Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Myrthe E. Sonneveld, Myrthe E. Sonneveld, Carolien A. M. Koeleman et al. · 2018 · Frontiers in Immunology
After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. The quality of the IgG-Fc-glycosylation has important functional consequences, which have been found to be skewed toward low fucosylation in some antigen-specific immune responses. This increases the affinity to IgG1-Fc-receptor (FcγR)IIIa/b and thereby directly affects downstream effector functions and disease severity. To date, antigen-specific IgG-glycosylation have not been analyzed for IgG3. Here, we analyzed 30 pregn
View details →DOI: 10.3389/fimmu.2018.00129 Failed Experiment ReportOpen accessPlant culture
Laura Cabero-Moreno, Ignacio Landeras-López, María Victoria Bravo-Navas et al. · 2025 · Frontiers in Plant Science
Abies pinsapo is an endangered species, endemic to southern Spain. Somatic embryogenesis and cryopreservation constitute important biotechnological tools, which can be used in order to improve the management and conservation of threatened species. The objective of this work was to develop somatic embryogenesis and cryopreservation protocols for A. pinsapo. Somatic embryogenesis was induced from mature zygotic embryos of A. pinsapo cultured on solid MS medium with macroelements at half-strength and supplemented with 20 g L-1 sucrose and 5 mg L-1 6-benzylaminopurine (BA). Embryogenic cultures su
View details →DOI: 10.3389/fpls.2025.1535113 Negative / Null Result ReportOpen accessChemical technology
Caterina Pagnini, Giacomo Sampietro, Gaia Santini et al. · 2023 · Foods
Microalgae, because of their high nutritional value and bioactive molecule content, are interesting candidates for functional foods, including fermented foods, in which the beneficial effects of probiotic bacteria combine with those of biomolecules lying in microalgal biomass. The aim of this work was to evaluate the potential of Tisochrysis lutea F&M-M36 as a substrate for Lactiplantibacillus plantarum ATCC 8014 and to verify fermentation effects on functionality. Bacterium selection among three lactobacilli was based on growth and resistance to in vitro digestion. Microalgal raw biomass and
View details →DOI: 10.3390/foods12061128 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maysa S. Campos, José B. Volpon, João Paulo B. Ximenez et al. · 2022 · Frontiers in Endocrinology
ObjectiveTo investigate the effects of vibration therapy on fracture healing in diabetic and non-diabetic rats.Methods148 rats underwent fracture surgery and were assigned to four groups: (1) SHAM: weight-matched non-diabetic rats, (2) SHAM+VT: non-diabetic rats treated with vibration therapy (VT), (3) DM: diabetic rats, and (4) DM+VT: diabetic rats treated with VT. Thirty days after diabetes induction with streptozotocin, animals underwent bone fracture, followed by surgical stabilization. Three days after bone fracture, rats began VT. Bone healing was assessed on days 14 and 28 post-fracture
View details →DOI: 10.3389/fendo.2022.909317 Negative / Null Result ReportMedicine
Xu, Wu, Liu et al. · 2026 · Annals of hematology
In adult patients with early-stage follicular lymphoma (FL), age-related differences in the risk of non-lymphoma-related death (LRD) during the follow-up period after treatment are unclear. We aimed to investigate the interactive effects…
View details →DOI: 10.1007/s00277-026-07144-4 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Ce Zhou, You Zhou, Niannian Shuai et al. · 2024 · Frontiers in Cardiovascular Medicine
Background and aimEstimated glomerular filtration rate (eGFR) is a key indicator of kidney function and is associated with numerous health conditions. This study examines the association between eGFR and cardiovascular disease (CVD) risk in a representative cohort of the US adult population.MethodsA cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. The study included 31,020 participants aged 20 years and older. The eGFR estimates were calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD
View details →DOI: 10.3389/fcvm.2024.1417926 Negative / Null Result ReportOpen accessMedicine
Lijing Ma, Heng Su, Yan Wang et al. · 2020 · European Journal of Inflammation
Variants of the interleukin-1β (IL-1β) gene have been associated with type 2 diabetes (T2D) and coronary artery diseases (CAD). However, association of IL-1β polymorphisms with diabetic patients having CAD clinical manifestation has not been studied yet. In this study, we aim to decipher the role of IL-1β common promoter variants with susceptibility/resistance to development of CAD in T2D patients. T2D patients with (n = 134) or without CAD (n = 533) were enrolled. A total of 513 essentially healthy individuals from the same population were included in this study as control. Plasma levels of I
View details →DOI: 10.1177/2058739220918047 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Keyi Wu, Huamin Liu, Jiazhen Zheng et al. · 2022 · Frontiers in Aging Neuroscience
