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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 512 of 663

Negative / Null Result ReportOpen accessMedicine

Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study.

Ryou S, Jung Y, Kim DS et al. · 2026 · The Korean journal of internal medicine

Background/aims Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR…

View details →DOI: 10.3904/kjim.2025.234
Negative / Null Result ReportMedicine

Effect of Mn²⁺ levels on caproic acid production during anaerobic fermentation using ethanol and butyric acid as co-substrates.

Liu L, Shen Y, Yang S et al. · 2026 · Journal of biotechnology

As an enzyme cofactor, antioxidant, and stabilizer of cellular structures, Mn²⁺is essential for microbial growth, metabolism, and environmental adaptation. In this work, the impact of varying Mn²⁺ levels on caproic acid formation and…

View details →DOI: 10.1016/j.jbiotec.2026.04.025
Negative / Null Result ReportMedicine

Comparison of different scoring systems for prediction of postoperative complications after robot-assisted radical prostatectomy.

Yilmaz AB, Karimzada K, Ozercan AY et al. · 2025 · Journal of robotic surgery

To evaluate the predictive value of the Estimation of Physiologic Ability and Surgical Stress (E-PASS) score, Comorbidity Score for Robotic Surgery (CRS) and Charlson Comorbidity Index (CCI) in relation to postoperative complications in…

View details →DOI: 10.1007/s11701-025-02406-1
Negative / Null Result ReportOpen accessMedicine

Revisiting Eysenck: The Association Between Personality and Acute Stress Reactivity.

Marshall MJ, Peck K, Hunter R et al. · 2024 · Behavioral sciences (Basel, Switzerland)

Eysenck's biopsychological model of stress posits that the extraversion-introversion distinction is associated with different thresholds of arousal, which in turn moderate the stress response. Although higher thresholds of activation have…

View details →DOI: 10.3390/bs14111098
Negative / Null Result Report

An Atypical Manifestation of Giant Cell Arteritis (GCA): Constitutional Symptoms & Lingual Ulcer in a 78-Year-Old Male with Negative Temporal Artery Biopsies

Gow J, Roofeh D · 2025 · Preprint

Abstract Background: Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features…

View details →DOI: 10.21203/rs.3.rs-5860997/v1
Negative / Null Result ReportMedicine

[Hydroxyurea-resistant primary erythrocytosis in a juvenile mixed-breed bitch].

Graf J, Buder A · 2025 · Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere

Primary erythrocytosis, also known as polycythemia vera, is a myoproliferative disease resulting in an increased red blood cell mass and is associated with increased hematocrit and hemoglobin concentrations. Patients have an augmented risk…

View details →DOI: 10.1055/a-2471-6729
Negative / Null Result ReportMedicine

Neoadjuvant chemoradiation and surgical excision versus definitive radiotherapy for locally advanced cervix uteri carcinoma: in terms of early and late complications and locoregional recurrence.

Khalifa H, Ayaty M, Oreaba R et al. · 2025 · Journal of the Egyptian National Cancer Institute

Objectives Following external beam radiation therapy (EBRT) with concurrent chemotherapy, we analyzed the benefits of surgical resection for locally advanced cervical carcinoma in terms of the frequency and severity of complications and…

View details →DOI: 10.1186/s43046-025-00292-0
Negative / Null Result ReportMedicine

[Comparison of the modified Kadish, AJCC T and Dulguerov T staging systems for olfactory neuroblastoma: analysis of the SEER database].

Lyu HH, Wen X, Lin JT et al. · 2025 · Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

Objective: To compare the Kadish T staging, AJCC T staging, and Dulguerov T staging system in terms of their impact on surgical treatment selection and survival prognosis in patients with olfactory neuroblastoma (ONB). Methods: The cases…

View details →DOI: 10.3760/cma.j.cn115330-20240723-00438
Negative / Null Result ReportMedicine

Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss After COVID-19 Vaccine in Asian Population: A Preliminary Study.

