Negative / Null Result ReportOpen accessMedicine
Hamide Abbaspour kasgari, Maria Tavakoli Ardakani, Abdollah Farhadinasab · 2019 · Journal of Mazandaran University of Medical Sciences
Background and purpose: Memantine is a medication used to treat moderate to severe Alzheimer’s disease. Memantine targeting the glutamatergic system specifically N-Methyl-D-Aspartate offer a novel approach in treatment of psychiatric disorders such as schizophrenia and schizoaffective disorder. The purpose of this study was to evaluate the efficacy and safety of memantine in combination with antipsychotics in patients with schizophrenia and schizoaffective disorder. Materials and methods: A double-blind, placebo-controlled trial was performed in patients aged 18-65 years old with confirmed dia
Negative / Null Result ReportOpen accessAnesthesiology
Christian Rothe, Jørgen Lund, Morten Troels Jenstrup et al. · 2020 · BMC Anesthesiology
Abstract Background The sensory innervation of the shoulder is complex and there are variations in the branching patterns of the sensory fibres. Articular branches from the axillary nerve to the subacromial bursa are described in more than 50% of investigated shoulders but the isolated contribution of sensory input from the axillary nerve has never been investigated clinically. We hypothesized that a selective block of the axillary nerve would reduce morphine consumption and pain after arthroscopic subacromial decompression. Methods We included 60 patients in a randomized, blinded, placebo-con
View details →DOI: 10.1186/s12871-020-0952-y Negative / Null Result ReportOpen accessAnimal culture
Ya-qian LIANG, Yong-lei YANG, Lei XU et al. · 2022 · Siliao yanjiu
The experiment was to investigate the effect of adding different levels of vitamin C (VC) to parent pigeons' diets on body weight, slaughter performance, meat quality, serum biochemical indexes and blood routine of squabs. 90 pairs of parent pigeons and 270 squabs with similar body weight at one-day-old were selected, and the parent pigeons and squabs were randomly divided into five groups, with six repelicates in each group. There were three cages in each cage with one pair of baby pigeons and three squabs. Group A, group B, group C, group D and group E were supplemented with 0, 200, 400, 800
Negative / Null Result ReportOpen accessMedicine
Hasan M. Al-Dorzi, Abdulaziz Al-Dawood, Fahad M. Al-Hameed et al. · 2022 · Scientific Reports
Abstract There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in c
View details →DOI: 10.1038/s41598-022-12336-9 Negative / Null Result ReportOpen accessOrthopedic surgery
Diego Zanolli de Solminihac MD, Emilio Wagner MD, Pablo Wagner MD et al. · 2017 · Foot & Ankle Orthopaedics
Category: Bunion Introduction/Purpose: Hallux Rigidus (HR) is characterized initially by a decrease in Hallux metatarsophalangeal joint (MTPJ) dorsiflexion, decreasing the total range of motion. To be able to study different surgical treatment options, a cadaveric model has to be developed that recreates the limited range of motion. Our objective was to develop an Hallux Rigidus cadaveric model by shortening the plantar fascia (PF). Hallux MTPJ range of motion and joint stiffness were evaluated. Methods: 8 cadaveric foot- ankle – distal tibia specimens were prepared, identifying all extensor a
View details →DOI: 10.1177/2473011417s000426 Negative / Null Result ReportOpen accessMedicine
Jae-Hong Kim, Chang-Su Na, Myoung-Rae Cho et al. · 2022 · PLoS ONE
This study aimed to provide preliminary evidence for the efficacy of invasive laser acupuncture (ILA) for chronic non-specific low back pain (CNLBP). This was a single-center, randomized, patient and assessor-blinded, placebo-controlled, parallel-arm, clinical trial with a 1:1:1 allocation ratio that included a full analysis set. Forty-five participants with CNLBP were randomly assigned to the control group (sham laser), 650 group (650 nm-wavelength ILA), or 830 group (830 nm-wavelength ILA) (n = 15/group). All participants received ILA for 10 min, followed by electroacupuncture for 10 min on
View details →DOI: 10.1371/journal.pone.0269282 Negative / Null Result ReportOpen accessTheory and practice of education
Ali Yakar, Bilal Duman · 2022 · International Journal of Contemporary Educational Research
