e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 452 of 724

Negative / Null Result ReportMedicine

Acute effects of intermittent hypoxia-hyperoxia exposure on cardiovascular autonomic function and blood pressure in sedentary older adults: A pilot randomized controlled trial.

Ladriñán-Maestro A, Sánchez-Sierra A, Elfoukahi O et al. · 2026 · PloS one

The aim of this study was to evaluate the acute effects of a single session of intermittent hypoxia-hyperoxia exposure on cardiovascular autonomic regulation, blood pressure, and arterial oxygen saturation in sedentary older adults. A…

View details →DOI: 10.1371/journal.pone.0350802
Negative / Null Result Report

The Effect of Mindfulness-Based Stress Reduction Training on Fear of Childbirth and Psychological Well-being in Women Experiencing Premenstrual Syndrome: A Randomized Controlled Trial

Akbeniz A, Baransel ES · 2026 · Preprint

Abstract Aim: This study aimed to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on premenstrual symptom severity, pre-pregnancy fear of childbirth, and psychological well-being in women experiencing…

View details →DOI: 10.21203/rs.3.rs-9502810/v1
Negative / Null Result ReportMedicine

Effects of gastric acid on milled and 3D printed interim crown materials.

Ekinci MS, Karci B, Secilmis A · 2026 · The Journal of prosthetic dentistry

Statement of problem The effects of acid exposure on interim crown materials have not been fully elucidated, and comparative data regarding different production methods are limited. Purpose This study investigated the effects of simulated…

View details →DOI: 10.1016/j.prosdent.2026.05.043
Negative / Null Result ReportMedicine

Effectiveness of gaseous ozone in reducing microbial contamination: evaluation of environmental disinfection in healthcare settings.

Mastrantonio R, Romantini A, Lombardo C et al. · 2026 · Infection control and hospital epidemiology

Objective Environmental contamination is a significant factor in the transmission of healthcare-associated infections. This study evaluated the effectiveness of gaseous ozone in reducing microbial contamination within hospital settings,…

View details →DOI: 10.1017/ice.2026.10468
Negative / Null Result ReportMedicine

Colonoscopic and oral microbiota transplant therapy yield similar stool and neoterminal ileal engraftment profiles in a single-blind pilot randomized trial.

Moutsoglou D, Staley C, Kabage AJ et al. · 2026 · Inflammatory bowel diseases

Background The intestinal microbiota play a key role in Crohn's disease (CD) and postoperative recurrence following ileocecal resection. Microbiota transplant therapy (MTT) could impact postoperative CD recurrence. This study aimed to…

View details →DOI: 10.1093/ibd/izag096
Negative / Null Result ReportOpen accessMedicine

A randomized controlled pilot trial comparing peri-implant tissue health beneath CAD/CAM-milled PEEK versus cobalt-chromium telescopic crowns for mandibular overdentures.

El Asfahani IA, Khalifa A, Tawfik D et al. · 2026 · International journal of implant dentistry

Purpose This pilot randomized clinical trial compared peri-implant tissue health around milled cobalt-chromium (CoCr) versus polyether ether ketone (PEEK) secondary telescopic crowns in implant-retained mandibular overdentures over 12…

View details →DOI: 10.1186/s40729-026-00690-6
Negative / Null Result ReportOpen accessMedicine

<i>Pseudomonas aeruginosa</i> gene expression changes during established biofilm infection in a cystic fibrosis lung model.

Harrington NE, Allen F, Garcia Maset R et al. · 2026 · Microbiology (Reading, England)

The opportunistic pathogen Pseudomonas aeruginosa forms biofilm infections in the lungs of people with the genetic condition cystic fibrosis (CF) that can persist for decades. There are numerous P. aeruginosa lifestyle changes associated…

View details →DOI: 10.1099/mic.0.001678
Negative / Null Result ReportOpen accessMedicine

Imidacloprid induces hepatorenal toxicity in male albino rats via oxidative, immune inflammatory, and proliferative effects: a 90-day study.

Khwanes SA, Mohamed RA, Abd El-Rahman HA et al. · 2026 · Scientific reports

Imidacloprid (IM), a systemic neonicotinoid pesticide, is widely used globally due to its high effectiveness against a broad range of insects at minimal application rates. The current study aimed to examine how this insecticide can induce…

View details →DOI: 10.1038/s41598-026-48767-x
Negative / Null Result ReportMedicine

Longitudinal Cortical Surface Signatures Distinguish Neuromyelitis Optica Spectrum Disorder from Multiple Sclerosis.

Okuda DT, Stanley TA, McCreary MC et al. · 2026 · AJNR. American journal of neuroradiology

Background and purpose Neuromyelitis optica spectrum disorder (NMOSD) is a chronic condition driven by selective injury to aquaporin 4 (AQP4) channels. Accurate diagnosis and effective disease surveillance are critical to preventing…

View details →DOI: 10.3174/ajnr.a9371
Negative / Null Result ReportMedicine

An Evaluation of the Influence of Natural Clay and Natural Clay/TiO<sub>2</sub> Nanocomposites on the Color Stability of Heat-Polymerized Maxillofacial Silicone After Disinfection.

Abdalqadir M, Raouf L, Mohammed K et al. · 2026 · Polymers

This study aimed to investigate the effect of time and different disinfecting agents on nanocomposite filler composed of natural clay nanoparticles (modified and non-modified) added to maxillofacial silicone elastomers and readymade…

View details →DOI: 10.3390/polym18050636
Negative / Null Result ReportMedicine

Ocular Safety of Unilateral Biportal Endoscopic Spinal Surgery: An Optical Coherence Tomography Angiography-Based Analysis.

