Negative / Null Result ReportMedicine
Goda S, Yamada T, Goto Y et al. · 2026 · BMC pulmonary medicine
Background The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation, with prognostic value in interstitial lung disease (ILD). However, the association between baseline NLR and the therapeutic efficacy of nintedanib…
View details →DOI: 10.1186/s12890-026-04347-3 Negative / Null Result ReportMedicine
Esmeray A, Yazili HB, Gelmis M et al. · 2026 · The Canadian journal of urology
Objectives Supracostal access during percutaneous nephrolithotomy (PCNL) increases the risk of pulmonary complications. Although routine postoperative thoracic imaging is commonly performed to detect these events, its clinical necessity…
View details →DOI: 10.32604/cju.2025.069657 Negative / Null Result ReportMedicine
Alhammadi S, Chalk C · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fatigable weakness and increased perioperative vulnerability. Postoperative myasthenic crisis, defined as respiratory failure requiring prolonged ventilation…
View details →DOI: 10.1017/cjn.2025.10524 Negative / Null Result ReportMedicine
Tsukagoshi J, Penaloza N, Laico AJ et al. · 2026 · Annals of vascular surgery
Background While carotid endarterectomy (CEA) and carotid artery stenting (CAS) reduce the long-term risk of stroke, patients with a short life expectancy or multiple medical comorbidities, including end-stage renal disease (ESRD), may not…
View details →DOI: 10.1016/j.avsg.2026.03.006 Negative / Null Result ReportMedicine
Davies F, Butler MK · 2026 · Eye (London, England)
Introduction This real-world, retrospective review of SLT outcomes at Lancashire Teaching Hospitals NHS Foundation Trust aimed to establish whether there is any net benefit in using topical drop treatment prior to SLT compared with…
View details →DOI: 10.1038/s41433-025-04221-2 Negative / Null Result ReportMedicine
Clocchiatti-Tuozzo S, Qureshi AI, Rivier CA et al. · 2026 · Neurology
Background and objectives Intensive blood pressure (BP) reduction may reduce the risk of poor functional outcomes in patients with acute intracerebral hemorrhage (ICH). Whether these potential benefits apply similarly to lobar and deep…
View details →DOI: 10.1212/wnl.0000000000214860 Negative / Null Result ReportMedicine
Cataldo-Miranda P, Koh HJW, Stub D et al. · 2026 · Current problems in cardiology
Aims Beta-blocker therapy has traditionally been recommended following coronary events based on clinical trials involving patients with systolic dysfunction. Its survival benefit in patients with preserved left ventricular ejection…
View details →DOI: 10.1016/j.cpcardiol.2026.103340 Negative / Null Result Report
Guillermo A, Domingo L, Fernando R · 2025 · Preprint
Background The DIGIT-HF trial reported that digitoxin reduced the composite risk of all-cause mortality or first heart failure hospitalization in patients with heart failure and reduced ejection fraction, summarized by a single hazard…
View details →DOI: 10.1101/2025.11.22.25339857 Negative / Null Result ReportMedicine
Tan W, Chen L, Li X et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Purpose Hydrosalpinx impairs embryo implantation and development, leading to infertility or miscarriage. Therefore, the effective treatment of hydrosalpinx is crucial for improving pregnancy outcomes. Here, we investigated the comparative…
View details →DOI: 10.1016/j.ejogrb.2026.115015 Negative / Null Result ReportMedicine
Hosseinzadeh E, Arefnia M, Bayat M et al. · 2026 · Cancer biotherapy & radiopharmaceuticals
Background Intense hepatobiliary uptake of [ 99m Tc]Tc-sestamibi in myocardial perfusion scintigraphy (MPS) often degrades image quality by obscuring the inferior myocardial wall, leading to equivocal studies. While nonpharmacological…
View details →DOI: 10.1177/10849785251376736 Negative / Null Result Report
Wen T, Ihlefeld A · 2025 · Preprint
