Negative / Null Result ReportOpen accessMedicine
Amudha Jayanthi Anand, Mei Chien Chua, Siok Hong Khoo et al. · 2017 · Proceedings of Singapore Healthcare
Introduction: Extended hospitalization of low birth weight infants increases risk of medical and psychosocial complications. Our aim was to reduce the length of hospitalization and assess safety and cost savings of discharging infants at a weight of 1900 g instead of 2000 g, as has been the practice. Methods: This is a single-centre, nurse led quality improvement project done at a tertiary neonatal unit in Singapore with primary outcome of reducing average length of stay in selected low birth weight infants. In phase 1, infants with birth weight between 1000 and 1700 g were discharged at 1900
View details →DOI: 10.1177/2010105816676827 Negative / Null Result ReportOpen accessMedicine (General)
Mori N, Kobayashi A, Yokogawa H et al. · 2025 · International Medical Case Reports Journal
Natsuko Mori, Akira Kobayashi, Hideaki Yokogawa, Tomomi Higashide Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, JapanCorrespondence: Akira Kobayashi, Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan, Tel +81-76-265-2403, Fax +81-76-222-9660, Email eyekoba@gmail.comPurpose: To describe two corneal adverse events temporally associated with anti–tumor necrosis factor-α (TNF-α) therapy—one with severe fibrovascular pannus and another with epithelial keratopath
Negative / Null Result ReportOpen accessSurgery
Takatsugu Fujii, Shigeo Toda, Yuki Nishihara et al. · 2020 · Surgical Case Reports
Abstract Background Ischemic colitis can occur after colectomy and is sometimes difficult to treat. We report 4 cases of refractory, delayed onset, regional congestive colitis occurring on the anal side of the anastomosis after laparoscopic left hemicolectomy. Case presentation A total of 191 patients underwent surgery for left colon cancer (transverse, descending, and sigmoid colon cancer) at our hospital from January 2012 to December 2017. During the procedures, the left colic artery (LCA) or sigmoid colic artery (SA) was dissected, the superior rectal artery (SRA) was preserved, and the inf
View details →DOI: 10.1186/s40792-020-00919-5 Negative / Null Result ReportOpen accessPsychology
Barrotul Jazilah · 2020
The aim of this research was to explore burnout, work engagement, and job demand among debt collector workers. The total available population of employees (N= 32) Consumer Collection and Remedial Unit Bank Tabungan Negara Cabang Surabaya…
View details →DOI: 10.26740/jim.v8n3.p1038-1049 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Pylväläinen J, Talala K, Murtola T et al. · 2019 · Clinical Epidemiology
Juho Pylväläinen,1–3 Kirsi Talala,4 Teemu Murtola,5–7 Kimmo Taari,8 Jani Raitanen,1,9 Teuvo L Tammela,6 Anssi Auvinen1 1Tampere University, Faculty of Social Sciences (Health Sciences), Tampere, Finland; 2Helsinki University, Faculty of Medicine, Department of Diagnostics and Therapeutics, Helsinki, Finland; 3Helsinki University Central Hospital, Medical Imaging Center, Helsinki, Finland; 4Cancer Society of Finland, Finnish Cancer Registry, Mass Screening Registry, Helsinki, Finland; 5Tampere University, Faculty of Medicine and Health Technology, Prostate Cancer Research
Negative / Null Result ReportOpen accessSports medicine
Phob Ganokroj MD, Bradley W. Fossum BA, Justin Hollenbeck MSc et al. · 2023 · Orthopaedic Journal of Sports Medicine
Background: Segmental medial meniscal allograft transplantation (MAT) has been shown to restore knee biomechanics; however, stable fixation of the transplantation is critical to avoid extrusion and maximize healing. Purpose: To evaluate the degree of meniscal extrusion and biomechanical function of segmental medial MAT performed with meniscocapsular sutures versus repair augmentation with knotless suture anchors. Study Design: Controlled laboratory study. Methods: Segmental midbody medial meniscectomy and subsequent segmental medial MAT were performed on 10 fresh-frozen cadaveric knees. The kn
View details →DOI: 10.1177/23259671231182978 Negative / Null Result ReportOpen accessDairy processing. Dairy products
Camélia Marchand, Isabelle Royer, Rachel Gervais et al. · 2024 · Journal of Dairy Science