Chen PY, Young TC, Lin CY et al. · 2025 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To determine the hearing outcomes in patients with sudden sensorineural hearing loss (SSNHL) after exposure to different brands of vaccines against COVID-19. Study design Cohort study. Setting Tertiary referral center. Patients…

View details →DOI: 10.1097/mao.0000000000004509
Negative / Null Result ReportMedicine

Effects of different positive end-expiratory pressure strategies on treating overweight patients with acute respiratory distress syndrome: A retrospective study based on large intensive care unit databases.

Zheng X, Zhang T, Zhan T et al. · 2025 · Respiratory medicine

Purpose Positive end-expiratory pressure (PEEP) refers to a vital respiratory therapeutic tool for treating ARDS. Since overweight individuals face a greater risk of pulmonary complications than others, this study aims to assess whether…

View details →DOI: 10.1016/j.rmed.2025.108093
Negative / Null Result ReportMedicine

Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of hypertriglyceridaemia-induced acute pancreatitis.

Syed-Abdul MM, Tian L, Hegele RA et al. · 2025 · The lancet. Diabetes & endocrinology

There is a well-established link between the severity of hypertriglyceridaemia and acute pancreatitis and long-term triglyceride-lowering therapies known to prevent episodes of acute pancreatitis. Therefore, it has been assumed, without…

View details →DOI: 10.1016/s2213-8587(25)00028-2
Negative / Null Result Report

The Autoimmune March: Bullous lichen planus and new-onset lupus erythematosus associated with COVID-19 mRNA vaccine in a Filipino female with rheumatoid arthritis

Gonzalez PA, Zamora-Abrahan G, Roa F et al. · 2024 · Preprint

Background: A 32-year-old Filipino female with rheumatoid arthritis and lichen planus of low activity was admitted following a five-week period of painful oral mucosal and cutaneous bullae and erosions over her prior lichen planus lesions…

View details →DOI: 10.22541/au.172880901.19591056/v1
Negative / Null Result ReportMedicine

Therapy resistant hypertrophic lichen planus and its response to oral tofacitinib with a priori tissue cytokine expression: a real-world hospital-based study.

Sharath S, Sardana K, Khurana A et al. · 2025 · Archives of dermatological research

Background Although there are several reports on use of tofacitinib in lichen planus (LP), its usage in hypertrophic LP is sparse with no data on tissue cytokine expression. Methods We retrospectively analyzed the records of recalcitrant…

View details →DOI: 10.1007/s00403-025-04088-z
Negative / Null Result ReportOpen accessMedicine

Refractory severe aplastic anemia in a child: treatment failure and access barriers in a low-resource setting.

Karaki Z, Chemaly C, Kotaich J et al. · 2025 · Annals of medicine and surgery (2012)

Introduction and importance Aplastic anemia (AA) is a rare but potentially fatal hematologic disorder in children, marked by bone marrow failure and pancytopenia. Early diagnosis and access to curative treatment such as hematopoietic stem…

View details →DOI: 10.1097/ms9.0000000000004007
Negative / Null Result ReportOpen accessMedicine

Development of Machine Learning Models to Predict Daily Gas Ebullition Flux in Waterways from Sediment Characteristics.

Mansouri M, Rockne KJ · 2026 · ACS environmental Au

Gas ebullition plays a critical role in facilitating contaminant transport from the sediment to the water column. Predicting gas ebullition accurately is necessary for managing sediments and assessing sediment/water flux, and many…

View details →DOI: 10.1021/acsenvironau.5c00221
Negative / Null Result ReportMedicine

Endovascular management of carotid blowout syndrome.

Nas OF, Kandemirli SG, Korkmaz B et al. · 2025 · Neurological research

Objectives To evaluate success, complications and efficacy for endovascular management for carotid blowout syndrome. Methods Images were evaluated for contrast extravasation, vessel wall irregularity, pseudoaneurysm/aneurysm formation.…

View details →DOI: 10.1080/01616412.2024.2448635
Negative / Null Result ReportMedicine

Continuous ropivacaine wound infiltration versus epidural morphine after unplanned caesarean delivery: A noninferiority randomised controlled study.

