Failed Experiment ReportOpen accessOphthalmology
Beatriz G. Armendariz, PhD, Ulrich F.O. Luhman, PhD, Brian Berger, MD et al. · 2025 · Ophthalmology Science
Objective: Nonproliferative diabetic retinopathy (NPDR) is a progressive disease that can lead to blindness. Current therapies for NPDR are invasive and not extensively used or accessible until the disease progresses, pointing to the need for an early noninvasive treatment. The objective of CANBERRA was to assess the safety, tolerability, and efficacy of oral administration of vicasinabin (RG7774) on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe NPDR and good vision. Design: CANBERRA was a global, multicentric randomized, double-masked, parallel-gro
View details →DOI: 10.1016/j.xops.2024.100650 Failed Experiment ReportOpen accessMedicine
Tahar Gargah, Majda Cherif, Rim Goucha-Louzir et al. · 2012 · Saudi Journal of Kidney Diseases and Transplantation
The hemolytic uremic syndrome (HUS), characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure, represents one of the major causes of acute renal failure in infancy and childhood. The typical form occurring after an episode of diarrhea caused by Escherichia coli is the most frequent in children. Other microorganisms also may be responsible for HUS, such as Streptococcus pneumoniae, which causes more severe forms of the disease. We report an 8-month-old girl who presented with pneumonia and subsequently developed HUS. Renal biopsy showed characteristic lesion
View details →DOI: 10.4103/1319-2442.100885 Negative / Null Result ReportOpen accessAnimal culture
Giovanni Martemucci, Angela Gabriella D’Alessandro · 2010 · Italian Journal of Animal Science
Three experiments were carried out with the aim of evaluating the efficiency of techniques of in vivo production, storage and transfer of embryos in dairy sheep. Experiment I - For embryo production, thirty-one ewes were synchronized with FGA (vaginal sponges, 40 mg, 9 d) and PGF2α (ICI; 50 μg, 7th d), and subdivided into three groups corresponding to the following superovulatory treatments over 3 days with purified gonadotrophic preparations: A) control, FSH/LH ratio = 1 (250 IU p-FSH : 250 UI p-LH); B) FSH/LH ratio = 2 (250 IU p-FSH : 125 IU p-LH) and daily FSH/LH ratio of 3.4 &ndas
View details →DOI: 10.4081/ijas.2003.131 Negative / Null Result ReportOpen accessMedicine
Rosamund Chapman, Michiel van Diepen, Shireen Galant et al. · 2020 · Vaccines
The HIV-1 envelope glycoprotein (Env) is present on the surface of the virion at a very low density compared to most other enveloped viruses. Substitution of various parts of the stalk domain of Env (gp41) with the corresponding elements from other viral glycoproteins has been shown to increase Env spike density on the cell membrane and surface of virus-like particles (VLPs). In this study, chimeric Env antigens were generated by replacing the transmembrane and cytoplasmic domains of HIV-1 Env with the corresponding regions from the influenza H5 hemagglutinin (HA) (gp140HA 2 tr) and by replaci
View details →DOI: 10.3390/vaccines8010054 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Sriyanti Sriyanti, Evy Damayanthi, Faisal Anwar · 2019 · Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition
Background : Rosela (Hibiscus sabdariffa L.) is an anthocyanin-rich plant that has good antioxidant capacity. However, the utilization was limited to red roselle, while previous studies showed that anthocyanin content was found to be higher in the thick roselle.therefore, this is an opportunity to develop purple roselle products as a preventive effort for degenerative diseases in men with fatness. Subjects in this study were male by considering the effect of estrogen on women which could play a role in suppressing oxidative stress. Objectives : This study aimed to analyze antioxidant (SOD/Supe
View details →DOI: 10.14710/jgi.7.2.75-85 Negative / Null Result ReportOpen accessMedicine
Duangdee Trangsuwan, Malai Wongchanchailert, Ladda Mo-suwan et al. · 2018 · Journal of Health Science and Medical Research (JHSMR)
Objective: To evaluate the volume of blood transfusion requirements as well as hemolytic and oxidative biochemical variables in transfusion-dependent β-thalassemia patients supplemented with vitamin E. Material and Methods: A prospective, double-blind, randomized, placebo-controlled, crossover study was undertaken between December, 2012 and September, 2014 in the Pediatric Clinic of Songklanagarind Hospital. The participants were β-thalassemia major and Hb E/β-thalassemia patients aged between 5 and 18 years. A random allocation sequence was generated to receiving either 6 months of vitamin E