ABSTRACT: Most trace minerals (TM) are fed above dairy cow requirements in commercial herds but their fate and effects on dairy cows have not been well documented. In this study, we evaluated the effects of feeding short-term sulfate TM above recommendations on apparent total-tract digestibility of nutrients, rumen fermentation characteristics, serum concentrations, and milk yield and composition, as well as milk, fecal, and urinary TM excretion in midlactation dairy cows. Eight multiparous Holstein cows with an average body weight (± SD) of 684 ± 29 kg at 82 ± 10 DIM in a quadruple 2 × 2 cros
View details →DOI: 10.3168/jds.2024-24761 Negative / Null Result ReportOpen accessMedicine
Ahmad-Ali Asadi-Noghabi, Mohammad Gholizadeh, Mitra Zolfaghari et al. · 2015 · Oman Medical Journal
Objectives: The diagnosis of pain in patients with low consciousness is a major challenge in the intensive care unit (ICU). Therefore, the use of behavioral tools for pain assessment could be an effective tool to manage pain in this group of patients. The aim of this study was to determine the effects on pain management by nurses using a critical care pain observational tool in patients with a decreased level of consciousness. Methods: Our research used a before and after design to evaluate the ability of nurses to manage pain in patients with low consciousness. A total of 106 ICU nurses were
View details →DOI: 10.5001/omj.2015.55 Negative / Null Result ReportOpen accessDentistry
Alvaro Carvajal-Flórez, Diana María Barbosa-Lis, Oscar Arturo Zapata-Noreña et al. · 2016 · Dental Press Journal of Orthodontics
ABSTRACT Objective: To evaluate the results of a finishing protocol implemented in patients treated in the Orthodontics graduate program at Universidad de Antioquia. Evaluation was carried out by means of the criteria set by the Objective Grading System (OGS) of the American Board of Orthodontics (ABO). Methods: Cast models and panoramic radiographs of 34 patients were evaluated. The intervention group (IG) consisted of 17 patients (19.88 ± 4.4 years old) treated under a finishing protocol. This protocol included training in finishing, application of a finishing guide, brackets repositioning a
View details →DOI: 10.1590/2177-6709.21.2.088-094.oar Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Shoji Kawashima, RCIP-Nagoya Study Group, Noriyuki Matsukawa · 2022 · BMC Neurology
Abstract Background Mild cognitive impairment in Parkinson’s disease (PD-MCI) is associated with an increased risk of cognitive decline. PD-MCI is characterized by impairments in executive function and visuospatial recognition. The visuospatial n-back test is useful for assessing both domains. The 0-back test reflects visuospatial recognition, while the 1-back and 2-back tests reflect working memory. Cholinesterase inhibitors are effective in the treatment of PD-MCI and dementia in PD (PDD). Although some studies have reported the efficacy of memantine for PDD, the therapeutic efficacy of mema
View details →DOI: 10.1186/s12883-022-02699-x Negative / Null Result ReportOpen accessEnvironmental sciences
· 2009 · Assiut University Bulletin for Environmental Researches
ABSTRACT: Several reports have suggested that soluble salts nickel may affect on hematopoiesis and development. In this study female Wistar albino rats (180-300g) received NiCl2, 6H2 O, subcutaneously (25, 50 and 100 mg/kg body weight (b w) or in drinking water (20 mg/100 ml). Selenium (0.3 mg/kg b w, s.c.) was combined to NiCl2 (100 mg/kg b w, s.c.). Control groups received NaCl 0.9% (0.3 ml s.c) or drinking distilled water. All groups of rats were injected on day 4 of pregnancy in pre-implantation period. Haematological parameters were recorded on day 6 and 21 of pregnancy. Developmental par
View details →DOI: 10.21608/auber.2009.149529 Negative / Null Result ReportOpen accessMedicine
Morton Sophie, Docherty Paul, Dickson Jennifer et al. · 2018 · Current Directions in Biomedical Engineering
Mechanical ventilation is a primary therapy for patients with respiratory failure. However, incorrect ventilator settings can cause lung damage. Optimising ventilation while minimising risk is complex in practice. A common lung protective strategy is to titrate positive end-expiratory pressure (PEEP) to the point of minimum elastance. This process can result in additional available lung volume due to alveolar recruitment but comes with the risk of subjecting the lungs to excessive pressure and lung damage. Predictive elastance models can mitigate this risk by estimating airway pressure at a hi
