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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 489 of 676

Negative / Null Result ReportMedicine

Maternal Mediterranean Diet during Pregnancy and Adiposity from Early Childhood through Preadolescence.

Gonzalez-Nahm S, Griffith E, Maguire RL et al. · 2026 · Childhood obesity (Print)

Objective To assess the longitudinal associations between maternal diet during pregnancy and child adiposity between ages 2 and 12 years. Methods Repeated measures linear regression models with autoregressive covariance were used to assess…

View details →DOI: 10.1177/21532176261420979
Negative / Null Result ReportOpen accessMedicine

Examining valproate's potential anticancer effect among patients with bipolar disorder: a territory-wide active-comparator new user study spanning two decades.

Wei C, Ng VWS, Wei Y et al. · 2025 · BMC psychiatry

AIMS: Preclinical studies have suggested potential anticancer effects of valproate, but clinical evidence is limited and inconclusive. This study aims to reexamine the relationship between valproate use and cancer incidence, using lithium…

View details →DOI: 10.1186/s12888-025-07622-5
Negative / Null Result ReportOpen accessMedicine

Glucagon-like Peptide-1 Receptor Agonists and Colorectal Cancer Risk.

Winkelman JW, Levine MJ · 2026 · AACE endocrinology and diabetes

Type 2 diabetes mellitus is a highly prevalent metabolic disorder and a well-established risk factor for colorectal cancer (CRC), mediated by hyperglycemia, hyperinsulinemia, chronic inflammation, and obesity-related metabolic dysfunction.…

View details →DOI: 10.1016/j.aed.2026.02.013
Negative / Null Result ReportOpen accessMedicine

Conformity to social norm interventions is not amplified in tighter nations.

Acierno J, Tedaldi E, Ginn J et al. · 2026 · Communications psychology

Social norms have a reliable and oftentimes strong influence on individual attitudes and behaviors across environmental and other domains. This influence has been theorized to differ by cultural tightness-the extent to which people adhere…

View details →DOI: 10.1038/s44271-026-00429-4
Negative / Null Result ReportMedicine

Cash transfers and mental health in Egypt.

El-Enbaby H, Hollingsworth B, Maystadt JF et al. · 2024 · Economics and human biology

The relationship between poverty and mental health is complex. Conditional cash transfers are seen as an important policy tool in reducing poverty and fostering social protection. Evidence on the impact of cash transfers on mental health…

View details →DOI: 10.1016/j.ehb.2024.101396
Negative / Null Result ReportOpen accessMedicine

Failure to detect entorhinal grid-like signals in a passive navigation human fMRI study.

Kransberg J, Sjøli Bråthen AC, Falch ES et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Grid cells in the human entorhinal cortex (EC) play a critical role in spatial navigation and memory. The EC is also one of the first regions affected by ageing and Alzheimer's disease. This pre-registered functional magnetic resonance…

View details →DOI: 10.1162/imag.a.1196
Negative / Null Result ReportOpen accessMedicine

Exploring the impact of a medication adherence intervention on recovery and mental health outcomes: A secondary analysis of the MAT-PLUS pilot RCT.

Wenzel K, Thomas J, Carrano J et al. · 2025 · Drug and alcohol dependence reports

Substance use disorders (SUDs) including opioid use disorder (OUD) and alcohol use disorder (AUD) contribute to significant morbidity and mortality in the United States. Pharmacotherapy treatment, including extended-release naltrexone…

View details →DOI: 10.1016/j.dadr.2025.100346
Negative / Null Result ReportOpen accessMedicine

Neonatal vitamin D status and asthma risk after age 5 years: A Danish population-based cohort study.

Liu X, Zhu Z, Chawes B et al. · 2026 · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

Background Vitamin D may play a role in early lung development, yet epidemiologic evidence on its association with later asthma risk is mixed. We aimed to investigate the associations of neonatal 25-hydroxyvitamin D (25(OH)D) and vitamin…

View details →DOI: 10.1111/pai.70299
Negative / Null Result ReportOpen accessMedicine

Can we refute a role for infections in Alzheimer's disease pathogenesis?