The purpose of the present study is to determine the effects of two multi-modal representations, the use of text and graph for learning, on problem solving, academic achievement and retention when used in a process-based instruction (PBI). The study was designed as quasi-experimental study complying with pretest-posttest control group design. The study group consists of (N=30+34=64) students from the department of classroom teacher education in the Education Faculty of a university from west of Turkey in 2015-2016 academic year. The data in the study were collected through problem solving inve
View details →DOI: 10.33200/ijcer.566067 Negative / Null Result ReportOpen accessBiochemistry
Alper Kucukbasmaci, Ali Sabir · 2019 · Acta Scientiarum Polonorum: Hortorum Cultus
Testing the globally popular grapevine rootstocks for affinity with new grape cultivars or tolerance potential to stress factors like drought is essential for districts where supplemental irrigation is more frequently needed due to the pressures of a global climate change. In this study, a seasonal evaluation of leaf gas exchange, leaf temperature, leaf greenness (chlorophyll content prediction) and vegetative development of Vitis vinifera L. cv. ‘Prima’ grafted to different rootstock genotypes having great variability in drought tolerance, were investigated. The experiment was conducted in a
View details →DOI: 10.24326/asphc.2019.4.6 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Jiagen Wen, Meizi Zeng, Zhaoqian Liu et al. · 2019 · Journal of Pharmacological Sciences
Metformin is the most widely used drug among type 2 diabetes mellitus patients. However, drug interaction on metformin will influence its glucose-lowering effect or increase its side effect of lactic acidosis. In this study, a randomized, two-stage, crossover study was conducted to unveil the potential drug interaction between metformin and the anti-hypertension drug, telmisartan. Totally, 16 healthy Chinese male volunteers were enrolled. Blood samples from various time-points after drug adminstration were analyzed for metformin quantification. Oral glucose tolerance test (OGTT) was conducted
View details →DOI: 10.1016/j.jphs.2018.11.007 Negative / Null Result ReportOpen accessGynecology and obstetrics
Yahya Irwanto · 2012 · Indonesian Journal of Obstetrics and Gynecology
Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI). Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a pos
View details →DOI: 10.32771/inajog.v36i4.325 Negative / Null Result ReportOpen accessScience (General)
Afsoon Motallebi, Mehdi Fathi, Fatemeh Mazhari et al. · 2024 · Heliyon
Background: This randomized clinical trial (RCT) investigated whether hypnosis would lead to favorable outcomes in reducing anxiety, enhancing cooperation, and improving physiological responses in school-aged children undergoing tooth extraction compared to nitrous oxide/oxygen (N2O/O2) and conventional behavior guidance (CBG). Methods: Sixty-six school-aged children (mean age: 7.87 ± 1.18 years) who needed one posterior primary tooth extraction were included. Children with low-to-moderate anxiety were randomly divided into three groups (n = 22 each): hypnosis, N2O/O2, and CBG. Anxiety levels
View details →DOI: 10.1016/j.heliyon.2024.e35223 Negative / Null Result ReportOpen accessMedicine
Joan Hermosura, Everett Lohman, Brenda Bartnik-Olson et al. · 2024 · PLoS ONE
Objectives The main purpose of this research study was to compare mean modified straight-leg raise test (mSLR) and hamstring muscle length (HL) between chronic non-specific low back pain (LBP) and healthy subjects to understand the possibility of neuropathic causes in LBP population as it may impact the diagnosis and treatment of LBP. Another purpose was to compare mean mSLR between those with lumbar nerve root impingement and those without as determine by magnetic resonance imaging (MRI). Methods The design of the study is cross sectional and included 32 subjects with ages ranging from 18-50
View details →DOI: 10.1371/journal.pone.0298257 Negative / Null Result ReportOpen accessDentistry
Sonam Mufti, Sarvagna Mayank Dadawala, Phoram Patel et al. · 2017 · Contemporary Clinical Dentistry