View details →DOI: 10.1515/cdbme-2018-0062 Negative / Null Result ReportOpen accessSurgery
Abdulaziz Asiry, MBBS, DESC, FEBOPRAS, EBHS, Armaghan Dabbagh, PT, PhD, Hatan Mortada, MBBS et al. · 2024 · Plastic and Reconstructive Surgery, Global Open
Background:. Triangular fibrocartilage complex (TFCC) injuries can cause significant patient dysfunction. Platelet-rich plasma (PRP) has emerged as a potential adjunctive treatment for arthroscopic TFCC repair, with some studies suggesting improved outcomes. This study aims to evaluate and compare PRP as an adjunctive treatment in arthroscopic TFCC tear repair. Methods:. This retrospective cohort study examined patients undergoing arthroscopic TFCC repair at Institut de la Main, Paris, France (December 2021–2022). Patients were split into two groups: arthroscopic repair alone (1) and repair wi
View details →DOI: 10.1097/gox.0000000000006237 Negative / Null Result ReportOpen accessSpecialties of internal medicine
Sanam Loghavi, Dawen Sui, Peng Wei et al. · 2018 · Blood Advances
Abstract: The 2017 revision of the World Health Organization (WHO) classification includes substantial changes to the subclassification of chronic myelomonocytic leukemia (CMML): (1) a 3-tiered blast-based scheme including a novel “CMML-0” category replacing a 2-tiered system in place since 2001 and (2) 2 CMML subtypes, myelodysplastic (MDS-CMML) and myeloproliferative (MP-CMML), based on a white blood cell count cutoff of 13 × 109/L. The clinical utility of this subclassification scheme, particularly the expansion of blast-based subgroups, has not been validated. In this study, a large single
View details →DOI: 10.1182/bloodadvances.2018019224 Negative / Null Result ReportOpen accessVeterinary medicine
Hélio Costa, Eloisa Saliba, Marco Bomfim et al. · 2020 · Animals
The aim of this study was to evaluate the effects of Zinc sulfate and propylene glycol (PG) on methane (CH 4 ) emission, nutrient intake, digestibility, and production in sheep grazing on a native Caatinga (Brazilian semi-arid savannah) pasture during the rainy season (from March to June 2014). Fifteen mixed Santa In s sheep, all non-castrated males, with initial body weight of 19.8 1.64 kg, and 4 0.35 months of age, were distributed in a complete randomized design into three treatments: control (CT) concentrate supplemented at 0.7% of body weight; CT + 300 mg of Zn/day; and CT + 2.5 mL of pro
View details →DOI: 10.3390/ani10030395 Negative / Null Result ReportOpen accessVeterinary medicine
Dipankar Sardar, Md. Taslim Hossain, Rudranil Baidya et al. · 2024 · Veterinary Integrative Sciences
Gene editing in large animals like buffalo is challenged by mosaicism, where cells contain both wild-type and mutant alleles, complicating the creation of genetically modified F0 animals in a single step. Traditionally, electroporation is performed on zygotes post in vitro fertilization (IVF), but mature oocytes’ higher permeability suggests earlier intervention might reduce mosaicism and enhance editing efficiency. We hypothesized that the timing of electroporation before in vitro fertilization (IVF) can increase the rates of biallelic mutation for multiple gene knockout as the permeability o
View details →DOI: 10.12982/vis.2025.069 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Yukako Murakami, Saki Matsui, Akiko Kijima et al. · 2011 · Allergology International
We report a case of 7-year-old monozygotic twin patients with atopic dermatitis. The HLA haplotypes were HLA A2, A11, B27, B61, DR1, and DR4. Both serum IgE levels and cedar pollen radioallergosorbent test (RAST) scores were high in the twins (elder/younger sister: IgE: 5170/3980 IU/ml and Japansese cedar pollen: >100/64.0) in contrast to low mite and food RAST scores (Dermatophagoides Pterygonium; 0.59/0.4 and egg white 9.24/4.6). The patients showed positive immediate (20 min in both sisters) and delayed (24 hours in elder sister, 24, 48, 72 hours in younger sister) reactions to a scratch te
View details →DOI: 10.2332/allergolint.10-cr-0268 Negative / Null Result ReportOpen accessMedicine (General)
Mercedes Navarro, Gonzalo Hijos, Carlos Sostres et al. · 2020 · Frontiers in Medicine
