A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19786 results in Negative / Null Result Report · page 45 of 660
Harry Sokol, Laurent Beaugerie, Marc Maynadié et al. · 2012 · Inflammatory Bowel Diseases
BACKGROUND: It remains to be shown whether inflammatory bowel disease (IBD) is associated with an increased risk of primary intestinal lymphoproliferative disorders (PILD). We assessed this risk in the CESAME French nationwide prospective…
Erick Cardenas, Wei‐Min Wu, Mary Beth Leigh et al. · 2010 · Applied and Environmental Microbiology
Massively parallel sequencing has provided a more affordable and high-throughput method to study microbial communities, although it has mostly been used in an exploratory fashion. We combined pyrosequencing with a strict indicator species…
Constantin Ahlmann-Eltze, Wolfgang Huber, Simon Anders · 2025 · Nature Methods
Abstract Recent research in deep-learning-based foundation models promises to learn representations of single-cell data that enable prediction of the effects of genetic perturbations. Here we compared five foundation models and two other…
Andrea L. Roberts, Susan Malspeis, Laura D. Kubzansky et al. · 2017 · Arthritis & Rheumatology
OBJECTIVE: To conduct the first longitudinal study examining whether trauma exposure and posttraumatic stress disorder (PTSD) are associated with increased risk of incident systemic lupus erythematosus (SLE) in a civilian cohort. METHODS:…
Linda Spiegelberg, Ruud Houben, Raymon Niemans et al. · 2019 · Clinical and Translational Radiation Oncology
Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of treatment resistance to conventional therapies. Despite promising preclinical and clinical phase I and II…
Rifat Latifi, GeorgeJ Hadeed, Judith Smith et al. · 2016 · Journal of Emergencies Trauma and Shock
OBJECTIVES: Early diagnosis and emergent surgical debridement of necrotizing soft tissue infections (NSTIs) remains the cornerstone of care. We aimed to study the effect of early surgery on patients' outcomes and, in particular, on…
Suzanna M. Zick, Benjamin D. Wright, Ananda Sen et al. · 2011 · BMC Complementary and Alternative Medicine
BACKGROUND: Despite being the most commonly used herbal for sleep disorders, chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia is unknown. We examined the preliminary efficacy and safety of chamomile for improving subjective sleep and daytime symptoms in patients with chronic insomnia. METHODS: We performed a randomized, double-blind, placebo-controlled pilot trial in 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6-months. Patients were randomized to 270 mg of chamomile twice daily or placebo for 28-days. The primary outcomes were sle
Gholam Ali Gholami, Babak Najafi, Fatemeh Mashhadiabbas et al. · 2011 · Clinical Oral Implants Research
OBJECTIVES: The aim of this study was to compare a nanocrystalline hydroxyapatite (NCHA), NanoBone(®) and a deproteinized bovine bone mineral (DBBM), Bio-Oss(®) with a collagen membrane on the horizontal ridge width alterations following…
Christopher Maldajian, Rim El Khoury · 2014 · International Journal of Economics and Finance
This research aims at investigating the factors determining the dividend payout policy in the Lebanese banks listed on the Beirut Stock Exchange. This study considers the impact of seven variables, namely, profitability, liquidity, leverage, firm size, growth, firm risk and previous year’s dividend payout on the dividend payout ratios by using an unbalanced panel dataset of listed banks between the years of 2005 and 2011. Two models were tested using the OLS and the dynamic panel regressions. Empirical results show that the dividend payout policies are positively affected by the firm size, ris
Simone Passarelli, Dawit Mekonnen, Elizabeth Bryan et al. · 2018 · Food Security
Interventions that aim to increase water availability for agriculture hold great potential for improving nutrition through increasing food production, generating income, enhancing water access and sanitation and hygiene conditions, and through strengthening women’s empowerment. Yet there is scarce evidence on the linkages between small-scale irrigation and the pathways through which nutrition outcomes can be achieved. Using data from a cross-sectional household survey collected in Ethiopia and Tanzania, we explored the potential for small-scale irrigation to contribute to improved diets, and i
Akhmad Darmawan, Kesih Kurnia, Sri Rejeki · 2019 · Jurnal Ilmiah Akuntansi dan Keuangan
This study aims to analyze the effect of investment knowledge, investment motivation, financial literacy and family environment on the interest in investing in the capital market. This type of research is quantitative. The population of this study were students of the Management Study Program of the Faculty of Economics and Business, Muhammadiyah Purwokerto University in the year 2016 and 2017 with the sample criteria of active students of FEB UMP and those who were / had taken financial management and entrepreneurship courses. Data collection in this study using the questionnaire method. Inst
Elizabeth Chipp, Lisa Charles, Clare Thomas et al. · 2017 · Burns & Trauma
BACKGROUND: It is commonly accepted that burns taking longer than 3 weeks to heal have a much higher rate of hypertrophic scarring than those which heal more quickly. However, some of our patients develop hypertrophic scars despite healing…
Michael Wahl, Joanna J. Phillips, Annette M. Molinaro et al. · 2016 · Neuro-Oncology
Background: Optimal adjuvant management of adult low-grade gliomas is controversial. Recently described tumor classification based on molecular subtype has the potential to individualize adjuvant therapy but has not yet been evaluated as…
Rahul Kapoor · 2013 · Organization Science
