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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 453 of 724

Negative / Null Result ReportMedicine

[C-Quant scattered light measurement and corneal densitometry in Fuchs endothelial dystrophy before and after DMEK].

Da Costa M, Seitz B, Munteanu C et al. · 2026 · Die Ophthalmologie

Background In Germany, each surgical corneal center defines individual criteria for the indications for Descemet membrane endothelial keratoplasty (DMEK). Clinical experience shows a clear discrepancy between best corrected visual activity…

View details →DOI: 10.1007/s00347-026-02422-y
Negative / Null Result ReportMedicine

Meme-Based Learning in Neuroanatomy: A Comparative Study on Effectiveness, Gender, and Student Performance Levels.

Eldesoqui M, Al-Batati A, Erfan OS et al. · 2026 · Clinical anatomy (New York, N.Y.)

Generation Z has different requirements, problems, expectations, and attitudes that they bring into the educational environment. Teachers have unprecedented challenges in addressing their needs and aspirations. Gamification involves…

View details →DOI: 10.1002/ca.70122
Negative / Null Result ReportMedicine

Eustachian Tube Balloon Dilation in Children: Prospective Clinical Outcomes of a Low-Cost Endovascular Balloon.

Hassan AM, Elgarem HF, Sheta E et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective Balloon dilation of the Eustachian tube (BDET) is increasingly used to treat pediatric obstructive Eustachian tube dysfunction (OETD); however, its broader adoption is limited by the cost of commercially available devices.…

View details →DOI: 10.1097/mao.0000000000004903
Negative / Null Result ReportMedicine

Challenges of heart failure treatment in patients with chronic kidney disease: A call to action.

Metry M, Bernard S · 2026 · JAAPA : official journal of the American Academy of Physician Assistants

Abstract Heart failure (HF) is one of the most common and consequential conditions encountered in clinical practice. It frequently coexists with chronic kidney disease (CKD), a highly prevalent and economically burdensome condition. The…

View details →DOI: 10.1097/01.jaa.0000000000000375
Negative / Null Result ReportOpen accessMedicine

Postbiotics in Dermatology: A Literature Review of Emerging Topical Therapies for Acne, Rosacea, and Eczema.

Flores Rodríguez JC, Morán Ortega MJ, Jimenez Ordoñez AC et al. · 2026 · Cureus

Postbiotics, defined as non-viable microbial cells and their metabolites, have emerged as topical therapies for inflammatory dermatoses and provide more clinical benefits than live postbiotics by eliminating infection risk and stability.…

View details →DOI: 10.7759/cureus.105440
Negative / Null Result ReportOpen accessMedicine

Constipation with bloating: a clinical approach to evaluation and management.

Cangemi DJ, Laitman AP, Faiman O et al. · 2026 · Annals of medicine

Introduction Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately.…

View details →DOI: 10.1080/07853890.2026.2684172
Negative / Null Result ReportMedicine

Intravaginal Aloe barbadensis and cervical HPV clearance: A retrospective observational study.

Gozde Ozdemir B, Avci F, Huseynli L et al. · 2026 · Pakistan journal of pharmaceutical sciences

Background Persistent infection with human papillomavirus (HPV) is a key factor in cervical carcinogenesis. Immune-mediated mechanisms play a central role in viral clearance, leading to interest in immunomodulatory supportive therapies.…

View details →DOI: 10.36721/pjps.2026.39.7.reg.190.1
Negative / Null Result ReportMedicine

Maltodextrin as sucrose replacer: Effect of dextrose equivalence and sucrose/maltodextrin ratio on physical and sensory properties of non-fat whipped cream analogue

Yang J, Han Y · 2026 · Food Hydrocolloids.

The development of non-fat whipped cream analogue (NFWCA) addresses the demand for low-fat and reduced-sucrose foods. This study systematically evaluated how the dextrose equivalent (DE) value of maltodextrin (MD) and the sucrose/MD ratio…

Negative / Null Result ReportMedicine

Efficacy of multimodal therapy for sudden sensorineural hearing loss: a propensity score-matched analysis of 1632 patients.

Li G, Wang C, Gao Y et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: This study evaluated the efficacy and safety of multimodal outpatient therapy compared with conventional inpatient therapy during the initial treatment of sudden sensorineural hearing loss (SSNHL). The goal was to provide…

View details →DOI: 10.1007/s00405-026-10175-2
Negative / Null Result ReportMedicine

Outcomes of secondary interventions in treatment of post-traumatic stiff shoulder in conservatively managed proximal humeral fractures: a scoping review.

Zhang Y, Sadeh N, Mitchell O et al. · 2026 · Irish journal of medical science

Aims There is no current gold standard in treating post-traumatic stiff (PTS) shoulder complicating conservatively managed proximal humeral fractures (PHFs). This scoping review seeks to present available outcome evidence in this cohort of…

View details →DOI: 10.1007/s11845-026-04474-0
Negative / Null Result ReportMedicine

Postoperative syphilitic scleritis following strabismus surgery.

Parunakian E, Yehezkeli V, Khitri M et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Syphilis can present with a wide range of ocular manifestations; however, scleritis is exceedingly rare. Although various infectious and noninfectious causes of scleritis following strabismus surgery have been documented, syphilitic…

View details →DOI: 10.1016/j.jaapos.2026.104883
Negative / Null Result ReportMedicine

Comparative Outcomes of the Modified Woodward Procedure Versus Conservative Management in Sprengel Deformity: A Retrospective Cohort Study.

