Negative / Null Result ReportOpen accessMedicine
Haley Appel, Rogger P Carmen-Orozco, Clayton P Santiago et al. · 2025 · eLife
The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes neurogenesis, recent genetic studies have failed to replicate glia-to-neuron conversion following Ptbp1 loss of function. To evaluate the role of Ptbp1 in developmental neurogenesis in vivo, we conditionally disrupted Ptbp1 in mouse retinal progenitors. Ptbp1 was robustly expressed in both retinal progenitors and Müller glia but absent from p
View details →DOI: 10.7554/elife.108331 Negative / Null Result ReportOpen accessSocial Sciences
Mark Nieuwenstein, Hedderik van Rijn · 2012 · Judgment and Decision Making
According to the deliberation without attention (DWA) hypothesis, people facing a difficult choice will make a better decision after a period of distraction than after an equally long period of conscious deliberation, an effect referred to as the unconscious thought advantage (UTA). The status of the DWA hypothesis is controversial, as many studies have tried but failed to replicate the UTA. Here, we report a series of experiments that sought to identify the conditions under which the UTA can be replicated. Our starting point was a recent meta-analysis that identified the conditions under whic
Negative / Null Result ReportOpen accessMedicine
Abraham D. Flaxman, Riley Hazard, Ian Riley et al. · 2020 · BMC Medicine
Abstract We recently published in BMC Medicine an evaluation of the comparative diagnostic performance of InSilicoVA, a software to map the underlying causes of death from verbal autopsy interviews. The developers of this software claim to have failed to replicate our results and appear to have also failed to locate our replication archive for this work. In this Correspondence, we provide feedback on how this might have been done more usefully and offer some suggestions to improve future attempts at reproducible research. We also offer an alternative interpretation of the results presented by
View details →DOI: 10.1186/s12916-020-01517-w Negative / Null Result ReportOpen accessSocial Sciences
Briony D. Pulford, Poonam Gill · 2014 · Judgment and Decision Making
We report a series of experiments investigating the influence of feeling lucky or unlucky on people’s choice of known-risk or ambiguous options using the traditional Ellsberg Urns decision-making task. We induced a state of feeling lucky or unlucky in subjects by using a rigged wheel-of-fortune game, which just missed either the bankrupt or the jackpot outcome. In the first experiment a large reversal of the usual ambiguity aversion effect was shown, indicating that feeling lucky made subjects significantly more ambiguity seeking than usual. However, this effect failed to replicate in five ref
View details →DOI: 10.1017/s1930297500005520 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Michael Weigl, Qi Shao, Qi Shao et al. · 2023 · Frontiers in Human Neuroscience
In recent years, several cross-cultural studies reported that Westerners focus more on central aspects of a scene (e.g., an object) relative to peripheral aspects (e.g., the background), whereas Easterners more evenly allocate attention to central and peripheral aspects. In memory tasks, Easterners exhibit worse recognition for the central object when peripheral aspects are changed, whereas Westerners are less affected by peripheral changes. However, most of these studies rely on hit rates without correcting for response bias, whereas studies accounting for response bias failed to replicate cu
View details →DOI: 10.3389/fnhum.2023.1233594 Negative / Null Result ReportOpen accessLanguage and Literature
Elisa Scerrati, Zachary Estes · 2025 · Language and Cognition
The spatial interference effect, whereby words with implicit spatial associations (e.g., ‘bird’) hinder identification of unrelated visual targets (e.g., a square) at the associated locations (i.e., at the top of a display), has been demonstrated many times in English, although it has failed to replicate several times in Italian. The current study tested whether the replication failures in Italian may be due to insufficient semantic processing of the words. Indeed, while languages with highly inconsistent pronunciations, such as English, are more likely to involve semantic processing during wo
