Negative / Null Result Report
Didin Muwahhidin, Henokh Ziw Apritoba · 2026 · Klabat Accounting Review
understanding that accounting functions as an economic language that reflects the influence of macroeconomic factors on company performance and value in the capital market. Fluctuations in stock returns in the property sector in Indonesia…
View details →DOI: 10.60090/kar.v7i1.1455.21-31 Negative / Null Result ReportOpen accessDentistry
Duaa Subhi Rasan, Firas Abdulameer Farhan · 2023 · Dental Hypotheses
Introduction: This study was designed to examine the effects of addition of the combination of polymerized polymethyl methacrylate (PMMA) and zirconia (ZrO2) particles to heat cure PMMA resin on impact strength, surface hardness, and roughness. Methods: The 70% (w/w) of polymerized PMMA powder (particle size: 0.70 µm) was mixed with 30% (w/w) of zirconia powder (ZrO2) (1 µm) to produce PMMA-ZrO2 filler. Ninety acrylic specimens created were divided into three groups containing 0% wt (Control group), 2% wt, and 4% wt, PMMA-ZrO2 filler. Ten specimens were used for impact strength, surface hardne
View details →DOI: 10.4103/denthyp.denthyp_151_22 Negative / Null Result ReportOpen accessMedicine
David J. Harris, Shawn D. Taylor, Ethan P. White · 2018 · PeerJ
Biodiversity forecasts are important for conservation, management, and evaluating how well current models characterize natural systems. While the number of forecasts for biodiversity is increasing, there is little information available on how well these forecasts work. Most biodiversity forecasts are not evaluated to determine how well they predict future diversity, fail to account for uncertainty, and do not use time-series data that captures the actual dynamics being studied. We addressed these limitations by using best practices to explore our ability to forecast the species richness of bre
View details →DOI: 10.7717/peerj.4278 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Megan Kristy Herbert, Marjolein B Aerts, Marijke eBeenes et al. · 2015 · Frontiers in Neurology
The differentiation between multiple system atrophy (MSA) and Parkinson’s disease (PD) is difficult, particularly in early disease stages. Therefore, we aimed to evaluate the diagnostic value of neurofilament light chain (NFL), fms-like tyrosine kinase ligand (FLT3L) and total tau protein (t-tau) in cerebrospinal fluid (CSF) as biomarkers to discriminate MSA from PD. Using commercially available enzyme-linked immunoassays (ELISAs), we measured CSF levels of NFL, FLT3L and t-tau in a discovery cohort of 36 PD patients, 27 MSA patients and 57 non-neurological controls and in a validation cohort
View details →DOI: 10.3389/fneur.2015.00091 Negative / Null Result ReportOpen accessMedicine (General)
O.E. Soares, A.A.V. Cruz · 2004 · Brazilian Journal of Medical and Biological Research
The objective of the present study was to describe, for the first time in Brazil, the use by a non-ophthalmologist of a community-based marginal rotation procedure by a posterior approach in the indigenous population from the Upper Rio Negro basin. Seventy-three upper eyelids of 46 Indians (11 males and 35 females) with cicatricial upper eyelid entropion and trichiasis were operated in the Indian communities using a marginal rotational procedure by a posterior approach by a non-ophthalmologist physician who had general surgery experience but only an extremely short period (one week) of ophthal
View details →DOI: 10.1590/s0100-879x2004000500007 Negative / Null Result ReportOpen accessMedicine
Cláudia Saraiva, Daniela Talhada, Akhilesh Rai et al. · 2018 · PLoS ONE
There is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential in an in vitro and in vivo model of stroke. For that, neuroprotective and neurogenic responses were assessed in an in vitro model of stroke. Here, we found that miR-124 NPs decreased cell death and imp
View details →DOI: 10.1371/journal.pone.0193609 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Maria Comas, Alejandra Solis Flores, Nicole Lovato et al. · 2023 · Brain Sciences
