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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19893 results in Negative / Null Result Report · page 551 of 664

Negative / Null Result ReportMedicine

Pharmacokinetics, pharmacodynamics, and radiomitigative efficacy of IEPA in a non-human primate model of acute radiation syndrome.

Wesolowski R, Asang C, Eibl M et al. · 2026 · International journal of radiation biology

Purpose The acute radiation syndrome (ARS) represents a significant public health threat following nuclear exposure, with limited available medical countermeasures (MCMs). Imidazolyl ethanamide pentandioic acid (IEPA), a novel orally…

View details →DOI: 10.1080/09553002.2026.2672477
Negative / Null Result ReportMedicine

[Translated article] Is one year follow-up sufficient to assess functional outcomes after rotator cuff repair?

Pasqualini I, Lucero Viviani N, Turan O et al. · 2026 · Revista espanola de cirugia ortopedica y traumatologia

Background Arthroscopic rotator cuff repair (ARCR) traditionally requires a 2-year follow-up to report results. However, most of the recovery occurs within the first year. The aim of this study was to determine if there are clinically…

View details →DOI: 10.1016/j.recot.2026.06.012
Negative / Null Result Report

Acceptability, Implementation Fidelity, and Preliminary Psychological Outcomes of a DBT- Informed Emotional Skills Program in a Secondary School: A Pre–Post Study Among Adolescents in Chile

Gaete J, Romo V, Contreras C et al. · 2026 · Preprint

Abstract Background School-based interventions grounded in evidence-based psychological approaches are increasingly used to promote adolescent mental health. Dialectical Behavior Therapy (DBT) skills training has shown promise; however,…

View details →DOI: 10.21203/rs.3.rs-9571403/v1
Negative / Null Result ReportOpen accessMedicine

IL-18 and MIG increase one year after transition to dolutegravir-based dual therapy despite sustained viral suppression.

Pérez-González A, Alonso-Domínguez J, Martínez-Barros I et al. · 2026 · Frontiers in immunology

Introduction Modern antiretroviral treatment allowed a significant improvement in the life expectancy of people with HIV (PWH), exhibiting robust and sustained efficacy with scarce toxicities, both in two-drug regimens (2DRs) and…

View details →DOI: 10.3389/fimmu.2026.1784890
Negative / Null Result ReportMedicine

Condylar Positional Changes Following Manual Proximal Segment Positioning During Bilateral Sagittal Split Ramus Osteotomy: A Cephalometric Study.

Tanrısever NC, Gökalp H · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Maintenance of condylar position during bilateral sagittal split ramus osteotomy (BSSRO) is important for preserving temporomandibular joint biomechanics and skeletal stability. During surgery, loss of muscle…

View details →DOI: 10.3390/medicina62061154
Negative / Null Result ReportMedicine

Efficacy of nonablative radiofrequency on sexual function in postmenopausal women: a randomized clinical trial.

Quezada-Bascuñán C, Ferri-Morales A, Martínez-Vizcaíno V et al. · 2026 · Menopause (New York, N.Y.)

Objective To evaluate the efficacy of nonablative capacitive-resistive monopolar radiofrequency on sexual function and vaginal health in postmenopausal women with genitourinary syndrome of menopause. Methods This was a single-blind,…

View details →DOI: 10.1097/gme.0000000000002743
Negative / Null Result ReportMedicine

Multiple switches between infliximab originator and biosimilars in pediatric inflammatory bowel disease.

De Groote S, Hoeve KV, Dreesen E et al. · 2026 · Journal of pediatric gastroenterology and nutrition

Objectives Infliximab (IFX) is highly effective but costly, driving the adoption of biosimilars. Data on switching from originator IFX to biosimilars in pediatric inflammatory bowel disease (IBD) patients remain limited. This study…

View details →DOI: 10.1002/jpn3.70483
Negative / Null Result ReportOpen accessMedicine

Effect of <i>Bacillus coagulans</i> DSM 32016 (TechnoSpore<sup>®</sup>) Supplementation on Growth Performance and Selected Blood Parameters and Serum Urea in Weaning Danube White Pigs.

Eneva K, Yordanova G, Petrova M et al. · 2026 · Life (Basel, Switzerland)

The present study evaluated the effects of dietary supplementation with Bacillus coagulans DSM 32016 on growth performance, hematological and biochemical parameters, and nitrogen metabolism in weaned Danube White pigs reared under standard…

View details →DOI: 10.3390/life16050715
Negative / Null Result ReportMedicine

Longitudinal Changes in Neutrophil-to-Lymphocyte and Monocyte-to-Lymphocyte Ratios During Multiple Sclerosis Relapse.

