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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 451 of 724

Negative / Null Result ReportOpen accessMedicine

Are HDAC and Glutamine Synthetase Expression Levels Associated with Ga68-DOTATATE PET/CT Data and Prognosis in Gastroenteropancreatic Neuroendocrine Tumours?

Ulas O, Yuceer RO, Hasbek Z et al. · 2025 · Medicina (Kaunas, Lithuania)

Background and Objectives : Neuroendocrine neoplasms are heterogeneous tumours arising from endocrine gland cells and the neuroendocrine system. Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) constitute two-thirds of this tumour…

View details →DOI: 10.3390/medicina61111952
Negative / Null Result ReportMedicine

Right ventricular systolic function in dogs with pulmonary hypertension can be assessed using tissue motion annular displacement.

Silva VBC, Lucina SB, Wolf M et al. · 2026 · American journal of veterinary research

Objective To assess right ventricular (RV) systolic function using conventional echocardiography and advanced techniques, including strain and tissue motion annular displacement (TMAD), in dogs with and without pulmonary hypertension (PH).…

View details →DOI: 10.2460/ajvr.26.03.0107
Negative / Null Result ReportMedicine

From Mother-Infant Dyad to Mother-Father-Infant Triad: A Cross-Sectional Study on Fathers' Breastfeeding Attitudes and Participation.

Çerçer Z, Biçer Şahin F, Kanarya T · 2026 · Journal of human lactation : official journal of International Lactation Consultant Association

Background and aim It is important to include fathers in the evaluation of the breastfeeding process. This study aimed to assess fathers' breastfeeding attitudes and participation. Methods The cross-sectional study data were collected…

View details →DOI: 10.1177/08903344261434532
Negative / Null Result ReportMedicine

Early postoperative corneal thickness and 12-month endothelial cell outcomes after descemet membrane endothelial keratoplasty: A multicentre analysis.

Igarashi A, Rekate A, Fujiwara K et al. · 2026 · Acta ophthalmologica

Purpose To evaluate whether early postoperative corneal thickness is associated with 12-month endothelial cell and visual outcomes after Descemet membrane endothelial keratoplasty (DMEK). Methods This retrospective multicentre study…

View details →DOI: 10.1111/aos.70166
Negative / Null Result ReportMedicine

Oral body temperature and cerebrospinal fluid pTau181 in older adults at increased risk of Alzheimer's disease.

Pillet P, Tremblay-Mercier J, Picard C et al. · 2026 · Neurobiology of aging

Preclinical studies consistently associate body temperature with tau phosphorylation in the brain. This study examined the relationship between body temperature taken at lumbar puncture (LP) and CSF pTau181 levels in 142 cognitively…

View details →DOI: 10.1016/j.neurobiolaging.2026.06.003
Negative / Null Result ReportMedicine

Reliability of point-of-care glucose in neonates: revisiting hypoglycemia protocols in the NICU.

Hamama I, Katodia V, Landry NM et al. · 2026 · Journal of pediatric endocrinology & metabolism : JPEM

Objectives Hypoglycemia is a common metabolic problem in newborns, often asymptomatic but can lead to cognitive impairment and neuromotor delays. This study assesses the practicality and accuracy of whole blood capillary bedside glucose…

View details →DOI: 10.1515/jpem-2025-0736
Negative / Null Result ReportMedicine

Three-dimensional evaluation of mandibular condyle changes following orthognathic surgery in Class III patients.

Bakaç E, Bayburt KA, Diker N et al. · 2026 · Cranio : the journal of craniomandibular practice

Objective To assess early temporomandibular joint (TMJ) adaptation by evaluating angular and volumetric changes of the mandibular condyle relative to the cranial base in skeletal Class III patients following orthognathic surgery using…

View details →DOI: 10.1080/08869634.2026.2656900
Negative / Null Result ReportOpen accessMedicine

Echocardiographic Findings in Small-Breed Dogs With Myxomatous Mitral Valve Disease and the Severity of Mitral Regurgitation, Heart Size and Clinical Signs Myxomatous Mitral Valve Disease in Dogs.

