Negative / Null Result ReportMedicine
Yoshida K, Hakozaki T, Hasegawa T et al. · 2025 · Journal of clinical monitoring and computing
The aim of the present study was to investigate the utility of the intraoperative high frequency variability index (HFVI) / Analgesia Nociception Index (ANI) for predicting postoperative pain in patients undergoing open liver or pancreatic…
View details →DOI: 10.1007/s10877-025-01332-9 Failed Experiment ReportOpen accessMedicine
Napora Z, Griffith O, Slobounov S · 2026 · Frontiers in neurology
The transition to active rehabilitation in concussion care requires precise tools to identify patients at risk of persistent post-concussive symptoms (PPCS). While machine learning (ML) offers the potential to personalize prognosis,…
View details →DOI: 10.3389/fneur.2026.1801044 Negative / Null Result ReportMedicine
Lemoine L, Adam V, Salleron J et al. · 2025 · Brachytherapy
Purpose Removal of brachytherapy applicator is routinely performed under premedication including Kalinox® gas inhalation without general anesthesia. The applicator removal is nevertheless associated with discomfort, anxiety or pain. We…
View details →DOI: 10.1016/j.brachy.2025.07.010 Replication FailureOpen accessMedicine
Xiao Y, Li Z, Hu B et al. · 2025 · Neurologia medico-chirurgica
For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant…
View details →DOI: 10.2176/jns-nmc.2025-0104 Replication FailureOpen accessMedicine
Stazi F · 2026 · European heart journal supplements : journal of the European Society of Cardiology
Despite the use of oral anticoagulants, the residual risk of recurrent ischaemic stroke in patients with atrial fibrillation (AF) is ∼4% per year; however, in patients who experience a stroke despite oral anticoagulant therapy (OAT), this…
View details →DOI: 10.1093/eurheartjsupp/suag052 Negative / Null Result ReportOpen accessMedicine
Özkaya AB, Ghaseminejad Y · 2025 · FEBS open bio
Autophagy plays a critical role in maintaining cellular homeostasis and is implicated in various physiological and pathological processes, including cancer, neurodegeneration, and metabolic disorders. Although typically associated with…
View details →DOI: 10.1002/2211-5463.70101 Failed Experiment ReportOpen accessMedicine
Comeau MO, Gascon F, Corbeil M et al. · 2025 · Acta neurochirurgica
Purpose Meningioma resection remains partial in over 25% of cases, with few known predictors of residual disease progression. This study aims to assess if dural attachment, identified on postoperative imaging, influences meningioma…
View details →DOI: 10.1007/s00701-025-06734-x Negative / Null Result ReportOpen accessMedicine
Lee JW, Kim CJ, Lee BK et al. · 2025 · JACC. Advances
Background Distal radial access (DRA) has emerged as an alternative to transradial access (TRA) in coronary procedures. However, evidence supporting its use in ST-segment elevation myocardial infarction (STEMI) remains limited. Objectives…
View details →DOI: 10.1016/j.jacadv.2025.102200 Negative / Null Result ReportOpen accessMedicine
El-Hajj VG, El Choueiri J, Vasella F et al. · 2026 · Brain & spine
Introduction Central nervous system (CNS) melanocytomas are rare, pigmented tumors derived from leptomeningeal melanocytes. Although generally benign, they can exhibit locally aggressive behavior and recur. Despite increasing recognition,…
View details →DOI: 10.1016/j.bas.2025.105922 Negative / Null Result ReportOpen accessMedicine
Barber D, Wijeratne T, Singh L et al. · 2025 · Life (Basel, Switzerland)
Sporadic Parkinson's Disease (PD) affects 3% of people over 65 years of age. People are living longer, thanks in large part to improvements in global health technology and health access for non-neurological diseases. Consequently,…
