A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19786 results in Negative / Null Result Report · page 48 of 660
H. Mike Kim, Leesa M. Galatz, Rosalina Das et al. · 2010 · Connective Tissue Research
The purpose of this study was to examine the role of two of the three transforming growth factor beta (TGF-β) isoforms at the healing tendon-to-bone insertion. The supraspinatus tendons of 64 rats were transected at their bony insertions…
Jennifer L. Dearborn, Yiyi Zhang, Ye Qiao et al. · 2017 · Neurology
OBJECTIVE: To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia. METHODS: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the…
Joris D. Veltman, Margaretha Lambers, Menno van Nimwegen et al. · 2010 · British Journal of Cancer
BACKGROUND: Suppressive immune cells present in tumour microenvironments are known to augment tumour growth and hamper efficacy of antitumour therapies. The amino-bisphosphonate Zoledronic acid (ZA) is considered as an antitumour agent, as…
Étienne Cavaignac, V. Lafontan, Nicolas Reina et al. · 2013 · The Bone & Joint Journal
The significance of weight in the indications for unicompartmental knee replacement (UKR) is unclear. Our hypothesis was that weight does not affect the long-term rate of survival of UKRs. We undertook a retrospective study of 212 UKRs at…
Véronique Campbell, Pierre Legendre, François-Joseph Lapointe · 2011 · BMC Evolutionary Biology
BACKGROUND: CADM is a statistical test used to estimate the level of Congruence Among Distance Matrices. It has been shown in previous studies to have a correct rate of type I error and good power when applied to dissimilarity matrices and to ultrametric distance matrices. Contrary to most other tests of incongruence used in phylogenetic analysis, the null hypothesis of the CADM test assumes complete incongruence of the phylogenetic trees instead of congruence. In this study, we performed computer simulations to assess the type I error rate and power of the test. It was applied to additive dis
Scott Carrell, Mark Hoekstra, James E. West · 2019 · American Economic Journal Economic Policy
This paper estimates the impact of racially diverse peers on white males’ subsequent behavior toward minorities. To overcome selection bias, we exploit data from the US Air Force Academy where students are randomly assigned to autonomous…
Ioannis Pavlidis, Panagiotis Tsiamyrtzis, Dvijesh Shastri et al. · 2012 · Scientific Reports
In the present study we quantify stress by measuring transient perspiratory responses on the perinasal area through thermal imaging. These responses prove to be sympathetically driven and hence, a likely indicator of stress processes in…
Carlos Cruchaga · 2011 · Archives of Neurology
BACKGROUND: Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late-onset Alzheimer disease (LOAD). The linkage disequilibrium pattern around the APOE gene has made it difficult to determine whether all…
Anne‐Marie Linnen, Mark A. Ellenbogen, Christopher Cardoso et al. · 2011 · Stress
Oxytocin facilitates pro-social behaviour and is proposed as a regulatory factor controlling stress reactivity. Previous research on oxytocin and stress has focused on achievement-related stressors among male participants. The aims of the…
John Chalmers, Jonathan Reuter · 2012 · Review of Financial Studies
Because life annuities can increase the level and decrease the volatility of lifetime consumption, economists have long been puzzled by the low demand for life annuities. One potential rational explanation is that adverse selection drives…
D. James Cooper, Jeffrey V. Rosenfeld, Lynnette Murray et al. · 2020 · Journal of Neurotrauma
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial of early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In the DECRA trial,…
Daniel S. Thoma, Manuel Sancho‐Puchades, Dominik A. Ettlin et al. · 2011 · Journal Of Clinical Periodontology
AIM: To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing. METHODS: In 15 volunteers, 6-mm punch biopsies were harvested at both palatal…
Shiu‐Dong Chung, Hsin‐Tzu Liu, Heng Lin et al. · 2011 · Neurourology and Urodynamics
AIMS: Chronic inflammation has been implicated in the development of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS). An elevation of C-reactive protein (CRP) has been associated with chronic inflammation…
Christopher T. Chan, Tom Greene, Glenn M. Chertow et al. · 2012 · Circulation Cardiovascular Imaging
BACKGROUND: An increase in left ventricular mass (LVM) is associated with mortality and cardiovascular morbidity in patients with end-stage renal disease. METHODS AND RESULTS: The Frequent Hemodialysis Network (FHN) Daily Trial randomized…
David Figlio, Jeremy Freese, Krzysztof Karbownik et al. · 2017 · Proceedings of the National Academy of Sciences
Accurate understanding of environmental moderation of genetic influences is vital to advancing the science of cognitive development as well as for designing interventions. One widely reported idea is increasing genetic influence on…
Paul E. Harrington, Kaustav Biswas, David J. Malwitz et al. · 2014 · ACS Medicinal Chemistry Letters
The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of unfolded protein accumulation in the endoplasmic reticulum that triggers the unfolded protein response (UPR), has been investigated as an anticancer target.…
Marie Løvoll, Marta Alarcón, Britt Bang Jensen et al. · 2012 · Diseases of Aquatic Organisms