Background: Diabetes mellitus (DM) is a recognised risk factor for cognitive dysfunction. The purpose of this study was to explore the relationship between active treatment for DM and cognitive function in middle-aged (< 60 years) and older adults (≥60 years), respectively.Methods: A total of 13,691 participants (58.55 ± 9.64 years, 47.40% of men) from the Chinese Health and Retirement Longitudinal Study (CHARLS) were included. The participants were classified into three groups according to whether or not they have diabetes and to their diabetes treatment status: diabetes-free, treated-diabete
View details →DOI: 10.3389/fnagi.2021.753129 Negative / Null Result ReportOpen accessPediatrics
Mohamad A. Alanbari, Mohamad A. Alanbari, Hebah M. Hamdan et al. · 2024 · Frontiers in Pediatrics
Background/AimManaging young children with negative behaviors can be challenging in dental settings. Moderate sedation (MS) is often used as a treatment option for such children. However, children's behavior during MS may vary depending on several variables. These variables include parental factors, such as parental anxiety, coping strategies, and pain catastrophizing. However, this area, particularly in Saudi Arabia, remains underexplored. Therefore, this study aimed to assess the association among parental anxiety, coping style, pain catastrophizing, and children's behavior during MS among S
View details →DOI: 10.3389/fped.2024.1456395 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Yanhua Liu, Shunping Ma, Xuemin Huang et al. · 2023 · Frontiers in Nutrition
BackgroundMany studies have suggested that the serum concentrations of vitamin A (VA) and vitamin E (VE) influence preeclampsia (PE) risk in pregnant women. However, few studies have assessed whether dietary intake and serum concentrations of VA and VE are correlated with PE risk.MethodsA 1:1 matched case-control study was conducted to explore the association between the dietary intake and serum concentrations of VA and VE and the risk of PE in pregnant Chinese women. A total of 440 pregnant women with PE and 440 control pregnant women were included in the study. Dietary information was obtain
View details →DOI: 10.3389/fnut.2023.1049055 Negative / Null Result ReportOpen accessPublic aspects of medicine
Chaoqun Feng, Junjie Yao, Yizhou Xie et al. · 2024 · BMC Public Health
Abstract Background Low back pain is the leading cause of productivity loss, imposes a significant economic burden on the patients and society. Oxidative stress is considered a critical factor in the complex pathophysiological process and pathogenic mechanism of low back pain. Adjustment dietary pattern can effectively increase antioxidant biomarkers levels within the body to reduce oxidative stress. The composite dietary antioxidant index (CDAI) serves a reliable scoring system for quantifying the potential dietary antioxidant capacity of daily diets. Objective We aim to investigate the poten
View details →DOI: 10.1186/s12889-024-17649-0 Negative / Null Result ReportMedicine
Beri, Patil, Sharma et al. · 2026 · Journal of glaucoma
Aqueous humor outflow (AHO) is significantly lower in primary angle closure glaucoma (PACG) compared to primary open angle glaucoma (POAG). To quantitatively compare circumferential,perilimbal aqueous humor outflow(AHO) pathways in…
View details →DOI: 10.1097/ijg.0000000000002728 Negative / Null Result ReportOpen accessPediatrics
Uchenna Modestus Nnaji, Christian Chukwukere Ogoke, Henrietta Uche Okafor et al. · 2020 · International Journal of Pediatrics
Background. Sickle cell nephropathy (SCN) is a serious complication of sickle cell anaemia (SCA) with asymptomatic onset in childhood and possible progression to chronic kidney disease (CKD). In Southeast Nigeria, few studies have evaluated renal function in paediatric SCA patients for early detection of renal impairment and early intervention to reduce morbidity and mortality. Therefore, this study evaluated the renal function of paediatric SCA patients in a steady state based on glomerular filtration rate and urinalysis findings (proteinuria and haematuria). Methods. A cross-sectional study
View details →DOI: 10.1155/2020/1286432 Negative / Null Result ReportMedicine
Ginesin, Barsheshet-Karif, Mayer et al. · 2026 · Dentistry journal
Background : Peri-implantitis is a prevalent inflammatory condition leading to progressive bone loss around dental implants. In vivo studies widely use murine peri-implantitis models. Micro-computed tomography (micro-CT) is the gold…
View details →DOI: 10.3390/dj14060343 Negative / Null Result ReportMedicine
Pinho, Novais, Gonçalves · 2026 · Dentistry journal
Background : Interceptive orthodontic treatment during mixed dentition aims to reduce malocclusion complexity and improve occlusal development. Although Invisalign ® First was introduced for Phase I therapy in growing patients,…
View details →DOI: 10.3390/dj14060338 Negative / Null Result ReportMedicine
Izbassarova, Imangaliyeva, Bakhshinyan et al. · 2026 · Audiology research
Background/Objectives: Hearing loss is a leading cause of disability worldwide, with speech perception representing a key functional outcome of auditory rehabilitation. While hearing aids improve audibility, outcomes vary substantially…
View details →DOI: 10.3390/audiolres16030086 Negative / Null Result ReportMedicine
Sucato, Serra, Buttà et al. · 2026 · Microbiology spectrum
