Iohexol-measured glomerular filtration rate and urinary biomarker changes between vancomycin and vancomycin plus piperacillin-tazobactam in a translational rat model
Chang J; Pais GM; Marianski S; Valdez K; Lesnicki E; Barreto EF; Rhodes NJ; Yarnold PR · 2023 · Preprint
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“However, preclinical models have failed to replicate this finding.”
Abstract (excerpt)
Recent clinical studies have reported additive nephrotoxicity with the combination of vancomycin and piperacillin-tazobactam. However, preclinical models have failed to replicate this finding. This study assessed differences in…
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Metadata source: Europe PMC · DOI 10.1101/2023.03.09.532007