A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21318 results · page 422 of 711
Lu, Liu, Guo et al. · 2026 · Scientific reports
The prognosis of heart failure is highly dependent on patient self-management, and short-video platforms have become a key channel for the public to access information about heart failure (HF). This cross-sectional study systematically…
Kashyap, Chang, Lu et al. · 2026 · Affective science
Social expectations are a ubiquitous part of human experience, yet little is known about the emotions associated with failing to fulfill others' social expectations. In two studies, we examined the effects of failing to fulfill others'…
Chi, Zheng, Guo et al. · 2026 · Drug design, development and therapy
Ischemia-percussion (I/R) injury describes a paradoxical phenomenon in which blood flow restoration following ischemia not only fails to salvage the tissue but also exacerbates tissue injury. Due to the unique physiological functions, cell…
He, Shen, Hu et al. · 2026 · The New phytologist
Interploidy hybridization in plants is constrained by a postzygotic barrier. Triploid production via 2x × 4x interploidy hybridization is an important strategy for obtaining seedless cultivar in some fruit tree crops…
Mol, van Munster, Weersma et al. · 2026 · Journal of gastroenterology
Although ursodeoxycholic acid (UDCA) is commonly prescribed for primary sclerosing cholangitis (PSC), a beneficial long-term effect on solid clinical endpoints has not yet been established. This study evaluated the efficacy of UDCA on…
Kobayashi, Naito, Tone et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
This study aimed to compare the accuracy of acetabular cup placement in total hip arthroplasty (THA) using a computed tomography (CT)-based augmented reality (AR) navigation system and a CT-based portable navigation system, both employed…
Helmy, Mahmoud Desouki, Mohamed Zayed et al. · 2026 · Medicina intensiva
To evaluate whether temporal changes in parasternal intercostal muscle thickening fraction during spontaneous breathing trials provide superior diagnostic accuracy for predicting outcomes of ventilator weaning compared to single…
Ferro, Thomas, Khattak et al. · 2026 · Clinical kidney journal
Cardiovascular disease (CVD) accounts for most of the increased morbidity and mortality associated with in chronic kidney disease (CKD). Cardiovascular risk emerges early in CKD, initially driven by atherosclerotic events but later…
Ng, Yeo, Neo · 2026 · Palliative care and social practice
This study aimed to identify how contextual, dispositional, and relational factors intersect to shape the participant experience of serious illness conversations (SICs) while exploring the nuances of appraisal across different clinical…
Kang, Zhou, Li et al. · 2026 · Frontiers in pharmacology
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by relentless cognitive decline. Despite decades of research dominated by the amyloid and tau hypotheses, clinical interventions targeting these classical…
Zhao, Fu, Li et al. · 2026 · Frontiers in neuroscience
Sleep apnea and hypopnea syndrome (SAHS) is a prevalent disorder with profound adverse effects on health and overall quality of life, thereby necessitating the development of accurate and accessible screening tools. Electrocardiogram…
Frick, Whyte-Fagundes, Baraban · 2026 · Pharmacology research & perspectives
Syntaxin-binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18-1 (STXBP1) C.…
Lindell, Sayed, Campos Duran et al. · 2026 · The Journal of clinical investigation
Sepsis is a leading cause of morbidity and mortality in critically ill children, yet heterogeneous immune responses complicate the development of targeted therapies and the host immune factors driving sepsis pathobiology remain unclear. We…
Nagaraj, Prasad, Bhat et al. · 2026 · Annals of Indian Academy of Neurology
Olfactory dysfunction is a common nonmotor symptom and prodromal marker of Parkinson's disease (PD). Despite its early occurrence, hyposmia is frequently underrecognized, emphasizing the need for objective, culturally appropriate tools.…
Gezer, Demir · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
Traumatic posterior meniscal root tears disrupt normal load transmission, resulting in meniscal extrusion and accelerated osteoarthritis. Although transtibial pull-out repair is widely used, creation of a 4.5-mm tibial tunnel at the joint…
