A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19735 results in Negative / Null Result Report · page 5 of 658
Mary E. Tinetti, Ling Han, David S. H. Lee et al. · 2014 · JAMA Internal Medicine
IMPORTANCE The effect of serious injuries, such as hip fracture and head injury, on mortality and function is comparable to that of cardiovascular events. Concerns have been raised about the risk of fall injuries in older adults taking…
MVE Veenendaal, R.C. Painter, Susanne R. de Rooij et al. · 2013 · BJOG An International Journal of Obstetrics & Gynaecology
OBJECTIVE: We previously showed that maternal under-nutrition during gestation is associated with increased metabolic and cardiovascular disease in the offspring. Also, we found increased neonatal adiposity among the grandchildren of women…
Natalie Hofmann, Felista Mwingira, Seif Shekalaghe et al. · 2015 · PLoS Medicine
BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be identified by surveillance with molecular methods, yet these infections also contribute to onward transmission to mosquitoes. The sensitivity of molecular detection by PCR is limited by the abundance of the target sequence in a DNA sample; thus, detection becomes imperfect at low densities. We aimed to increase PCR diagnostic sensitivity by targeting multi-copy genomic sequences for reliable det
David E. Harrison, Randy Strong, David B. Allison et al. · 2013 · Aging Cell
Four agents--acarbose (ACA), 17-α-estradiol (EST), nordihydroguaiaretic acid (NDGA), and methylene blue (MB)--were evaluated for lifespan effects in genetically heterogeneous mice tested at three sites. Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lifespan by only 5% (P = 0.01). This sexual dimorphism in ACA lifespan effect could not be explained by differences in effects on weight. Maximum lifespan (90th percentile) increased 11% (P < 0.001) in males and 9% (P = 0.001) in females. EST increased male median lifespan by 12% (P = 0.002), but did not le
Amir Englund, Paul D. Morrison, Judith Nottage et al. · 2012 · Journal of Psychopharmacology
Community-based studies suggest that cannabis products that are high in Δ⁹-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue…
Nabil Tamimi, Rose Sebastianelli · 2017 · Management Decision
Purpose The purpose of this paper is to explore the state of S&P 500 companies’ transparency by analyzing their Bloomberg ESG (Environmental-Social-Governance) disclosure scores. Additionally, the effects of industry sector, firm size,…
Michael G. Branstetter, Bryan N. Danforth, James P. Pitts et al. · 2017 · Current Biology
The stinging wasps (Hymenoptera: Aculeata) are an extremely diverse lineage of hymenopteran insects, encompassing over 70,000 described species and a diversity of life history traits, including ectoparasitism, cleptoparasitism, predation, pollen feeding (bees [Anthophila] and Masarinae), and eusociality (social vespid wasps, ants, and some bees) [1]. The most well-studied lineages of Aculeata are the ants, which are ecologically dominant in most terrestrial ecosystems [2], and the bees, the most important lineage of angiosperm-pollinating insects [3]. Establishing the phylogenetic affinities o
Bradley C. Leibovich, Christine M. Lohse, Paul L. Crispen et al. · 2010 · The Journal of Urology
PURPOSE: There are significant differences in clinicopathological features among renal cell carcinoma histological subtypes but controversy exists regarding the independent impact of histological subtype on patient outcome after…
Luigi Angelo Vaira, Giovanna Deiana, Alessandro Giuseppe Fois et al. · 2020 · Head & Neck
BACKGROUND: The first European case series are detecting a very high frequency of chemosensitive disorders in COVID-19 patients, ranging between 19.4% and 88%. METHODS: Olfactory and gustatory function was objectively tested in 72 COVID-19…
Larelle Chapple, Peter Clarkson, Daniel L. Gold · 2013 · Abacus
In M arch 2008, the A ustralian Government announced its intention to introduce a national Emissions Trading Scheme ( ETS ), now expected to start in 2015. This impending development provides an ideal setting to investigate the impact an…
Luis E. Escobar, Alvaro Molina-Cruz, Carolina Barillas‐Mury · 2020 · Proceedings of the National Academy of Sciences
Significance The COVID-19 pandemic is one of the most devastating in recent history. The bacillus Calmette−Guérin (BCG) vaccine against tuberculosis also confers broad protection against other infectious diseases, and it has been proposed that it could reduce the severity of COVID-19. This epidemiological study assessed the global linkage between BCG vaccination and COVID-19 mortality. Signals of BCG vaccination effect on COVID-19 mortality are influenced by social, economic, and demographic differences between countries. After mitigating multiple confounding factors, several significant assoc
US Preventive Services Task Force, Douglas K Owens, Karina W. Davidson et al. · 2019 · JAMA
Importance: Potentially harmful mutations of the breast cancer susceptibility 1 and 2 genes (BRCA1/2) are associated with increased risk for breast, ovarian, fallopian tube, and peritoneal cancer. For women in the United States, breast…
Hadi Zokaeifar, José Luís Balcázar, Che Roos Saad et al. · 2012 · Fish & Shellfish Immunology
We studied the effect of two probiotic Bacillus subtilis strains on the growth performance, digestive enzyme activity, immune gene expression and disease resistance of juvenile white shrimp (Litopenaeus vannamei). A mixture of two…
Jiaxiu He, Haoming Liu, Alberto Salvo · 2019 · American Economic Journal Applied Economics
We examine day-to-day fluctuations in worker-level output at two manufacturing sites in China. Ambient fine-particle (PM2.5) pollution is severe but significantly variable, largely due to exogenous atmospheric ventilation. We obtain an…