Elyasi B · 2026 · Veterinary medicine and science

Background The main goal of this study was to identify various brightness, motion and Doppler echocardiographic variables in small-breed dogs with myxomatous mitral valve disease. Animals Sixty client-owned small-breed dogs with mitral…

View details →DOI: 10.1002/vms3.70922
Negative / Null Result ReportOpen accessMedicine

Relationship of arterial stiffness value with hemodynamic parameters in patients undergoing cardiac surgery.

Aydemir M, Sarkılar G, Atay T et al. · 2026 · Turk gogus kalp damar cerrahisi dergisi

Background Hypotension during anesthesia induction is a clinically significant event linked to perioperative complications. This study aimed to assess if arterial stiffness and stiffness index, measured by Doppler ultrasonography (USG),…

View details →DOI: 10.4274/tjtcs.2025.28548
Negative / Null Result ReportMedicine

EXPRESS: Longitudinal comparison of serum pancreatic lipase activity and pancreatic lipase immunoreactivity with clinical signs in cats with suspicion of pancreatitis.

Kook PH · 2026 · Journal of feline medicine and surgery

ObjectivesIt remains unclear whether pancreatic lipase immunoreactivity (PLI) and lipase activity similarly reflect clinical status and disease severity in cats with suspected pancreatitis. This retrospective cohort study aimed to directly…

View details →DOI: 10.1177/1098612x261451449
Negative / Null Result ReportMedicine

Neurofluid fluctuation analysis using dynamical network biomarker MRI in idiopathic normal pressure hydrocephalus.

Sakai M, Miyati T, Ohno N et al. · 2026 · Magnetic resonance imaging

Purpose To apply dynamical network biomarker (DNB) theory to diffusion MRI and develop the diffusion MRI-derived DNB (dMRI-DNB) index for evaluating neurofluid fluctuation in idiopathic normal pressure hydrocephalus (iNPH). Methods…

View details →DOI: 10.1016/j.mri.2026.110728
Negative / Null Result ReportMedicine

Incorporating WGCNA and Machine Learning to Identify ADAP2 as a Critical Efferocytosis-Related Gene in Sepsis.

Zhang C, Xie C, Zhang Z et al. · 2026 · Pathogens (Basel, Switzerland)

Background Sepsis, a life-threatening organ dysfunction caused by dysregulated host responses to infection, frequently involves impaired macrophage efferocytosis that leads to apoptotic cell accumulation, secondary necrosis, and persistent…

View details →DOI: 10.3390/pathogens15060596
Negative / Null Result ReportMedicine

Does kinematic alignment accurately restore anterior trochlear thickness in TKA?

Ito K, Hiranaka T, Basaqr AA et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR

Background Kinematic alignment (KA) aims to restore the distal and posterior joint surfaces by matching the resected bone to the implant thickness. However, whether KA also accurately reproduces the anterior femoral anatomy, including the…

View details →DOI: 10.1016/j.otsr.2026.104767
Negative / Null Result ReportMedicine

Reliability of Patellar Height Measurement in Children and Adolescents on MRI.

Jiang C, Cheng P, Liu Y et al. · 2025 · Journal of pediatric orthopedics

Introduction Imaging-based measurement indices of patellar height are essential for diagnosing patella alta in children and adolescents. The Patellotrochlear Index (PTI) measures the cartilaginous anatomy which is crucial for identifying…

View details →DOI: 10.1097/bpo.0000000000003057
Negative / Null Result ReportMedicine

All-Suture Anchors Exhibit Less Perianchor Fluid Formation Independent of Healing Quality Compared With PEEK Anchors in Arthroscopic Rotator Cuff Repair: A Propensity Score-Matched Comparative Study.

Gül O, Ayazoglu MA, Yazıcı A et al. · 2026 · Journal of shoulder and elbow surgery

Background Perianchor fluid collection may differ according to anchor material following arthroscopic rotator cuff repair (ARCR), but its relationship with tendon healing remains unclear. This study aimed to compare perianchor fluid…

View details →DOI: 10.1016/j.jse.2026.05.033
Negative / Null Result ReportMedicine

Evaluation of Hypermobility in Rhinoplasty: A Case-Control and Cross-Sectional Study.

