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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 441 of 724

Negative / Null Result ReportMedicine

Mood stabilizers and systemic inflammatory burden in euthymic patients with bipolar disorder: a comparative study of lithium and valproate.

Bakay H, Kılavuz FA · 2026 · Psychopharmacology

Rationale Systemic inflammation is increasingly recognized as a key component of the pathophysiology and neuroprogression of bipolar disorder (BD). Novel hematologic indices, including the NLR, PLR, SII, SIRI, and PIV, provide accessible…

View details →DOI: 10.1007/s00213-026-07111-x
Negative / Null Result ReportMedicine

Examination of the relationship between post-voiding residual urine volume and patient-reported urinary symptoms in postmenopausal women.

Umudova K, Demir Ö · 2026 · BMC women's health

Introduction and hypothesis Post-void residual (PVR) urine volume is routinely evaluated in women with urinary incontinence and/or pelvic organ prolapse (POP). However, its clinical relevance in postmenopausal women without these…

View details →DOI: 10.1186/s12905-026-04626-5
Negative / Null Result ReportMedicine

Study of phosphorylated ribosomal protein S6 (pS6) in the clinical outcomes of patients undergoing hepatectomy for metastatic colorectal cancer.

Henriques Cavalcanti Torres de Melo R, de Barros Silva PG, Neto HFEC et al. · 2026 · World journal of surgical oncology

Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with up to 50% of patients developing metastatic disease, predominantly involving the liver. Hepatectomy remains the gold standard for resectable…

View details →DOI: 10.1186/s12957-026-04453-w
Negative / Null Result ReportMedicine

Mechanical diagnosis and therapy as a clinical diagnostic approach in lumbar disc herniation: association with radiological findings.

Aghdasi Z, Negahban H, Movahedi Aliabadi M et al. · 2026 · The Journal of manual & manipulative therapy

Background Lumbar disc herniation (LDH) is a leading causes of low back pain (LBP). Conservative approaches, such as the McKenzie Method of Mechanical Diagnosis and Therapy (MDT), are widely used as first-line treatments. MDT is based on…

View details →DOI: 10.1080/10669817.2026.2683051
Negative / Null Result ReportMedicine

Evaluation of the mechanical properties of 3D printed interim resins polymerized with different postpolymerization units.

Lee W, Kim S, Ahmed KE et al. · 2026 · The Journal of prosthetic dentistry

Statement of problem The effect of different postpolymerization units on the mechanical reliability and degree of conversion (DC) of 3-dimensional (3D) printed interim resins remains unclear, particularly when third-party units are used…

View details →DOI: 10.1016/j.prosdent.2026.05.038
Negative / Null Result ReportMedicine

The Association of G Protein-Coupled Estrogen Receptor (GPER) Polymorphisms with Ionizing Radiation Exposure in Healthcare Workers.

Öztürk Ü, Kurutaş EB, Üremiş N et al. · 2026 · Journal of clinical medicine

Background/Objectives: The G protein-coupled estrogen receptor (GPER) is known to interact with cellular stress responses and DNA damage pathways. Therefore, exposure to ionizing radiation may modulate the biological consequences of…

View details →DOI: 10.3390/jcm15124821
Negative / Null Result ReportMedicine

Impact of Preoperative Depression on Motor Recovery Following Brachial Plexus Reconstruction: A 24-Month Prospective Cohort Study.

Jianmongkol S, Wattanakamolchai S, Wainipitapong S et al. · 2026 · Hand (New York, N.Y.)

Background Depression is frequently diagnosed in patients experiencing traumatic injury and chronic neuropathic pain. Psychological factors may undermine patient motivation, potentially adversely affecting surgical outcomes. This study…

View details →DOI: 10.1177/15589447261453553
Negative / Null Result ReportMedicine

Independent and joint associations of social participation and depressive symptoms with incident stroke risk in older adults: a prospective cohort study based on CHARLS and ELSA.

Ma L, Ma Y, Huang Z et al. · 2026 · BMC public health

Stroke remains a leading cause of death and disability among older adults. Depressive symptoms and low social participation have been linked to stroke risk via behavioral and biological pathways. This study examined the independent and…

View details →DOI: 10.1186/s12889-026-28217-z
Negative / Null Result ReportMedicine

A Pilot Study Investigating the Clinically Significant Association Between Overweight, Hyperlipidemia, and Insulin Resistance in Dogs With Chronic Liver Disease.

Cogozzo A, Habermaass V, Dini R et al. · 2026 · Veterinary medicine international

The liver plays a central role in glucose and lipid metabolism. In human medicine, glucose metabolism alterations and insulin resistance are commonly associated with chronic liver disease (CLD), particularly in metabolic…

View details →DOI: 10.1155/vmi/4827011
Negative / Null Result ReportMedicine

Short-term visual acuity responder rates after full-thickness macular hole surgery stratified by hole size: a retrospective cohort study.

Timoceanu L, Lang C, Tschuppert S et al. · 2026 · BMC ophthalmology

Purpose To quantify early real-world visual acuity (VA) responder rates at 25-35 days after idiopathic full-thickness macular hole (FTMH) surgery and evaluate the influence of hole size, gas tamponade, and prescribed duration of face-down…

View details →DOI: 10.1186/s12886-026-05046-7
Negative / Null Result ReportMedicine

Overutilization of helicopter emergency medical services compared to ground transport in moderate-severe penetrating abdominal trauma & associated outcomes.