View details →DOI: 10.3390/life15081169 Replication FailureOpen accessMedicine
Florens N, Demiselle J · 2026 · Kidney360
Iodinated contrast media have long been feared for causing contrast-induced AKI (CI-AKI), a concern rooted in early reports with high-osmolar agents. Experimental data suggest potential nephrotoxic mechanisms, yet clinical evidence from…
View details →DOI: 10.34067/kid.0000001019 Methods Dead-EndMedicine
Koretz RL · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review To assess the quality of recently published (18 months from date of article request) randomized trials/systematic reviews of such trials that addressed the use of nutritional support in critically ill patients. Recent…
View details →DOI: 10.1097/mco.0000000000001080 Failed Experiment ReportMedicine
Karim B, Alwi I, Yamin M et al. · 2025 · Acta medica Indonesiana
Background Inflammation plays a role in ST-segment elevation myocardial infarction (STEMI), especially in reperfusion injury (RI). Colchicine, an anti-inflammatory drug, can suppress inflammation during RI. We assessed the effectiveness of…
Failed Experiment ReportOpen accessMedicine
Zhuang L, Woo J, Francisco F et al. · 2024 · Journal of clinical apheresis
The majority of the time hematopoietic progenitor cells (HPC) are collected through leukapheresis, where anticoagulants are necessary to prevent clotting of the apheresis circuit and HPC product. Although clotting of the product is a…
View details →DOI: 10.1002/jca.70002 Negative / Null Result ReportOpen accessMedicine
Lazarevic Lindblad M, Pålsson E, Lazarevic V et al. · 2026 · Infection prevention in practice
Background Central venous catheters (CVCs) are commonly used in patients with haematological diseases but are associated with infectious complications. The CVC Anti-infection Double Lumen Bundle was introduced in December 2020 to reduce…
View details →DOI: 10.1016/j.infpip.2026.100536 Negative / Null Result ReportOpen accessMedicine
Sunwoo JS, Cho YW, Shin WC et al. · 2025 · Journal of clinical neurology (Seoul, Korea)
Background and purpose To evaluate the clinical efficacy and safety of pregabalin in Korean adults with restless legs syndrome (RLS). Methods In this randomized, multicenter, double-blind, placebo-controlled trial, 78 patients with RLS…
View details →DOI: 10.3988/jcn.2025.0092 Abandoned HypothesisOpen accessMedicine
Derakhshan A, Zia MJ, Tavakkol Afshari J et al. · 2026 · Medical hypothesis, discovery & innovation ophthalmology journal
Background Primary open-angle glaucoma (POAG) is characterized by increased resistance to aqueous humor outflow. Transforming growth factor beta-1 (TGF-beta1) contributes to this resistance by promoting synthesis and remodeling of the…
View details →DOI: 10.51329/mehdiophthal1537 Short NoteMedicine
de Graaf IM, de Jonghe A, Golüke NMS et al. · 2026 · Journal of clinical medicine
Background: Basal ganglia calcifications (BGCs) are frequently detected on brain CT scans in older adults, but their clinical relevance for mobility and fall risk is unclear. This study investigated the association of BGCs with impaired…
View details →DOI: 10.3390/jcm15124732 Negative / Null Result ReportMedicine
Gaeini Z, Mirmiran P, Azizi F · 2026 · Scientific reports
While emerging evidence from Western populations suggests that higher carbohydrate quality (assessed by indices incorporating fiber, glycemic index, whole grains, and solid carbohydrate sources) is inversely associated with cardiovascular…
View details →DOI: 10.1038/s41598-026-55845-7 Negative / Null Result ReportMedicine