Insomnia is a highly prevalent sleep disorder with strong bidirectional associations with depressive symptoms. The circadian preference for eveningness has been shown to be associated with depressive symptoms in insomnia and other mental health conditions. However, there is a lack of studies in insomnia investigating whether objective measures, such as dim light melatonin onset (DLMO) or polysomnographic (PSG) sleep, are associated with depressive symptoms. Therefore, we investigated the associations between subjective measures (questionnaires assessing anxiety, sleep quality and circadian pre
View details →DOI: 10.3390/brainsci13040613 Negative / Null Result ReportOpen accessVeterinary medicine
William Taylor Fair, Jeffrey Bryan Breeden, Thomas Wayne Atchley et al. · 2022 · Animals
Mesquite ( Prosopis L.) is considered an invasive browse species in most of the American Southwest. Mechanical intervention removes yields an excess of organic debris. Anecdotal evidence in the past has supported using such browse as feed for livestock. Thus, our objectives were to (1) determine the nutritive value and fermentation characteristics of silage produced with mesquite biomass, and (2) evaluate solvent treatment of mesquite biomass prior to ensiling. In Experiment 1, we evaluated mesquite inclusion rate (0, 250, 500, 750, or 1000 g kg −1 DM), length of fermentation (28, 56, or 84 d)
View details →DOI: 10.3390/ani12202795 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Michał Sobstyl, Nina Kożuch, Magdalena Iwaniuk-Gugała et al. · 2023 · Epilepsy & Behavior Reports
Progressive myoclonic epilepsy (PME) is characterized by prominent myoclonus, generalized tonic-clonic seizures, and less often focal, tonic, or absence seizures. The KCNC1 mutation is responsible for specific clinical phenotype of PME which has been defined as myoclonic epilepsy and ataxia due to potassium channel mutation (MEAK). We present a case of a 44 years-old male patient with genetically proven MEAK who underwent subthalamic nucleus/substantia nigra (STN/SNr) deep brain stimulation (DBS) for his pharmacological-refractory myoclonus and drug-resistant epilepsy (DRE). Since the age of 4
View details →DOI: 10.1016/j.ebr.2023.100627 Negative / Null Result ReportOpen accessPsychiatry
Jiaojiao Zhou, Xu Chen, Le Xiao et al. · 2021 · Frontiers in Psychiatry
Background: Insomnia is a common clinical manifestation in patients with depression. Insomnia is not only a depression symptom but also an independent risk factor for recurrence. Cordyceps militaris (C. militaris) is thought to have the potential to treat insomnia. This study aimed to examine the efficacy and safety of duloxetine with C. militaris in improving sleep symptoms in patients with depression.Methods: This study was a single-center, randomized, double-blind, placebo-controlled study that recruited outpatients admitted to Beijing Anding hospital from January 2018 to January 2019. Majo
View details →DOI: 10.3389/fpsyt.2021.754921 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Sylvain Rheims, Vania Herbillon, Ségolène Gaillard et al. · 2024 · Epilepsia Open
Abstract Background Attention‐deficit hyperactivity disorder (ADHD) is a frequent comorbidity in children with epilepsy, which management mostly relies on the usual treatments of ADHD, especially methylphenidate. Supplementation with polyunsaturated n‐3 Fatty Acid (PUFA) has been proposed as an alternative therapeutic approach in ADHD without epilepsy but has never been evaluated in epilepsy‐associated ADHD. Methods A multicenter double blind randomized placebo‐controlled trial evaluating supplementation with PUFA, in eicosapentaenoic‐ and docosahexaenoic‐acid form, conjugated to a phospholipi
View details →DOI: 10.1002/epi4.12892 Negative / Null Result ReportOpen accessMedicine (General)
Hiroaki Kuroda, Junji Ichinose, Katsuhiro Masago et al. · 2021 · Medicina
