Failed Experiment ReportOpen accessMedicine
Senda A, Suginaka H, Morishita K et al. · 2025 · Stroke and vascular neurology
Introduction Cerebral venous thrombosis (CVT) is a rare but serious disease. Despite anticoagulation being the cornerstone therapy, some patients experience worsening disease, necessitating alternative treatment. Endovascular treatment is…
View details →DOI: 10.1136/svn-2024-003639 Failed Experiment ReportMedicine
Sandoval JL, Kiavue N, Djerroudi L et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose In patients with metastatic breast cancer, ≥5 circulating tumor cells (CTC)/7.5 mL of blood is a validated adverse prognostic marker. The STIC CTC phase III trial (N = 778, hormone receptor-positive HER2- metastatic breast cancer)…
View details →DOI: 10.1158/1078-0432.ccr-25-0807 Failed Experiment ReportMedicine
Grossmann NC, Barmettler L, Sava M et al. · 2025 · World journal of urology
PURPOSE: To assess the effect of single-dose perioperative antibiotic prophylaxis (PAP) on surgical site infection (SSI) rates and related outcomes in elective scrotal or inguinal testicular surgery. METHODS: Retrospective cohort study of…
View details →DOI: 10.1007/s00345-025-05966-x Failed Experiment ReportMedicine
Das UN · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)
The failed regimens for sepsis include but are not limited to steroids, antibiotic coverage for gram-negatives, and activated protein C. Reports of dramatic successes with vitamin C, its low cost and virtual absence of side effects in…
View details →DOI: 10.1016/j.nut.2025.112924 Negative / Null Result ReportMedicine
Arnold SV, Wang K, Kirtane AJ et al. · 2025 · European heart journal. Quality of care & clinical outcomes
Background Renal-artery stenosis can be associated with difficult to control hypertension, although renal-artery stenting has not been shown to improve clinical outcomes. Alternative antihypertensive medications could potentially result in…
View details →DOI: 10.1093/ehjqcco/qcae087 Negative / Null Result Report
Nasrallah OG, Herrera MT, Nasr RW et al. · 2025 · Preprint
Abstract Background : Standardization of multi-parametric MRI (mp-MRI) prior to prostate biopsy and the incorporation of ultrasound fusion allowed precise and accurate targeted prostate biopsies. Random biopsies, still performed as…
View details →DOI: 10.21203/rs.3.rs-6950274/v1 Negative / Null Result ReportMedicine
Ugarte R, Noguchi D, Jaeger C et al. · 2025 · Journal of the American College of Surgeons
Background High-acuity post-liver transplantation (LT) patients often have a prolonged hospital course. In response, we developed a novel, intensive inpatient group physical therapy (PT) program and sought to evaluate its impact on…
View details →DOI: 10.1097/xcs.0000000000001473 Negative / Null Result ReportOpen accessMedicine
Asali M, Asali G · 2026 · Advances in urology
Background Partial nephrectomy represents a nephron-sparing strategy aimed at preserving renal function while balancing increased technical complexity and potential oncological considerations. Innovations in minimally invasive surgery,…
View details →DOI: 10.1155/aiu/5540611 Negative / Null Result ReportOpen accessMedicine
Guerrero-Ramos F, Gómez-Cañizo C, Rodríguez-Izquierdo M et al. · 2026 · The oncologist
Background BladderGATE evaluated the safety, tolerability, and efficacy of intravenous (IV) atezolizumab combined with intravesical Bacillus Calmette-Guérin (BCG) in patients with BCG-naïve high-risk non-muscle invasive bladder cancer…
View details →DOI: 10.1093/oncolo/oyag177 Negative / Null Result ReportMedicine
Hara R, Watanabe S, Murase Y et al. · 2025 · Chest
Case presentation A 72-year-old man with progressive dyspnea was referred to our hospital for evaluation of diffuse lung disease. His medical history was unremarkable except for a 20-year history of smoking 20 cigarettes per day. Abnormal…
View details →DOI: 10.1016/j.chest.2025.02.024 Negative / Null Result ReportOpen accessMedicine
McDermott MM, Zhang D, Zhao L et al. · 2025 · Journal of the American Heart Association
Background Supervised treadmill exercise improves walking performance in people with lower extremity peripheral artery disease, but benefits are not immediate. This study identified the time course of attaining meaningful improvement in…
View details →DOI: 10.1161/jaha.124.040058 Negative / Null Result ReportMedicine
Humes LE, Dhar S, Singh J · 2025 · International journal of audiology
Objective To evaluate use of the Hearing Handicap Inventory for the Elderly (HHIE), and its derivatives, as hearing-aid outcome measures. Design A targeted narrative literature review identified 12 studies in the primary research…
View details →DOI: 10.1080/14992027.2025.2511218 Failed Experiment ReportOpen accessMedicine
Dalbeni A, Vicardi M, Natola LA et al. · 2026 · Oncology research
Objectives The combination of atezolizumab plus bevacizumab (A+B) represents one of the standards first-line treatments for unresectable hepatocellular carcinoma (HCC). Metformin has garnered attention for its potential antitumour and…
View details →DOI: 10.32604/or.2026.073063 Failed Experiment ReportMedicine
Lapner P · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Rotator cuff retears remain the most frequently observed complication after arthroscopic cuff repair, with tendon nonhealing rates reported between 20% and 68%. Biological solutions to improve healing rates are needed, and bone marrow…
View details →DOI: 10.1016/j.arthro.2025.03.025 Negative / Null Result ReportOpen accessMedicine
Cai J, Li W, Xu S · 2025 · BMC medical education
Introduction To explore the impact of teaching by clinical educators and faculty educators on the academic performance of vocational medical students, this study analyzed the final exam scores of four classes in the General Surgery course…
View details →DOI: 10.1186/s12909-025-08371-5 Negative / Null Result ReportOpen accessMedicine