View details →DOI: 10.1017/langcog.2025.10031 Negative / Null Result ReportOpen accessPharmacy and materia medica
Bazigha K. Al –Temimy, Alaa A. Abdul –Rasool · 2017 · Iraqi Journal of Pharmaceutical Sciences
ABSTRACT: Salbutamol sulphate nebules is considered as the most rapid effective route of administration for treatment of acute attacks of asthma . This study was carried out to formulate a stable formula of salbutamol nebules containing 0.1% (2.5mg / 2.5ml) of the active ingredient in a buffered solution . Stability study in different buffers at pH 3 showed that the longest shelf life was equal to 3.5 years for formula F .In addition the bioequivalency of this formula incomparison to ventolin nebules was measured and it was equal to (± 5.2) %. Also it was found that there was no significant d
Negative / Null Result ReportOpen accessTechnology
Alessandro Guarnieri, Fabiana Laurenti, Salvatore Mazzei et al. · 2025 · Applied Sciences
Table tennis (TT) is a high-speed sport requiring integrated cognitive and motor skills. However, the existing assessment tools have failed to replicate its sport-specific demands. Therefore, this study aimed to evaluate the validity and reliability of the Reactive Table Tennis test designed to assess cognitive–motor performance in TT. Sixty athletes were recruited from TT, combat sports (CS), team sports (TS), and track and field (TF). Participants were required to react to 10 visual stimuli randomly emitted from three devices placed 3 m frontally by performing 1.5 m lateral or frontal displa
View details →DOI: 10.3390/app151810163 Negative / Null Result ReportOpen accessPsychology
Sophie Gillet, Cristina Anca Barbu, Martine Poncelet · 2020 · Frontiers in Psychology
Advantages in diverse aspects of cognitive functioning have been reported in early bilinguals (Bialystok, 2011) as well as in children frequenting an early bilingual immersion school program (Nicolay and Poncelet, 2015). However, during the last decade, some studies failed to replicate these advantages. Currently, the presence of cognitive benefits in children frequenting an immersion program remains debated. The lack of consistency between the studies could come from the fact that time spent by children within the immersion program is variable from one study to the other and that studies used
View details →DOI: 10.3389/fpsyg.2020.587574 Negative / Null Result ReportOpen accessPhysics
Javier De Miguel, Evanthia Hatziminaoglou, Frédéric Poidevin et al. · 2026 · Physics Letters B
We report a mm-wave search for axion dark matter from SGR 1745–2900, based on 4.8 h of ALMA observations. No candidate features are found between 133.99–135.78, 135.91–137.70, 145.99–147.78, and 147.99–149.78 GHz, corresponding to 0.55–0.62 meV. Interpreting this null result within a state-of-the-art stellar framework, we derive sensitivity to the axion–photon coupling at the level of gγ≳2×10−11 GeV−1 under a standard Navarro–Frenk–White profile; down to gγ≳2×10−13 GeV−1 upon accounting for a dense dark-matter spike around Sagittarius A*, probing the quantum chromodynamics axion parameter spac
View details →DOI: 10.1016/j.physletb.2026.140567 Negative / Null Result ReportOpen accessPolitical science (General)
Jeremy Ferwerda, Sascha Riaz · Political Science Research and Methods
Recent research suggests that local exposure to refugees does not increase support for far-right parties. We challenge this null result by drawing on granular data from Berlin in the wake of the Syrian refugee crisis. While prior work in the German context has generally assumed that refugee exposure is exogenous at the local level, we demonstrate that refugee housing was disproportionately concentrated in neighborhoods with young, non-citizen residents. To address this selection bias, we harmonize in-person and mail-in precinct boundaries across elections and implement a difference-in-differen
View details →DOI: 10.1017/psrm.2025.10061 Negative / Null Result ReportOpen accessAstrophysics
B. King, T. Heinzl, T. G. Blackburn · 2023 · European Physical Journal C: Particles and Fields