Chatila ZK, Duggan MR, Silberberg E et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association

While a growing body of literature suggests a role for infections in Alzheimer's disease (AD), microbial contributions to AD remains a contentious topic, in part due to challenges in reconciling the positive evidence with studies reporting…

View details →DOI: 10.1002/alz.71288
Negative / Null Result ReportMedicine

Secondhand smoke exposure and resting heart rate in young US adults: analysis of NHANES 2013-2018.

Sarfraz S, Fouad Elganainy M, Waris U et al. · 2026 · Proceedings (Baylor University. Medical Center)

Background Secondhand smoke (SHS) is a major cardiovascular risk factor, but its relationship with resting tachycardia, a marker of autonomic imbalance and adverse prognosis, remains unclear in young adults. Methods We analyzed adults aged…

View details →DOI: 10.1080/08998280.2026.2637414
Negative / Null Result ReportOpen accessMedicine

Misinformation interventions and online sharing behaviour: lessons learned from two pre-registered field studies.

Roozenbeek J, Lasser J, Marks M et al. · 2025 · Royal Society open science

The spread of misinformation on social media continues to pose challenges. While prior research has shown some success in reducing susceptibility to misinformation at scale, how individual-level interventions impact the quality of content…

View details →DOI: 10.1098/rsos.251377
Negative / Null Result ReportOpen accessMedicine

Mendelian randomization analysis reveals no causal association between non-alcoholic fatty liver disease and hepatocellular carcinoma: implications for lipid metabolomics and shared pathophysiological mechanisms.

Wei Y, Li J · 2025 · Discover oncology

Background Non-alcoholic fatty liver disease (NAFLD) has been increasingly associated with hepatocellular carcinoma (HCC) risk in observational studies, yet the causal nature of this relationship and its impact on systemic lipid metabolism…

View details →DOI: 10.1007/s12672-025-03582-0
Negative / Null Result ReportOpen accessMedicine

Atezolizumab plus bevacizumab and chemotherapy in metastatic nonsquamous NSCLC: the randomized double-blind phase 3 IMpower151 trial.

Zhou C, Dong X, Chen G et al. · 2025 · Nature medicine

After the global approval of atezolizumab plus bevacizumab and chemotherapy as first-line metastatic nonsquamous non-small-cell lung cancer (nsqNSCLC) treatment, the IMpower151 ( NCT04194203 ) trial was conducted in China to address…

View details →DOI: 10.1038/s41591-025-03658-y
Negative / Null Result ReportMedicine

Olaparib in recurrent isocitrate dehydrogenase mutant high-grade glioma: A phase 2 multicenter study of the POLA Network.

Esparragosa Vazquez I, Sanson M, Chinot OL et al. · 2024 · Neuro-oncology advances

Background Based on preclinical studies showing that IDH-mutant (IDHm) gliomas could be vulnerable to PARP inhibition we launched a multicenter phase 2 study to test the efficacy of olaparib monotherapy in this population. Methods Adults…

View details →DOI: 10.1093/noajnl/vdae078
Negative / Null Result Report

A prospective multicenter phase II study of FOLFIRINOX as a first-line treatment for patients with advanced and recurrent biliary tract cancer

Takahara N, Nakai Y, Isayama H et al. · 2022 · Preprint

Purpose: Given the promising activity and tolerability of FOLFIRINOX as a second-line treatment for advanced biliary tract cancer (BTC), it can be an attractive first-line treatment option as well. Materials: and Methods: This is a…

View details →DOI: 10.21203/rs.3.rs-2075157/v1
Negative / Null Result ReportOpen accessMedicine

The 2024 Public Health Emergency of International Concern: A Global Failure to Control Mpox.

