A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21328 results · page 466 of 711
Pitz V, Makarious M, Bandrés-Ciga S et al. · 2023 · Preprint
Abstract Objective Although many rare variants have been reportedly associated with Parkinson’s disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants.…
Chang J, Pais GM, Marianski S et al. · 2023 · Preprint
Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam. However, preclinical models have failed to replicate this finding. This study assessed differences in…
Odintsova VV, van Dongen J, van Beijsterveldt CEM et al. · 2023 · Twin research and human genetics : the official journal of the International Society for Twin Studies
In studies of singletons, a range of early-life characteristics have been reported to be associated with handedness, but some of these associations have failed to replicate. We examined associations between 23 early life characteristics…
Legendre M, Sabourin S, Bégin C · 2022 · Eating and weight disorders : EWD
Purpose A higher risk of food addiction (FA) in individuals reporting childhood sexual abuse (CSA) has been well demonstrated with community samples, but studies including clinical samples failed to replicate this relation. This study…
Zhang J, Whitehurst LN, Mednick SC · 2022 · Neurobiology of learning and memory
Prior studies suggest a role for sleep in memory consolidation, with specific contributions from slow oscillations and sleep spindles (Rasch & Born, 2013). However, recent studies failed to replicate sleep's superiority over wake in…
Aitken-Buck HM, Moore MK, Bingham KT et al. · 2024 · Forensic science, medicine, and pathology
Epicardial adipose tissue (EAT) deposition has been long associated with heart weight. However, recent research has failed to replicate this association. We aimed to determine the association of EAT volume with heart weight in post-mortem…
Forestier C, de Chanaleilles M, Boisgontier MP et al. · 2021 · Preprint
The replication crisis in psychology has led to question popular phenomena such as ego depletion, which has been criticized after studies failed to replicate. Here, we describe limitations in the literature that contributed to these…
Dora J, Van Lissa CJ, Shinn M et al. · 2026 · Preprint
Laboratory studies consistently support the hypothesis that people drink alcohol to regulate stress and negative affect, yet ecological momentary assessment (EMA) studies have repeatedly failed to detect the predicted within-person…
Taheri F, Tanha AS, Aboutorabi RB et al. · 2026 · Clinical nuclear medicine
A 78-year-old woman with medullary thyroid carcinoma (MTC) demonstrated persistently elevated serum calcitonin despite prior surgery and radiotherapy. 99mTc-octreotide imaging failed to detect skeletal metastases, while 68Ga-FAPI PET/CT…
Huang Y, Huang X, Ling L et al. · 2024 · Kardiologiia
Aim Elevated levels of pro-inflammatory factors in plasma have been linked to worse prognosis after on-pump cardiac surgery, yet interventions that reduce the levels in patients have failed to improve prognosis. Therefore, we explored…
Hanazawa R, Sato H, Hirakawa A · 2025 · Therapeutic innovation & regulatory science
Background Alzheimer's disease (AD) is a neurodegenerative disease for which many clinical trials failed to detect treatment effects, possibly due to the heterogeneity of disease progression among the patients. Predicting and clustering a…
Knappich C, Bohmann B, Kirchhoff F et al. · 2025 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective Various studies have failed to detect a difference in outcomes between carotid endarterectomy (CEA) with patch angioplasty and eversion CEA. This study aimed to assess whether surgical technique and related department policy are…
Ledesma V, Vanbaelen T, Gestels Z et al. · 2024 · FEMS microbiology letters
The ResistAZM randomized controlled trial found that the receipt of ceftriaxone/azithromycin, compared to ceftriaxone was not associated with an increase in the proportion of oral commensal Neisseria spp. and streptococci with azithromycin…
Zeidan AM, Aakko S, Stahl M et al. · 2026 · Expert review of anticancer therapy
Introduction Higher-risk myelodysplastic syndromes (HR-MDS) remain an area of high unmet need in which multiple randomized late-stage trials have failed to improve outcomes beyond hypomethylating agent monotherapy, despite encouraging…
Olluri A · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Experimental drugs lowering brain tau are heralded as improvements in the treatment of Alzheimer's disease. However, the outcomes in clinical trials testing these agents have consistently failed to improve patient outcomes, i.e. slow down…
