A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21733 results · page 479 of 725
Medeiros CNA, Azevedo IG, Gomes Fernandes SG et al. · 2026 · PeerJ
Background Urinary incontinence (UI) is a common complaint among middle-aged and older women, associated with many negative impacts in health. The aim of this study was to analyze whether an association exists between UI and sarcopenic…
Fowler TE, Bloomquist RF, James JN · 2025 · BMC oral health
Background The incidence of fascial space infections of the head and neck has long been suggested to correlate with weather patterns, though objective evidence is inconsistent, and a causative effect is difficult to prove. One issue in the…
Viskupič F, Wiltse DL · 2025 · PLOS global public health
It is possible that the negative attitudes toward COVID-19 vaccination developed by some people, such as self-identified Republicans, might spill over toward other vaccines. We conducted a survey experiment to investigate if mentioning…
Meade MJ, Jensen S, Ju X et al. · 2024 · International orthodontics
Objective The aim of the present study was to evaluate the quality and readability of content contained within clear aligner therapy (CAT) informed consent forms. Methods CAT informed consent forms were identified via an online search. The…
Chhaya D, Gress M, Raja A et al. · 2024 · International journal of environmental research and public health
The objective of this study is to investigate the potential mutagenic effects of the exposure of mice to aerosols produced from the component liquids of an electronic nicotine delivery system (ENDS). The use of electronic cigarettes…
Xu L, Yu D, Li F et al. · 2024 · Preprint
Abstract Objective To determine the efficacy and tolerability of Anlotinib plus temozolomide (TMZ) as a first-line treatment for recurrent malignant glioma (rMG). Methods A total of 30 eligible patients who relapsed from the standard…
Maier F, Luttenberger I, Dreisoerner A et al. · 2026 · Stress and health : journal of the International Society for the Investigation of Stress
Chronic stress has well-documented adverse effects on physical and psychological health. Beyond contributing to the development of fatigue, its impact is intensified by social stressors such as loneliness, making the development of…
Turner TJ, Brun P, Gruber R et al. · 2024 · Preprint
Tolebrutinib is a covalent BTK inhibitor designed and selected for potency and CNS exposure to optimize impact on BTK-dependent signaling in CNS-resident cells. We applied a translational approach to evaluate three BTK inhibitors in Phase…
Al-Khalaifah H, Al-Nasser A, Al-Surrayai T · 2025 · Life (Basel, Switzerland)
There is growing interest in adding marine algae to poultry feed rations. The aim of the present study is to examine the effect of various inclusions of Sargassum sp., Gracilaria sp., and Spirulina sp. on productive performance, serum…
Zamora Veliz HY, Paredes Cabanillas RY, Gomez Trejo JE et al. · 2025 · Cureus
Introduction Intestinal anastomotic leakage is a serious postoperative complication associated with high morbidity and mortality. Although acute-phase reactants such as procalcitonin (PCT) and CRP have been proposed as early biomarkers,…
Halačová M, Mieresová M, Kubele J et al. · 2026 · Pharmacological reports : PR
BACKGROUND: Beta-lactams are the cornerstone of therapy for the treatment of the most serious infections in the intensive care unit (ICU) setting. However, individualization of dosing remains challenging because pharmacokinetics are highly…
Dumont JR, Sheppard PAS, Fodor C et al. · 2025 · Genes, brain, and behavior
Alzheimer's disease is a debilitating neurodegenerative condition characterized by amyloid beta plaques and tau neurofibrillary tangles, which leads to progressive cognitive decline. Several new mouse models of fast amyloid deposition have…
Langevin P, Frémont P, Fait P et al. · 2024 · Disability and rehabilitation
Purpose The objective of this study was to compare the effects of an in-clinic cervicovestibular rehabilitation program (education, home exercises, manual techniques, sub-symptom threshold aerobic exercise [STAE] program) to a similar…
Schleifenbaum L, Stern J, Driebe JC et al. · 2024 · Hormones and behavior
Previous research on the endogenous effects of ovarian hormones on motivational states in women has focused on sexual motivation. The Motivational Priority Shifts Hypothesis has a broader scope. It predicts a shift from somatic to…
Fumagalli D, Sonik R, De Vitis LA et al. · 2024 · Gynecologic oncology
Background Advanced epithelial ovarian cancer (OC) patients often present with malnutrition; however, the ideal nutritional evaluation tool is unclear. We aimed to evaluate the role of preoperative albumin, Prognostic Nutritional Index…