Konieczna M, Puz P, Gałuszewski M et al. · 2026 · Journal of clinical medicine

Background: The neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) reflect the balance between innate and adaptive immunity and may indicate systemic inflammation. Objectives: To evaluate longitudinal changes in…

View details →DOI: 10.3390/jcm15124539
Negative / Null Result ReportOpen accessMedicine

Salivary responses to an experimental activation of the HPA axis in pigs: Effects of ACTH on analytes related to stress, immune system, inflammation, redox status and metabolism.

Botía M, Cerón JJ, Martínez-Subiela S et al. · 2026 · Veterinary and animal science

Non-invasive biomarkers are essential for assessing stress and welfare. Saliva is a suitable sample type because it can reflect endocrine, immune, inflammatory and redox responses without causing stress from handling. This study examined…

View details →DOI: 10.1016/j.vas.2026.100650
Negative / Null Result ReportMedicine

No evidence for depletion of circulating lymphocyte populations in primary brain tumor patients receiving radiotherapy alone.

Beekman C, Morita S, Neibart S et al. · 2026 · International journal of radiation oncology, biology, physics

Purpose To investigate the impact of radiotherapy (RT) for brain tumors on circulating lymphocyte populations and understand this from a dosimetric perspective. Methods This prospective study enrolled primary brain tumor patients treated…

View details →DOI: 10.1016/j.ijrobp.2026.05.051
Negative / Null Result ReportMedicine

Comparison of the Effects of Incubator and Radiant Environments on Physiological Criteria and Pain-Stress Levels during Heel Lance in Neonates in the Neonatal Intensive Care Unit: A Randomized Controlled Trial.

Gürsu S, Saydam BK, Kalkanlı O · 2026 · Saudi medical journal

Objectives To compare the effects of incubator and radiant heat on physiological criteria and pain-stress levels during heel prick procedures in newborns in the neonatal intensive care unit (NICU). Methods This randomized controlled…

View details →DOI: 10.15537/1658-3175.8806
Negative / Null Result ReportOpen accessMedicine

Impact of Synbiotics Intake on Body-Composition-Related Indicators and Physical Performance in Judokas Before the Match.

Yoshikawa T, Yokoyama Y, Kuno T et al. · 2026 · Nutrients

Background/Objectives: This study aimed to investigate the effects of synbiotics intake on body-composition-related indicators and physical performance in judokas from 4 weeks to 3 days before the match. The associations between the…

View details →DOI: 10.3390/nu18101503
Negative / Null Result ReportMedicine

Serum and synovial lactate dehydrogenase levels after allogeneic mesenchymal stem cell implantation in rabbit cartilage defects.

Anatolitou A, Mavrogenis AF, Sideri KI et al. · 2026 · Polish journal of veterinary sciences

Cartilage defects have limited regenerative potential and remain a significant clinical challenge. Mesenchymal stem cell (MSC) therapy offers promise in tissue engineering, yet monitoringpost-implantation responses remains difficult.…

View details →DOI: 10.24425/pjvs.2026.1266
Negative / Null Result ReportMedicine

Postoperative nutritional risk following bariatric surgery: a comparative evaluation of the Naples Prognostic Score, PNI, and CONUT score.

Arslan K, Baş S, Temizel M et al. · 2026 · Nutricion hospitalaria

Objective this study aimed to assess and compare nutritional status in patients undergoing sleeve gastrectomy using the Naples Prognostic Score, PNI, and CONUT indices, with the objective of facilitating early identification of…

View details →DOI: 10.20960/nh.06714
Negative / Null Result ReportMedicine

Assessing the effects of high concentration of pure Cry proteins exposure on the Eisenia fetida by allying transcriptome analysis with toxicological evaluation.

He M, Huang Z, Pooe OJ et al. · 2026 · Ecotoxicology (London, England)

Most of eco-toxicity studies of Bacillus thuringiensis (Bt) proteins on terrestrial organism were conducted with Bt-crops straw or leaves on earthworm Eisenia fetida. Nevertheless, extra nutrition from straw or leaves degradation affected…

View details →DOI: 10.1007/s10646-026-03031-w
Negative / Null Result ReportMedicine

Efficacy of a nurse-led frailty prevention program on frailty reduction and functional health improvement in community-dwelling older adults in Taiwan: a quasi-experimental longitudinal study.

Lin CH, Liu MY · 2026 · Geriatric nursing (New York, N.Y.)

