Negative / Null Result ReportOpen accessMedicine
Gorka J, Putowski Z, Wludarczyk A et al. · 2025 · Anaesthesiology intensive therapy
Background The PREVENT-MINS trial investigated whether perioperative heart rate reduction with ivabradine could prevent myocardial injury after noncardiac surgery (MINS). Although ivabradine modestly reduced heart rate, it did not reduce…
View details →DOI: 10.5114/ait/216162 Negative / Null Result ReportMedicine
Liu Y, Ren Y, Yang Y et al. · 2025 · Acta cardiologica
Background In 2012, the randomised trial IABP SHOCK II demonstrated that IABP did not reduce 30-day mortality in patients with acute myocardial infarction complicating cardiogenic shock (CS). However, SCAI proposed a new standardised…
View details →DOI: 10.1080/00015385.2025.2569023 Negative / Null Result ReportMedicine
Perkins JA, Price RS, Vizcarra JA · 2026 · Neurology
We describe a 70-year-old man with no significant medical history who developed progressive left leg numbness, gait dysfunction, and recurrent falls. Within a year, he reported difficulty with both initiating steps and perceiving his left…
View details →DOI: 10.1212/wnl.0000000000218062 Negative / Null Result ReportMedicine
Yamaguchi T, Akai S, Uozumi N et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
A 53-year-old male patient presented with dyspnea and was admitted with the diagnosis of bacterial pneumonia.His respiratory condition did not improve despite the resolution of fever with antibiotic therapy, and he was eventually diagnosed…
Negative / Null Result ReportMedicine
Diprose W, Fahed R, Volders D et al. · 2026 · Journal of neurointerventional surgery
Background Randomized trials showed that endovascular thrombectomy (EVT) did not improve outcomes in medium vessel occlusion (MeVO) stroke compared with usual care. We investigated whether patients randomized to EVT who achieved…
View details →DOI: 10.1136/jnis-2025-024733 Negative / Null Result ReportMedicine
Olatunji BO, Cusack CE, Levinson CA · 2026 · Journal of anxiety disorders
Although disgust proneness has been implicated in the development of obsessive-compulsive disorder (OCD), studies to date have failed to identify the core symptom of disgust proneness that may be most strongly associated with OCD and its…
View details →DOI: 10.1016/j.janxdis.2026.103204 Failed Experiment ReportMedicine
Turner D, DeMaet MA, Bundage D et al. · 2026 · American journal of infection control
During an 87-week interrupted time series, we evaluated screening positivity after de-escalating dedicated cohort units for Candida auris and later implementing enhanced nursing engagement. Discontinuing cohort units did not increase…
View details →DOI: 10.1016/j.ajic.2026.06.001 Negative / Null Result ReportMedicine
Balziano S, Margalit I, Kollender R et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Fever often delays urgent hip fracture surgery due to infection concerns. This study found that operating early, despite fever, did not increase complications or death compared to waiting. Thus, early surgery appears to be a feasible…
View details →DOI: 10.1007/s00198-026-07904-y Negative / Null Result ReportMedicine
Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…
View details →DOI: 10.1007/s00198-026-08113-3 Negative / Null Result ReportOpen accessMedicine
Parisi T, Santibanez Ocampo B, Adelman J et al. · 2026 · JCI insight
Age-related blood cell mutations (clonal hematopoiesis) reshape immune cells and lung tumor immune structures, but did not increase lung cancer growth in a genetically engineered mouse model. .
View details →DOI: 10.1172/jci.insight.203981 Negative / Null Result ReportMedicine
Yata N, Hollό G, Ishida T et al. · 2026 · Journal of glaucoma
Précis Combined phacoemulsification and Kahook Dual Blade goniotomy significantly increased the iridocorneal angle dimensions in POAG/NTG, but postoperative pilocarpine instillation did not further increase the dimensions, suggesting that…
View details →DOI: 10.1097/ijg.0000000000002666 Negative / Null Result ReportOpen accessMedicine
Li Z, Hu X, Feng H et al. · 2026 · Animals : an open access journal from MDPI
We evaluated the effects of different levels of DON (LD 441 and HD 1223 μg DON/kg in diet) on the growth performance, immunity, reproductive hormones, and intestinal health of immature gilts. No significant differences were observed in…
View details →DOI: 10.3390/ani16111751 Negative / Null Result ReportMedicine
Fisher JP, Roche J, Duffy AG et al. · 2026 · Autonomic neuroscience : basic & clinical
We investigated whether three days of hypoxic exposure in a hypobaric chamber, and the associated nocturnal periodic breathing (nPB), reduce sympathetic nerve activity (MSNA) transduction to blood pressure (BP). While hypoxia did not…
View details →DOI: 10.1016/j.autneu.2026.103386 Negative / Null Result ReportMedicine
Liu CX, Blair BA, Tenney ER · 2026 · Psychological science
In 2012, Livingston et al. found that Black women were buffered against gender backlash; whether Black women were dominant or supportive toward an employee did not affect people's perceptions of them as leaders in an organization.…
View details →DOI: 10.1177/09567976261436988 Negative / Null Result ReportOpen accessMedicine
Wang L, Sardella BR, Aronson EK et al. · 2026 · NPJ breast cancer
We utilized the K14-Cre Brca1 f/f Tp53 f/f mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development.…
View details →DOI: 10.1038/s41523-026-00892-6 Failed Experiment ReportMedicine
Kanazawa R, Goto R, Harada T et al. · 2024 · Scandinavian journal of immunology
