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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 454 of 724

Negative / Null Result ReportMedicine

Asialoglycoprotein receptor-1 promotes hyperandrogenism in polycystic ovary syndrome through direct interaction with FSHR, leading to the cAMP-PKA-CREB pathway inhibition.

Liu X, Shi J, Wang T · 2026 · Reproduction (Cambridge, England)

Polycystic ovary syndrome (PCOS) is a prevalent multifactorial disorder characterized by hormone dysregulation and follicular development defects. Asialoglycoprotein receptor 1 (ASGR1), a C-type lectin predominantly expressed on the…

View details →DOI: 10.1093/reprod/xaag073
Negative / Null Result ReportMedicine

The effect of structured older adult care training on nursing students' attitudes toward ageism: a randomized controlled trial.

Yilmaz Ü, Çalişkan BB · 2026 · Gerontology & geriatrics education

Ageism remains a global challenge that undermines the quality of care for older adults. Nursing students, as future healthcare professionals, are in a key position to prevent age-related discrimination through educational interventions.…

View details →DOI: 10.1080/02701960.2026.2672041
Negative / Null Result ReportOpen accessMedicine

No Difference Between Open and Arthroscopic ATFL Repair, Both Yielding Clinically Significant Improvement in Chronic Ankle Instability: A Randomized Controlled Trial.

Vuurberg G, Maria PA, Baalbaki R et al. · 2026 · Orthopaedic journal of sports medicine

Background Lateral ligament repair is a reliable surgical approach for the treatment of chronic ankle instability (CAI). Although the open technique has shown success over time, technological advancements have enabled the increasing use of…

View details →DOI: 10.1177/23259671261417357
Negative / Null Result ReportOpen accessMedicine

Implementing a Climate Health Education Curriculum for Emergency Medicine Trainees and Faculty.

Lewis E, Smalley CM, Kostura M · 2026 · The western journal of emergency medicine

As climate-related health impacts intensify, emergency physicians (EP) increasingly encounter patients whose conditions are influenced by environmental change. To provide care for climate- vulnerable patients in the emergency department…

View details →DOI: 10.5811/westjem.50824
Negative / Null Result ReportMedicine

Effects of Photobiomodulation Therapy in Lateral Luxation of Anterior Permanent Teeth: A Randomized, Double-Blind Clinical Trial.

Belmonte FM, Soares PC, Azevedo LH et al. · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Background Among the traumatic dental injuries (TDIs), lateral luxation may present poor prognosis due to frequent root resorption and consequent tooth loss. Photobiomodulation therapy (PBMT) modulates cellular activities (proliferation,…

View details →DOI: 10.1111/edt.70064
Negative / Null Result ReportMedicine

Simulating Compassion: Enhancing Graduate Nurses' Preparedness for End-of-Life and Palliative Care.

Lewis L, Snowden K, Garcia Rivero G et al. · 2026 · Nursing education perspectives

Advanced practice registered nurses often feel unprepared for end-of-life (EOL) care due to gaps in training. This study assessed the impact of an EOL simulation on the attitudes and preparedness of 83 students who completed pre- and…

View details →DOI: 10.1097/01.nep.0000000000001544
Negative / Null Result ReportOpen accessMedicine

Mid-Term Outcomes of Posterior Pelvic Reconstruction Combined with Lateral Abdominal Wall Suspension versus Sacrocolpopexy for Advanced Pelvic Organ Prolapse: A Retrospective Comparative Study.

Chu G, Hu C, Deng Q · 2026 · International journal of women's health

Purpose To compare mid-term efficacy, safety, and functional outcomes of laparoscopic sacrocolpopexy (LSC) versus laparoscopic lateral abdominal wall suspension (LAWS), both combined with standardized posterior repair, for advanced…

View details →DOI: 10.2147/ijwh.s594551
Negative / Null Result Report

Evaluating the Introduction Module of Mentalization-Based Treatment

Bachrach N, Brugman S, Berkers R et al. · 2026 · Preprint

Abstract Background Mentalization-Based Treatment Introduction (MBT-I) is a psychoeducational group module preceding long-term Mentalization-Based Treatment (MBT) for patients with borderline personality disorder (BPD). MBT-I aims to…

View details →DOI: 10.21203/rs.3.rs-9737698/v1
Negative / Null Result ReportMedicine

The Effects of Personalized Observation, Execution, and Mental Imagery (POEM) Therapy in Logopenic Primary Progressive Aphasia: A Telepractice-Based Single-Case Study.