Jia Y, Dong Y, Jiang R et al. · 2026 · Journal of pediatric orthopedics

Background Sprengel deformity is a rare congenital malformation of the scapula. To date, there have been limited reports analyzing the clinical outcomes of the modified Woodward procedure and conservative management in the treatment of…

View details →DOI: 10.1097/bpo.0000000000003387
Negative / Null Result ReportMedicine

Fortitude as a Key to Reducing Burnout: Its Critical Role in Influencing the Relationship Between Organizational Support and Burnout.

Weinzimmer LG, Hippler SE · 2026 · Journal of healthcare management / American College of Healthcare Executives

Goal Burnout in healthcare remains a significant problem, with implications not only for physicians and advanced practice providers but also for the entire US healthcare system, including patients and payers. Significant work has been done…

View details →DOI: 10.1097/jhm-d-24-00244
Negative / Null Result ReportOpen accessMedicine

Effect of temporomandibular joint exercises on mechanical low back pain: a preliminary randomized controlled study.

Rathi M, Mali N, Gazbare P et al. · 2026 · BMC musculoskeletal disorders

BACKGROUND: Low back pain and temporomandibular Dysfunction (TMD) have a coexistence in clinical practice. To find the effect of temporomandibular exercises (TME) along with conventional physiotherapy in patients with mechanical low back…

View details →DOI: 10.1186/s12891-026-09657-5
Negative / Null Result ReportMedicine

Editorial Commentary: Lumbar Pathology Likely Negatively Affects Surgical Outcomes in Patients With Femoroacetabular Impingement Syndrome, Though the Strength of the Relationship is Unclear.

Kaplan DJ · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

A complex interplay exists between the hip joint and the lumbosacralpelvis. As a patient moves from a standing to seated position, the lower back, pelvis, and hips must move in concert to properly function. Conceptually, any deviation from…

View details →DOI: 10.1002/arj.70202
Negative / Null Result ReportMedicine

An Occupation-Focused Intervention to Promote Functioning Among Adults Aging With Diabetes and Heart Disease.

Mirza M, Fischer H, Arias D · 2026 · OTJR : occupation, participation and health

Background Aging adults with chronic diseases are at risk of functional decline. Objectives This pilot randomized control trial examined the feasibility, acceptability, and preliminary efficacy of an occupational therapy intervention to…

View details →DOI: 10.1177/15394492261446563
Negative / Null Result ReportMedicine

Comparative Evaluation of Unilateral Recession-Plication Versus Bilateral Three-Muscle Surgery for Large-Angle Exotropia.

Anand K, Nagpal V, Dutta P et al. · 2026 · Journal of pediatric ophthalmology and strabismus

Purpose To evaluate and compare unilateral recession-plication versus bilateral three-muscle surgery for large-angle exotropia. Methods A prospective interventional non-randomized comparative study was conducted involving 66 patients with…

View details →DOI: 10.3928/01913913-20260521-01
Negative / Null Result ReportOpen accessMedicine

Precision in Medial pivot total knee arthroplasty: A retrospective study on mechanical axis alignment and functional outcomes with CT-guided patient-specific instrumentation.

Mat Salleh F, Nizam I · 2026 · SICOT-J

Background Total Knee Arthroplasty (TKA) is the standard treatment for end-stage osteoarthritis, with optimal outcomes dependent on precise mechanical alignment and accurate implant positioning. Patient-specific instrumentation (PSI),…

View details →DOI: 10.1051/sicotj/2026034
Negative / Null Result ReportMedicine

Olfactory outcomes after primary endoscopic sinus surgery and dupilumab for post-operative recurrence in eosinophilic chronic rhinosinusitis.

Saito T, Hirose T, Haruna T et al. · 2026 · The Journal of laryngology and otology

Objective. To compare subjective and psychophysical olfactory outcomes in patients with eosinophilic chronic rhinosinusitis controlled after primary functional endoscopic sinus surgery (FESS) alone versus those treated with dupilumab for…

View details →DOI: 10.1017/s0022215126104976
Negative / Null Result ReportOpen accessMedicine

The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.

Song X, Wang Y, Chen H · 2026 · International journal of cardiology. Cardiovascular risk and prevention

Objective To identify distinct multi-year cognitive function trajectories in middle-aged and older Chinese adults with established cardiovascular disease (CVD) and evaluate their independent associations with all-cause mortality. Methods…

View details →DOI: 10.1016/j.ijcrp.2026.200583
Negative / Null Result ReportOpen accessMedicine

Dupilumab-Induced Psoriasiform Eruption in an 83-Year-Old Patient.

Pham VX, Gilbertson E · 2026 · Cureus

This case report describes an 83-year-old female who developed severe psoriasiform lesions suspected to be induced by dupilumab. The patient initially presented with eczematous papules affecting her back, arms, torso, and scalp, and a…

View details →DOI: 10.7759/cureus.109041
Negative / Null Result ReportMedicine

Investigating the Effect of Tumour Necrosis Factor Antagonist on Olfaction.

Espehana A, Macfarlane G, Garden EM et al. · 2026 · Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

Objectives Tumour Necrosis factor antagonists is a potent anti-inflammatory medication and has shown to improve olfactory function in murine models. The primary aim was to determine the effect of TNF antagonists on olfactory performance in…

View details →DOI: 10.1111/coa.70093