Introduction: The fecal immunochemical test (FIT) has been established as a cost-effective test in colon cancer screening programmes. This test could also be helpful in symptomatic patients prior to colonoscopy, but data about diagnostic performance, and accurate cut-off values for these patients are still scarce.Materials and Methods: Prospective study that included consecutive unselected patients with gastrointestinal symptoms referred for colonoscopy between November 2016 and June 2018. We performed a FIT (FOB Gold® test, cut-off 20 micrograms of Hb/gram of feces) prior to colonoscopy and d
View details →DOI: 10.3389/fmed.2020.00410 Negative / Null Result ReportOpen accessAnimal biochemistry
Zi-Hai Wei, Shu-Lin Liang, Feng-Fei Gu et al. · 2025 · Animal Nutriomics
One hundred and thirteen mid-lactation cows fed same diets and supplemented with 20 g/d rumen-protected methionine (RPM) for 8 weeks were used to investigate the individual responses of dairy cows to RPM in terms of lactation performance, amino acids (AA) metabolism, and milk metabolites. Among the cows, 10 cows exhibited positive responses (PR) and 10 cows showed limited responses (LR) in energy-corrected milk yield to RPM were used for further analysis. The lactation performance changed from gradual decline to steady increase in PR cows, while kept downward trend in LR cows following RPM sup
View details →DOI: 10.1017/anr.2024.25 Negative / Null Result ReportOpen accessPediatrics
Judy Ibrahim, Mohammad Alashqar, Shamma Al Zaabi et al. · 2021 · Case Reports in Pediatrics
Immune thrombocytopenia (ITP) is a disorder characterized by immune-mediated destruction of thrombocytes leading to peripheral blood platelet count of <100 × 10^9/L. Primary ITP is a terminology used in the absence of other causes or disorders that may be associated with thrombocytopenia, i.e., isolated thrombocytopenia. The term secondary ITP is used if such diseases coexist. We present here a case of a 14-year-old female diagnosed with immune thrombocytopenia. When her evaluation was not strongly supportive of primary ITP, she was screened and proved to have a concomitant Hashimoto thyroidit
View details →DOI: 10.1155/2021/6649155 Negative / Null Result ReportOpen accessPhysiology
Ryan M. Corrick, Huiyin Tu, Dongze Zhang et al. · 2018 · Frontiers in Physiology
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use of a tourniquet as an intervention is necessary for treatment to an injured limb; however, the tourniquet and subsequent release results in serious acute ischemia-reperfusion (IR) injury in the skeletal muscle and neuromuscular junction (NMJ). Much evidence demonstrates that inflammation is an important factor to cause acute IR injury. To find effective therapeutic interventions for tourniquet-induced acute IR injuries, our current study investigated effect of dexameth
View details →DOI: 10.3389/fphys.2018.00244 Negative / Null Result ReportOpen accessMedicine
Kyung-Hee Cho, Seol-Hee Baek, Sung-Hee Kim et al. · 2024 · The Journal of Headache and Pain
Abstract Background Currently, there is a relative lack of detailed reports regarding clinical presentation and outcome of idiopathic intracranial hypertension in Asians. This study aims to describe the clinical features and treatment outcomes of Korean patients with idiopathic intracranial hypertension. Methods We prospectively recruited patients with idiopathic intracranial hypertension from one hospital and retrospectively analyzed the medical records of 11 hospitals in Korea. We collected data regarding preceding medical conditions or suspected medication exposure, headache phenotypes, oth
View details →DOI: 10.1186/s10194-024-01794-3 Negative / Null Result ReportOpen accessPsychology
Liana eAmunts, Amit eYashar, Dominique eLamy · 2014 · Frontiers in Psychology
Visual search is considerably speeded when the target’s characteristics remain constant across successive selections. Here, we investigated whether such inter-trial priming increases the target’s attentional priority, by examining whether target repetition reduces search efficiency during serial search. As the study of inter-trial priming requires the target and distractors to exchange roles unpredictably, it has mostly been confined to singleton searches, which typically yield efficient search. We therefore resorted to two singleton searches known to yield relatively inefficient performance,
View details →DOI: 10.3389/fpsyg.2014.00957 Negative / Null Result ReportOpen accessAnimal culture
D.W. Liu, J.J. Zang, L. Liu et al. · 2014 · Czech Journal of Animal Science
