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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21322 results · page 441 of 711

Negative / Null Result Report

P0603 Early tumour necrosis factor inhibitor initiation is associated with increased persistence in Crohn’s Disease but not Ulcerative Colitis, whereas early ustekinumab, vedolizumab and tofacitinib did not improve persistence

B Gu, J Chetwood, A Pudipeddi et al. · 2026 · Journal of Crohn’s and Colitis

Abstract Background Emerging evidence suggests early initiation of advanced therapies (AT) may improve outcomes, but optimal timing remains unclear. We aimed to assess the impact of AT timing on persistence. Methods We interrogated the…

View details →DOI: 10.1093/ecco-jcc/jjaf231.784
Failed Experiment Report

The Novel Use of Hyperbaric Oxygen Therapy to Improve Umbilical Cord Blood Stem Cell Engraftment in Irradiated NOD/SCID Mice: What Did We Learn?

Omar S. Aljitawi, Jeff Radel, Bruce Kimler et al. · 2011 · Blood

Abstract Abstract 4695 Introduction: UCB is also an attractive stem cell source for transplantation because of the ease of procurement, the absence of donor risks, and reduced risk of transmissible infections. Unfortunately, outcomes of…

View details →DOI: 10.1182/blood.v118.21.4695.4695
Negative / Null Result Report

A Novel Honey Powder-Based Supplement Containing Carbohydrate and Protein Did Not Improve Endurance Performance in Recreationally Trained Cyclists

Taíse Toniazzo, Rafael de Almeida Azevedo, Tamires Nunes Oliveira et al. · 2025 · International Journal of Sport Nutrition and Exercise Metabolism

Sports supplements composed of carbohydrate and protein are widely used by endurance athletes and recreational practitioners, mostly aimed at improving performance. This study investigated the effect of a novel carbohydrate + protein honey…

View details →DOI: 10.1123/ijsnem.2025-0021
Negative / Null Result Report

Rapamycin adjuvant therapy did not improve the outcome of severe influenza virus infection in an experimental mouse model system

Ching-Tai Huang, Avijit Dutta, Tse-Ching Chen et al. · 2016 · The Journal of Immunology

Abstract The host immune system responds to influenza virus infection for eradication of the virus but the immune response associated inflammation causes tissue injury and damage to the host as well. Severe influenza with morbidity and…

View details →DOI: 10.4049/jimmunol.196.supp.76.21
Negative / Null Result ReportMedicine

Inhibitory Effects of Oxytocin on Jejunal Migrating Myoelectric Complex Activity in Fasted Rats: Role of Oxytocin and GLP-1 Receptors.

Balcı, Saltık, Aktemur et al. · 2026 · Life (Basel, Switzerland)

The migrating myoelectric complex (MMC) is the electrical basis of fasting small intestinal motility. Although oxytocin (OT) regulates gastrointestinal functions through oxytocin receptors (OTRs), its effect on jejunal MMC activity during…

View details →DOI: 10.3390/life16061029
Negative / Null Result Report

Utility of platelet indices as a diagnostic indicator of hemodynamically significant PDA in preterm infants: a comparative cross-sectional study

Samar Mahmoud Elbahy, Ola Galal Ali, Sara Soliman Ali et al. · 2024 · Egyptian Pediatric Association Gazette

Abstract Background Among preterm babies, patent ductus arteriosus (PDA) is a prevalent condition, and hemodynamically significant patent ductus arteriosus (hsPDA) constitutes an important problem that impacts their outcome. There has…

View details →DOI: 10.1186/s43054-024-00339-2
Negative / Null Result Report

OA09 Significant association between disease duration in axial spondyloarthritis and the occurrence of uveitis and inflammatory bowel disease, with no such association found for psoriasis

Brona Dinneen, Marcus Kenyon, Finbar O'Shea · 2024 · Rheumatology

Abstract Background/Aims Axial spondyloarthritis is a chronic inflammatory condition primarily impacting the spine and sacroiliac joints. In addition to spinal inflammation and peripheral symptoms, it frequently presents with…

View details →DOI: 10.1093/rheumatology/keae163.009
Negative / Null Result Report

PATHOLOGICAL AND MOLECULAR PARAMETERS SHOW NO SIGNIFICANT ASSOCIATION WITH RESIDUAL CANCER BURDEN IN BREAST CARCINOMA

Fishella Aprista Rahmanti, Willy Sandhika, Lusiani Tjandra · 2025 · Folia Medica Indonesiana

Residual Cancer Burden (RCB) is a validated scoring system that quantifies the amount of tumour remaining after neoadjuvant chemotherapy (NAC) for breast cancer, providing prognostic information beyond binary outcomes, such as pathologic…

