Challenges and strategies in the soluble expression of CTA1-(S14P5)4-DD and CTA1-(S21P2)4-DD fusion proteins as candidates for COVID-19 intranasal vaccines.
Simson Tarigan; Gita Sekarmila; Apas; Sumarningsih; Ronald Tarigan; Riyandini Putri; Damai Ria Setyawati · 2024 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Developing intranasal vaccines against pandemics and devastating airborne infectious diseases is imperative. The superiority of intranasal vaccines over injectable systemic vaccines is evident, but developing effective intranasal vaccines presents significant challenges. Fusing a protein antigen with the catalytic domain of cholera toxin (CTA1) and the two-domain D of staphylococcal protein A (DD) has significant potential for intranasal vaccines. In this study, we constructed two fusion proteins containing CTA1, tandem repeat linear epitopes of the SARS-CoV-2 spike protein (S14P5 or S21P2), a
Abstract by Simson Tarigan; Gita Sekarmila; Apas; Sumarningsih; Ronald Tarigan; Riyandini Putri; Damai Ria Setyawati, PLoS ONE (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0306153