The newly described piscine reovirus (PRV) appears to be associated with the development of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon Salmo salar L. PRV seems to be ubiquitous among fish in Norwegian salmon…
Stephanie A. Kazanas, Jeanette Altarriba · 2015 · Evolutionary Psychology
Recently, researchers have begun to investigate the function of memory in our evolutionary history. According to Nairne and colleagues (e.g., Nairne, Pandeirada, and Thompson, 2008; Nairne, Thompson, and Pandeirada, 2007), the best…
Charles R. Ebersole, Maya B. Mathur, Erica Baranski et al. · 2020 · Advances in Methods and Practices in Psychological Science
Replication studies in psychological science sometimes fail to reproduce prior findings. If these studies use methods that are unfaithful to the original study or ineffective in eliciting the phenomenon of interest, then a failure to…
J. Vermorken, Pol Specenier · 2013 · Biologics
Head and neck cancer is the sixth most common cancer worldwide. At present, globally about 650,000 new cases of squamous cell carcinoma of the head and neck (SCCHN) are diagnosed each year. The epidermal growth factor receptor (EGFR) is…
Andreas Seebeck, Devrimi Kaya · 2022 · European Accounting Review
We examine the communicative value of extended auditor reports in the United Kingdom (UK), where ISA 700 (UK and Ireland) requires auditors to disclose the risks of material misstatement that had the greatest effect on the audit – key…
Martin Mynarek, Katja von Hoff, Torsten Pietsch et al. · 2020 · Journal of Clinical Oncology
PURPOSE The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy. PATIENTS AND METHODS From 2001-2011, 87 patients received systemic chemotherapy and intraventricular methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After 2006, local radiotherapy was introduced for nonresponders or patients with classic medulloblastoma (CMB) or large-cell/anaplastic medulloblastoma (LCA). DNA met
Shilpa Trivedi, Nand Lal, Abbas Ali Mahdi et al. · 2013 · Journal of Periodontology
BACKGROUND: The aim of this study is to investigate the impact of diabetes, a known risk factor for periodontitis, on activities of antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CAT) as well as…
E. Mahler, M. Blom, Nicol C. Voermans et al. · 2011 · Lara D. Veeken
OBJECTIVE: To assess the efficacy of rituximab on disease activity and muscle strength in patients with inflammatory myopathies refractory to conventional therapy. METHODS; Thirteen patients were treated with rituximab 1000 mg i.v., twice,…
Harrison G. Pope, Arthur M. Jacobs, Jean-Paul Mialet et al. · 2010 · Psychotherapy and Psychosomatics
BACKGROUND: In an exploratory study, we used a novel computerized battery of neuropsychological tests of attention to assess residual cognitive impairment in marijuana users. METHODS: We compared 25 college students who were heavy…
Miguel Martín, Aleix Prat, Álvaro Rodríguez-Lescure et al. · 2013 · Breast Cancer Research and Treatment
To identify a group of patients who might benefit from the addition of weekly paclitaxel to conventional anthracycline-containing chemotherapy as adjuvant therapy of node-positive operable breast cancer. The predictive value of PAM50…
John D. Bagert, Yushu Joy Xie, Michael J. Sweredoski et al. · 2014 · Molecular & Cellular Proteomics
An approach to proteomic analysis that combines bioorthogonal noncanonical amino acid tagging (BONCAT) and pulsed stable isotope labeling with amino acids in cell culture (pSILAC) provides accurate quantitative information about rates of cellular protein synthesis on time scales of minutes. The method is capable of quantifying 1400 proteins produced by HeLa cells during a 30 min interval, a time scale that is inaccessible to isotope labeling techniques alone. Potential artifacts in protein quantification can be reduced to insignificant levels by limiting the extent of noncanonical amino acid t
Steven H. Kelder, Dale S. Mantey, Duncan Van Dusen et al. · 2020 · Public Health Reports
Objectives: From 2017 to 2018, electronic cigarette (e-cigarette) use increased 78% among high school students and 48% among middle school students in the United States. However, few e-cigarette prevention interventions have been…
Matthew S. Willsey, Samuel R. Nason, Scott R. Ensel et al. · 2022 · Nature Communications
Despite the rapid progress and interest in brain-machine interfaces that restore motor function, the performance of prosthetic fingers and limbs has yet to mimic native function. The algorithm that converts brain signals to a control signal for the prosthetic device is one of the limitations in achieving rapid and realistic finger movements. To achieve more realistic finger movements, we developed a shallow feed-forward neural network to decode real-time two-degree-of-freedom finger movements in two adult male rhesus macaques. Using a two-step training method, a recalibrated feedback intention
Li He, Guoying Zhou, Junang Liu et al. · 2016 · PLoS ONE
The filamentous fungus Colletotrichum fructicola is found in all five continents and is capable of causing severe diseases in a number of economically important plants such as avocado, fig, cocoa, pear, and tea-oil trees. However, almost nothing is known about its patterns of genetic variation and epidemiology on any of its host plant species. Here we analyzed 167 isolates of C. fructicola obtained from the leaves of tea-oil tree Camellia oleifera at 15 plantations in seven Chinese provinces. Multilocus sequence typing was conducted for all isolates based on DNA sequences at fragments of four