Background: One of the most common aesthetic problem encountered in the field of periodontology is gingival recession, which is, perceived by the patients as increase in length of teeth. The treatment of buccal gingival recession is a common requirement due to aesthetic concern or root sensitivity. This study was planned to evaluate the efficacy of PRF membrane compared to that of CTG in Miller's class I gingival recessions. Materials and Methods: 32 sites with Miller's Class I gingival recessions, out of which 16 sites received PRF (test) and 16 sites received CTG (control). Each patient had
View details →DOI: 10.4103/ccd.ccd_325_17 Negative / Null Result ReportOpen accessDentistry
Huiying Li, Huiying Li, Tong Wang et al. · 2025 · Frontiers in Dental Medicine
BackgroundReattachment of root fragments with appropriate adhesive materials is expected to be the last conservative treatment for preserving teeth with vertical root fractures (VRFs).ObjectiveThis study evaluated the biocompatibility of 4-META/MMA-TBB resin for root repair, compared with iRoot BP Plus, Fuji IX GIC, and Clearfil SA Luting. Fracture resistance and microleakage of the reattached roots were also tested.MethodsThe biocompatibility of set materials was evaluated on L929 fibroblasts. Cell Counting Kit-8 (CCK-8) assay, live/dead cells staining and flow cytometry were used to assess c
View details →DOI: 10.3389/fdmed.2025.1593189 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Saixin Li, Zheng Wang, Zheng Li et al. · 2024 · BMC Gastroenterology
Abstract Background T-tube cholangiography and choledochoscopy are commonly used techniques for detecting residual bile duct stones after biliary surgery. However, the utility of routine cholangiography before T-tube removal needs further investigation. This study aims to evaluate the diagnostic efficacy of various methods for detecting residual calculi following biliary surgery. Methods We retrospectively analyzed the clinical data of 287 adult patients who underwent common bile duct exploration with T-tube drainage, followed by T-tube cholangiography and choledochoscopy, at the Department of
View details →DOI: 10.1186/s12876-024-03474-7 Negative / Null Result ReportOpen accessEnvironmental sciences
Fahrimal Yudha, Asmilia Nuzul, Aisyah Siti et al. · 2020 · E3S Web of Conferences
As one of the Local wisdom in Aceh, farmer prefers raising polled cow than horned cow for breeding purposes. They believe pole cow is more resilient in harsh conditions and reproductively better than the horned cow. The aim of this study was to evaluate blood profile and blood biochemistry of the aceh polled and horned cow. The blood profile examined includes erythrocyte value, erythrocyte indices MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Hemoglobin), MCHC (Mean Corpuscular Hemoglobin Concentration), thrombocyte, leukocyte, hematocrit, and hemoglobin, while blood biochemistry includ
View details →DOI: 10.1051/e3sconf/202015101056 Negative / Null Result ReportOpen accessEngineering (General). Civil engineering (General)
Amar Thamir Hamad, Musaab Al-Tamer · 2011 · Tikrit Journal of Engineering Sciences
In this study the characteristics of raw and treated wastewater from Ninava drug factory were evaluated. The results revealed that the strength of raw wastewater can be classified as medium concentrated wastewater with respect to its BOD5 since the average value is 231.7 mg/l. In addition a strong correlations were found between many characteristics of raw waste. The characteristics of produced effluent from waste water treatment plant of the factory were within the Iraqi specification for the disposed wastewater constraints in 1997, where the average is 7.8 for pH, 40mg/l for SS, 2.8 mg/l for
View details →DOI: 10.25130/tjes.18.4.12 Negative / Null Result ReportOpen accessMedicine
Hadi Ghaedi, Siamak Takesh, Ebrahim Banitalebi · 2020 · Journal of Shahrekord University of Medical Sciences
Background and aims: Exercise training is a well-established therapeutic tool for treating type 2 diabetes. The purpose of this study is to examine the beneficial effects of personalized sprint interval training (SIT) and combined aerobic endurance and resistance training (Com) on insulin resistance and glycated hemoglobin A1c (HbA1c) concentration in women with type 2 diabetes. Methods: Fifty-two overweight female type 2 diabetic patients (age 45-60 years and body mass index [BMI] > 30) with HbA1c value of 6.5% or higher and fasting blood glucose (FBG) ≥ 126 mg/dL (7.0 mmol/L) were selected.