Objectives Frailty negatively impacts quality of life and increases pressure on healthcare systems. This study aimed to evaluate the effects of a nurse-led Frailty Prevention Care Management Program (FPCMP-Old Age), based on the Chronic…

View details →DOI: 10.1016/j.gerinurse.2026.104102
Negative / Null Result ReportOpen accessMedicine

Effect of Moderate-to-High-Intensity Interval Aerobic Exercise on Clinical Symptoms During the Menstrual Cycle: A Pilot Randomized Controlled Trial.

Pio-Soria A, Zahran D, Roldán-Ruiz A · 2025 · Healthcare (Basel, Switzerland)

Introduction Primary dysmenorrhea is one of the most prevalent gynecological disorders. It has been shown to negatively impact quality of life and overall wellbeing, as recent studies have associated stress and physical inactivity with…

View details →DOI: 10.3390/healthcare13233113
Negative / Null Result ReportMedicine

Effects of acute ebselen add-on treatment on resting state function connectivity in depressed patients with inadequate response to antidepressants.

Ramli FF, Villa LM, Martens MAG et al. · 2026 · Scientific reports

Ebselen has been shown to induce a positive emotional processing bias and brain neurochemistry in healthy volunteers. However, little is known about its effects on resting-state functional connectivity (rs-FC) in depressed patients who…

View details →DOI: 10.1038/s41598-026-58393-2
Negative / Null Result ReportMedicine

Autonomic Nervous System Response to Intermittent Theta-Burst Transcranial Magnetic Stimulation in Those With Major Depressive Disorder​​​: A Randomized Sham-Controlled Comparison of Heart Rate Variability and Pupillary Light Reflex.

Sharma M, McCall WV, Rosenquist PB · 2026 · The journal of ECT

Objectives To examine the acute and longitudinal effects of repetitive transcranial magnetic stimulation (rTMS) on-autonomic nervous system measures (ANS)-heart rate variability (HRV) and pupillary light reflex (PLR)-in adults with major…

View details →DOI: 10.1097/yct.0000000000001271
Negative / Null Result ReportMedicine

The relationship between erythrocyte transfusion in very preterm infants and inflammatory cytokines and morbidities: a prospective observational study.

Osmanova F, Bulbul A, Bas EK et al. · 2026 · BMC pediatrics

Background It is essential to assess not only the hematologic outcomes but also the immunologic and inflammatory consequences of RBC transfusion in preterm infants. Aims This study aimed to evaluate changes in serum cytokine levels…

View details →DOI: 10.1186/s12887-026-07193-8
Negative / Null Result Report

Differential Effects of Cultural Performing Arts on Anti-Aging Biomarkers and Well-Being: A Non- Randomized Pre–Post Comparative Study of Traditional Noh/Kyogen and Comedy

Tomisawa T, Nanashima N, In N et al. · 2026 · Preprint

Abstract This study examined how cultural performing arts affect psychological well-being and stress-related biomarkers, comparing traditional Japanese Noh and Kyogen (TNKP) with live comedy (CLP). Participants aged 18–64 years were…

View details →DOI: 10.21203/rs.3.rs-9490822/v1
Negative / Null Result ReportMedicine

Echoes of the pandemic: Patterns in youth suicide risk screening in an urban emergency department.

Vidal C, Prichett L, Yang A et al. · 2026 · The American journal of emergency medicine

Objective Youth suicide rates have increased over the last three decades, translating into an increase in related pediatric emergency department (ED) visit demands. However, these trends shifted during the pandemic. We describe demographic…

View details →DOI: 10.1016/j.ajem.2026.06.015
Negative / Null Result ReportOpen accessMedicine

Obesity simulation suits in health professions education: a scoping review.

Steinacker AC, Bischof L, Herchet D et al. · 2026 · BMC medical education

Background Weight-related stigma toward people living with obesity is widespread in healthcare settings and has been documented among students and professionals across health disciplines. Such stigma may negatively affect communication,…

View details →DOI: 10.1186/s12909-026-09565-1
Negative / Null Result ReportMedicine

[Weight change following a self-selected, type-tailored lifestyle modification program for employees with suspected visceral fat accumulation: A single-arm before-after study].

Hari S, Kumamoto M, Suzuki M et al. · 2026 · Sangyo eiseigaku zasshi = Journal of occupational health

Objectives This single-arm before-after study examined short-term changes in body weight following a 28-day self-selected, type-tailored lifestyle modification program implemented before workplace health checkups. Participants…

View details →DOI: 10.1539/sangyoeisei.2026-008-b