Negative / Null Result ReportOpen accessAnimal culture
Samadi F, Sahneh M · 2015 · Poultry Science Journal
A total of 240, one-day-old quail chicks (Coturnix coturnix japonica) were used to study the effects of Artichoke leaf meal (ALM) and vitamin E in diet on growth performance, ileal microbial populations and intestinal morphology in a 42-d trial. This experiment was performed as a completely randomized design with 4 replicates of 15 quails each, using a 4 × 2 factorial arrangement with diet and gender as the main effects. Four dietary treatments were formulated by addition of 2 levels (1.5 and 3 percent) of ALM and 300 mg/Kg vitamin E to the basal diet. Supplementing basal diet with ALM did not
Null DatasetOpen accessMaterials of engineering and construction. Mechanics of materials
· 2009 · eXPRESS Polymer Letters
The thermal and reaction to fire characteristics of a flame retardant unsaturated polyester (UP) ternary system are presented here. Thermal gravimetric analysis showed an improved thermal stability between 200–600°C with the addition of ammonium polyphosphate (APP) and aluminium trihydroxide (ATH) formulation. Cone calorimetry tests indicated that ATH is more efficient than calcium carbonate at delaying the ignition time, lowering the carbon monoxide yield and lowering the peak heat release (PHRR). However the addition of APP and ATH to the formulation failed to demonstrate any significant syn
View details →DOI: 10.3144/expresspolymlett.2009.92 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Oh Young Bang, Mi Ji Lee, Sookyung Ryoo et al. · 2015 · Journal of Stroke
Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis, and the emergence of endovascular device closure as a treatment option. However, recent randomized controlled trials of the management of patients with ESUS and PFO failed to demonstrate the superiority of closure over medical treatment. The mechanisms of stroke other than paradoxical embolism may be important in patients with ESUS and PFO. This
View details →DOI: 10.5853/jos.2015.17.3.229 Abandoned HypothesisOpen accessPhilosophy (General)
Mostafa Taqavi · 2019 · Journal of Philosophical Investigations
There are two main sections in this paper. First, we will show that some of the chief 20th-century theories of science either have failed to demonstrate that value judgments do not influence the context of consolidation and determination of science or have accepted the role of value judgments in the context of consolidation and determination of science and theorized accordingly. For this purpose, the ideas of logical positivists, Willard Quine, Karl Popper, Thomas Kuhn, Imre Lakatos, Paul Feyerabend, and Roy Bhaskar on science are briefly reviewed. Finally, the validity of the following statem
View details →DOI: 10.22034/jpiut.2019.27618.2029 Failed Experiment ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Ma Li, Men Yu, Feng Lingling et al. · 2019 · Radiology and Oncology
The mainstay therapy for locally advanced non-small cell lung cancer is concurrent chemoradiotherapy. Loco-regional recurrence constitutes the predominant failure patterns. Previous studies confirmed the relationship between increased biological equivalent doses and improved overall survival. However, the large randomized phase III study, RTOG 0617, failed to demonstrate the benefit of dose-escalation to 74 Gy compared with 60 Gy by simply increasing fraction numbers.
View details →DOI: 10.2478/raon-2019-0006 Short NoteOpen accessMedical physics. Medical radiology. Nuclear medicine
Farhana Ebrahim Suleman, Margaret Kisansa · 2010 · South African Journal of Radiology
Macrodystrophia lipomatosa (MDL) is described as a rare, non-hereditary, congenital condition presenting with localized macrodactyly and a proliferation of mesenchymal elements. There is in particular a marked increase in fibroadipose tissue(1). We describe two cases presenting to our department in a six month period, with a history of disproportionately large limbs since birth. While our first case demonstrated all the typical features of MDL, our second case failed to demonstrate osseous gigantism although the other features of MDL were present. An extensive search of the literature failed t
View details →DOI: 10.4102/sajr.v14i2.425 Failed Experiment ReportOpen accessMedicine
Wallon S, Williamsson C, Karlsson V et al. · 2026 · Trials
Background Routine use of surgical drains after abdominal operations has largely been abandoned over the past decades. Studies have failed to demonstrate benefits of routine drainage following liver, gallbladder, gastric, and colorectal…
View details →DOI: 10.1186/s13063-026-09762-9 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Richard Morter, Alfred B. Tiono, Alfred B. Tiono et al. · 2022 · Frontiers in Immunology
The experimental malaria vaccine ChAd63 MVA ME-TRAP previously showed protective efficacy against Plasmodium falciparum infection in Phase IIa sporozoite challenge studies in adults in the United Kingdom and in a Phase IIb field efficacy trial in Kenyan adults. However, it failed to demonstrate efficacy in a phase IIb trial in 5-17 month-old children in an area of high malaria transmission in Burkina Faso. This secondary analysis investigated whether exposure to malaria or nutritional status might be associated with reduced responses to vaccination in this cohort. Parasite blood smears and ant
