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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 440 of 724

Negative / Null Result ReportMedicine

<i>Aronia melanocarpa</i> extract modulates gut microbiota and induces dose-dependent metabolic shifts in broiler chickens.

Can MB, Kara A, Adigüzel MC et al. · 2026 · British poultry science

1. Following the ban on prophylactic antibiotic use in feed for poultry, interest in natural alternatives has increased, particularly plant-derived extracts. In this study, the effects of Aronia melanocarpa fruit extract (AMF) on growth…

View details →DOI: 10.1080/00071668.2026.2673525
Negative / Null Result ReportOpen accessMedicine

Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells.

Marinello WP, Zylka MJ · 2026 · Frontiers in toxicology

Introduction Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA), are persistent environmental contaminants known for bioaccumulation and adverse health effects, including neurodevelopmental toxicity.…

View details →DOI: 10.3389/ftox.2026.1814052
Negative / Null Result Report

Imatinib Reduces Right Ventricular Systolic Pressure Independent of Arterial or Venous Remodeling in an Inflammatory Murine Model of Pulmonary Hypertension

McGlynn M, Steffes LC, Shah A et al. · 2026 · Preprint

Pulmonary arterial hypertension is a progressive, fatal disease driven by pathologic vascular remodeling including arterial medial hypertrophy, occlusive neointimal lesion formation, and venous muscularization. Current vasodilatory…

View details →DOI: 10.64898/2026.05.05.723006
Negative / Null Result Report

Effect of CCW OTR Kinematic on Instrumentation Time and Apical Debris Extrusion in Mildly and Severely Curved Root Canals: An In Vitro Study

Albanna RH, El-Farraj H, Awawdeh S et al. · 2026 · Preprint

Abstract Apical debris extrusion is an unavoidable phenomenon; however, evidence remains limited regarding the effect of newer motion kinematics, specifically counterclockwise optimum torque reverse (CCW OTR). Sixty-six mandibular molars…

View details →DOI: 10.21203/rs.3.rs-9615788/v1
Replication FailureMedicine

Facial shape and self-perceived personality traits in young adults.

Gkantidis N, Tsikouriadou E, Halazonetis D et al. · 2026 · Scientific reports

The present study investigated the association between facial shape and self-perceived personality and psychosocial traits. The study population consisted of 613 young adults (399 females and 214 males) aged 21-35 years, with similar…

View details →DOI: 10.1038/s41598-026-47895-8
Negative / Null Result ReportMedicine

Distinct Pause Patterns in Autism: Effects of Sex and Conversational Context in French-Speaking (Pre)adolescents.

Belenger M, Dumont C, Geelhand P et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Purpose We investigated sex differences in the production of pauses in autistic (pre-)adolescents in two conversational contexts: a monologue and an interactive discussion. Method This study included 107 French-speaking participants ( M…

View details →DOI: 10.1044/2026_jslhr-25-00565
Negative / Null Result ReportMedicine

Efficacy analysis of CAR-T cells against CD123-positive malignant tumors and exploration of the feasibility of combination therapy with venetoclax.

Zhang M, Chai X, Zhang X et al. · 2026 · Annals of hematology

Chimeric antigen receptor T cells (CAR-T cells) have been widely applied in hematologic malignancies. It has shown limited efficacy in the treatment of myeloid neoplasms. We retrospectively analyzed the safety and efficacy of CD123 CAR-T…

View details →DOI: 10.1007/s00277-026-07097-8
Replication Failure

No Additional Benefit of 185 Hz versus 130 Hz at Equivalent Energy in Deep Brain Stimulation for Tremor - A randomized prospective clinical trial

van der Linden C, Trapp P, Dembek TA et al. · 2026 · Preprint

Background Deep brain stimulation (DBS) of the ventral intermediate nucleus and posterior subthalamic area (VIM/PSA) in Essential Tremor (ET) and the subthalamic nucleus (STN) in Parkinson’s disease (PD) are established treatment for…

View details →DOI: 10.64898/2026.05.31.26354199
Replication FailureMedicine

The effects of temperature, urbanisation, and artificial light on phototaxis in eusocial and non-eusocial bees.

Webster E, Ng L, Prendergast K et al. · 2026 · Journal of insect physiology

Climate change and urbanisation are major drivers of global insect pollinator decline. However, the combined effects of these stressors remain poorly understood, particularly in relation to pollinator behaviour. Understanding how these…

View details →DOI: 10.1016/j.jinsphys.2025.104927
Replication FailureMedicine

[Adaptation Mechanism and Strategy of Ecological Resilience and High-quality Development in the Yellow River Basin].

Sheng YC, Chen X, Zhang YF et al. · 2026 · Huan jing ke xue= Huanjing kexue

Achieving ecological protection and high-quality development is the fundamental goal of sustainable development in the Yellow River Basin, and it is also an inevitable choice for the practice of the concept of Chinese-style modernization.…

View details →DOI: 10.13227/j.hjkx.202503345
Replication FailureMedicine

Association of vitamin D deficiency with incident depression in patients with hearing impairment: an observational retrospective cohort study.

Cheng WJ, Kao CL, Hung IY · 2026 · Frontiers in nutrition

Background Hearing impairment is associated with an elevated risk of depression, yet modifiable risk factors in this population remain poorly characterized. Although vitamin D deficiency (VDD) has been linked to depression in general…

View details →DOI: 10.3389/fnut.2026.1856953
Negative / Null Result ReportMedicine

Impact of an Individualized Dietary Intervention on Body Composition and Clinical Outcomes in Patients with Neovascular Age-Related Macular Degeneration: A Pilot Study.