Basaglia-Pappas S, Solignac H, Durand É · 2026 · Brain sciences

Background/Objectives: Verb anomia is a common symptom of primary progressive aphasia (PPA), particularly in the logopenic variant (lvPPA). Despite the central role of verbs in sentence construction, interventions specifically targeting…

View details →DOI: 10.3390/brainsci16060653
Negative / Null Result ReportMedicine

Practice Effects and the Lanthony D15.

Ho J, Ng JS · 2026 · Vision (Basel, Switzerland)

Purpose Recent studies have shown that subjects with congenital colour vision deficiency (CVD) can pass the saturated Farnsworth D15 (FD15) through practice. The Lanthony D15 (LD15) uses desaturated colours and is a difficult test even for…

View details →DOI: 10.3390/vision10020033
Negative / Null Result ReportMedicine

Enhancing Resilience and Well-Being Among Nurse Leaders: A Randomized Controlled Trial of Mindfulness and Narrative Interventions.

Kim M, Owens R, Tucker S et al. · 2026 · The Journal of nursing administration

Objective Evaluate the short-term effectiveness of interventions to address nurse leader resilience and well-being. Background Nurse leaders face unique stressors in their role. Evidence-based, feasible interventions are urgently needed.…

View details →DOI: 10.1097/nna.0000000000001749
Negative / Null Result ReportMedicine

Pain Catastrophizing Improves After Total Knee Arthroplasty, But Still Has a Negative Effect on Outcomes in Japanese Patients.

Kubo T, Kinoshita T, Kutsuna T et al. · 2026 · The Journal of arthroplasty

Background Preoperative pain catastrophizing has been reported to influence postoperative outcomes in total knee arthroplasty (TKA). However, little is known about how catastrophizing changes after surgery. This study assessed the…

View details →DOI: 10.1016/j.arth.2026.06.038
Negative / Null Result ReportOpen accessMedicine

Preliminary Evidence of Motor Outcomes in Children with Autism Spectrum Disorder Following Equine-Assisted Therapy and Dual-Task Training: A Pilot Study.

Della Valle C, Di Martino G, Melis A et al. · 2026 · Sports (Basel, Switzerland)

Background Equine-assisted therapy (EAT) is a supportive intervention for children with autism spectrum disorder (ASD). Aim This pilot study evaluated the feasibility of a cognitive-motor EAT intervention to explore its preliminary effects…

View details →DOI: 10.3390/sports14050190
Negative / Null Result ReportOpen accessMedicine

Long-Term Results of Medial Fixed-Bearing Unicompartmental Knee Arthroplasty with Miller-Galante Prosthesis: A Minimum 10-Year Follow-Up Study.

Lim S, Kim TH, Park DY et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Medial unicompartmental knee arthroplasty (UKA) has emerged as an effective surgical option for isolated medial compartment osteoarthritis (OA), offering advantages in bone preservation, knee kinematics, and…

View details →DOI: 10.3390/medicina62040663
Negative / Null Result ReportOpen accessMedicine

Impact of hearing aid use on cognitive function in elderly individuals with hearing loss: a prospective study.

Velho HC, Schichi MASC, da Silveira Sassi TS et al. · 2026 · Brazilian journal of otorhinolaryngology

Objective To evaluate the cognition and the depressive symptoms of elderly individuals with hearing impairment before and after the use of Hearing Aids (HA), in order to determine whether auditory rehabilitation can influence cognition and…

View details →DOI: 10.1016/j.bjorl.2026.101785
Negative / Null Result ReportMedicine

Developing facilitative interpersonal skills: A randomized controlled study of an apprenticeship training for first-year clinical psychology students.

Fagerbakk SA, Brattland H, Laugen NJ et al. · 2026 · Psychotherapy research : journal of the Society for Psychotherapy Research

Objective This study aimed to evaluate whether apprenticeship training could enhance facilitative interpersonal skills (FIS) in first-year students enrolled in a six-year integrated clinical psychology study program, compared to…

View details →DOI: 10.1080/10503307.2026.2615393
Negative / Null Result ReportMedicine

Effects of melatonin and vitamin E on bone healing following alloplastic grafting in osteoporotic cranial bone defects: an experimental study.