Three experiments were conducted to compare raw corn, extruded corn, and dehulled-extruded corn in piglets' feeding. In Experiment (Exp.) 1, 8 barrows (19.9 ± 0.6 kg) were fed experimental diets containing one out of three corn samples and a rice-soybean meal basal diet in a double 4 × 4 Latin square design to determine the digestible energy (DE) and metabolizable energy (ME) in the corn samples using the difference method. The DE content in extruded (14.29 MJ/kg) and dehulled-extruded (14.42 MJ/kg) corn was greater (P < 0.05) than in raw corn (13.57 MJ/kg). In Exp. 2, 5 barrows (26.2 ± 1.3 kg
View details →DOI: 10.17221/7231-cjas Negative / Null Result ReportOpen accessAgriculture
Karin I. Köhl, Gedif Mulugeta Aneley, Manuela Haas et al. · 2021 · Agronomy
Potato is an important food crop with high water-use-efficiency but low drought tolerance. The bottleneck in drought tolerance breeding is phenotyping in managed field environments. Fundamental research on drought tolerance is predominantly done in container-based test systems in controlled environments. However, the portability of results from these systems to performance under field conditions is debated. Thus, we analyzed the effects of climate conditions, container size, starting material, and substrate on yield and drought tolerance assessment of potato genotypes compared to field trials.
View details →DOI: 10.3390/agronomy11050865 Negative / Null Result ReportOpen accessMedicine
Sonia Rekik, Hela Sahli, Khaoula Zouaoui et al. · 2022 · F1000Research
Background: Digital gangrene is a rare but serious complication of systemic lupus erythematosus (SLE). It occurs usually in middle-aged patients with longer disease duration. Case: Herein we report the case of a 56-year-old man (with no history suggestive of Raynaud’s phenomenon, diabetes mellitus, smoking, trauma, infection, or chemical exposure), who presented with SLE and digital gangrene was among the first signs. He presented with a one-month history of joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Physical examination revealed painful and d
View details →DOI: 10.12688/f1000research.124225.2 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
M. Oksman, H. Iivonen, E. Hogyes et al. · 2006 · Neurobiology of Disease
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginning at a young adult age (6 months). Hippocampal Aβ levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Aβ levels comp
View details →DOI: 10.1016/j.nbd.2006.04.013 Negative / Null Result ReportOpen accessMedicine
Edward C. Y. Liew, Maureen Phelan, Keith L. McDougall · 2023 · Scientific Reports
Abstract Phytophthora cinnamomi is an oomycete found in the soil and capable of invading the roots of a wide range of host plants globally, potentially killing them and affecting the ecosystems they inhabit. This pathogen is often inadvertently dispersed in natural vegetation on the footwear of humans. A range of equipment is often provided or recommended to be carried for cleaning footwear in places where P. cinnamomi poses a threat to biodiversity. These are typically a brush for mechanically removing soil and/or a disinfectant for killing the pathogen. Despite their widespread use, to our k
View details →DOI: 10.1038/s41598-023-32681-7 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Talia Golan, Ravit Geva, Donald Richards et al. · 2018 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Cachexia is a formidable clinical challenge in pancreatic cancer. We assessed LY2495655 (antimyostatin antibody) plus standard‐of‐care chemotherapy in pancreatic cancer using cachexia status as a stratifier. Methods In this randomized, phase 2 trial, patients with stage II–IV pancreatic cancer were randomized to 300 mg LY2495655, 100 mg LY2495655, or placebo, plus physician‐choice chemotherapy from a prespecified list of standard‐of‐care regimens for first and later lines of care. Investigational treatment was continued during second‐line treatment. The primary endpoint was
View details →DOI: 10.1002/jcsm.12331 Negative / Null Result ReportMedicine
Kute, Fujino, Centauri et al. · 2026 · Experimental and therapeutic medicine
Ultra-low anterior resection (ULAR) and total mesorectal excision (TME) are sphincter-preserving treatments for low rectal cancer. However, these techniques face challenges in patients with a narrow pelvis, particularly those with a high…
View details →DOI: 10.3892/etm.2026.13207 