View details →DOI: 10.3389/fimmu.2022.1058227 Negative / Null Result ReportOpen accessSpecial aspects of education
Ning Zhang, Fan Ouyang · 2023 · International Journal of Educational Technology in Higher Education
Abstract Collaborative knowledge construction (CKC) involved students’ sharing of information, improvement of ideas, and construction of collective knowledge. In this process, knowledge extraction and analysis can provide valuable insights into students’ knowledge capacities, depths, and levels in order to improve the CKC quality. However, existing studies tended to extract and analyze knowledge from a single perspective (e.g., the number of certain knowledge types and knowledge structures), which failed to demonstrate the complexity and dynamics of knowledge construction and advancement. To f
View details →DOI: 10.1186/s41239-023-00414-5 Methods Dead-EndOpen accessMedical emergencies. Critical care. Intensive care. First aid
Leslie Bilello, Andrew Ketterer, Shaked Yarza et al. · 2021 · Clinical and Experimental Emergency Medicine
Objective Optimal training methods remain controversial for rarely performed emergency procedures. Previous research has failed to demonstrate the superiority or inferiority of live anesthetized animal models (LAA) as compared to other modalities. Most of the data on LAA use comes from military contexts; less information is available for civilian emergency medicine (EM) training. We sought to characterize the prevalence of LAA use among civilian EM residency programs and reasons for its use or discontinuation. Methods Survey study of program directors of EM residency programs accredited by the
View details →DOI: 10.15441/ceem.20.088 Abandoned HypothesisOpen accessImmunologic diseases. Allergy
John P. Veluchamy, John P. Veluchamy, Nina Kok et al. · 2017 · Frontiers in Immunology
Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of large numbers of cytolytic NK cells and their potential to induce relevant antitumor responses are widely explored in cancer immunotherapy. Early studies from autologous NK cells have failed to demonstrate significant clinical benefit. In this review, the clinical benefits of adoptively transferred allogeneic NK cells in a transplant and non-transplant setting are compared and discussed in the context of re
View details →DOI: 10.3389/fimmu.2017.00631 Short NoteOpen accessMedicine
Jennifer Huberty, Lara Baez, Kelsey McAlister et al. · 2026 · JMIR Formative Research
AbstractThe digital mental health (DMH) industry has grown drastically over the last decade; yet, many DMH products have failed to demonstrate meaningful clinical outcomes, in large part due to lack of scientific evidence. This viewpoint paper highlights an example of how early-stage DMH companies can prioritize science as a strategic advantage. We discuss Moment for Parents, an artificial intelligence–driven maternal mental health app built entirely with support from the National Institutes of Health (NIH) Small Business Innovation Research (SBIR) program. We illustrate the advantages and cha
View details →DOI: 10.2196/85642 Negative / Null Result ReportOpen accessMedicine
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2026 · Stroke (Hoboken, N.J.)
Background Intracranial atherosclerotic disease is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to demonstrate…
View details →DOI: 10.1161/svin.125.002111 Negative / Null Result Report
Creamer MS, Leifer AM, Pillow JW · 2024 · Preprint
A fundamental goal of neuroscience is to understand how anatomy determines the functional properties of the nervous system. However, previous work has failed to show how the functional connections between neurons are derived from the…
View details →DOI: 10.1101/2024.09.22.614271 Negative / Null Result ReportOpen accessEcology
Sánchez-Ledesma Judith A., Águila Bernardo, Garibay-Orijel Roberto et al. · 2025 · Folia Oecologica
Using ITS1-based metabarcoding, we investigated the structure of the soil fungal communities in the central and peripheral zones of a 25-hectare pecan nut (Carya illinoinensis) orchard located in the arid region of Coahuila, Mexico. While environmental conditions such as soil moisture and temperature varied between zones, physicochemical soil properties (pH, organic carbon, total carbon, organic matter, electrical conductivity, and zinc) remained homogeneous. A total of 4,443 fungal OTUs were detected at 97% similarity. Alpha diversity indices did not differ significantly between zones. The fu
View details →DOI: 10.2478/foecol-2025-0015 Negative / Null Result ReportOpen accessChemistry
Yu Jia, Cao Yu, Song Hang et al. · 2012 · Journal of the Serbian Chemical Society