Background and Objectives : Lobe-specific nodal dissection (L-SND) is currently acceptable for the dissection of early-stage non-small cell lung cancer (NSCLC) but not for cancers of more advanced clinical stages. We aimed to assess the efficacy of L-SND, compared to systemic nodal dissection (SND). Materials and Methods : We retrospectively collected the clinical data of patients with carcinoembryonic antigen (CEA) abnormality who underwent complete resection of NSCLC via lobectomy or more in addition to either SND or L-SND at two cancer-specific institutions from January 2006 to December 201
View details →DOI: 10.3390/medicina57121365 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Chen F, Shen J, Wang J et al. · 2018 · Cancer Management and Research
Fawen Chen,1,2 Jing Shen,3 Jianwei Wang,1 Pengwei Cai,1 Yi Huang3 1Department of Clinical Laboratory, Fujian Provincial Hospital South Branch, 2Department of Blood Transfusion, 3Department of Clinical Laboratory, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, People’s Republic of China Purpose: To investigate the diagnostic values of human epididymis protein 4 (HE4), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) for ovarian tumors. Methods: The participants were divided into three gr
Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Jenna A. Fryer, Elizabeth Tomasino · 2025 · Beverages
Wines produced from grapes exposed to wildfire smoke exhibit smoke-related flavors, such as smoky, burnt, and an ashy finish. While grapes are impacted on the vine, winemaking strategies can influence the perception of smoke-related properties in the resulting wine. This case study evaluated eight smoke-affected wines across three vintages from commercial production to assess how oak influences smoke-related flavors. Each vintage explored a different usage of oak, including oak origin, oak chips with carbon fining, and potential carryover of flavors through reused barrels. Wines were assessed
View details →DOI: 10.3390/beverages11040122 Negative / Null Result ReportOpen accessBusiness
Daniel Hailu · 2020 · International Journal of Agricultural Economics
Ethiopia is the second largest wheat producing countries in Sub-Saharan Africa and most people rely on rain fed agriculture for their livelihoods. Wheat production has increased from 2,176,603 tons in 2005 to 4,219,257 tons in 2016 with…
View details →DOI: 10.11648/j.ijae.20200505.19 Negative / Null Result ReportOpen accessInternal medicine
Xiangyan Liu, Tian Shen, Zhuoyi Wang et al. · 2014 · Journal of Infection in Developing Countries
Hepatitis E virus (HEV) infection in most individuals is known as a self-limiting, acute, icteric hepatitis, but evidence shows HEV is responsible for choric hepatitis and rapid progressed liver cirrhosis in immuno-compromised patients. We present the case of a patient whose diagnosis of acute graft failure was due to a HEV infection 7 years after his first liver transplantation because of Wilson’s disease. The process showed severe jaundice with fatigue, poor appetite and continually rising serum aminopherase. The blood serum was found positive for the anti-HEV IgG antibody but negative for a
View details →DOI: 10.3855/jidc.3638 Negative / Null Result ReportOpen accessMedicine
Athan P Papailiou, David V Yokum, Christopher T Robertson · 2015 · PLoS ONE
In recent decades, social scientists have shown that the reliability of eyewitness identifications is much worse than laypersons tend to believe. Although courts have only recently begun to react to this evidence, the New Jersey judiciary has reformed its jury instructions to notify jurors about the frailties of human memory, the potential for lineup administrators to nudge witnesses towards suspects that they police have already identified, and the advantages of alternative lineup procedures, including blinding of the administrator. This experiment tested the efficacy of New Jersey's jury ins
View details →DOI: 10.1371/journal.pone.0142695 Negative / Null Result ReportOpen accessEducation
Reza sharifinia, Abdolhussein Shakurnia · 2022 · Journal of Medical Education Development
