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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 421 of 724

Negative / Null Result ReportOpen accessMedicine

A single site, multi-operator precision study for second-generation HR-pQCT.

Stapleton JR, Heilmann NZ, Cattell K et al. · 2026 · JBMR plus

As HR-pQCT increases in popularity for studying bone dynamics, it becomes increasingly important to quantify the factors that impact rigor and reproducibility in research, particularly for longitudinal studies. Previously reported data for…

View details →DOI: 10.1093/jbmrpl/ziag097
Negative / Null Result ReportMedicine

Temporal change in patients with mitral annular calcification after successful aortic valve intervention.

Abdul-Kafi O, Chedid M, Ansani T et al. · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background Patients with severe aortic valve stenosis and concomitant mild to moderate mitral stenosis (MS) or mitral regurgitation (MR) from mitral annular calcification (MAC) often undergo aortic valve replacement (AVR) while sparing the…

View details →DOI: 10.1016/j.carrev.2026.03.018
Negative / Null Result ReportMedicine

Early impact of Japan's 2024 physician work hour reform on cardiovascular revascularization: a multi-center interrupted time series analysis using a National-Level DPC database.

Morishita T, Takada D, Itoshima H et al. · 2026 · Cardiovascular intervention and therapeutics

Japan introduced nationwide physician work-hour limits in April 2024. Because cardiovascular emergencies require continuous in-hospital availability, concerns existed that restricting duty hours could reduce access to revascularization or…

View details →DOI: 10.1007/s12928-026-01283-1
Negative / Null Result ReportOpen accessMedicine

The Frontal QRS-T Angle Remains Unchanged in Patients Without Structural Heart Disease Receiving Flecainide Therapy.

Kucukosmanoglu M, Ardıc ML, Koca F et al. · 2026 · Journal of cardiovascular development and disease

Introduction: Prolongation of the QT interval and QRS duration, which are markers of ventricular repolarization and depolarization, has been reported in patients receiving flecainide therapy. However, the effects of flecainide on the QRS-T…

View details →DOI: 10.3390/jcdd13040167
Negative / Null Result ReportOpen accessMedicine

Imidacloprid induces hepatorenal toxicity in male albino rats via oxidative, immune inflammatory, and proliferative effects: a 90-day study.

Khwanes SA, Mohamed RA, Abd El-Rahman HA et al. · 2026 · Scientific reports

Imidacloprid (IM), a systemic neonicotinoid pesticide, is widely used globally due to its high effectiveness against a broad range of insects at minimal application rates. The current study aimed to examine how this insecticide can induce…

View details →DOI: 10.1038/s41598-026-48767-x
Negative / Null Result ReportMedicine

Longitudinal Cortical Surface Signatures Distinguish Neuromyelitis Optica Spectrum Disorder from Multiple Sclerosis.

Okuda DT, Stanley TA, McCreary MC et al. · 2026 · AJNR. American journal of neuroradiology

Background and purpose Neuromyelitis optica spectrum disorder (NMOSD) is a chronic condition driven by selective injury to aquaporin 4 (AQP4) channels. Accurate diagnosis and effective disease surveillance are critical to preventing…

View details →DOI: 10.3174/ajnr.a9371
Negative / Null Result ReportMedicine

An Evaluation of the Influence of Natural Clay and Natural Clay/TiO<sub>2</sub> Nanocomposites on the Color Stability of Heat-Polymerized Maxillofacial Silicone After Disinfection.

Abdalqadir M, Raouf L, Mohammed K et al. · 2026 · Polymers

This study aimed to investigate the effect of time and different disinfecting agents on nanocomposite filler composed of natural clay nanoparticles (modified and non-modified) added to maxillofacial silicone elastomers and readymade…

View details →DOI: 10.3390/polym18050636
Negative / Null Result ReportMedicine

Ocular Safety of Unilateral Biportal Endoscopic Spinal Surgery: An Optical Coherence Tomography Angiography-Based Analysis.

Gulec A, Eravsar E, Ciftci S et al. · 2026 · Journal of clinical medicine

Background : UBE has gained popularity as a minimally invasive alternative to open spinal procedures. However, it raises concerns about potential ocular complications. Despite these concerns, there is a lack of studies evaluating UBE's…

View details →DOI: 10.3390/jcm15051774
Negative / Null Result ReportMedicine

Pelvic Floor Health Knowledge With Enhanced Education During Pregnancy.