Gulec A, Eravsar E, Ciftci S et al. · 2026 · Journal of clinical medicine

Background : UBE has gained popularity as a minimally invasive alternative to open spinal procedures. However, it raises concerns about potential ocular complications. Despite these concerns, there is a lack of studies evaluating UBE's…

View details →DOI: 10.3390/jcm15051774
Negative / Null Result ReportMedicine

Pelvic Floor Health Knowledge With Enhanced Education During Pregnancy.

Nicola-Ducey L, Ward L, Holland A et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Prior to delivery, there are postpartum pelvic floor recovery topics to provide education on; however, because of a variety of factors, the majority of these are commonly unaddressed, leaving a patient unknowledgeable and…

View details →DOI: 10.1097/spv.0000000000001661
Negative / Null Result ReportMedicine

Enhancing Intercultural Sensitivity Through Collaborative Online International Learning Among Three Countries: A Mixed-Method Study.

Ying Z, Kondo A, De D et al. · 2026 · Journal of transcultural nursing : official journal of the Transcultural Nursing Society

Introduction We evaluated a Collaborative Online International Learning (COIL) programme in enhancing nursing students' intercultural sensitivity and understanding of cultural safety. Methods From April to May 2024, nursing students in…

View details →DOI: 10.1177/10436596261452389
Negative / Null Result ReportMedicine

Curcumin nanoparticles combined with narlumosbart regulate wingless-type MMTV integration site (wnt)/β-catenin signaling pathway in osteoblast-like cells.

Zhang H, Zhao Y · 2026 · Pakistan journal of pharmaceutical sciences

Background Narlumosbart is a key agent for modulating bone cell function. Given the potential of curcumin nanoparticles to inhibit cell growth when applied alone. Objectives This study aims to investigate the role of their combination with…

View details →DOI: 10.36721/pjps.2026.39.7.196.1
Negative / Null Result ReportMedicine

Mitochondrial dysfunction in schizophrenia and its modulation by atypical antipsychotic drugs: A randomized controlled trial.

Shaju A, Mishra BR, Mohapatra D et al. · 2026 · Journal of psychopharmacology (Oxford, England)

BackgroundRecent evidence increasingly links schizophrenia to mitochondrial dysfunction, implicating altered mitochondrial respiratory and metabolic processes in its pathophysiology. Preclinical data suggest that atypical antipsychotics…

View details →DOI: 10.1177/02698811261453937
Negative / Null Result ReportMedicine

Contribution of biomaterials analysis to the study of extractables from neonatal central venous catheters.

Le Basle Y, Sautou V, Sarraute S et al. · 2026 · Biomedical materials (Bristol, England)

The study of extractable chemicals is used to evaluate whether a medical device contains harmful substances susceptible to migrate and contaminate the patients they are used in. The analysis of the biomaterial itself after extraction is…

View details →DOI: 10.1088/1748-605x/ae7523
Negative / Null Result ReportMedicine

Acute effects of norepinephrine infusion on electrocardiographic parameters: A prospective study focusing on the frontal QRS-T angle.

Yılmaz T, Özdemir S · 2026 · Heart & lung : the journal of critical care

Background Norepinephrine is widely used as a first-line vasopressor in acute hypotension and septic shock. Its acute effects on electrocardiographic (ECG) parameters, particularly the frontal QRS-T angle, remain unclear. Objectives To…

View details →DOI: 10.1016/j.hrtlng.2026.102742
Negative / Null Result ReportMedicine

Organ dose modulation: a useful tool for dose reduction in clinical practice?

Wentink N, van Gent M, Borns C · 2026 · The British journal of radiology

Objectives To quantify the reduction in effective dose achieved through organ dose modulation (ODM) on a General Electric Revolution Apex CT scanner, while preserving image quality. Methods First, the noise index (NI) corresponding to…

View details →DOI: 10.1093/bjr/tqag098
Negative / Null Result ReportMedicine

The Age of Definitive Fusion Surgery for Early Onset Scoliosis Has Remained Constant Over the Past 2 Decades.

Abid R, Murphy RF, Hogue GD et al. · 2026 · Journal of pediatric orthopedics

Background Treatment options for early-onset scoliosis (EOS) are confounded by the risks associated with intervention at a younger age. Spinal instrumentation must be considered carefully due to potentially adverse effects to the spine,…

View details →DOI: 10.1097/bpo.0000000000003199
Negative / Null Result ReportOpen accessMedicine

UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Migraine.

Hooper L, Erridge S, Clarke E et al. · 2026 · Brain and behavior

Introduction Migraine is a primary headache disorder, which leads to diminished health-related quality of life (HRQoL). There is limited evidence assessing efficacy of cannabis-based medicinal products (CBMPs) for migraine. This study…

View details →DOI: 10.1002/brb3.71323
Negative / Null Result ReportMedicine

Effects of iodine content in school meals on the results of iodine nutritional surveys using spot urine samples.

Fuse Y, Tsukada N, Yamaguchi M et al. · 2026 · Biological trace element research

Adequate iodine intake is essential for maintaining thyroid function. School meal iodine content (SMIC) is one of the main sources of iodine for schoolchildren. The median urinary iodine concentration (mUIC) in spot urine samples is a…

View details →DOI: 10.1007/s12011-026-05183-6