Aydın NE, Çetiner S · 2026 · BMC oral health

Background Bone healing in osteoporotic bone represents a significant clinical challenge in oral and maxillofacial surgery. The aim of this experimental study was to evaluate the effects of melatonin and vitamin E supplementation on bone…

View details →DOI: 10.1186/s12903-026-08956-6
Negative / Null Result ReportMedicine

Development of virtual reality in the upper extremities function in children with Cerebral Palsy. A pilot randomized controlled trial.

Iamchaimongkol A, Sangkrai S, Alberts P et al. · 2026 · Journal of neuroengineering and rehabilitation

Objective To evaluate the effect of the Virtual Reality (VR) in upper extremities function in children with Cerebral Palsy (CP). Study design Pilot randomization study. Methods A total of 42 children with CP, aged 10 to15 years, were…

View details →DOI: 10.1186/s12984-026-02043-1
Negative / Null Result ReportMedicine

Health Promotion for Sun Protection: A Community Approach in a Mountain Setting.

Buja A, Cinquetti S, Coller M et al. · 2026 · High altitude medicine & biology

Buja, Alessandra, Sandro Cinquetti, Marco Coller, Angela Padoin, Chiara Trevisiol, Ilaria Pantaleo, Claudio Palmeri, Vincenzo Marcotrigiano, Erica Bino, Silvia Flesia, and Simone Mocellin. Health promotion for sun protection: a community…

View details →DOI: 10.1177/15578682261462208
Negative / Null Result ReportOpen accessMedicine

Functional and Radiological Benefits of Adding Fibular Osteotomy to Supramalleolar Osteotomy in Ankle Osteoarthritis.

Li P, Liu H, Huang F et al. · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Ankle arthritis is a chronic degenerative disease; its typical symptom is pain in the ankle joint. This retrospective study of 65 patients with mid-stage ankle osteoarthritis aimed to compare clinical outcomes from…

View details →DOI: 10.12659/msm.951712
Negative / Null Result ReportMedicine

Short-Term Effects of Four Common Semioccluded Vocal Tract Exercises in Primary Muscle Tension Dysphonia: A Randomized Controlled Trial.

Aziz R, Khoddami SM, Jalaie S et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objectives This study investigated the effects of four common semioccluded vocal tract exercises (SOVTEs)-tongue trill, lip trill, straw phonation, and water resistance therapy (WRT)-in primary muscle tension dysphonia (MTD). Study design…

View details →DOI: 10.1016/j.jvoice.2025.12.036
Negative / Null Result ReportOpen accessMedicine

Types of physical activity and applied outcome measures in physical activity interventions among patients with inflammatory bowel disease: a scoping review.

Fromberg EB, Brink MT, Villumsen M et al. · 2026 · BMC gastroenterology

BACKGROUND: While pharmacological treatments remain essential in inflammatory bowel disease (IBD), complementary approaches such as physical activity are increasingly being explored for their potential benefits. This scoping review aimed…

View details →DOI: 10.1186/s12876-026-04792-8
Negative / Null Result ReportMedicine

Supporting incarcerated autistic individuals: evaluation of an autism awareness training for prison staff.

Maljaars J, De Roo L, Van der Paelt S et al. · 2026 · International journal of prison health

Purpose Prison environments are particularly challenging for autistic people experiencing incarceration due to a lack of knowledge and awareness of autism among prison staff. The study aimed to evaluate the level of satisfaction and…

View details →DOI: 10.1108/ijoph-09-2025-0081
Negative / Null Result ReportMedicine

Bridging the Gap from "Paper" to "Patient": An Overview and Quality Assessment of PET/CT-Based Radiomics for Prostate Cancer Using the Updated RQS 2.0.

Bian S, Yang Y, Wang Z et al. · 2026 · Academic radiology

Rationale and objectives To apply the updated Radiomics Quality Score (RQS 2.0) and the Radiomics Readiness Level (RRL) framework to systematically evaluate the methodological quality and clinical translation maturity of Positron-emission…

View details →DOI: 10.1016/j.acra.2026.05.016