Abstract By combining an adiabatic approach based on a ‘locally monochromatic’ approximation with a local Hilbert transform, it is demonstrated how vacuum birefringence in the strong field regime can be calculated using a rate approach suitable for Monte Carlo simulation codes. Results for the flipping of the photon’s polarisation (helicity) are benchmarked with evaluation of exact expressions in a circularly (linearly) polarised plane wave of finite extent. For the circularly polarised case, the Heisenberg–Euler approach predicts a null result; an approximation similar to the ‘locally constan
View details →DOI: 10.1140/epjc/s10052-023-12074-w Negative / Null Result ReportMedicine
Mykolow G, Guyodo J, Cartigny MC · 2026 · Soins. Psychiatrie
The randomized SIPRéS study, conducted at Montpellier University Hospital, compares an outpatient nursing follow-up program aimed at preventing post-hospitalization suicide recurrence with standard care. Although it has no significant…
View details →DOI: 10.1016/j.spsy.2026.03.007 Negative / Null Result ReportOpen accessAstrophysics
Chen Du, Yong-Feng Huang, Zhi-Bin Zhang et al. · 2024 · The Astrophysical Journal
Fast radio bursts (FRBs) are bright radio transients with millisecond durations, which typically occur at extragalactic distances. The association of FRB 20200428 with the Galactic magnetar SGR J1935+2154 strongly indicates that they could originate from neutron stars, which naturally leads to the expectation that periodicity connected with the spinning of magnetars should exist in the activities of repeating FRBs. However, previous studies have failed to find any signatures supporting such a conjecture. Here we perform a thorough search for short-timescale periodicity in the four most active
View details →DOI: 10.3847/1538-4357/ad8cd5 Negative / Null Result ReportOpen accessMedicine
Katie Finning, David A Richards, Victoria A Goodwin et al. · 2019 · BMJ Open
Objectives Physical rehabilitation is a complex process, and trials of rehabilitation interventions are increasing in number but often report null results. This study aimed to establish treatment success rates in physical rehabilitation trials funded by the National Institute of Health Research Health Technology Assessment (NIHR HTA) programme and examine any relationship between treatment success and the quality of intervention development work undertaken.Design This is a mixed methods study.Setting This study was conducted in the UK.Methods The NIHR HTA portfolio was searched for all complet
View details →DOI: 10.1136/bmjopen-2018-026289 Negative / Null Result ReportOpen accessPhysics
H. C. Eggers, B. Buschbeck · 2013 · Advances in High Energy Physics
A detailed understanding of all effects and influences on higher-order correlations is essential. At low charged multiplicity, the effect of a non-Poissonian multiplicity distribution can significantly distort correlations. Evidently, the reference samples with respect to which correlations are measured should yield a null result in the absence of correlations. We show how the careful specification of desired properties necessarily leads to an average-of-multinomials reference sample. The resulting internal cumulants and their averaging over several multiplicities fulfill all requirements of c
View details →DOI: 10.1155/2013/230515 Negative / Null Result ReportOpen accessPhysics
C. Abel, N. J. Ayres, G. Ban, G. Bison, K. Bodek, V. Bondar, E. Chanel, C. B. Crawford, M. Daum, B. Dechenaux, S. Emmenegger, P. Flaux, W. C. Griffith, P. G. Harris, Y. Kermaidic, K. Kirch, S. Komposch, P. A. Koss, J. Krempel, B. Lauss, T. Lefort, Prajwal MohanMurthy, Oscar Naviliat Cuncic, D. Pais, F. M. Piegsa, Guillaume Pignol, M. Rawlik, D. Ries, Stephanie Roccia, D. Rozpedzik, Philipp Schmidt-Wellenburg, N. Severijns, Y. V. Stadnik, J. A. Thorne, A. Weis, E. Wursten, Jacek Zejma, Geza Zsigmond · 2023 · SciPost Physics
Ultra-low-mass axions are a viable dark matter candidate and may form a coherently oscillating classical field. Nuclear spins in experiments on Earth might couple to this oscillating axion dark-matter field, when propagating on Earth's trajectory through our Galaxy. This spin coupling resembles an oscillating pseudo-magnetic field which modulates the spin precession of nuclear spins. Here we report on the null result of a demonstration experiment searching for a frequency modulation of the free spin-precession signal of \magHg in a 1 $\mu$T magnetic field. Our search covers the axion mass rang