Dan Frampton, Tommy Rampling, Aidan Cross et al. · 2021 · The Lancet Infectious Diseases
BACKGROUND: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of…
Nitin Shivappa, James R. Hébert, Ernst Rietzschel et al. · 2015 · British Journal Of Nutrition
Previous research has shown that nutrients and certain food items influence inflammation. However, little is known about the associations between diet, as a whole, and inflammatory markers. In the present study, we examined the ability of…
Silvana Galderisi, Alessandro Rossi, Paola Rocca et al. · 2014 · World Psychiatry
In people suffering from schizophrenia, major areas of everyday life are impaired, including independent living, productive activities and social relationships. Enhanced understanding of factors that hinder real-life functioning is vital…
Michelle L. O’Donoghue, Eugene Braunwald, Harvey D. White et al. · 2014 · JAMA
IMPORTANCE: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been hypothesized to be involved in atherogenesis through pathways related to inflammation. Darapladib is an oral, selective inhibitor of the Lp-PLA2 enzyme. OBJECTIVE: To…
Lei Wu, Lin Liu, Bin Gao et al. · 2013 · Langmuir
Although graphene oxide (GO) has been used in many applications to improve human life quality, its environmental fate and behavior are still largely unknown. In this work, a novel approach that combines experimental measurements and…
Silvana Tenreyro, Gregory Thwaites · 2013
We estimate the impulse response of key US macro series to the monetary policy shocks identified by Romer and Romer (2004), allowing the response to depend flexibly on the state of the business cycle. We find strong evidence that the…
Charlotte J. Stagg, Gowri Jayaram, Damien Pastor et al. · 2011 · Neuropsychologia
Transcranial direct current stimulation (tDCS) is attracting increasing interest as a therapeutic tool for neurorehabilitation, particularly after stroke, because of its potential to modulate local excitability and therefore promote functional plasticity. Previous studies suggest that timing is important in determining the behavioural effects of brain stimulation. Regulatory metaplastic mechanisms exist to modulate the effects of a stimulation intervention in a manner dependent on prior cortical excitability, thereby preventing destabilization of existing cortical networks. The importance of s
Sarah R. Preis, Joseph M. Massaro, Udo Hoffmann et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
BACKGROUND: Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat. METHODS AND RESULTS: Participants with neck circumference measures who…
Elhadi Adam, Onisimo Mutanga, John Odindi et al. · 2014 · International Journal of Remote Sensing
Mapping of patterns and spatial distribution of land-use/cover (LULC) has long been based on remotely sensed data. In the recent past, efforts to improve the reliability of LULC maps have seen a proliferation of image classification…
Sèverine Sabia, Aline Dugravot, Jean‐François Dartigues et al. · 2017 · BMJ
This study found no evidence of a neuroprotective effect of physical activity. Previous findings showing a lower risk of dementia in physically active people may be attributable to reverse causation-that is, due to a decline in physical activity levels in the preclinical phase of dementia.
Niklas Potrafke · 2014 · World Economy
Abstract Globalisation is blamed for many socioeconomic shortcomings. I discuss the consequences of globalisation by surveying the empirical globalisation literature. My focus is on the KOF indices of globalisation that have been used in…
Almudena Marí Sáez, Sabrina Weiß, Kathrin Nowak et al. · 2014 · EMBO Molecular Medicine
The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2-year-old boy in Meliandou, Guinea. We investigated the zoonotic origins of the epidemic using wildlife surveys, interviews, and molecular analyses of bat and environmental samples. We found no evidence for a concurrent outbreak in larger wildlife. Exposure to fruit bats is common in the region, but the index case may have been infected by playing in a hollow tree housing a colony of insectivorous free-tailed bats (Mops condylurus). Bats in this family have previously been dis
Peter de Barros Damgaard, Rui Martiniano, Jack Kamm et al. · 2018 · Science
The Yamnaya expansions from the western steppe into Europe and Asia during the Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages and possibly horse husbandry. We analyzed 74 ancient whole-genome…
Kevin Gross, Bradley J. Cardinale, Jeremy W. Fox et al. · 2013 · The American Naturalist
The relationship between biological diversity and ecological stability has fascinated ecologists for decades. Determining the generality of this relationship, and discovering the mechanisms that underlie it, are vitally important for…
Melinda C. Power, Marc G. Weisskopf, Stacey Alexeeff et al. · 2010 · Environmental Health Perspectives
BACKGROUND: Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment. OBJECTIVE: We assessed the association between black carbon (BC), a marker of traffic-related air pollution, and cognition in older men. METHODS: A total of 680 men (mean ± SD, 71 ± 7 years of age) from the U.S. Department of Veterans Affairs Normative Aging Study completed a battery of seven cognitive tests at least once between 1996 and 2007. We assessed long-term exposure to traffic-related air pollution using a validat
Thomas J. Lynch, Taral Patel, Luke Dreisbach et al. · 2010 · Journal of Clinical Oncology
PURPOSE To evaluate the efficacy of cetuximab plus taxane/carboplatin (TC) as first-line treatment of advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS This multicenter, open-label, phase III study enrolled 676…