Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01
Guillem Pascual‐Pasto; Miriam Bazán‐Peregrino; Nagore G. Olaciregui; Camilo A. Restrepo‐Perdomo; Ana Mato-Berciano; Daniela Ottaviani; Klaus Weber; Genoveva Correa · 2019 · Science Translational Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
VCN-01 is an oncolytic adenovirus designed to replicate selectively in tumor cells with high abundance of free E2F-1, a consequence of a dysfunctional RB1 pathway. Thus, we reasoned that VCN-01 could provide targeted therapeutic activity…
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Metadata source: OpenAlex · DOI 10.1126/scitranslmed.aat9321