Nicola-Ducey L, Ward L, Holland A et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Prior to delivery, there are postpartum pelvic floor recovery topics to provide education on; however, because of a variety of factors, the majority of these are commonly unaddressed, leaving a patient unknowledgeable and…

View details →DOI: 10.1097/spv.0000000000001661
Negative / Null Result ReportMedicine

Enhancing Intercultural Sensitivity Through Collaborative Online International Learning Among Three Countries: A Mixed-Method Study.

Ying Z, Kondo A, De D et al. · 2026 · Journal of transcultural nursing : official journal of the Transcultural Nursing Society

Introduction We evaluated a Collaborative Online International Learning (COIL) programme in enhancing nursing students' intercultural sensitivity and understanding of cultural safety. Methods From April to May 2024, nursing students in…

View details →DOI: 10.1177/10436596261452389
Negative / Null Result ReportMedicine

Curcumin nanoparticles combined with narlumosbart regulate wingless-type MMTV integration site (wnt)/β-catenin signaling pathway in osteoblast-like cells.

Zhang H, Zhao Y · 2026 · Pakistan journal of pharmaceutical sciences

Background Narlumosbart is a key agent for modulating bone cell function. Given the potential of curcumin nanoparticles to inhibit cell growth when applied alone. Objectives This study aims to investigate the role of their combination with…

View details →DOI: 10.36721/pjps.2026.39.7.196.1
Negative / Null Result ReportMedicine

Ocular Effects of Topical 1% Cyclopentolate in New Zealand White Rabbits: A Controlled Evaluation of Intraocular Pressure, Pupil Size, and Tear Production.

Arfaee F, Shariati S, Armin A · 2026 · Veterinary ophthalmology

Objective Mydriatic and cycloplegic agents are widely used in veterinary ophthalmology to enable posterior segment examination. This study evaluated the effects of topical 1% cyclopentolate on intraocular pressure (IOP), horizontal pupil…

View details →DOI: 10.1111/vop.70199
Negative / Null Result Report

Intraoperative phrenic nerve stimulation during supratentorial craniotomy: a pilot trial of feasibility, safety, and patient-centered outcomes

Zhang D, Qi X, Zhang M et al. · 2026 · Preprint

Abstract Background Postoperative pulmonary complications (PPCs) are a significant source of morbidity and mortality in neurosurgical patients. Intraoperative phrenic nerve stimulation (PNS) may preserve diaphragm function and mitigate…

View details →DOI: 10.21203/rs.3.rs-9634246/v1
Negative / Null Result ReportMedicine

Metagenomic Insights into Gut Microbiota Alterations Following <i>Dendrobium huoshanense</i> Water Extract Intervention in Streptozotocin-Induced Type 1 Diabetic Rats.

Xu HJ, Liu QL, Zhang YF et al. · 2026 · International journal of molecular sciences

Dendrobium huoshanense water extract (DHWE) exhibits hypoglycemic effects in streptozotocin-induced type 1 diabetic (STZ-T1D) rats. However, its regulatory impact on the gut microbiota of T1D rats remains largely unclear. In this study,…

View details →DOI: 10.3390/ijms27125308
Negative / Null Result ReportMedicine

The impact of postoperative calcaneocuboid joint articular surface gap and step on long-term outcomes in surgically treated calcaneal fractures: a brief report.

Sayyed-Hosseinian SH, Samadi S, Yazdi P et al. · 2026 · BMC musculoskeletal disorders

Background Calcaneal fractures, the most common tarsal fractures, often result in significant long-term disability and impose substantial healthcare burdens. Surgical intervention aims to restore hindfoot anatomy, but the role of…

View details →DOI: 10.1186/s12891-026-10085-8
Negative / Null Result ReportMedicine

Effects of Combined Lipid-Based Nutrient Supplements and Malaria Preventive Treatment during Pregnancy on Malaria, Maternal Nutrition, and Birth Outcomes: A Scoping Review.

Parikh P, Zeilani M, Pieret A et al. · 2026 · Nutrition reviews

Malaria and malnutrition adversely affect maternal and neonatal health in Sub-Saharan Africa. While intermittent preventive treatment of malaria in pregnancy (IPTp) is widely used to reduce malaria incidence, the potential additional…

View details →DOI: 10.1093/nutrit/nuaf112
Negative / Null Result ReportMedicine

Early nutritional adequacy in a neurocritical care unit and short-term clinical outcomes: A single-center retrospective cohort pilot study.