Bruillot M, Pieper A, Sourd D et al. · 2025 · European journal of anaesthesiology

Background Treatment programs designed to enhance recovery after caesarean delivery include multimodal analgesia to ensure optimal analgesia while reducing exposure to systemic opioids. Evidence for the effectiveness of continuous wound…

View details →DOI: 10.1097/eja.0000000000002135
Negative / Null Result ReportMedicine

Comparison of post-stroke white matter assessment using disconnectome-symptom mapping versus quantitative diffusion MRI.

Domin M, Liew SL, Hordacre B et al. · 2025 · NeuroImage

Indirect structural disconnection-symptom mapping allows white matter impairment to be determined without the need for multi-directional diffusion (MDDW) imaging for each individual. Although widely used this method has not been validated.…

View details →DOI: 10.1016/j.neuroimage.2025.121347
Negative / Null Result ReportOpen accessMedicine

Multimodal Analgesia for Cardiothoracic Procedures: Nonpharmacological and Alternative Pain Management Techniques: Part 2.

Bhatt HV, Patel D, Rogando D et al. · 2025 · Annals of cardiac anaesthesia

Although thoracic epidural analgesia and paravertebral blocks have well-documented benefits in cardiac surgery, the theoretical risk of neuraxial hematoma in anticoagulated patients limits their use. Fascial plane blocks are recently…

View details →DOI: 10.4103/aca.aca_216_24
Negative / Null Result ReportOpen accessMedicine

Congee Containing Carotenoids-Enriched Functional Ingredient from Tomato Improves Cognition, Serum α-Synuclein, Monoaminergic Function, and Gut-Brain Axis Functions in the Elderly Volunteers.

Wattanathorn J, Muchimapura S, Thukham-Mee W et al. · 2025 · Life (Basel, Switzerland)

Owing to the need for a brain supplement targeting neuroprotection against age-related brain disorders and the known effect of carotenoids on brain function, we aimed to assess the effect of consuming carotenoid-rich functional congee for…

View details →DOI: 10.3390/life15071093
Negative / Null Result ReportMedicine

Inadequate consumption of dietary fatty acids is a risk factor for ovarian cancer: evidence from the prostate, lung, colorectal, and ovarian cancer screening trial.

Lao J, Wei Y, Liu F et al. · 2025 · European journal of nutrition

Purpose Currently, there is controversy surrounding the association between dietary fatty acids (FAs) and ovarian cancer (OC) risk. We aimed to elucidate the aforementioned topic using data from a large cohort. Methods Women participating…

View details →DOI: 10.1007/s00394-025-03650-9
Negative / Null Result Report

Dynamic risk and protective factors in mentally disordered offenders: forensic psychiatry treatment monitoring, prison release and length of stay

Weber K, Magnenat L, Morier S et al. · 2024 · Preprint

Abstract Background The reduction of violence risk and crime recidivism is the core marker of progress in forensic psychiatry treatment for mentally disordered offenders, and commonly used to decide prison release. While dynamic risk is…

View details →DOI: 10.21203/rs.3.rs-5296154/v1
Negative / Null Result ReportMedicine

The Effect of External Distractions on Simulated Laparoscopic Performance.

Ingram I, Hughes MA · 2024 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background: Surgeons are exposed to unavoidable distractions while operating. Distractions can cause stress, and stress can impair cognition and motor skills to the detriment of surgeon performance. This study assessed the impact of…

View details →DOI: 10.1089/lap.2024.0280
Negative / Null Result ReportOpen accessMedicine

Inflammation in atherosclerosis: a Big Idea that has underperformed so far.

Williams KJ · 2025 · Current opinion in lipidology

Purpose of review For many years, inflammation has been a major concept in basic research on atherosclerosis and in the development of potential diagnostic tools and treatments. The purpose of this review is to assess the performance of…

View details →DOI: 10.1097/mol.0000000000000973