Background & Objective: Critical thinking (CT) is essential in medical education and improves physicians' clinical ability and competency. The present study aimed to determine the CT level and the trend of its changes in medical education at Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, in 2021. Materials & Methods: In this cross-sectional descriptive study, the CT levels of 165 medical students in three curricular phases, namely basic sciences, externship, and internship courses were examined. The data collection tool was the California Critical Thinking Skills Questionnaire
View details →DOI: 10.52547/edcj.15.45.26 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Ye Li Lee, Sang Yeoup Lee, Sang Yeoup Lee et al. · 2022 · Frontiers in Nutrition
IntroductionOysters possess an excellent nutritional profile containing γ-aminobutyric acid (GABA). Previous data suggest that GABA is a potent bioactive compound for improving muscle health. Lactic acid fermentation is thought to increase GABA content. However, the effect of oral supplementation of fermented oyster extracts (FO) on human muscle strength and mass is unclear. Therefore, we tested the effects and safety of consumption of FO combined with regular walking for 12 weeks on muscle strength and mass in older adults with relatively low muscle mass.Materials and methodsA randomized cont
View details →DOI: 10.3389/fnut.2022.935395 Negative / Null Result ReportOpen accessVeterinary medicine
Lina Fernanda Pulido-Rodríguez, Alfredo Manuel Franco Pereira, Fábio Luís Henrique et al. · 2025 · Veterinary Sciences
Shearing to improve heat dissipation is common in sheep farming. This study evaluated the influence of shearing on thermoregulatory responses of crossbred sheep from adapted breeds exposed to heat stress. Ten ewes were kept in a climate chamber exposed to heat stress (10–13 h), reaching 37 ± 1.0 °C for nine days, during two consecutive periods, without shearing, and then at 14 days after shearing, evaluating all variables. Rectal temperature, respiration rate, sweating rate, ocular surface temperature, and skin temperature were analyzed at 7, 10, 13, 17, and 20 h, and blood cortisol was analyz
View details →DOI: 10.3390/vetsci12040358 Negative / Null Result ReportOpen accessOphthalmology
Mahmoud F. Abdelaal, Soheir M. Esmat, Mohamed A. Salah Eldein et al. · 2026 · Delta Journal of Ophthalmology
Purpose This study aimed to compare the anatomical and functional outcomes of pars plana vitrectomy (PPV), intravitreal ranibizumab (IVR), and intravitreal triamcinolone acetonide (IVTA) injection in chronic persistent diabetic macular edema (DME) with nontractional epiretinal membrane (NT-ERM). Patients and methods This is a randomized prospective study that included 52 patients having chronic DME with NT-ERM who were divided into three groups: PPV with internal limiting membrane peeling group, IVR group, and IVTA group. The patients were evaluated by optical coherence tomography angiography
View details →DOI: 10.4103/djo.djo_36_25 Negative / Null Result ReportOpen accessMedicine
Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE
Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des
View details →DOI: 10.1371/journal.pone.0294767 Negative / Null Result ReportOpen accessVeterinary medicine
Jesús A. Quezada-Rubio, Alfredo Estrada-Angulo, Beatriz I. Castro-Pérez et al. · 2026 · Animals
Due to their specific properties, the autolyzed yeast Saccharomyces cerevisiae (SC) and bacterial Bacillus subtilis (BS) theoretically can have a synergistic effect when combined and offered in ruminant diets. Thus, the aim of this experiment was to evaluate the effect of their combination as feed additives on growth performance, dietary energy, carcass traits, and visceral organ mass in finishing lambs. For this reason, 48 Pelibuey × Katahdin lambs (98 ± 17 d age; initial weight = 20.25 ± 3.37 kg) were used in a feeding trial lasting 83 d. Lambs were blocked by weight and assigned to 24 pens.
