Genome-Wide Association Study of Personality Traits in the Long Life Family Study
Harold Bae; Paola Sebastiani; Jenny X. Sun; Stacy L. Andersen; E. Warwick Daw; Antonio Terracciano; Luigi Ferrucci; Thomas T. Perls · 2013 · Frontiers in Genetics
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p < 10(-8)) and replicated in a
Abstract by Harold Bae; Paola Sebastiani; Jenny X. Sun; Stacy L. Andersen; E. Warwick Daw; Antonio Terracciano; Luigi Ferrucci; Thomas T. Perls, Frontiers in Genetics (2013) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fgene.2013.00065