Graft-infiltrating lymphocytes (GILs) play an important role in promoting rejection after organ transplantation. We recently reported that GILs that accumulated up to 3 days post-transplantation did not promote rejection, whereas GILs…
View details →DOI: 10.1111/sji.13397 Negative / Null Result ReportMedicine
Yang EH, Lopez C, Shay SL et al. · 2026 · Infection control and hospital epidemiology
The clinical outcomes associated with using commercial versus open ISDTs (initial specimen diverting techniques) remain unclear. This multicenter study showed that switching from the commercial to open ISDT did not change blood culture…
View details →DOI: 10.1017/ice.2026.10412 Negative / Null Result ReportMedicine
Thomas A, Tucker CB, Lunn DE et al. · 2026 · Journal of biomechanics
Studies investigating the concurrent validity of markerless motion capture (MMC) systems for obtaining joint and segment kinematics have largely failed to consider the impact of ambient lighting and camera position, which can both affect…
View details →DOI: 10.1016/j.jbiomech.2026.113343 Negative / Null Result ReportMedicine
Tazumi T, Prados J, Urcelay GP · 2026 · Journal of comparative psychology (Washington, D.C. : 1983)
This study examined whether saline acts as an aversive stimulus for planarians and how it influences learning and memory. Using saline as an unconditioned stimulus, we first tested conditioned place avoidance. Saline did not support…
View details →DOI: 10.1037/com0000449 Negative / Null Result Report
Treeratanapun N, Lerttiendamrong B, Vacharathit V et al. · 2026 · Preprint
Abstract Background The implementation of sentinel lymph node biopsy (SLNB) with permanent section (PS) analysis alone in patients who satisfied the ACOSOG Z0011 criteria did not alter the standard of care offered by the additional frozen…
View details →DOI: 10.21203/rs.3.rs-9454590/v1 Negative / Null Result ReportOpen accessMedicine
Lee N, Yang Y, Tian D et al. · 2026 · Journal of ginseng research
We determined whether Korean Red Ginseng (KRG) extract and ginsenosides (Rb1, Rg1, or Rg3) have estrogen receptor-mediated or androgen receptor-mediated activities using OECD TG455/458 assays with S9 metabolic activation. They did not…
View details →DOI: 10.1016/j.jgr.2026.100989 Negative / Null Result ReportMedicine
Adams MS, Mensink RP, Plat J et al. · 2026 · European journal of clinical nutrition
Background Previous almond intervention studies involving relatively healthy populations did not demonstrate improvements in cognitive performance. However, a long-term study with participants at risk of cognitive decline, such as those…
View details →DOI: 10.1038/s41430-026-01705-6 Negative / Null Result ReportMedicine
Kant N, Garssen SH, Vernooij CA et al. · 2024 · Studies in health technology and informatics
Adding continuous monitoring to usual care at an acute admission ward did not have an effect on the proportion of patients safely discharged. Implementation challenges of continuous monitoring may have contributed to the lack of effect…
View details →DOI: 10.3233/shti240764 Negative / Null Result ReportMedicine
Sanders JF, de Boer SE, Jonker J et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points Low-dose tacrolimus, everolimus, and prednisolone did not result in a higher rate of successful transplantation in older kidney transplant recipients. Low-dose tacrolimus, everolimus, and prednisolone did not result in better…
View details →DOI: 10.1681/asn.0000000924 Negative / Null Result ReportMedicine
Hüther A, Sherman CL, Sumaroka A et al. · 2026 · Ophthalmic genetics
Purpose To describe the phenotype of a patient with bi-allelic pathogenic variants in NR2E3 that did not result in an overt enhanced S-cone syndrome (ESCS) phenotype. Methods The patient underwent a comprehensive ophthalmic exam, imaging…
View details →DOI: 10.1080/13816810.2026.2635611 Negative / Null Result ReportMedicine
Wu C, Zhu X, Dai Q et al. · 2026 · Chest
Case presentation A 74-year-old woman sought treatment with a 4-day history of high fever and rapidly progressive dyspnea. A 2-day course of ceftriaxone and betamethasone administered in an outpatient setting did not result in any clinical…
View details →DOI: 10.1016/j.chest.2025.07.4069 Negative / Null Result ReportMedicine
Stewart D, Greenberg M, Heppell S et al. · 2025 · Emergency medicine Australasia : EMA
Objective To determine the proportion of patients who are admitted to hospital following a 'did not wait' (DNW) encounter that are related to the initial episode of care, and to assess the frequency of clinical deterioration in this…
View details →DOI: 10.1111/1742-6723.70134 Negative / Null Result Report
Furne Gouveia G · 2026 · Preprint
The Michelson–Morley experiment yielded a null result, indicating equal light travel times in the longitudinal and transverse arms of an interferometer, traditionally interpreted as evidence against a light-propagating medium. This paper…
View details →DOI: 10.20944/preprints202601.0623.v2 Negative / Null Result Report
Furne Gouveia G · 2026 · Preprint
The Michelson–Morley experiment yielded a null result, indicating equal light travel times in the longitudinal and transverse arms of an interferometer, traditionally interpreted as evidence against a light-propagating medium. This paper…
View details →DOI: 10.20944/preprints202601.0623.v1 Negative / Null Result Report
Schwab S, Giuachin K, Held L · 2020 · Preprint
Publication bias is a persisting problem in meta-analyses for evidence based medicine. As a consequence small studies with large treatment effects are more likely to be reported than studies with a null result which causes asymmetry. Here,…
View details →DOI: 10.31222/osf.io/t6cjx 