Soral S, Bargale S, Dave B et al. · 2026 · Journal of the Indian Society of Pedodontics and Preventive Dentistry
Background Orthodontic treatment has long been associated with visible wires in the mouth. Clear aligners, once limited to mild crowding/spacing, are now supported for correcting more complex malocclusions. While Clear Aligner Therapy…
View details →DOI: 10.4103/jisppd.jisppd_15_26 Negative / Null Result ReportMedicine
Manca A, Palermiti A, Corcione S et al. · 2026 · Antibiotics (Basel, Switzerland)
Background/Objectives: Cefiderocol (FDC) is a siderophore-containing cephalosporin that retains activity against many β-lactamase-producing bacteria, such as New Delhi metallo-β-latamase-producing (NDM) K. pneumoniae . Its use in…
View details →DOI: 10.3390/antibiotics15060619 Negative / Null Result ReportOpen accessOils, fats, and waxes
刘芳1，吴苏喜1，2，蒋明芳1，谭传波3，李普选2LIU Fang1, WU Suxi1,2, JIANG Mingfang1, TAN Chuanbo3, LI Puxuan2 · 2022 · Zhongguo youzhi
为了了解不同制油工艺对油茶籽油生物活性成分含量和抗氧化活性的影响，以油茶果为原料，采取鲜榨法、浸提法、新水法、冷榨法和热榨法5种制油工艺分别制取油茶籽油，研究对比了5种制油工艺的提油率，所制取的油茶籽油的脂肪酸组成、生物活性成分(生育酚、角鲨烯及多酚)含量及其对DPPH自由基和ABTS自由基的清除能力。结果表明，5种制油工艺的提油率均在73%以上，其中浸提法（（96.45±3.02）%）最高，冷榨法（（73.72±2.76）%）最低，鲜榨法（（82.36±224）%）、新水法（（81.91±3.21）%）和热榨法（（80.34±2.09）%）没有显著差异；5种工艺所制取的油茶籽油具有相似的脂肪酸组成；在α-生育酚和总生育酚含量方面，新水法制取的油茶籽油含量最高（α-生育酚含量（263.77±1.58）mg/kg，总生育酚含量（280.55±1.64）mg/kg），鲜榨法、冷榨法和热榨法制取的油茶籽油中总生育酚含量接近，在233~244 mg/kg之间，浸提法制取的油茶籽油中总生育酚含量只有（17.10±0.76）mg/kg；在角鲨烯和多酚含量方面，鲜榨法制取的油茶籽油明显高于其他工艺的，分别为（350.56±7.60）mg/kg和（45.04±4.50）mg/kg，新水法制取的油茶籽油角鲨烯含量最低，为（249.99±3.73）mg/kg，浸提法制取的油茶籽油多酚含量最低，为（7
View details →DOI: 10.19902/j.cnki.zgyz.1003-7969.210470 Negative / Null Result ReportOpen accessBiology (General)
Muhammad Abba Isah Audu, Yusuf Idris, Muhammad Liman Muhammad et al. · 2022 · Botanica
The nutritional attributes of sesame, Sesamum indicum, vary substantially and are primarily influenced by the plant’s genetic makeup. This investigation accessed the biochemical composition of sesame mutants from two generations. Seeds of eleven M3 lines were planted in a Randomized Complete Block Design (RCBD) to raise M4 lines, which were advanced to M5 generation. The seeds were harvested at maturity, and their biochemical compositions were quantitatively determined following standard procedures. Results revealed significant differences (p 0.05) was observed in ash content of M4 and M5 muta
View details →DOI: https://doi.org/10.35513/botlit.2022.2.6 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Xiao-Xiao Han, Jia Qiao, Zhan-Ao Meng et al. · 2023 · Brain Sciences
Objectives: Investigate the biomechanical characteristics in tracheostomized patients with aspiration following acquired brain injury (ABI) and further explore the relationship between the biomechanical characteristics and aspiration. Methods: This is a single-center cross-sectional study. The tracheostomized patients with aspiration following ABI and age-matched healthy controls were recruited. The biomechanical characteristics, including velopharynx (VP) maximal pressure, tongue base (TB) maximal pressure, upper esophageal sphincter (UES) residual pressure, UES relaxation duration, and subgl
View details →DOI: 10.3390/brainsci13010091 Negative / Null Result ReportMedicine
Deng, Zhu, Cao et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
The clinical evaluation of lumbar degenerative disease (LDD) severity relies on symptoms and imaging, lacking biologically specific diagnostic markers. This study investigated the role of serum complements in LDD to assess their potential…
View details →DOI: 10.1007/s00586-026-10086-0 Negative / Null Result ReportOpen accessMedicine
Xiuwen Sun, Xiaoling Li, Lingyu Ji et al. · 2018 · PeerJ