Human papillomavirus (HPV) represents the most prevalent sexually transmitted infection worldwide, often presenting as asymptomatic or subclinical in males. There is still uncertainty about the most suitable biological specimen for an…
View details →DOI: 10.1128/spectrum.00440-26 Negative / Null Result ReportMedicine
Yang · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research
Atypical meningiomas have higher recurrence and mortality than benign variants, and age may influence treatment decisions and outcomes. We evaluated associations between age, treatment modality, and survival in patients with atypical…
View details →DOI: 10.1080/08941939.2026.2687182 Negative / Null Result ReportMedicine
Matsubara, Pletschacher, Schaeffer et al. · 2026 · Cardiology in the young
In hypoplastic left heart syndrome with aortic atresia, the non-functional left ventricle may influence right ventricular performance. We evaluated serial changes in tricuspid and mitral valve diameters after the Norwood procedure and…
View details →DOI: 10.1017/s1047951126113365 Negative / Null Result ReportMedicine
Zhang, Li, Ma et al. · 2026 · Brain research bulletin
This study used event-related potentials (ERPs), time-frequency analysis, and multivariate pattern analysis (MVPA) to investigate how hypnosis modulates visual and auditory processing. Twenty-two highly hypnotizable participants performed…
View details →DOI: 10.1016/j.brainresbull.2026.112018 Negative / Null Result ReportMedicine
Wali, Abbara, Ekhelikar et al. · 2026 · Postgraduate medical journal
Diastolic dysfunction is an important early indicator of heart failure (HF) with preserved ejection fraction (HFpEF). Type 2 diabetes mellitus (T2DM) may contribute to HFpEF, as it is associated with an increased risk of hospitalization…
View details →DOI: 10.1093/postmj/qgag079 Negative / Null Result ReportMedicine
Elganzory, Baraka, Elkholy et al. · 2026 · La Clinica terapeutica
Helicobacter pylori infection affects nearly half of the global population and is a major cause of peptic ulcer disease and gastric cancer. Increasing antibiotic resistance, particularly to clarithromycin, has reduced the efficacy of…
View details →DOI: 10.7417/ct.2026.2058 Negative / Null Result ReportMedicine
Kilinc, Günaydin, Demirtas et al. · 2026 · Revista da Associacao Medica Brasileira (1992)
The success of anterior cruciate ligament reconstruction depends on anatomical tunnel placement. The aim of this was to compare the effects of 30° and 70° arthroscopes on femoral and tibial tunnel positioning and their…
View details →DOI: 10.1590/1806-9282.20251578 Negative / Null Result ReportMedicine
Nishimura, Oyama, Hasegawa et al. · 2026 · The Journal of dermatology
Psoriasis is a chronic, immune-mediated inflammatory disease with heterogeneous manifestations. Reliable biomarkers reflecting disease severity and treatment response remain limited. Glycans-carbohydrate structures attached to proteins and…
View details →DOI: 10.1111/1346-8138.70316 Negative / Null Result ReportMedicine
Cakar, Karagulle, Komek et al. · 2026 · Journal of cardiothoracic surgery
Penetrating injuries to the left thoracoabdominal (LTA) region pose significant diagnostic challenges due to the diaphragm's anatomical location. Early diaphragmatic injuries may be clinically silent and radiologically occult, whereas…
View details →DOI: 10.1186/s13019-026-04319-y Negative / Null Result ReportMedicine
Mc Caughey, Gustainis, Ambrosio et al. · 2026 · Ultrasound quarterly
This study evaluates whether contrast-enhanced ultrasound (CEUS) serves as an effective next-step imaging modality for patients with end-stage renal disease (ESRD) who have indeterminate renal lesions on computed tomography (CT), assessing…
View details →DOI: 10.1097/ruq.0000000000000749 Negative / Null Result ReportMedicine
Merres, Koryllos, Galetin et al. · 2026 · Updates in surgery
The use of clips for ligation of segmental arteries in thoracoscopic surgery has not yet been validated in clinical studies and is currently authorized based primarily on technical specifications. Clips are advantageous in endoscopic…
View details →DOI: 10.1007/s13304-026-02723-6 Failed Experiment ReportMedicine
Sercombe, Frankel, Hatzifotis · 2026 · Obesity surgery
There is a complex relationship between gastroesophageal reflux disease (GORD), hiatus hernia, obesity, and metabolic bariatric surgery. We report the outcomes of laparoscopic hiatus hernia repair (HHR) with BIO-A ® mesh in the…
View details →DOI: 10.1007/s11695-026-08798-9 Negative / Null Result ReportMedicine
Xing, Zhang, Huang et al. · 2026 · Journal of pediatric gastroenterology and nutrition
Nutritional management is crucial for improving outcomes in children on prolonged mechanical ventilation (PMV); but detailed data are lacking. This study aimed to investigate the nutritional management of children on PMV in China and to…
View details →DOI: 10.1002/jpn3.70489 Negative / Null Result ReportMedicine
Zhao, Xu, Zhou et al. · 2026 · Theriogenology
As a member of the Groucho/TLE family, Transducin-like enhancer of split 3 (TLE3) functions as a transcriptional co-repressor that is highly expressed in the testis. It recruits histone deacetylases (HDACs) and binds histones to mediate…
View details →DOI: 10.1016/j.theriogenology.2026.118035 