Immunohistochemical Assay Variability and Human Epidermal Growth Factor Receptor 2 (HER2)-Low Breast Cancer Detection: A Laboratory Comparison in the Netherlands.
Kain ZE; Schuurman E; Baez-Navarro X; Høeg H; Kanneganti P; Hart N'; van Deurzen CHM · 2026 · Laboratory investigation; a journal of technical methods and pathology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Purpose HER2-low breast cancer has gained clinical relevance owing to the efficacy of trastuzumab deruxtecan. However, variability in detecting low HER2 expression may affect patient eligibility. This nationwide study in the Netherlands…
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Metadata source: Europe PMC · DOI 10.1016/j.labinv.2026.106136