View details →DOI: 10.65346/2599-056x.2407
Negative / Null Result Report

THE ASSOCIATION OF LONELINESS AND CHRONIC CLINICALLY SIGNIFICANT PAIN AMONG AFRICAN AMERICAN AND WHITE OLDER ADULTS

David Camacho, Denise Burnette, Maria P Aranda et al. · 2019 · Innovation in Aging

Abstract Loneliness and pain are significant public health problems in later life, yet limited research has examined how these factors interact among racially diverse older adults. Guided by the Biopsychosocial Model of Pain, we used data…

View details →DOI: 10.1093/geroni/igz038.2281
Negative / Null Result Report

The Association Between Significant Mitral Regurgitation and Atrial Fibrillation Recurrence Post-Ablation

Arni Gershman, Rivka Farkash, Amjad Abu-Salman et al. · 2025 · Journal of Clinical Medicine

Background: Atrial fibrillation (AF) is a common tachyarrhythmia associated with increased morbidity. AF frequently occurs alongside mitral regurgitation (MR). Although the impact of MR severity on AF is well proven, its effect on AF…

View details →DOI: 10.3390/jcm14207300
Negative / Null Result Report

Association between global longitudinal strain and coronary artery calcium in the diagnosis of significant coronary artery disease

M Shvydka, M Lutay, I Golikova · 2026 · European Heart Journal - Cardiovascular Imaging

Abstract Introduction Non-invasive diagnostic methods for coronary artery disease (CAD) are gaining increasing importance due to their accessibility, diagnostic value, safety, and cost-effectiveness. Both global longitudinal strain (GLS)…

View details →DOI: 10.1093/ehjci/jeaf367.070
Negative / Null Result Report

Significant Association between Sleep Deprivation and Somato Testicular Index: an experimental study on Albino Rats

Ameera Al-Humidi, Mohammed Abdulsalam · 2025 · Yemeni Journal for Medical Sciences

Background: Sleep deprivation is total or partial absence of sleep. It is a risk factor for many diseases including disorders of reproductive system. Objective: This study aimed to investigate the correlation between sleep deprivation and…

View details →DOI: 10.20428/yjms.v19i4.2793
Negative / Null Result Report

Significant Association Between Snapping Scapula Syndrome and Anterior Angulation of the Superomedial Scapular Angle

Peter J. Millett, Sean Smith, Charles Ho et al. · 2014 · Orthopaedic Journal of Sports Medicine

Objectives: Significant Association Between Snapping Scapula Syndrome and Anterior Angulation of the Superomedial Scapular Angle. Methods: In this Institutional Review Board approved study, bony morphologies of the scapula were evaluated…

View details →DOI: 10.1177/2325967114s00063
Negative / Null Result Report

Abstract 10858: Significant Association Between Washout Ratio of Renal 123i-metaiodobenzylguanidine and Muscle Sympathetic Nerve Activity in Patients With Hypertension

Yoshitaka Okabe, Hisayosi Murai, souichiro usui et al. · 2015 · Circulation

Background: Simplicity HTN-3 trial showed the negative result for renal denervation (RDN) in patient with resistant hypertension. One of limitations was that no appreciate evaluation of renal sympathetic nerve activity (RSNA) was applied…

View details →DOI: 10.1161/circ.132.suppl_3.10858
Negative / Null Result Report

P–212 Mitochondrial DNA content shows a significant association with timing of human embryo development and fertility diagnosis in euploid embryos

C Hur, V Nanavaty, A Chehab et al. · 2021 · Human Reproduction

Abstract Study question Does mitochondrial DNA content (mtDNA) correlate with clinical parameters and embryo morphokinetics using advanced time-lapse technology? Summary answer mtDNA correlated with embryo morphokinetics and the growth…

View details →DOI: 10.1093/humrep/deab130.211
Negative / Null Result Report

Linkage Disequilibrium between LDLR rs688 and AvaII Genes and its Significant Association with Ischemic Stroke

Yabin Chen, Hehui Cai, Jianming Zhang et al. · 2023 · Journal of Integrative Neuroscience

Background: To analyze the polymorphism distribution of low density lipoprotein receptor rs688, AvaII, NcoI gene in ischemic stroke, and explore the linkage disequilibrium among them. The correlation between the linkage disequilibrium and…

View details →DOI: 10.31083/j.jin2204094
Negative / Null Result Report

Use of Direct‐Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Significant Tricuspid Regurgitation

Yujin Yang, Mijin Kim, Jun Kim et al. · 2024 · Journal of the American Heart Association

Background There are limited data on the efficacy and safety of direct oral anticoagulants (DOACs) in patients with atrial fibrillation with significant tricuspid regurgitation (TR), which can lead to hepatic dysfunction and intestinal…