Kocak OF, Alpayci M, Demir CY et al. · 2025 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Objective To determine the frequency and severity of joint hypermobility (JH) in rhinoplasty patients and to assess rhinoplasty satisfaction in rhinoplasty cases with JH. Study design Comparative cross-sectional study. Place and Duration…

View details →DOI: 10.29271/jcpsp.2025.12.1603
Negative / Null Result ReportMedicine

Paired analysis of meconium and neonatal hair reveals distinct biomarker profiles of prenatal exposure to trace metal elements.

Alsayegh MMA, Sallom BA, Fadel EA et al. · 2026 · Scientific reports

Prenatal exposure to trace metal elements remains a significant public health concern, particularly because these elements can cross the placental barrier and accumulate in fetal tissues. Meconium and neonatal hair are commonly used as…

View details →DOI: 10.1038/s41598-026-54043-9
Negative / Null Result Report

Hallucination Mitigation in Large Language Model-Based Tool Recommendation: A Cross-Provider Architectural Ablation Study Across Two Model Generations

Menxhiqi L, Marinova G · 2026 · Preprint

In a closed-inventory Large Language Model (LLM) system such as Online-CADCOM, which recommends engineering tools from a verified inventory, mention-level hallucination occurs when the model recommends tools not present in the inventory.…

View details →DOI: 10.20944/preprints202606.0008.v1
Failed Experiment Report

Computational Transcriptional Deconvolution and Purity-Corrected Analysis Characterizes Invasion Programs in IDH-Wildtype Glioblastoma: Proneural Distinctiveness, Transcription Factor Proxy Activity, and Dual Mechanisms of Therapeutic Resistance

Saadawy M, Elkoumi O, Saadawy E · 2026 · Preprint

Abstract Background Glioblastoma (GBM) recurrence originates from the non-resectable invasive margin. While the Mesenchymal (ME) subtype has traditionally been considered the most invasive, this assignment is confounded by tumor purity and…

View details →DOI: 10.21203/rs.3.rs-9716905/v1
Negative / Null Result ReportMedicine

Seroprevalence and molecular detection of Toxoplasma gondii in patients with obsessive-compulsive disorder: a case-control study in northern Iran.

Zakariaei Z, Hosseini SH, Alizadeh-Navaei R et al. · 2026 · BMC infectious diseases

Background The infectious hypothesis of obsessive-compulsive disorder (OCD) has gained traction, with Toxoplasma gondii (T. gondii) proposed as a potential risk factor due to its neurotropic properties and ability to alter neurotransmitter…

View details →DOI: 10.1186/s12879-026-13855-w
Negative / Null Result Report

Application of [ 18 F]NaF and [ 18 F]FDG PET/CT to Assess Molecular Calcification and Glucose Metabolism in Thyroid Cartilage

Motamedi N, Singh SB, Gandhi OH et al. · 2026 · Preprint

Objective: Thyroid cartilage calcification and glucose metabolism may vary with age and gender. This study aimed to investigate the role of [18F]-sodium fluoride ([18F]NaF) and 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) PET/CT for the…

View details →DOI: 10.20944/preprints202605.1265.v1
Negative / Null Result ReportMedicine

Assessment of active fibrotic remodeling in patients with idiopathic pulmonary fibrosis (IPF)/progressive pulmonary fibrosis (PPF) using dual-time-point [<sup>68</sup>Ga]Ga-FAPI-46-PET/CT.

Grunert M, Horn V, Baudrexl JC et al. · 2026 · European journal of radiology

Background Progressive fibrosing interstitial lung diseases (ILD) continue to have a poor prognosis. To date, there is no imaging method that can reliably detect fibrotic remodeling processes or distinguish between active and dormant…

View details →DOI: 10.1016/j.ejrad.2026.113036
Negative / Null Result ReportMedicine

Impact of epidemiological and nutritional factors on outcomes following traumatic brain injury in a prospective cohort study.

Afsar E, Sadeghi-Bazargani H, Salehpour F et al. · 2026 · Scientific reports

Traumatic brain injury (TBI) continues to be one of the world's top causes of mortality and long-term disability. It is a severe and frequently fatal disorder. Patients with traumatic brain injury (TBI) not only sustain neurological…

View details →DOI: 10.1038/s41598-026-56795-w