View details →DOI: 10.3390/ani16040610 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Anoek L. I. van Leeuwen, Nicole A. M. Dekker, Paul Van Slyke et al. · 2021 · Intensive Care Medicine Experimental
Abstract Background Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic shock-induced vascular leakage. We hypothesized that as a consequence of vascular leakage, renal perfusion and function is impaired and that activating Tie2 restores renal perfusion and function. Methods Rats underwent 1 h of hemorrhagic shock and were treated with either vasculotide or PBS as control, followed by fluid resuscitation for 4 h. Microcirculatory perfusion w
View details →DOI: 10.1186/s40635-021-00389-5 Negative / Null Result ReportOpen accessBusiness
H. M. Zakaria, Gusganda Suria Manda, Arif Rakhman · 2020
This study is aiming to determine the effect of mudharabah financing on the profitability (ROA) in Sharia Commercial Banks (BUS) for the 2015-2018 period, the effect of musyarakah financing on the profitability (ROA) on Sharia Commercial…
View details →DOI: 10.34308/eqien.v7i2.146 Negative / Null Result ReportOpen accessMedicine
Benedikt J. Wiggli, Reno Frei, Reto Laffer et al. · 2017 · Swiss Medical Weekly
PURPOSE Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding mortality attributed to SA BSI caused by methicillin-sensitive S. aureus (MSSA) strains. In the unusual setting of a very low MRSA prevalence institution, we investigated incidence, mortality and trends of BSI caused by MSSA over the last 20 years. OBJECTIVE To evaluate and demonstrate trends in incidence and mortality of MSSA BSI as well as risk factors
View details →DOI: 10.4414/smw.2017.14508 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
George D. Fulk, Regina Bell, Keenan Batts et al. · 2026 · Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sleep–wake disruption is common after stroke and may impede recovery. The Sleep Regularity Index (SRI) quantifies the probability that an individual is in the same sleep or wake state at the same clock time on consecutive days. This study evaluates SRI during poststroke recovery, estimating associations with stroke outcomes and characterizing transitions between SRI states over time. Methods We analyzed data from 71 participants who were part of a larger ongoing study exploring the impact of nonobstructive sleep apnea sleep disorders post stroke. Data were collected at 10, 60, and 9
View details →DOI: 10.1161/jaha.125.048392 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
A. DeMichele, A. C. Dueck, D. Hlauschek et al. · 2025 · Breast Cancer Research
Abstract Background The PALLAS trial investigated the addition of palbociclib to standard adjuvant endocrine therapy to reduce breast cancer recurrence. This pre-specified analysis was conducted to determine whether adjuvant palbociclib benefited patients diagnosed with lower risk stage IIA disease compared to those with higher stage disease. Methods PALLAS was an international, multicenter, randomized, open-label, phase III trial, representing a public–private partnership between Pfizer, the Austrian Breast Cancer Study Group, and the U.S. ALLIANCE Foundation. Patients diagnosed with stage II
View details →DOI: 10.1186/s13058-024-01941-3 Negative / Null Result ReportOpen accessMedicine
Hiroyuki Daida, Tomoyuki Takura, Tetsuya Shiina et al. · 2022 · BMJ Open
Objectives Follow-up invasive coronary angiography (FUICA) after percutaneous coronary intervention (PCI) has been shown to increase the rate of early coronary revascularisation without reducing the incidence of subsequent myocardial infarction or death. However, no studies have evaluated the cost-effectiveness of FUICA in patients after coronary stenting. Therefore, this study aimed to evaluate the cost-effectiveness of FUICA after PCI.Design Retrospective observational cohort study.Setting 497 hospitals.Participants and interventions Overall, 558 patients who underwent coronary artery stenti
View details →DOI: 10.1136/bmjopen-2022-061617 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Andrew P. McBride, Thibault Lafosse, Alex N. Karanja et al. · 2025 · BMC Musculoskeletal Disorders
Abstract Background Long term studies have shown the Latarjet procedure to be successful in preventing re-dislocation in primary and recurrent anterior inferior shoulder instability. It provides stability through the sling effect of the conjoint tendon and the bone block. It is unclear whether augmentation with capsular repair provides an added benefit or leads to restricted range of external rotation. The primary aim of this study is to evaluate the effect of capsular repair in the open Latarjet procedure on rotational range of active external rotation in 90 degrees abduction (RoM-ER90). The
View details →DOI: 10.1186/s12891-025-08278-8 