View details →DOI: 10.1161/jaha.123.032272
Negative / Null Result Report

LACK OF SIGNIFICANT ASSOCIATION BETWEEN COMPONENT ALIGNMENT AND FUNCTIONAL OUTCOME IN TOTAL HIP ARTHROPLASTY

Ismail Hadisoebroto Dilogo, Wildan Latief, Muh Trimugroho Fahrudhin · 2018 · Journal of Southeast Asian Medical Research

Background : Total hip replacement (THR) failure isinfluenced bythe prosthesis component orientation. The debate is still ongoing to determine the best angles for acetabular or femoral components. Objective :To evaluate the functional…

View details →DOI: 10.55374/jseamed.v2i1.21
Negative / Null Result Report

No significant association between 40bp ins/del promoter polymorphism of MDM2 and breast cancer susceptibility in Pakistani women

Sania Gull, Nabeela Tariq, Hamida Ali et al. · 2025 · LIAQUAT MEDICAL RESEARCH JOURNAL

Breast cancer remains the most prevalent malignancy among women, and is the second leading cause of mortality worldwide. Genetic heterogeneity in the MDM2 promoter region has been associated with increased cancer susceptibility. The study…

View details →DOI: 10.38106/lmrj.2025.7.4-06
Negative / Null Result Report

No significant association between term premature rupture of membranes and neonatal APGAR score: A cross-sectional study

Shelvy Era Chintia, Henidekasari, Veronica Ela Rimawati et al. · 2025 · Jurnal Ilmiah Kesehatan Sandi Husada

Introduction: Premature rupture of membranes (PROM) is defined as the rupture of the amniotic sac before the onset of labor, potentially increasing the risk of infection, hypoxia, and a low APGAR score in newborns. The APGAR score assesses…

View details →DOI: 10.35816/jiksh.v14i2.269
Negative / Null Result Report

No significant association between term premature rupture of membranes and neonatal APGAR score: A cross-sectional study

Shelvy Era Chintia, Henidekasari Henidekasari, Veronica Ela Rimawati et al. · 2025 · Jurnal Ilmiah Kesehatan Sandi Husada

Introduction: Premature rupture of membranes (PROM) is defined as the rupture of the amniotic sac before the onset of labor, potentially increasing the risk of infection, hypoxia, and a low APGAR score in newborns. The APGAR score assesses…

View details →DOI: 10.35816/jiskh.v14i2.1293
Negative / Null Result Report

Heparinized venous blood gas syringes are associated with a significant decrease in measured packed cell volume in dogs due to hemodilution

Coyne M. Hopey, Dana Caldwell, Erin Binagia et al. · 2025 · Journal of the American Veterinary Medical Association

Abstract OBJECTIVE To assess the effect of hemodilution on PCV when commercial preheparinized venous blood gas (PH-VBG) syringes are used compared to directly filled Hct tubes, and to evaluate the impact of delayed centrifugation on PCV.…

View details →DOI: 10.2460/javma.24.11.0718
Negative / Null Result Report

Allergies, asthma treatment, and eviction diet have a significant impact on the respiratory effort during sleep and the apnea-hypopnea index in children with obstructive sleep apnea-obesity/asthma association: A STROBE-compliant study

Kalomoira Kefala, Philippe Guerin · 2026 · Medicine

The pathophysiological mechanisms implicated in obstructive sleep apnea (OSA) associated with asthma/allergies remain unclear. Apnea-hypopnea index (AHI) alone is insufficient to accurately guide adequate treatment without identifying the…

View details →DOI: 10.1097/md.0000000000041730
Negative / Null Result Report

Association of Dyslipidemia with Clinically Significant Macular Edema (CSME) in Type – II Diabetes Mellitus

Md. Mufakh Kharul Islam, Md. Mizanur Rahman, Md. Khalid Hossain et al. · 2022 · Scholars Journal of Applied Medical Sciences

Aim: To observe the association between dyslipidemia and CSME in Type – II diabetes mellitus. Method: With convenience type of sampling technique 36 patients of diabetic retinopathy (DR) with CSME (Group–I) and another 35 patients of DR…

View details →DOI: 10.36347/sjams.2022.v10i08.002
Negative / Null Result Report

Single nucleotide polymorphism of the promotor region of Interleukin-10 gene did not show significant association with spontaneous clearance of hepatitis C virus infection in Egyptian patients

Fatma Waly, Maysaa El Sayed Zaki, Hany Shabana et al. · 2023 · Gastroenterology & Hepatology: Open Access

Introduction: Accurate etiologies of spontaneous clearance of HCV infection are hard to be clarified. However, it is proposed that genetically determined interleukin-10 (IL-10) changes play an important function in HCV elimination.…

View details →DOI: 10.15406/ghoa.2023.14.00565