It has been widely believed that a key factor in creating realistic spatial audio in virtual reality (VR) is the head-related transfer function (HRTF), which is unique to each individual, but costly to measure for widespread use. This…
View details →DOI: 10.1101/2025.10.25.681945 Replication FailureMedicine
Arenas Hoyos J, Dalela D, Schlomer BJ et al. · 2026 · Journal of pediatric urology
Background There is insufficient evidence to support the effectiveness of preoperative antibiotic prophylaxis in reducing surgical site infections (SSI) during urgent testicular torsion (TT) surgeries. Objective The primary objective was…
View details →DOI: 10.1016/j.jpurol.2026.105844 Negative / Null Result ReportMedicine
Ren J, Sun X, Zhang Z et al. · 2026 · The American journal of clinical nutrition
Background Body weight is a critical determinant of cardiovascular disease (CVD) risk among people with type 2 diabetes mellitus (T2DM), substantially contributing to the incidence of and outcomes from CVD. However, the impact of body…
View details →DOI: 10.1016/j.ajcnut.2026.101282 Negative / Null Result ReportMedicine
Shah S, Kaul A, Pandey P et al. · 2026 · Indian pediatrics
Objectives To evaluate the efficacy of oral Lactobacillus rhamnosus GG (LGG) in reducing neonatal enterocolitis (NEC), sepsis and mortality in very low birth weight (VLBW) infants. Methods This open-label randomized controlled trial…
View details →DOI: 10.1007/s13312-025-00252-w Negative / Null Result Report
Parikh E · 2025 · Preprint
Background: Rheumatoid arthritis (RA) is a chronic inflammatory condition affecting joints. It is managed with pharmacological therapies, but it is speculated that dietary intervention may be of significant benefit to patients in helping…
View details →DOI: 10.20944/preprints202511.0743.v1 Negative / Null Result ReportOpen accessMedicine
Pellegrino N, Eliasziw M, Fortinsky R et al. · 2026 · Scientific reports
Exposure to particulate matter is associated with adverse health outcomes such as cardiovascular and neurological diseases. However, there are few intervention studies that have examined short-term changes in air particulate exposure and…
View details →DOI: 10.1038/s41598-026-48063-8 Negative / Null Result ReportMedicine
Tlili S, Ben Mahfoudh H, Zoudji B · 2025 · Perceptual and motor skills
Generated drawing is a specific instructional approach that has been investigated in academic settings. However, in sports, tactical drawings are often presented based more on coaches' preferences than on empirical evidence. This study…
View details →DOI: 10.1177/00315125251391658 Failed Experiment ReportMedicine
Schmidt ME, Gargano C, Zhou X et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
JNJ-42165279 is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for degradation of the endocannabinoid N-arachidonoylethanolamide (anandamide), which plays a role in regulation of fear and anxiety…
View details →DOI: 10.1016/j.euroneuro.2026.112771 Negative / Null Result ReportMedicine
Scherer C, Fung V, Anzellini D et al. · 2026 · Breast cancer (Tokyo, Japan)
Background We report outcomes of patients who received intraoperative radiation therapy (IORT) using 50 kV after lumpectomy and sentinel lymph node biopsy. Methods Women with age > 45 and post-menopausal status, localized, unifocal,…
View details →DOI: 10.1007/s12282-026-01824-9 Negative / Null Result ReportMedicine
Kanthar T, Vatcharavongvan P, Prasert V · 2025 · Journal of evaluation in clinical practice
Rationale The global prevalence rate of glaucoma blindness is extremely high and is a leading cause of irreversible blindness. Despite many advancements in treatment, evaluating glaucoma blindness remains challenging due to the long time…
View details →DOI: 10.1111/jep.70341 Negative / Null Result ReportMedicine