Petr V, Tichanek F, Liu SL et al. · 2025 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Targeting peritransplant inflammation via tumor necrosis factor alpha blockade failed to improve kidney transplantation outcomes in the CTOT-19 trial that tested infliximab (IFX) induction. As natural antibodies (nAbs) to cardiolipin and…
Lähteenmäki EI, Lehti S, Jauhiainen M et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Although high-density lipoprotein (HDL) has cardiometabolic protecting properties, interventions to raise HDL cholesterol concentration have failed to improve cardiometabolic health. Hence, HDL composition and functionality might be key…
El Jalkh J, Obeid PM, Guermazi D et al. · 2025 · Dermatopathology (Basel, Switzerland)
A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and…
Mohammed SA, Gorica E, Albiero M et al. · 2025 · Diabetes
Revascularization strategies failed to improve outcome in patients with diabetes with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role in angiogenic response. This study…
Zhang H, Yang Y, Sun S · 2024 · Acta psychologica
In response to the public's puzzle about why maternity leave has unexpectedly failed to improve fertility problem in the Chinese context of a widespread extension of maternity leave, our study concentrates on a prevailing stigmatization…
Glynatsis MN, Economou M, Papadopoulou K et al. · 2024 · Cureus
This report presents a rare case of a central retinal artery occlusion in an eight-year-old girl attributed to an undiagnosed patent ductus arteriosus (PDA). Despite intensive treatment, the patient's eyesight failed to improve. Cases of…
Barakzie A, Jansen AJG, Cavalcante F et al. · 2025 · Journal of thrombosis and haemostasis : JTH
Background Intravenous thrombolysis (IVT) using recombinant tissue plasminogen activator prior to endovascular thrombectomy treatment (EVT) failed to improve treatment effect in acute ischemic stroke (AIS) patients compared with EVT alone.…
Sanabria A, Rodrigo JP, Araújo ALD et al. · 2025 · Cancers
Background/Objectives : Oropharyngeal squamous cell carcinoma (OPSCC) management has shifted following recognition of HPV-driven disease. Neoadjuvant chemotherapy (NAC) has historically failed to improve overall survival (OS) in mixed head…
Altun A, Balcı BK, Celik C et al. · 2025 · Preprint
Abstract Backround: The aim of thisprospectivecohortstudywastoevaluatethedevelopmentalpotential of metaphase I (MI) oocytes that failed to reach maturation following rescue in vitro maturation (IVM). Method: ICSI was performed to these…
Li H, Man X, Cai T · 2024 · Journal of Environmental Management
Despite decades of recovery, soil carbon in heavily burned areas has failed to reach pre-fire levels. It is unclear whether stand management practices can promote soil organic carbon accumulation at such sites. This study evaluated the…
Li H, Man X, Cai T · 2024 · Journal of environmental management
Despite decades of recovery, soil carbon in heavily burned areas has failed to reach pre-fire levels. It is unclear whether stand management practices can promote soil organic carbon accumulation at such sites. This study evaluated the…
Calabrese SK, Bor J, Dukashe M et al. · 2025 · Journal of the International AIDS Society
Introduction The Undetectable = Untransmittable (U = U) message has failed to reach many people living with HIV (PLHIV) and their communities despite evidence of its favourable impacts. Discussion We describe and contextualize six global…
Gordon EJ, Gacki-Smith J, Smith JD et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN
Key points Apolipoprotein L1 genetic testing did not reduce potential living donors' willingness to donate, supporting integration of testing into practice. The Apolipoprotein L1 Testing and Counseling Program did not reduce potential…
Kittipibul V, Nguyen M, Welsh P et al. · 2026 · American heart journal
Background In the EXSCEL trial, exenatide did not reduce major adverse cardiovascular events (MACE), but heterogeneity of benefit and the role of cardiac biomarkers remain uncertain. We evaluated the prognostic value of baseline and 1-year…
Sanna AC, Gendreau S, Desnos C et al. · 2026 · American journal of respiratory and critical care medicine
Rationale Patients with severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)-related diffuse alveolar hemorrhage (DAH) face high mortality. In the PEXIVAS trial, plasma exchange (PLEX) did not reduce death or…