Learning from late-stage trial failures in higher-risk myelodysplastic syndromes: towards adaptive and biomarker-enriched designs.
Zeidan AM; Aakko S; Stahl M; Bewersdorf JP; Bono P; Huttunen T; Jalkanen J; Louramo E · 2026 · Expert review of anticancer therapy
WASTE classifies this as Failed Experiment Report · AI classification, approximate
An experimental approach did not work as intended — learn what to avoid before investing the same effort.
Abstract (excerpt)
Introduction Higher-risk myelodysplastic syndromes (HR-MDS) remain an area of high unmet need in which multiple randomized late-stage trials have failed to improve outcomes beyond hypomethylating agent monotherapy, despite encouraging…
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Metadata source: Europe PMC · DOI 10.1080/14737140.2026.2640238