Ito, Spellman, Khan et al. · 2026 · Paediatric anaesthesia
In pediatric-aged patients, distributive (vasoplegic) shock is commonly caused by sepsis, anaphylaxis, or the humoral/immunologic response following cardiopulmonary bypass. In general, the first-line vasoactive agent for children is…
Mohamed, Alharbi, Alanazi et al. · 2026 · Cureus
Internuclear ophthalmoplegia (INO) is a distinct ocular motility disorder localizing to the medial longitudinal fasciculus (MLF). Because the MLF is a microscopic, highly myelinated tract, small inflammatory lesions can cause significant…
Mohamed, Farah, Elhamaky et al. · 2026 · Radiology case reports
Inferior vena cava (IVC) filter penetration is an increasingly recognized complication, particularly after prolonged dwell time or failed retrieval. Although often asymptomatic, multidirectional penetration into adjacent structures may…
Abukhalaf, Al-Ihribat, Sabarna et al. · 2026 · International journal of surgery case reports
Pancreaticoduodenal artery (PDA) pseudoaneurysms are rare vascular complications, accounting for approximately 2% of all visceral artery aneurysms. They are often associated with chronic pancreatitis and have a high risk of rupture, which…
Niu, Liu, Sun et al. · 2026 · Journal of nanobiotechnology
Urethral reconstruction often fails due to the foreign body reaction (FBR) triggered by the graft, leading to chronic inflammation, fibrosis, and lumen obstruction. To address this challenge, we developed an innovative strategy: a…
Ciani Berlingeri, Phillips, Mejia Bibriesca et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
The mammalian vestibular system has two types of sensory receptors (hair cells), type I and type II. Understanding the roles of type I and II hair cells in the vestibular system's control of motor behaviors is difficult because most…
Chen, Yang, Liu et al. · 2026 · Journal of hazardous materials
Assessing water quality comprehensively is crucial for predicting environmental risks. However, existing toxicity assessments are limited to specific physiological processes or reference organisms, failing to capture holistic hazards. Here…
Liao, Xiang, Chen et al. · 2026 · PloS one
The neutrophil-to-lymphocyte ratio (NLR) has shown inconsistent prognostic value in individuals with sepsis. This study aimed to clarify its ability to predict 28-day mortality via a machine learning-based analysis of a large ICU database.…
Ippoliti, Gori, Coscarella et al. · 2026 · Skin health and disease
Abrocitinib, a selective Janus kinase 1 (JAK1) inhibitor, has demonstrated efficacy in moderate-to-severe atopic dermatitis (AD), although data in patients whose AD is resistant to multiple systemic therapies remain limited. We report the…
Terry, Isenberg, Gomoll et al. · 2026 · Video journal of sports medicine
Multifocal cartilage defects about the knee have become increasingly prevalent. When left untreated, these injuries may progress to diffuse knee osteoarthritis. Operative management for patients with multifocal chondral defects typically…
Wang, Yu · 2026 · SAGE open medical case reports
A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…
Puppala, Chodavarapu, Sami et al. · 2026 · Indian journal of orthopaedics
Femoral head impaction injuries, sometimes referred to as the "Hill-Sachs lesion" of the femoral head, are an uncommon yet significant consequence of posterior hip dislocations. These occur due to compressive forces on the femoral head,…
Gan, Abu Hassan, Tan et al. · 2026 · Therapeutic advances in neurological disorders
Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes. Despite these…
Bedia Cadelo, García Feijoo, Zamorano-Fernandez et al. · 2026 · BMJ case reports
A boy in his early teens presented with transient visual disturbances and headache. Brain imaging revealed bilateral occipital infarctions, while vascular studies demonstrated bilateral V3 vertebral artery wall abnormalities with…
Dong, Patel, Wang et al. · 2026 · Environment international
Phthalates are pervasive endocrine-disrupting chemicals widely used in consumer products. The wide use of many phthalates results in chronic human exposure to complex mixtures rather than single compounds. Despite extensive studies on…