View details →DOI: 10.31584/jhsmr.2018.36.3.19 Negative / Null Result ReportOpen accessAnimal culture
S. Lürzel, K. Barth, I. Windschnurer et al. · 2018 · Animal
Cattle’s relationship with humans is a crucial factor regarding their welfare. In dairy cows, interactions with humans occur regularly during milking. We tested the effect of gentle interactions (stroking, talking in a gentle voice) during milking on avoidance distance and milk composition, yield and flow characteristics as well as behaviour during milking. Over the course of 15 days, an experimenter interacted gently with 14 German Holstein cows for 2 min during morning and evening milkings, totalling 60 min; the experimenter stayed at a similar distance to 12 control cows of the same breed f
View details →DOI: 10.1017/s1751731117001495 Negative / Null Result ReportOpen accessBotany
Xiang-Gui Chen, Yi-Hua Wu, Neng-Qi Li et al. · 2022 · BMC Plant Biology
Abstract Background Orchids require specific mycorrhizal associations for seed germination. During symbiotic germination, the seed coat is the first point of fungal attachment, and whether the seed coat plays a role in the identification of compatible and incompatible fungi is unclear. Here, we compared the effects of compatible and incompatible fungi on seed germination, protocorm formation, seedling development, and colonization patterns in Dendrobium officinale; additionally, two experimental approaches, seeds pretreated with NaClO to change the permeability of the seed coat and fungi incub
View details →DOI: 10.1186/s12870-022-03760-0 Negative / Null Result ReportOpen accessAgriculture (General)
Jasanmol Singh, Ali Bulent Koc, Matias Jose Aguerre et al. · 2024 · Smart Agricultural Technology
Alfalfa is a high-yielding forage crop that is widely grown in the United States for grazing, hay and silage making. A proper maintenance of these grasslands is necessary to ensure optimum productivity and profits. The pre-harvest estimation of biomass yield helps in quantifying the profits and optimizing the forage allocation in advance. Most traditional methods of forage estimation are relatively laborious and time-consuming. Recent developments in contact and remote sensing technologies opened numerous paths for performing aboveground biomass estimation tasks with flexibility and easiness.
View details →DOI: 10.1016/j.atech.2024.100597 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ophélie Vacca, Amel Saoudi, Mathilde Doisy et al. · 2025 · Molecular Therapy: Nucleic Acids
The mdx52 mouse model exhibits a common mutation profile associated with brain involvement in Duchenne muscular dystrophy (DMD), characterized by heightened anxiety, fearfulness, and impaired associative fear learning. Deletion of exon 52 disrupts the expression of two dystrophins found in the brain (Dp427 and Dp140) and is eligible for therapeutic exon-skipping strategies. We previously demonstrated that a single intracerebroventricular administration of an antisense oligonucleotide (ASO) targeting exon 51 of the Dmd gene could restore 5%–15% of Dp427 expression. This treatment reduced anxiet
View details →DOI: 10.1016/j.omtn.2025.102779 Negative / Null Result ReportOpen accessMedicine
Noriyuki Oka, Masaharu Sakoh, Misato Hirayama et al. · 2023 · Scientific Reports
Abstract The corticofugal tracts (CFT) are key agents of upper limb motor function. Although the tracts form high-intensity regions relative to surrounding tissue in T2-weighted magnetic resonance images (T2WI), the precise relations of signal intensities of the left and right CFT regions to hand function are unknown. Here, we tested the hypothesis that the different signal intensities between the left and right CFT signify clinically important differences of hand motor function. Eleven right-handed and eleven left-handed healthy volunteers participated in the study. Based on horizontal T2WI e
View details →DOI: 10.1038/s41598-023-29557-1 Negative / Null Result ReportOpen accessMedicine (General)
Xiaomin Liang, Qian Wang, Zemao Xing et al. · 2026 · Frontiers in Medicine