View details →DOI: 10.34172/jsums.2020.18 Negative / Null Result ReportOpen accessDentistry
Gustavo Vicentis De Oliveira Fernandes, Nuno Bernardo Malta Santos, Rafael Amorim Cavalcanti De Siqueira et al. · 2021 · Journal of Indian Society of Periodontology
Background: Autologous platelet concentrate (APC)/platelet-rich fibrin (PRF) of second and third generations has increased use in periodontics to optimize wound healing. Few systematic reviews (SRs) have reported improved clinical outcomes, while other studies reported significantly better results for the connective tissue graft (CTG). There is still unclear clinical evidence about APC/PRF use to treat gingival recession (GR) defects. Then, the purpose of this SR was to evaluate the use of APC/PRF membranes (2nd and 3rd generations) in root coverage (RC) procedures and assess its efficacy as a
View details →DOI: 10.4103/jisp.jisp_515_20 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Chiu Rossa WK, Chim Stephen SC, Wu Alan KL et al. · 2005 · BMC Infectious Diseases
Abstract Background It has been postulated that genetic predisposition may influence the susceptibility to SARS-coronavirus infection and disease outcomes. A recent study has suggested that the deletion allele (D allele) of the angiotensin converting enzyme ( ACE ) gene is associated with hypoxemia in SARS patients. Moreover, the ACE D allele has been shown to be more prevalent in patients suffering from adult respiratory distress syndrome (ARDS) in a previous study. Thus, we have investigated the association between ACE insertion/deletion (I/D) polymorphism and the progression to ARDS or requ
View details →DOI: 10.1186/1471-2334-5-26 Negative / Null Result ReportOpen accessMedicine
Seyed Jalal Hashemi, Hamidreza Shetabi, Shayan Saki et al. · 2018 · مجله دانشکده پزشکی اصفهان
Background: The purpose of this study was to compare the effect of endotracheal intubation in three methods of oral, and nasal with and without the help of Magill forceps, on heart rate and blood pressure in patients undergoing maxillofacial surgery. Methods: In this single-blind randomized clinical trial study, 96 patients who underwent facial and maxillofacial surgery, were randomly divided into three groups of oral, and nasal (with or without the use of Magill forceps) endotracheal intubation. Heart rate and blood pressure were studied in patients before the intubation, and 0, 1, 2, 5, and
View details →DOI: 10.22122/jims.v36i499.10673 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Yuling Zhang, Xiaowei Chen, Ming Zhou et al. · 2024 · Infectious Diseases and Therapy
Abstract Introduction In this single-center retrospective cohort study, we investigated the efficacy of letermovir in preventing Cytomegalovirus (CMV) infection in patients with aplastic anemia (AA) who have undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods Based on whether or not letermovir was used for preventing CMV infection, the patients were categorized into two groups: letermovir and control groups. The overall survival (OS) rate and cumulative incidence of CMV infection during the first 100 days after allo-HSCT were evaluated. The study included 21 match
View details →DOI: 10.1007/s40121-024-00917-2 Negative / Null Result ReportOpen accessSports
Farnaz Torabi, Mahmud Sheikh, Elahe Arabameri et al. · 2009 · رشد و یادگیری حرکتی ورزشی
The aim of this study was to compare the effect of audience and music on learning and performance of basketball free throw. Subjects were 36 healthy non-athlete girls (age: 22.8±1.59 years, height: 163.1± 5.63 cm and weight: 54.5±7.06) who were randomly divided into three groups of audience (n=12), music (n=12) and control (n=12). Protocol of acquisition phase included basketball free throw for 6 weeks, 3 sessions per week, and 15 trails each session with the presence of motivational factors in separate groups. Score of free throw test was recorded per session. Then, posttest was carried out a
Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Mohammadreza Emamhadi, Hamid Behzadnia, Seifollah Jafari et al. · 2019 · Caspian Journal of Neurological Sciences
Background: Postoperative pain is a common phenomenon, and its management affects considerably on the recovery process, and patients’ satisfaction. Apotel and pethidine are two conventional medicines used to relieve pain after operation. Objectives: The present study aimed to compare the effect of intravenous injection of Apotel and intramuscular injection of pethidine in relieving pain after hemilaminectomy. Materials & Methods: In the present cross-sectional study, 150 patients who underwent hemilaminectomy were recruited between May 2015 and November 2015. They were taking either Apotel (n=