View details →DOI: 10.21468/scipostphys.15.2.058 Negative / Null Result ReportOpen accessMedicine
Alexis David James Makin, Afzal Rahman, Marco Bertamini · 2020 · PLoS ONE
Previous work has shown that symmetrical stimuli are judged as lasting longer than asymmetrical ones, even when actual duration is matched. This effect has been replicated with different methods and stimuli types. We aimed to a) replicate the effect of symmetry on subjective duration, and b) assess whether it was further modulated by the number of symmetrical axes. There was no evidence for either effect. This null result cannot be explained by reduced statistical power or enhanced floor or ceiling effects. There is no obvious stimulus-based explanation either. However, we are mindful of the r
View details →DOI: 10.1371/journal.pone.0238554 Negative / Null Result ReportOpen accessConsciousness. Cognition
Ronald Andringa, Walter R. Boot, Nelson A. Roque et al. · 2018 · Cognitive Research
Abstract Placing one’s hands near an object has been reported to enhance visual processing in a number of ways. We explored whether hand proximity confers an advantage when applied to complex visual search. In one experiment, participants indicated the presence or absence of a target item in a baggage x-ray image by pressing response boxes located at the edge of a tablet computer screen, requiring them to grip the display between their hands. Alternatively, they responded using a mouse held within their lap. Contrary to expectations, hand position did not influence search performance. In a sec
View details →DOI: 10.1186/s41235-018-0094-7 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Maximiliano A. Hawkes, Mauricio F. Farez, Ismael L. Calandri et al. · Arquivos de Neuro-Psiquiatria
ABSTRACT Lack of stroke awareness and slow activation of emergency medical services (EMS) are frequently reported reasons for delayed arrival to the hospital. We evaluated these variables in our population. Methods Review of hospital records and structured telephone interviews of 100 consecutive stroke patients. Forward stepwise logistic regression was used for the statistical analysis. Results Seventy patients (75%) arrived at the hospital 4.5 hours after stroke symptoms onset. The use of EMS did not improve arrival times. Most patients who recognized their symptoms did not use EMS (p < 0.02)
View details →DOI: 10.1590/0004-282x20160142 Negative / Null Result ReportMedicine
Suda Y, Ishida K, Shibanuma N et al. · 2026 · BMC musculoskeletal disorders
Background Previously, it was reported that preoperative medial tibial bone marrow lesions (BMLs) were not associated with worse postoperative outcomes after medial unicompartmental knee arthroplasty (UKA). However, the effect of BMLs in…
View details →DOI: 10.1186/s12891-026-10001-0 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Qirui Chen, Yan Liu, Yi Liu et al. · 2023 · Thoracic Cancer
Abstract Background To investigate the effect of continuous oral aspirin in perioperative period on bleeding in pneumonectomy. Methods A total of 170 patients who underwent pneumonectomy in our hospital from March 2021 to March 2022 were selected as the study objects. All patients took oral aspirin before surgery and did not take other antiplatelet agent or anticoagulants at the same time. The continuation group included 85 cases and continued to take aspirin 100 mg/day during the perioperative period, and the interruption group included 85 cases who stopped aspirin for 7 days before surgery a
View details →DOI: 10.1111/1759-7714.14846 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
C. Rust, D. Tonge, L. L. van denHeuvel et al. · 2025 · Brain and Behavior
ABSTRACT Introduction Recent studies have challenged the idea of sterile blood, suggesting the presence of a blood microbiome. The detection of microbial nucleic acids in blood is thought to reflect the status of distant microbial niches, including the gut. However, the origins and viability of these microbes remain debated. In this study, blood microbiome signatures in Parkinson's disease (PD), schizophrenia (SCZ), and posttraumatic stress disorder (PTSD) were evaluated by extracting RNA‐sequencing (RNA‐seq) reads that did not map to the human genome. Furthermore, we investigated the correlat
