Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials
Linda Spiegelberg; Ruud Houben; Raymon Niemans; Dirk De Ruysscher; Ala Yaromina; Jan Theys; Christopher P. Guise; Jeffrey B Smaill · 2019 · Clinical and Translational Radiation Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of treatment resistance to conventional therapies. Despite promising preclinical and clinical phase I and II…
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Metadata source: OpenAlex · DOI 10.1016/j.ctro.2019.01.005