Szulim D, Kucharska E, Machalińska A et al. · 2026 · Nutrients

Background/Objectives : Age-related macular degeneration (AMD) is a leading cause of permanent deterioration of central vision in elderly people. While anti-VEGF therapy remains the standard of care for neovascular AMD, disease progression…

View details →DOI: 10.3390/nu18121870
Negative / Null Result ReportMedicine

Standing work and low back pain: An experimental analysis of risk factors.

Osorio-Vasco J, Rojas-Mora J, Barrera-Causil C et al. · 2026 · Work (Reading, Mass.)

BackgroundStanding work is common across a wide range of industries and service sectors and has been associated with the development of low back pain.ObjectiveTo analyze changes in low back pain across eight experimental scenarios…

View details →DOI: 10.1177/10519815261438027
Negative / Null Result ReportMedicine

The Impact of a Unique Military Treatment Facility-Based Sports Medicine Model on Readiness in the Army: A Prospective Longitudinal Analysis Comparing 2 Military Health System Entry Portal Pathways on the Duration of Healthcare Management and the Incidence of Recurrence Within 24 Months.

Suttles S, Boeth RR, Frazier M et al. · 2026 · Military medicine

Objective Describe an innovative Sports Medicine clinic design implemented in an outpatient Physical Therapy (PT) clinic within a Military Treatment Facility (MTF) for both referral and direct access (DA) entry portal pathways, and to…

View details →DOI: 10.1093/milmed/usaf423
Negative / Null Result ReportMedicine

Effect of hydrogen peroxide disinfectant on the flexural strength of different custom impression tray materials fabricated using conventional and digital methods.

Lengerli Efe A, Özen Sütüven E, Uçar Y et al. · 2026 · International journal of computerized dentistry

Aim The aim was to evaluate the effect of hydrogen peroxide disinfectant exposure for 60 minutes -representing the longest exposure time recommended for achieving the widest antimicrobial spectrum- on the flexural strength (FS) of…

View details →DOI: 10.3290/j.ijcd.b7003304
Negative / Null Result ReportOpen accessMedicine

Haptic perception of 2.5D surface feature height.

Hwang I, Yun S, Park J · 2026 · Scientific reports

The present study investigates the human haptic perception of 2.5D dome-shaped surface features in terms of difference and absolute thresholds. We conducted two experiments to measure the thresholds, analyzing the effect of sample base…

View details →DOI: 10.1038/s41598-026-42333-1
Negative / Null Result ReportMedicine

What factors prolong symptoms in patients with hemorrhoidal disease who require surgery?

Zayas-Bórquez R, Diaz-Barrientos CZ, Canto-Losa J et al. · 2026 · Revista de gastroenterologia de Mexico (English)

Introduction and aims Hemorrhoidal disease is a common condition and may affect quality of life. Although it tends to respond to conservative treatment, some cases require surgery. The present study examined clinical and demographic…

View details →DOI: 10.1016/j.rgmxen.2026.05.004
Negative / Null Result ReportOpen accessMedicine

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension.

Yaman İ, Korkmaz H, Akağaç AE et al. · 2026 · Journal of cardiovascular development and disease

Background Pulmonary arterial hypertension (PAH) is a rare and progressive disorder characterized by increased pulmonary vascular resistance and vascular remodeling. Genetic polymorphisms, epigenetic modifications, and ion channel…

View details →DOI: 10.3390/jcdd13060283
Negative / Null Result ReportOpen accessMedicine

Association between Helicobacter pylori infection and thyroid dysfunction in adults visiting a tertiary care hospital in Karachi, Pakistan: a cross-sectional study.

Jahangeer A, Jabeen R, Fatima S et al. · 2026 · BMC endocrine disorders

Background Thyroid dysfunction and Helicobacter pylori (H. pylori) infection are both highly prevalent in Pakistan. Several studies have proposed a potential immunological link between H. pylori infection and autoimmune thyroid disease,…

View details →DOI: 10.1186/s12902-026-02293-z
Negative / Null Result ReportOpen accessMedicine

Immunohistochemical expression of Stomatin-Like protein 2 and trophoblast cell surface antigen 2 in papillary thyroid carcinoma in comparison to other thyroid lesions.

Elmetwally AA, Khashaba MH, Wagih HM et al. · 2026 · Diagnostic pathology

BACKGROUND: Thyroid carcinoma is a common tumor affecting the Egyptian population accounting for 2% of newly diagnosed cases of cancer in Egypt yearly and constituting 7.73% of 5 year prevalence in Egypt. Stomatin-Like Protein 2 (SLP-2)…

View details →DOI: 10.1186/s13000-026-01772-0
Negative / Null Result ReportMedicine

The Association Between the STOP-Bang Score and the Integrated Pulmonary Index in Patients Undergoing Endobronchial Ultrasound with Sedation: The STOP OSA-IPI Cohort Study.

Ozden Sertcelik U, Turker M, Sertcelik A et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Perspectives : Obstructive sleep apnea (OSA) is a prevalent condition associated with increased perioperative risks. Endobronchial ultrasound (EBUS), a diagnostic and staging procedure requiring deep sedation, may pose…

View details →DOI: 10.3390/medicina62061034