Based on the existing research on sound symbolism and crossmodal correspondence, this study proposed an extended research on cross-modal correspondence between various sound attributes and color properties in a group of non-synesthetes. In Experiment 1, we assessed the associations between each property of sounds and colors. Twenty sounds with five auditory properties (pitch, roughness, sharpness, tempo and discontinuity), each varied in four levels, were used as the sound stimuli. Forty-nine colors with different hues, saturation and brightness were used to match to those sounds. Result revea
View details →DOI: 10.7717/peerj.4443 Negative / Null Result ReportOpen accessAnimal culture
QIAN Ren-dong, WANG Lian-sheng, LUO Qiao-hua et al. · 2023 · Siliao yanjiu
The purpose of the study was to investigate the effects of wheat gluten replacing fish meal on growth performance, serum biochemistry, liver antioxidant and intestinal digestive enzyme activities of Cyprinus carpio . A total of 180 healthy Cyprinus carpio with an initial body weight of (9.16±0.03) g were selected and divided into three experimental groups, with three replicates in each group and 20 fish in each replicate. The control group (CW) was with 5% fish meal, and the experimental groups were with 50% (WA) and 100% (WB) fish meal replaced by wheat gluten. The experiment lasted for 56 d.
Failed Experiment ReportOpen accessScience
Tareq Al-Attar, Ahmed Taha · 2018 · Engineering and Technology Journal
This paper investigates the durability of high-volume Fly ash self-compacting concrete, HVFASCC that exposed to internal sulfate attack. At the present work, HVFASCC was produced with two Fly ash replacements: 50 and 60% by weight of Portland cement. The internal sulfate attack was simulated by adding natural gypsum (CaSO4) that contain ion (SO3-2) to fine aggregate by two weight percentages: 1 and 2%. Limestone dust was used as filler with a content of 100 kg/m3. The cementitious materials, cement and Fly ash, content was 400 kg/m3 and the water to powder ratio for the studied mixes was 0.34
View details →DOI: 10.30684/etj.36.12a.7 Negative / Null Result ReportOpen accessAnimal culture
Hang Wang, Xiaojie Qin, Xia Li et al. · 2020 · Poultry Science
This study was conducted to investigate the effects of air chilling (AC), water chilling (WC), combined chilling consisting of WC for 20 min and AC (CO20), and combined chilling consisting of WC for 30 min and AC (CO30) on the microbiological status, surface color, processing yield, and moisture content of yellow-feathered chicken carcasses. After chilling, the carcasses treated by AC exhibited the highest total viable counts (TVC) (4.7 cfu/cm2), followed by those treated by CO20 and CO30, whereas the carcasses treated by WC showed the lowest (P 0.05) was found among the carcasses treated by C
View details →DOI: 10.1016/j.psj.2019.11.020 Negative / Null Result ReportOpen accessPsychiatry
ّForough Farshidmanesh, Hosein Davoudi, Hasan Heidari et al. · 2019 · Taḥqīqāt-i ̒Ulūm-i Raftārī
Aim and Background: Many women begin their marital life with high intimate relationships, but with time, these intimate relationships are becoming less and more difficult, and it is just when then couple burnout has begun. The purpose of this study was to comparison of the effectiveness of mindfulness education and Emotional Focused Therapy (EFT) on couple intimacy, commitment and happiness women with couple burnout. Methods and Materials: The semi-experimental study was performed as pretest-posttest with a control group. The population included all women with couple burnout who was referred t