ObjectiveAcute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Hematocrit (HCT), the proportion of blood volume occupied by red blood cells, has been associated with outcome in AIS patients, but the relationship remains controversial. This study aimed to investigate the association between HCT levels and 3-month adverse outcome in South Korean patients with AIS, with a focus on potential sex differences.MethodsThis secondary analysis utilized data from an existing South Korean prospective cohort study involving 1,896 AIS patients. HCT was assessed both as a cont
View details →DOI: 10.3389/fmed.2026.1721251 Negative / Null Result ReportOpen accessArctic medicine. Tropical medicine
André Luiz Bortoliero, Ana Maria Bonametti, Helena Kaminami Morimoto et al. · 2006 · Revista do Instituto de Medicina Tropical de São Paulo
A cross-sectional study was carried out among 996 volunteer blood donors enrolled from May 1999 to December 1999 to determine the seroprevalence of hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná, Brazil, and to evaluate whether the rate of seroprevalence of IgG anti-HEV antibodies is associated with sociodemographic variables and with seropositivity for hepatitis A virus (HAV) infection. All participants answered the questionnaire regarding the sociodemographic characterisitcs. Serum samples were tested for IgG antibodies
View details →DOI: 10.1590/s0036-46652006000200006 Negative / Null Result ReportOpen accessMedicine (General)
Mohammad-Ali Seif-Rabiei, Mehrdad Hajilooi, Uldoz Roustaei et al. · 2011 · Acta Medica Iranica
There is some evidence indicating the role of Helicobacter pylori infection in pathogenesis of extragastrointestinal diseases including skin, vascular, and autoimmune disorders, as well as some respiratory diseases. The aim of this study was to investigate the association between H. pylori and chronic obstructive pulmonary disease (COPD). In a case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-H. pylori and anti-CagA IgG by ELISA. A physician completed a questionnaire including demographic characteristics, h
Negative / Null Result ReportOpen accessMedicine
Noura A. Almadhi, Ayman M. Sulimany, Hamad A. Alzoman et al. · 2021 · Saudi Dental Journal
Objective: To evaluate parents’ knowledge about halitosis, and to compare parents’ perception of halitosis in their children to the presence of halitosis clinically. Methods: Children between 3 and 8 years attended to Dental University Hospital, King Saud University, were screened. Children satisfying inclusion criteria and their parents agreed to participate were included. Questionnaires regarding parents’ knowledge and perception about halitosis in their children were filled by attending parents. Then, the assessment of halitosis in the participating children carried out by portable gas chro
View details →DOI: 10.1016/j.sdentj.2020.08.005 Negative / Null Result ReportOpen accessSpecialties of internal medicine
Dawn Yi Xin Lee, Chun En Yau, Maeve Pin Pin Pek et al. · 2024 · Resuscitation Plus
Background: Socioeconomic status (SES) is a well-established determinant of cardiovascular health. However, the relationship between SES and clinical outcomes in long-term out-of-hospital cardiac arrest (OHCA) is less well-understood. The Singapore Housing Index (SHI) is a validated building-level SES indicator. We investigated whether SES as measured by SHI is associated with long-term OHCA survival in Singapore. Methods: We conducted an open cohort study with linked data from the Singapore Pan-Asian Resuscitation Outcomes Study (PAROS), and the Singapore Registry of Births and Deaths (SRBD)
View details →DOI: 10.1016/j.resplu.2024.100610 Negative / Null Result ReportOpen accessMedicine
Patil PB, Chougule PG, Kamat SB et al. · 2026 · Journal of conservative dentistry and endodontics
Aim The aim of this in vitro study was to evaluate the effect of antacid syrup on surface roughness and microhardness of composites. Materials and methods Two different composite resin materials, Nanofilled and Suprananofilled were used.…
View details →DOI: 10.4103/jcde.jcde_121_26 Negative / Null Result ReportOpen accessMedicine (General)
Jiao LI, Qi LI, Shuang CHENG et al. · 2026 · 环境与职业医学
BackgroundGestational weight gain is closely related to maternal and infant health outcomes. Pregnant women are simultaneously exposed to four metals—lithium (Li), vanadium (V), uranium (U), and bismuth (Bi)—through inhalation of fine particulate matter and consumption of contaminated food and water. Existing studies suggest that exposure to these metals may be associated with gestational weight gain. However, no study has yet explored the complex relationships between exposure to mixtures of these four metals and weight gain at different stages of pregnancy.ObjectiveTo investigate the associa
