: 10.1111/ctr.70259 Negative / Null Result ReportMedicine
Drost M, Fuhrmann G · 2026 · ACS infectious diseases
Pseudomonas aeruginosa is a notorious bacterial pathogen causing chronic pulmonary infections in people with cystic fibrosis (CF) due to its high tolerance to antibiotics and ability to form recalcitrant biofilms. A newer approach to…
View details →DOI: 10.1021/acsinfecdis.5c00759 Negative / Null Result Report
Shynar · 2024 · Preprint
Abstract This study was carried out to determine the effect of biochar produced from different agricultural wastes on lettuce seedling development characteristics in some vegetable species. In the research, biochars obtained from 6…
View details →DOI: 10.21203/rs.3.rs-5492606/v1 Negative / Null Result ReportMedicine
Stanley M, Huang K, Garlich J et al. · 2025 · Journal of orthopaedic trauma
Objectives To compare time, fluoroscopic utilization, and number of misses for placement of far interlocking screws in tibial and femoral nails using a targeting arm (Targeter) versus perfect circle technique (Control). Methods . Design…
View details →DOI: 10.1097/bot.0000000000003066 Negative / Null Result ReportMedicine
Gewiss C, Gehrdau K, Hischke S et al. · 2025 · Journal of wound care
Objective The application of cold atmospheric plasma (CAP) has been described as a promising therapeutic approach for wound healing. Its use in immunologically mediated wounds such as pyoderma gangrenosum (PG) has not yet been sufficiently…
View details →DOI: 10.12968/jowc.2024.0018 