Hus A, Brown A, Bundschu I et al. · 2026 · Injury

Background Helicopter emergency medical services (HEMS) play a crucial role in trauma transport, accounting for approximately 550,000 transportations annually. However, HEMS holds a disproportionate share of trauma causes, highlighting its…

View details →DOI: 10.1016/j.injury.2026.113437
Negative / Null Result ReportMedicine

Development of a Prediction Model for Skin Graft Failure Following Skin Cancer Excision: The GRAFT Score.

Asfour H, Aram K, Hassouna M et al. · 2026 · Annals of surgical oncology

Background Skin grafting after skin cancer excision is a commonly performed procedure. Preoperative identification and optimization of patients at risk of graft failure can improve outcomes and healthcare cost effectiveness. This study…

View details →DOI: 10.1245/s10434-026-19853-1
Negative / Null Result ReportMedicine

Association between adherence to the Dietary Approaches to Stop Hypertension diet and depression and anxiety severity in the Mashhad Stroke and Heart Atherosclerotic Disorder study population.

Soltani S, Rahimi HR, Seifi N et al. · 2026 · Public health nutrition

Objective The present study aimed to investigate the association between adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and the risk of depression and anxiety severity in a large group of Iranian adults. Design In…

View details →DOI: 10.1017/s1368980026102110
Negative / Null Result Report

Association Between Physical Function, Pulmonary Function, and Social Determinants of Health in Individuals with Post-Tuberculosis Lung Disease

de Souza NM, de Lima Silva PHP, de Souza Penna ER et al. · 2026 · Preprint

Although poverty and tuberculosis are insidiously linked, knowledge of the relationship between social determinants of health (SDH) and post-tuberculosis lung disease (PTLD) is limited. This study aimed to analyze the association between…

View details →DOI: 10.20944/preprints202606.1594.v1
Negative / Null Result Report

Nurses' CPR knowledge in Bangladesh

Islam MF · 2026 · Preprint

Abstract Background Cardiopulmonary resuscitation (CPR) is a life-saving intervention where nurses often serve as first responders. In Bangladesh, limited data exists on nurses’ CPR knowledge, particularly in regional hospitals. This study…

View details →DOI: 10.21203/rs.3.rs-9561256/v1
Negative / Null Result ReportMedicine

Associations of Pregnancy History and Complications with Cardiovascular Disease Among American Indian Women: The Strong Heart Family Study.

Ebadani L, Reese JA, Sitlani CM et al. · 2026 · Journal of women's health (2002)

Introduction In the United States, cardiovascular disease (CVD) is a leading cause of death among American Indian women. We examined the associations of parity and pregnancy complications (history of preeclampsia, protein in urine,…

View details →DOI: 10.1177/15409996261455858
Negative / Null Result ReportMedicine

A Greek Case-Control Replication Study of <i>IKZF1</i> rs4132601 and <i>CDKN2A</i> rs3731217 in Childhood Acute Lymphoblastic Leukemia.

Kyriakidis I, Katsarou SD, Zervou MI et al. · 2026 · Genes

Background/objectives Inherited variants in IKZF1 and CDKN2A/2B are among the most consistently reported germline susceptibility markers for childhood acute lymphoblastic leukemia (ALL). Nonetheless, effect sizes differ across ancestry…

View details →DOI: 10.3390/genes17060682
Negative / Null Result Report

A Clinical Predictor of Lung Molecular Endotype Identifies Heterogeneity in Corticosteroid Response in Severe COVID-19: an Emulated Target Trial

Sines BJ, Hagan RS, Jiang X et al. · 2026 · Preprint

ABSTRACT Background Corticosteroids reduce mortality in severe COVID-19 requiring oxygen or invasive mechanical ventilation, yet emerging data suggest that SARS-CoV-2-associated acute lung injury is biologically heterogeneous and that…

View details →DOI: 10.64898/2026.06.08.26355201
Negative / Null Result ReportMedicine

Vitamin D Levels and Uropathogen Distribution in Urinary Tract Infections: A Six-Year Retrospective Study from Cyprus.

Arık H, Tınazlı M, Süer K · 2026 · Medicina (Kaunas, Lithuania)

Backgroun d and Objectives : Urinary tract infections (UTIs) represent one of the most frequently encountered bacterial infections in clinical practice. Although vitamin D (vit D) is recognised for its immunomodulatory properties, its…

View details →DOI: 10.3390/medicina62061113
Negative / Null Result ReportMedicine

Association of IL-18 gene variants with depressive symptoms and metabolic syndrome in Mexican adults.

Ramirez De Los Santos ML, Ramírez-De Los Santos S, Becerra Solano LE et al. · 2026 · Nutricion hospitalaria

Introduction Introduction: metabolic syndrome (MS) affects approximately 27 % of the global population and represents a growing public health concern. Identifying factors associated with its presence is essential for prevention, early…

View details →DOI: 10.20960/nh.06008
Negative / Null Result ReportOpen accessMedicine

Impact of Postpartum Hemorrhage in Postpartum Depressive and Anxiety Symptoms in Twin Delivery: A Retrospective Cohort Study.

Ye H, Tian Y, He G et al. · 2026 · Journal of clinical medicine

Objectives : This study aimed to investigate the association between postpartum hemorrhage (PPH) and the risk of postpartum depressive and anxiety symptoms. Methods : A retrospective cohort study of twin delivery was conducted at a…

View details →DOI: 10.3390/jcm15082953