View details →DOI: 10.11836/jeom25403 Negative / Null Result ReportOpen accessArctic medicine. Tropical medicine
Felipe da Silva Krawczak, Ilka Afonso Reis, Julia Angélica da Silveira et al. · 2015 · Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: The present study was designed to assess the occurrence of co-infection or cross-reaction in the serological techniques used for detecting the anti-Leishmania spp., -Babesia canis vogeli and -Ehrlichia canis antibodies in urban dogs from an area endemic to these parasites. METHODS: The serum samples from dogs were tested for the Babesia canis vogeli strain Belo Horizonte antigen and Ehrlichia canis strain São Paulo by immunofluorescence antibody test (IFAT) and by anti-Leishmania immunoglobulin G (IgG) antibody detection to assess Leishmania infection. We used the following four
View details →DOI: 10.1590/0037-8682-0291-2014 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yangyang Guo, Bingyang Zhang, Lianmei Zhong et al. · 2026 · Frontiers in Neurology
BackgroundIntracranial and/or extracranial atherosclerotic stenosis is a common etiology of acute ischemic stroke (AIS). This study aimed to evaluate the impact of intracranial or extracranial atherosclerotic stenosis on early neurological deterioration (END), hemorrhagic transformation (HT) and 90-day clinical outcomes in patients receiving intravenous thrombolysis.MethodsWe retrospectively enrolled patients with AIS who received intravenous alteplase (0.9 mg/kg) at the First Affiliated Hospital of Kunming Medical University between February 2019 and August 2022. Data on demographics, stroke
View details →DOI: 10.3389/fneur.2025.1700753 Negative / Null Result ReportOpen accessMedicine
Piyusha Milani Atapattu, Chemindra Biyanwila, Manamalabaduge Upul Jerard Fernando · 2017 · American Journal of Experimental and Clinical Research
Chest radiographs are widely available, even in most hospitals in developing countries, and can detect a variety of lung pathologies. When adults are admitted to hospital with acute asthma, chest radiographs are often obtained. Studies on the usefulness of chest radiographs in acute asthma have shown varying results. This study aimed at evaluating the usefulness of chest radiographs in the management of acute asthma in adult asthmatics in a developing country. Plain chest radiographs performed within 24 hours of admission in 115 consecutive adult asthmatic patients (asthma defined by Asthma Ed
Negative / Null Result ReportOpen accessMedicine
Hawra Al-Ghafli, Bright Varghese, Mushira Enani et al. · 2019 · PLoS ONE
Despite low infectious potential of extrapulmonary tuberculosis (EPTB), it poses significant clinical challenges in terms of diagnosis and treatment monitoring. Understanding the main demographical risk factors for disease characteristics of EPTB plays a crucial role in speeding up diagnosis process and improving overall clinical experience. The aim of this study was to investigate the main demographical and clinical risk factors for EPTB among adults and adolescents for the first time in Saudi Arabia. A cross-sectional multicenter study was carried out on a collection of 902 extrapulmonary My
View details →DOI: 10.1371/journal.pone.0213846 Negative / Null Result ReportOpen accessMedicine
Martin Söderholm, Yan Borné, Bo Hedblad et al. · 2015 · PLoS ONE
Increased red cell distribution width (RDW) has been related to poor prognosis in patients with cardiovascular disease, and is a predictor of cardiovascular mortality in the general population. The purpose of the present study was to investigate if RDW is associated with increased incidence of stroke and its subtypes in individuals from the general population.Red cell distribution width was measured in 26,879 participants (16,561 women and 10,318 men aged 45-73 years) without history of coronary events or stroke, from the population-based Malmö Diet and Cancer Study. Incidences of total stroke
View details →DOI: 10.1371/journal.pone.0124957 Negative / Null Result ReportMedicine
Lauer, Leng, Chembe et al. · 2026 · The British journal of nutrition