Shankar DA, Bosch NA, Jafarzadeh SR et al. · 2025 · CHEST pulmonary
Background Corticosteroids are a mainstay of treatment for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF), but dosing practices vary. We leveraged between-hospital variation in propensity to administer pulse dose…
View details →DOI: 10.1016/j.chpulm.2025.100207 Negative / Null Result ReportMedicine
Saithna A · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Evaluations of practice patterns after rotator cuff repair reveal that both simple slings and abduction braces are commonly used, with the latter most frequently preferred in the United States. A preference for a shoulder abduction brace…
View details →DOI: 10.1016/j.arthro.2025.04.001 Negative / Null Result ReportOpen accessMedicine
Stróżyk A, Horvath A, Kozłowska-Jalowska A et al. · 2026 · Frontiers in pediatrics
Objective Evidence supporting the effectiveness of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (low-FODMAP) diet in treating functional abdominal pain disorders remains limited. We aimed to assess the…
View details →DOI: 10.3389/fped.2026.1809053 Negative / Null Result ReportMedicine
Tabaru A, Yigit O, Akyel S et al. · 2025 · Ear, nose, & throat journal
Objective The use of mastoid pressure dressings (MPDs) after otologic surgery has been a standard practice for decades, believed to minimize complications such as hematoma and wound infection. However, the efficacy of MPDs in improving…
View details →DOI: 10.1177/01455613251333644 Negative / Null Result ReportMedicine
Tsubakimoto Y, Takahara M, Soga Y et al. · 2025 · Cardiovascular intervention and therapeutics
Drug-coated balloon (DCB) angioplasty is an effective endovascular therapy for femoropopliteal artery (FPA) disease in patients with peripheral artery disease (PAD). However, the long-term impact of statin and anticoagulant therapy on…
View details →DOI: 10.1007/s12928-025-01172-z Negative / Null Result ReportMedicine
Feliberti J, Alam A, Maulion C · 2025 · Current opinion in cardiology
Purpose of review Hypertension is one of the most common comorbidities affecting patients after solid organ transplantation. Here we review the mechanisms leading to hypertension, along with common practices in terms of medical management.…
View details →DOI: 10.1097/hco.0000000000001230 Negative / Null Result ReportOpen accessMedicine
Jamal F, Sahvan O, Junior PLSU et al. · 2025 · The oncologist
Background The increasing reliance on accelerated approvals and surrogate endpoints for Food and Drug Administration (FDA) approvals of gastrointestinal (GI) cancer therapies raises concerns about their clinical benefit and long-term…
View details →DOI: 10.1093/oncolo/oyaf381 Negative / Null Result ReportMedicine
Cristarella E, Ambrosini M, Di Maio M et al. · 2025 · European journal of cancer (Oxford, England : 1990)
Background In the ARMANI trial, switch maintenance with paclitaxel plus ramucirumab improved progression-free survival and overall survival versus continuation of oxaliplatin-based chemotherapy in patients with HER2-negative advanced…
View details →DOI: 10.1016/j.ejca.2025.116060 Negative / Null Result ReportMedicine
Vang K, Panich J, Folz C et al. · 2025 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
IntroductionImmune checkpoint inhibitors (CPIs) work by engaging the patient's immune system against tumor cells and have demonstrated a significant benefit in the treatment of cancers. Activation of the patient's immune system can lead to…
View details →DOI: 10.1177/10781552251349459 Negative / Null Result ReportMedicine
Schonhaut EB, Scherpereel KL, Young AJ · 2026 · IEEE transactions on bio-medical engineering
Objective Accurate, non-invasive methods for estimating joint and muscle physiological states have the potential to greatly enhance control of wearable devices during real-world ambulation. Traditional modeling approaches and current…
View details →DOI: 10.1109/tbme.2025.3577084 Negative / Null Result ReportOpen accessMedicine
Lusilla Lopez A, Fält UA, Buchwald P et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Aim Treatment of complex anal fistulae remains a significant challenge for physicians and patients. A sphincter-preserving technique with bioactive platelet-rich fibrin matrix is one option. This three-year study aimed to evaluate the…
View details →DOI: 10.1111/codi.70447 Negative / Null Result ReportOpen accessMedicine
Marsh A, Quelch D, Mackonochie M et al. · 2026 · The international journal of neuropsychopharmacology
The incidence of cognitive disorders is rising, and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence…
View details →DOI: 10.1093/ijnp/pyag003 Negative / Null Result ReportMedicine
Godoy MR, Brochado-Neto FC, Martins Cury MV et al. · 2025 · Journal of vascular surgery
Objective This study aimed to assess whether duplex ultrasound (DUS) surveillance yielded a better outcome compared with ankle-brachial index (ABI) surveillance after femoropopliteal endovascular therapy (EVT) in a cohort of patients…
View details →DOI: 10.1016/j.jvs.2025.07.043 Negative / Null Result ReportMedicine
Aggarwal A, Adie S, Harris IA et al. · 2025 · The Cochrane database of systematic reviews
Background Total knee replacement (TKR) is a common intervention for people with end-stage symptomatic knee osteoarthritis, resulting in significant improvements in pain, function and quality of life within three to six months. It is,…
View details →DOI: 10.1002/14651858.cd007911.pub4 Negative / Null Result ReportMedicine
Bi Z, Ren T, Wang Y · 2025 · Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
The latest data from the NATALEE trial showed the absolute 3-year invasive disease-free survival benefit was 4.9% between the experimental and control groups. That is to say, in the intermediate-risk hormone receptor positive/human…
View details →DOI: 10.21147/j.issn.1000-9604.2025.01.08 