Although the stylized model of industry evolution suggests that firms transform from vertical integration to specialization over time, many industries still exhibit a continued persistence of integrated firms. In exploring this puzzle, I…
Merit Cudkowicz, Stacy Lindborg, Namita Goyal et al. · 2021 · Muscle & Nerve
INTRODUCTION/AIMS: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative illness with great unmet patient need. We aimed to evaluate whether mesenchymal stem cells induced to secrete high levels of neurotrophic factors…
Rebecca Zadroga, David N. Williams, Richard L. Gottschall et al. · 2012 · Clinical Infectious Diseases
BACKGROUND: Antimicrobial removal devices in blood culture media are designed to remove antibiotics from the blood culture solution, thereby facilitating bacterial growth. How well these devices function clinically has not been…
Abha A. Gupta, Alberto S. Pappo, Natasha Saunders et al. · 2010 · Cancer
BACKGROUND: As Ewing sarcoma (EWS) can affect children and adults, these patients can be treated at either a pediatric or an adult institution. This study investigated whether differences in therapeutic strategy undertaken in pediatric and…
Tracey A. Martin, David Wan, Kaveh Hajifathalian et al. · 2020 · The American Journal of Gastroenterology
INTRODUCTION: Although current literature has addressed gastrointestinal presentations including nausea, vomiting, diarrhea, abnormal liver chemistries, and hyperlipasemia as possible coronavirus disease 2019 (COVID-19) manifestations, the…
Stella Edström Halling, Magnus Söderberg, U. Berg · 2011 · Nephrology Dialysis Transplantation
BACKGROUND: There has been a lack of international consensus on the classification and the predictive value of the histopathology findings in IgA nephropathy (IgAN). Recently, the International IgA Nephropathy Network has developed the…
Andrew A. Abeyta, Clay Routledge, Christina Roylance et al. · 2014 · Journal of Social and Personal Relationships
The reported research tested whether the social and agentic content of nostalgic memories varies as a function of attachment-related avoidance. We measured individual differences in attachment-related avoidance and anxiety and coded the…
Chris K.Y. Lo, Frank Wiengarten, Paul Humphreys et al. · 2013 · Journal of Operations Management
Abstract This study investigates the importance of contextual factors on the efficacy of ISO 9000 adoption. We explore the role of various contextual factors at the firm‐level (i.e., technology intensity, labor productivity, and labor…
Michael R. Perkin, Kirsty Logan, Henry T. Bahnson et al. · 2019 · Journal of Allergy and Clinical Immunology
BACKGROUND: The Enquiring About Tolerance (EAT) study was a randomized trial of the early introduction of allergenic solids into the infant diet from 3 months of age. The intervention effect did not reach statistical significance in the intention-to-treat analysis of the primary outcome. OBJECTIVE: We sought to determine whether infants at high risk of developing a food allergy benefited from early introduction. METHODS: A secondary intention-to-treat analysis was performed of 3 groups: nonwhite infants; infants with visible eczema at enrollment, with severity determined by SCORAD; and infants
Guillem Pascual‐Pasto, Miriam Bazán‐Peregrino, Nagore G. Olaciregui et al. · 2019 · Science Translational Medicine
VCN-01 is an oncolytic adenovirus designed to replicate selectively in tumor cells with high abundance of free E2F-1, a consequence of a dysfunctional RB1 pathway. Thus, we reasoned that VCN-01 could provide targeted therapeutic activity…
Rebecca J. Welly, Tzu‐Wen Liu, Terese M. Zidon et al. · 2016 · Medicine & Science in Sports & Exercise
UNLABELLED: Cardiometabolic impairments that begin early in life are particularly critical, because they often predict metabolic dysfunction in adulthood. Obesity, high-fat diet (HFD), and inactivity are all associated with adipose tissue…
Rianne Dekker, Henrik Emilsson, Bernhard Krieger et al. · 2015 · International Migration Review
This study examines three theses on local integration policies by a qualitative comparative case study of integration policies in three cities in three different countries (Berlin, Malmö, and Rotterdam). We found little evidence of a…
Dilip R. Karnad, Rakesh Bhadade, Pradeep Kumar Verma et al. · 2014 · Intensive Care Medicine
PURPOSE: Ulinastatin, a serine protease inhibitor, inhibits several pro-inflammatory proteases and decreases inflammatory cytokine levels and mortality in experimental sepsis. We studied the effect of ulinastatin on 28-day all-cause…
Umar Zahid, Preethi Ramachandran, Samuel Spitalewitz et al. · 2020 · American Journal of Nephrology
BACKGROUND: Although diffuse alveolar damage and respiratory failure are the key features of coronavirus disease 2019 (COVID-19), the involvement of other organs such as the kidney has also been reported. The reports of the incidence of…
Sarah E. Boston, Xiaomin Lu, William T. N. Culp et al. · 2014 · Journal of the American Veterinary Medical Association
OBJECTIVE: To determine prognostic factors for and compare outcome among dogs with oral malignant melanoma following excision with or without various systemic adjuvant therapies. DESIGN: Retrospective case series. ANIMALS: 151 dogs with…
Leonardo Bursztyn, Davide Cantoni · 2015 · The Review of Economics and Statistics
This paper examines the impact of exposure to foreign media on the economic behavior of agents in a totalitarian regime. We study private consumption choices focusing on the former East Germany, where differential access to Western…
L Thibaut, Sean R. Connolly, Hugh Sweatman · 2011 · Ecology
Biodiversity may provide insurance against ecosystem collapse by stabilizing assemblages that perform particular ecological functions (the "portfolio effect"). However, the extent to which this occurs in nature and the importance of…