Small-quantity lipid-based nutrient supplements (SQ-LNS) have been shown to improve growth, development, and survival among young children in low-resource settings. One hypothesized pathway is through improvements in intestinal health,…
View details →DOI: 10.1017/s0007114526107818 Negative / Null Result ReportOpen accessPublic aspects of medicine
Machiko Minatoya, Sachiko Itoh, Keiko Yamazaki et al. · 2018 · Environmental Health and Preventive Medicine
Abstract Background Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age. Methods The Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels
View details →DOI: 10.1186/s12199-018-0732-1 Negative / Null Result ReportOpen accessMedicine
Fauziyyah Ramadhani, Mohammad Ghozali, Leni Lismayanti · 2018 · Global Medical & Health Communication
Dengue hemorrhagic fever (DHF) is still the leading cause of hospitalization and death among children in Indonesia because of plasma leakage leading to shock syndromes. This study aimed to associate the hematocrit difference (first and second) from serial hematocrit (Hct) examination just after admission with DHF severity. A analytical cross-sectional study was involving medical records of pediatric patients with DHF admitted at the pediatric ward and the Pediatric Intensive Care Unit (PICU) of Dr. Hasan Sadikin General Hospital, Bandung in January–December 2015. The subjects excluded if other
View details →DOI: 10.29313/gmhc.v6i3.3079 Negative / Null Result ReportOpen accessMedicine (General)
Kelly Lim, Meng‐Ni Wu, Wei‐Chia Tsao et al. · 2026 · Kaohsiung Journal of Medical Sciences
ABSTRACT The long‐term cumulative impact of metabolic syndrome (MS) on cognitive decline remains uncertain. This study investigated how changes in MS status over 10 years relate to cognition and whether sex modifies this relationship. A total of 766 participants (mean baseline age: 54 years) from the Kaohsiung Atherosclerosis Longitudinal Study were enrolled. MS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asian populations. Participants were categorized into four groups based on changes in MS status over the 10‐year follow‐up: ne
View details →DOI: 10.1002/kjm2.70138 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Xing Zhang, Xiao-He Hou, Ya-Hui Ma et al. · 2020 · BMC Neurology
Abstract Background Inflammation plays an important role in atherosclerosis but the contribution of neutrophils to this process is unclear. We sought to assess whether neutrophil count is associated with intracranial atherosclerotic stenosis (ICAS). Methods A total of 2847 individuals were included in our study, including 1363 with acute ischemic stroke and 1484 normal controls without stroke. The presence of ICAS was confirmed by magnetic resonance angiography. The association between neutrophil count and ICAS was evaluated by multivariable logistic regression analysis. Results Among 2847 ind
View details →DOI: 10.1186/s12883-020-01641-3 Negative / Null Result ReportOpen accessScience (General)
Berliana Hamidah, Cennikon Pakpahan, Laksmi Wulandari et al. · 2024 · Heliyon
Excessive inflammatory response is a hallmark of severe COVID-19. This study investigated the associations between interferon-stimulated genes (ISGs) expression, genetic variation in the interferon α/β receptor 2 (IFNAR2) gene, and COVID-19 mortality.We investigated 67 patients with moderate-to-severe COVID-19. Of them, 22 patients (32.8 %) died because of COVID-19. We examined the expression of ISGs in total RNA of peripheral whole blood. We observed a significant increase in the expression of all ISGs examined in non-surviving patients, indicating a heightened interferon type I signaling act
View details →DOI: 10.1016/j.heliyon.2024.e39002 Negative / Null Result ReportOpen accessMedicine
Tamás Sebestyén, Zita Iloskics · 2020 · PLoS ONE
The spread of economic shocks in an increasingly interconnected global economy has been subject to several studies recently. These studies mostly focus on the synchronization of business cycles among economies and search for the relationship between trade linkages and shock contagion. In contrast to previous studies in the field, this paper focuses on the topological properties of the shock contagion network as measured by pairwise Granger causality between economic output of countries. This topological approach can bring new insights into the dynamics of contagion and the relationship between
View details →DOI: 10.1371/journal.pone.0238626 