Blin P, Danchin N, Benichou J et al. · 2026 · American journal of cardiovascular drugs : drugs, devices, and other interventions
Introduction Antiplatelet therapy with low-dose aspirin, alone or as dual antiplatelet therapy (DAPT) with a P2Y 12 inhibitor, is used in secondary prevention following myocardial infarction (MI). However, the optimal duration of DAPT is…
View details →DOI: 10.1007/s40256-025-00782-5 Negative / Null Result ReportMedicine
Romagnoli A, Marcellusi A, Lasala R · 2025 · Recenti progressi in medicina
Introduction Rapid access to safe and effective oncological therapies is crucial. In recent years, many expensive drugs have been commercialized, making it essential to prioritize those with significant clinical benefits. For this purpose,…
View details →DOI: 10.1701/4518.45175 Negative / Null Result ReportOpen accessMedicine
Yang M, Yang S, Zhang W et al. · 2026 · BMC cancer
AIM: The role of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with locally advanced colorectal cancer (LACRC) remains controversial. This study aimed to evaluate the perioperative safety and survival…
View details →DOI: 10.1186/s12885-026-16073-4 Negative / Null Result ReportMedicine
Leggett CL, Plowman RS, Surace L et al. · 2026 · Gastrointestinal endoscopy
Background and aims Computer-aided polyp detection (CADe) systems can enhance polyp detection, although their performance has largely been evaluated at academic rather than community practices. This randomized controlled trial evaluated…
View details →DOI: 10.1016/j.gie.2025.12.290 Negative / Null Result ReportMedicine
Gupta Y, Baranwal M, Chudasama B · 2025 · Biotechnology journal
Despite the challenge in generating adequate immunogenicity, peptide-based vaccines offer a significant benefit in terms of improving immunity when combined with conjugates. In previous studies, three computationally designed immunogenic…
View details →DOI: 10.1002/biot.70140 Negative / Null Result ReportMedicine
Guo Z, Liu X, Yu S et al. · 2025 · Journal of neurointerventional surgery
Background and purpose While endovascular therapy (EVT) is established for acute basilar artery occlusion (BAO), the clinical value of remedial angioplasty or stenting (RAS) is debated. This study investigated the efficacy and safety of…
View details →DOI: 10.1136/jnis-2025-024443 Negative / Null Result ReportMedicine
Mimura T, Moghaddamjou A, Badhiwala JH et al. · 2026 · Spinal cord
Study design Cohort study. Objectives Although the effectiveness of methylprednisolone sodium succinate (MPSS) in spinal cord injury (SCI) is controversial, it is hypothesized that the effectiveness and safety profile of MPSS may vary in…
View details →DOI: 10.1038/s41393-025-01163-0 Negative / Null Result ReportMedicine
Beshr MS, Shembesh RH, Nounou MV et al. · 2026 · Clinical oncology (Royal College of Radiologists (Great Britain))
Aim This study reconstructed patient-level data to provide updated evidence on survival outcomes across PD-L1 expression subgroups. Materials and methods A systematic search was conducted on March 2, 2025, using PubMed, Embase, Web of…
View details →DOI: 10.1016/j.clon.2026.104032 Negative / Null Result ReportMedicine
Yang X, Zhu L, Chen R et al. · 2026 · Human reproduction open
Study question Does adding vaginal estradiol to standard progesterone luteal phase support improve ongoing pregnancy rates in normal-responder IVF/ICSI patients undergoing GnRH antagonist cycles? Summary answer The addition of vaginal…
View details →DOI: 10.1093/hropen/hoag042 Negative / Null Result ReportMedicine
Ortiz-Gutiérrez S, Serralde-Zúñiga AE, González-Salazar LE et al. · 2026 · Scientific reports
Iron deficiency without anemia (IDNA) may be linked to obesity-related inflammation. Weight reduction and heme-iron intake from red meat are proposed to improve iron status. This randomized controlled trial (NCT06104800) assessed the…
View details →DOI: 10.1038/s41598-026-53056-8 