Zumla A, Rosenthal PJ, Sam-Agudu NA et al. · 2025 · The American journal of tropical medicine and hygiene

On August 14, 2024, following a regional declaration by the Africa Centres for Disease Control and Prevention, the World Health Organization declared mpox a Public Health Emergency of International Concern, marking the second such…

View details →DOI: 10.4269/ajtmh.24-0606
Negative / Null Result ReportMedicine

Gastrointestinal tract exposure to particles and DNA damage in animals: A review of studies before, during and after the peak of nanotoxicology.

Møller P, Roursgaard M · 2024 · Mutation research. Reviews in mutation research

Humans ingest particles and fibers on daily basis. Non-digestible carbohydrates are beneficial to health and food additives are considered safe. However, titanium dioxide (E171) has been banned in the European Union because the European…

View details →DOI: 10.1016/j.mrrev.2024.108491
Negative / Null Result ReportOpen accessMedicine

Pro-inflammatory dietary patterns and their association with cardiovascular disease and pancreatic cancer in a hospital population: a cross-sectional study.

Jin Q, Liu Y, Tong Q et al. · 2025 · Frontiers in nutrition

Objective To examine whether a concise, clinic-feasible Patient Inflammatory Diet Score (PIDS) relates to prevalent pancreatic cancer and cardiovascular disease (CVD) in a hospital population, and to explore associations with systemic…

View details →DOI: 10.3389/fnut.2025.1666682
Negative / Null Result ReportMedicine

Learning to draw parametric faces.

Davidenko N, Day J · 2025 · Memory & cognition

Humans' ability to draw faces accurately from memory is extremely rare. One source of difficulty is the drawing process itself, which requires converting a complex, three-dimensional mental representation to a two-dimensional drawing. To…

View details →DOI: 10.3758/s13421-023-01498-0
Negative / Null Result ReportMedicine

Extreme ambient heat and outcomes of assisted reproduction in the continental United States, 1996 to 2018.

Gaskins AJ, Newman AJ, Kawwass JF et al. · 2026 · Environmental research

Background While extreme ambient heat has been associated with several adverse pregnancy and birth outcomes little is known regarding the link between extreme ambient temperatures and human fertility. Objective To evaluate the associations…

View details →DOI: 10.1016/j.envres.2026.123783
Negative / Null Result ReportOpen accessMedicine

No evidence that visual impulses enhance the readout of retrieved long-term memory contents from EEG activity.

van Bree S, Mackenzie AS, Wimber M · 2024 · Imaging neuroscience (Cambridge, Mass.)

The application of multivariate pattern analysis (MVPA) to electroencephalography (EEG) data allows neuroscientists to track neural representations at temporally fine-grained scales. This approach has been leveraged to study the locus and…

View details →DOI: 10.1162/imag_a_00330
Negative / Null Result ReportOpen accessMedicine

Sodium Reduction Program Incorporating Genetic Profile and an AI-Based App: A Randomized Clinical Trial.

Sato K, Inoue K, Yamaguchi T et al. · 2025 · JAMA network open

Importance Excess salt intake is a major modifiable risk factor for hypertension and cardiovascular disease. Personalized interventions using genetic information and digital tools, such as smartphone applications, may enhance sodium…

View details →DOI: 10.1001/jamanetworkopen.2025.37540
Negative / Null Result ReportOpen accessMedicine

No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis.

Liu P, Zeng Q · 2025 · Journal of multidisciplinary healthcare

Background The causal relationship between HIV infection and insulin resistance, as well as diabetes mellitus, remains uncertain. This study explores these associations using genome-wide association study data and Mendelian randomization…

View details →DOI: 10.2147/jmdh.s546669
Negative / Null Result ReportOpen accessMedicine

New Vistas for the Relationship between Empathy and Political Ideology.

Zebarjadi N, Kluge A, Adler E et al. · 2024 · eNeuro

The study of ideological asymmetries in empathy has consistently yielded inconclusive findings. Yet, until recently these inconsistencies relied exclusively on self-reports, which are known to be prone to biases and inaccuracies when…

View details →DOI: 10.1523/eneuro.0086-24.2024