Ab initio Hartree-Fock (HF) method and Density Functional Theory (DFT) were used to calculate the optical rotation of 26 chiral compounds. The effects of theory and basis sets used for calculation, solvents influence on the geometry and values of calculated optical rotation were all discussed. The polarizable continuum model, included in the calculation, did not improve the accuracy effectively, but it was superior to γs. Optical rotation of five or sixmembered of cyclic compound has been calculated and 17 pyrrolidine or piperidine derivatives which were calculated by HF and DFT methods gave a
View details →DOI: 10.2298/jsc110905207y Negative / Null Result ReportMedicine
Mazdarani, Miles · 2026 · Veterinary research communications
Cranial cruciate ligament (CCL) rupture is uncommon in cats but may cause persistent stifle instability. Previous ex vivo assessments of tibial plateau levelling osteotomy and tibial tuberosity advancement have failed to restore stability…
View details →DOI: 10.1007/s11259-026-11361-7 Replication FailureMedicine
Ramphul R, McCurdy SA, Lee J et al. · 2026 · Drug and alcohol dependence
Background In 2023, an estimated 39.6 million adults aged ≥ 18 years had a substance use disorder (SUD) and 94.7 % did not seek treatment. Recovery residences provide essential support for individuals recovering from SUD, yet their…
View details →DOI: 10.1016/j.drugalcdep.2026.113044 Negative / Null Result ReportMedicine
Janz C, Timpka J, Storch A et al. · 2026 · Journal of Parkinson's disease
BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient…
View details →DOI: 10.1177/1877718x261461073 Negative / Null Result ReportOpen accessMedicine
Le J, Patel M, Atschinow A et al. · 2026 · Cureus
The platelet-rich plasma in achilles tendon healing 2 (PATH-2) trial is the largest randomized study of platelet-rich plasma (PRP) in acute Achilles tendon rupture. While the original frequentist analysis showed no significant benefit,…
View details →DOI: 10.7759/cureus.102519 Negative / Null Result ReportOpen access
Vilela, Judith M · 1984
The activity of beta-amylase in crosses of Saccharum spontaneum L. and S. officinarum L. and their hybrids was determined. Results showed that the parents did not differ significantly in their enzyme activity. Variability in enzyme…
Negative / Null Result ReportOpen access
Robert Ladouceur, Marie Mayrand · 1987
The perceptions of control regarding an objectively uncontrollable task (American Roulette) by depressive and nondepressive subjects were compared. Monetary risk behavior and subjective control did not differ significantly between the two…
View details →DOI: 10.2466/pr0.1987.60.3.1019 Negative / Null Result ReportOpen accessMedicine
Wang J, Liu LL, Huang L et al. · 2026 · BMC nephrology
Background The European STOP study showed that glucocorticoids (with/without immunosuppressants) did not delay disease progression in adults with IgA nephropathy (IgAN). However, pediatric IgAN is characterized by more severe acute…
View details →DOI: 10.1186/s12882-026-05101-x Negative / Null Result ReportOpen accessMedicine
Park HJ, Park S, Heo S et al. · 2026 · Journal of microbiology and biotechnology
Leuconostoc lactis DMLL10 is a novel strain isolated from kimchi. The strain did not exhibit toxicity in genetic tests. This study aims to conduct a preclinical safety assessment by performing repeated-dose toxicity studies in animals. In…
View details →DOI: 10.4014/jmb.2601.01021 Negative / Null Result ReportOpen accessMedicine
Said C, Hayward C, Stevens M et al. · 2026 · Bioengineering (Basel, Switzerland)
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has failed to demonstrate mortality benefit in randomised controlled trials of cardiogenic shock. We aimed to determine whether a novel 'Hemi-ECMO' configuration, involving aortic…
View details →DOI: 10.3390/bioengineering13050499 Negative / Null Result ReportMedicine
Endo S, Tanaka R, Yamaguchi T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Large type 3 (≥ 8 cm) and type 4 gastric cancers are associated with extremely poor prognoses. The phase III JCOG0501 trial, which evaluated neoadjuvant S-1 plus cisplatin, failed to demonstrate any survival benefits. Docetaxel,…
View details →DOI: 10.1007/s10120-025-01705-8 Negative / Null Result Report
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2025 · Preprint
Background Intracranial atherosclerotic disease (ICAD) is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to…
View details →DOI: 10.1101/2025.09.17.25336036 Negative / Null Result ReportMedicine
Schreiner M, Thien H, Braasch T et al. · 2025 · Abdominal radiology (New York)
Background Many patients are instructed to fast before abdominal ultrasound examinations in order to obtain better image quality. However, the few available studies on this topic have so far failed to demonstrate an advantage of several…
View details →DOI: 10.1007/s00261-025-04947-3 Negative / Null Result ReportMedicine
Thery G, Noly PE, Cavayas YA et al. · 2025 · Seminars in thoracic and cardiovascular surgery
ECLS-SHOCK is the largest randomized control trial on Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in Acute Myocardial Infarction-related Cardiogenic Shock (AMI-CS). Unfortunately, ECLS-SHOCK failed to demonstrate a…
View details →DOI: 10.1053/j.semtcvs.2025.01.004 Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →DOI: 10.1093/oncolo/oyae295 