View details →DOI: 10.1002/brb3.70629 Negative / Null Result ReportOpen accessMining engineering. Metallurgy
Srija Balachandran, Kerstin Forsberg, Tom Lemaître et al. · 2021 · Metals
Selective leaching of Li from spent LIBs thermally pretreated by pyrolysis and incineration between 400 and 700 °C for 30, 60, and 90 min followed by water leaching at high temperature and high L/S ratio was examined. During the thermal pretreatment Li 2 CO 3 and LiF were leached. Along with Li salts, AlF 3 was also found to be leached with an efficiency not higher than 3.5%. The time of thermal pretreatment did not have a significant effect on Li leaching efficiency. The leaching efficiency of Li was higher with a higher L/S ratio. At a higher leaching temperature (80 °C), the leaching of Li
View details →DOI: 10.3390/met11081240 Negative / Null Result ReportMedicine
Fontaine E · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review Many clinical trials have failed to demonstrate the superiority of one nutritional protocol over another. This raises questions about the assessment tools used. In particular, intention-to-treat data analysis can mask…
View details →DOI: 10.1097/mco.0000000000001145 Negative / Null Result ReportOpen accessMedicine
Shi-gui Yang, Bin Cao, Li-rong Liang et al. · 2012 · PLoS ONE
BACKGROUND: There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset. METHODS: During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models. RESULTS: 920 adults and 541 children with pneumonia who didn't receive corticosteroids were analyzed. In-hospital mortality was higher in adults who did not receive antiviral therapy
View details →DOI: 10.1371/journal.pone.0029652 Negative / Null Result ReportOpen accessBotany
Yuliang Liu, Xinye Liu, Xue Wang et al. · 2020 · BMC Plant Biology
Abstract Background As global warming becomes increasingly severe, it is urgent that we enhance the heat tolerance of crops. We previously reported that Arabidopsis thaliana PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C9 (AtPLC9) promotes heat tolerance. Results In this study, we ectopically expressed AtPLC9 in rice to examine its potential to improve heat tolerance in this important crop. Whereas AtPLC9 did not improve rice tolerance to salt, drought or cold, transgenic rice did exhibit greater heat tolerance than the wild type. High-throughput RNA-seq revealed extensive and dynamic transcriptome
View details →DOI: 10.1186/s12870-020-02709-5 Negative / Null Result ReportMedicine
Yang G, Milne GL, Nogueira MS et al. · 2026 · International journal of cancer
Despite widespread interest, large randomized controlled trials have failed to demonstrate chemopreventive benefits of antioxidant supplementation, raising concerns about its efficacy and safety. Building on our prior observation of a…
View details →DOI: 10.1002/ijc.70585 Negative / Null Result ReportMedicine
Samaniego-González E, Podlipnik S, Ribero S et al. · 2026 · Actas dermo-sifiliograficas
Background Management of patients with cutaneous melanoma and positive sentinel lymph node biopsy (SLNB) has shifted toward surveillance rather than complete lymph node dissection (CLND), because CLND has failed to demonstrate a survival…
View details →DOI: 10.1016/j.ad.2026.104648 Negative / Null Result ReportOpen accessMedicine (General)
MM. Tahmasbi, F. Farahmand , AA. Amis · 1999 · Acta Medica Iranica
The resistant* of pateSa against lateral displacement (Le. the stability), was studied tinder a range of conditions in vitro, at a range of knee flexion angles. Muscle forces were applied in physiological directions along the separate quadriceps muscles. Normal muscle actions with constant tension showed constant patellar stability up to sixty degrees knee flexion, and then a significant increase at ninety degrees. A pathological knee was simulated by relaxing vastus medians, and ■ lateral stability then dropped by 47%. Isolated rttlnaeular release in the pathological knee did not improv