Cheung J, Huang T, Tarar A et al. · 2026 · Clinical nutrition ESPEN

Background Neurocritically ill patients often face challenges in achieving adequate nutrition due to hypermetabolism and feeding difficulties, which may influence neurological recovery and overall clinical outcomes. Methods This…

View details →DOI: 10.1016/j.clnesp.2026.103418
Negative / Null Result ReportMedicine

Incidence of periprocedural myocardial injury and clinical outcomes after rotational atherectomy vs. intravascular lithotripsy.

Emori H, Shiono Y, Yamanobe H et al. · 2026 · International journal of cardiology

Background Intravascular lithotripsy (IVL) and rotational atherectomy (RA) are established plaque-modifying strategies for heavily calcified coronary lesions. Despite their different mechanisms, the incidence of significant periprocedural…

View details →DOI: 10.1016/j.ijcard.2026.134630
Negative / Null Result ReportMedicine

Moderate Dietary <i>Lactobacillus acidophilus</i> Supplementation Enhances Mid-Growth Nutrient Utilization and Shifts Intestinal <i>Lactobacillus</i> and <i>Escherichia coli</i> Counts in Yellow-Feathered Broilers.

Yushanaji B, Zhang X, Tian T et al. · 2026 · Animals : an open access journal from MDPI

This study tested the hypothesis that dietary L. acidophilus would improve nutrient utilization in yellow-feathered broilers mainly through intestinal changes rather than a consistent increase in growth performance. A total of 195…

View details →DOI: 10.3390/ani16121778
Failed Experiment ReportMedicine

Evaluating the hepatotoxicity and nephrotoxicity of herbal medicine on swiss albino mice: an in-vivo, in-vitro and in-silico insights.

Alom MM, Zamir MR, Islam N et al. · 2026 · In silico pharmacology

Herbal medicines, including traditional formulations such as Carmina, a polyherbal remedy widely prescribed for gastric ailments, require rigorous safety validation to support their clinical use. Here, we evaluate the hepato-renal toxicity…

View details →DOI: 10.1007/s40203-026-00658-9
Negative / Null Result ReportMedicine

Mitochondrial dysfunction in schizophrenia and its modulation by atypical antipsychotic drugs: A randomized controlled trial.

Shaju A, Mishra BR, Mohapatra D et al. · 2026 · Journal of psychopharmacology (Oxford, England)

BackgroundRecent evidence increasingly links schizophrenia to mitochondrial dysfunction, implicating altered mitochondrial respiratory and metabolic processes in its pathophysiology. Preclinical data suggest that atypical antipsychotics…

View details →DOI: 10.1177/02698811261453937
Negative / Null Result ReportMedicine

Contribution of biomaterials analysis to the study of extractables from neonatal central venous catheters.

Le Basle Y, Sautou V, Sarraute S et al. · 2026 · Biomedical materials (Bristol, England)

The study of extractable chemicals is used to evaluate whether a medical device contains harmful substances susceptible to migrate and contaminate the patients they are used in. The analysis of the biomaterial itself after extraction is…

View details →DOI: 10.1088/1748-605x/ae7523
Negative / Null Result ReportMedicine

Acute effects of norepinephrine infusion on electrocardiographic parameters: A prospective study focusing on the frontal QRS-T angle.

Yılmaz T, Özdemir S · 2026 · Heart & lung : the journal of critical care

Background Norepinephrine is widely used as a first-line vasopressor in acute hypotension and septic shock. Its acute effects on electrocardiographic (ECG) parameters, particularly the frontal QRS-T angle, remain unclear. Objectives To…

View details →DOI: 10.1016/j.hrtlng.2026.102742
Negative / Null Result ReportMedicine

Organ dose modulation: a useful tool for dose reduction in clinical practice?

Wentink N, van Gent M, Borns C · 2026 · The British journal of radiology

Objectives To quantify the reduction in effective dose achieved through organ dose modulation (ODM) on a General Electric Revolution Apex CT scanner, while preserving image quality. Methods First, the noise index (NI) corresponding to…

View details →DOI: 10.1093/bjr/tqag098
Negative / Null Result ReportMedicine

The Age of Definitive Fusion Surgery for Early Onset Scoliosis Has Remained Constant Over the Past 2 Decades.

Abid R, Murphy RF, Hogue GD et al. · 2026 · Journal of pediatric orthopedics

Background Treatment options for early-onset scoliosis (EOS) are confounded by the risks associated with intervention at a younger age. Spinal instrumentation must be considered carefully due to potentially adverse effects to the spine,…

View details →DOI: 10.1097/bpo.0000000000003199