Figueiredo RR, de Azevedo AA, Figueiredo GMR et al. · 2026 · Brazilian journal of otorhinolaryngology
Objectives COVID-19 is a respiratory disease caused by the coronavirus SARS-CoV-2. Previous studies reported cases of tinnitus following COVID infection, most of them mild and with similar characteristics to other forms of tinnitus. Our…
Bello RJ, Palleiko BA, Kennedy K et al. · 2024 · Surgical oncology
Background Pain management following mastectomy is a significant challenge often requiring opioids. Nonopioid pain management utilizing nerve blocks has been shown in other fields to reduce postoperative opioid use and may be effective for…
Pan L, Kaku Y, Tolentino JE et al. · 2025 · Frontiers in microbiology
In the 21st century, three severe human coronavirus infections have occurred. One of them is the Middle East respiratory syndrome coronavirus (MERS-CoV), a merbecovirus belonging to the family Coronaviridae , is a human pathogenic…
Khan M, Yousaf H, Naqqash M et al. · 2025 · Cureus
Introduction There is limited local data comparing the outcomes of core decompression and fibular strut grafting in early-stage avascular necrosis (AVN) of the hip. International findings may not be directly applicable due to…
Yaşar NF, Badak B, Salış M et al. · 2024 · Revista da Associacao Medica Brasileira (1992)
Objective Endogenous melatonin is produced from tryptophan which is an essential amino acid. Besides its role in the regulation of sleep patterns, melatonin has anti-inflammatory effects. In this case-control study, we aimed to compare…
Beaulieu A, Saint-Georges C, Hagbarth I et al. · 2026 · Scientific reports
General movements (GMs) refer to infants’ spontaneous motor activities before the emergence of voluntary motor activity. Abnormal GMs in neonates have been regarded as a marker of poor neurodevelopmental outcomes, with preliminary findings…
Iljazi A, Sørensen MS, Winther-Jensen M et al. · 2024 · Acta orthopaedica
Background and purpose Dislocation is a severe complication following total hip arthroplasty (THA). Hip precautions have been recommended in the initial postoperative period but evidence supporting this practice is limited. We therefore…
Klüwer B, Gleditsch R, Rydland KM et al. · 2024 · Vaccine
Aims To explore public confidence in influenza vaccination through the use of attitudinal indicators, and study whether educational attainment is related to attitudes towards influenza vaccination. Methods Confidence in influenza…
Jang S, Gwak HS, Joo J et al. · 2024 · Acta neurochirurgica
Purpose This study aimed to evaluate the symptomatic response and side effects of ventriculolumbar perfusion (VLP) methotrexate chemotherapy with a low perfusion rate in patients with leptomeningeal metastasis. Methods Patients in a…
Chen J, Hou S, Feng R et al. · 2023 · Preprint
CRISPR homing gene drive is a potent technology with considerable potential for managing populations of medically and agriculturally significant insects. It induces a bias in the inheritance of the drive allele in progeny, rapidly…
nema sk, ramsubramani P, S s · 2023 · Preprint
Abstract Background Transmembrane proteins of the Wnt family and receptor tyrosine kinase (ROR1 and ROR2) suppression or overexpression has been implicated in the causation of cancers. We determined the expression of ROR2 among patients of…
Mann S, Juhl CB, Paarup HM et al. · 2024 · Work (Reading, Mass.)
Background Playing the violin often requires a rotated and lateral flexed neck, leading to potential neck and shoulder problems. An ergonomic chinrest (EC) with or without a shoulder rest (SR or WSR) may enhance neutral neck positioning,…
Wiener RC, Abuhalimeh B, Cochran J · 2025 · Community dentistry and oral epidemiology
Objective The objective of this research was to determine if the ratio of family income to poverty index is a modifier in the relationship of sugar-sweetened beverages (SSB) and dental caries in U.S. children. Methods A cross-sectional…
Schwarzer NH, Behringer N, Dees P et al. · 2026 · BMC psychology
Background The Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) assesses individual differences in epistemic stances. Although widely used, its German translation has not yet undergone an independent psychometric evaluation.…
Taniajura N, Rincon C, Kennedy S et al. · 2026 · Addictive behaviors reports
Research has demonstrated that exposure to alcohol-related cues (e.g., sight or smell of a preferred beverage) elicits heightened self-reported craving and psychophysiological responses, including changes in heart rate (HR) and heart rate…