Negative / Null Result ReportOpen accessInfectious and parasitic diseases
João Paulo Cola, Thiago Nascimento do Prado, Bárbara Manuella Cardoso Sodré Alves et al. · 2025 · BMC Infectious Diseases
Abstract Background Monotherapy with the drug isoniazid (INH) was for a long time the main therapeutic regimen used for tuberculosis preventive treatment (TPT). Research is progressing into the use of new therapeutic regimens that provide more complete TPT. The objective was to analyze the completion and safety of TPT with the drug INH in the form of 300 mg tablets. Methods Pragmatic, randomized, non-blinded, multicenter clinical trial conducted in Brazil from January 2019 to December 2022. Subjects over the age of 18 years with an indication for TPT was included and those whose index case of
View details →DOI: 10.1186/s12879-025-10678-z Negative / Null Result ReportOpen accessSports medicine
Mark V. Paterno PhD, PT, Staci Thomas MS, Timothy E. Hewett PhD, FACSM et al. · 2017 · Orthopaedic Journal of Sports Medicine
Objectives: The incidence of second anterior cruciate ligament (ACL) injury after ACL reconstruction (ACLR) and return to sport (RTS) in a young, active population is likely between 25-33% with the greatest risk in the first 12 months after RTS. Although the use of allograft tissue in young athletes has been reported to result in increased risk of graft failure, differences in graft and contralateral ACL injury risk between patients who receive a hamstrings (HS) autograft and bone-patellar tendon- bone (BTB) autograft has yet to be reported in a young, athletic population. The tested hypothesi
View details →DOI: 10.1177/2325967117s00301 Negative / Null Result ReportOpen accessPublic aspects of medicine
Santos Luciana Urbano dos, Andrade Carlos Fernando S. de · 1997 · Revista de Saúde Pública
INTRODUCTION: Cyclopid copepods are known to be good mosquito controllers, specially as regards the larvae of the dengue vectors Aedes aegypti and Ae. albopictus. MATERIAL AND METHOD: The objective of the study was to survey the local copepod fauna and search for new strains of M. longisetus var. longisetus, comparing the potential of the samples found with the current strain ML-01 against Ae. albopictus larvae, under laboratory conditions. Eleven bodies of water in Campinas, SP, Brazil, were screened for copepods by collecting 1.5 l of water from each of then. The predatory potential of adult
Negative / Null Result Report
Richard Nyaanga Ongeri, Peterson Obara Magutu, Kate Litondo · 2020 · Archives of Business Research
The main objective of the study was to determine if there any significant effect of business process re-engineering strategy on service delivery in the contextualization of food manufacturing companies in Kenya. Accordingly, the study…
View details →DOI: 10.14738/abr.89.9075 Negative / Null Result ReportOpen accessDentistry
Nader Abolfazli, Masoumeh Faramarzi, Fariba Salehsaber et al. · 2018 · Journal of Advanced Periodontology and Implant Dentistry
Background. Acentric double pedicle graft is an alternative to double pedicle graft, which can improve clinical outcomes by removing tension in sutures. This study examined the effect of using platelet-rich fibrin (PRF) on the success rate of acentric double pedicle graft in treating patients with Miller Class I and II recessions. Methods. A total of 16 Miller Class I and II lesions were studied in 8 patients. The samples were divided into two groups in terms of PRF use: with PRF and without PRF. Indices, including recession depth, width of keratinized gingiva and pocket depth, were measured w
View details →DOI: 10.15171/japid.2018.010 Negative / Null Result ReportOpen accessPsychiatry
Subodh Kumar, Divye Kartikey, Jayeeta Biswas · 2022 · Indian Journal of Private Psychiatry
Background: The deadly second wave of coronavirus disease-2019 (COVID-19) pandemic swept through the whole of India during the month of April–May 2021. Restrictions like lockdowns and social distancing impacted the normal functioning of life. It is in this backdrop that we need to understand the perceived stress and quality of life among people. Aim and objective: The aim and objective of this study was to evaluate and study the relationship between perceived stress and quality of life among adults living in Delhi NCR, during the second wave of the COVID-19 pandemic. Materials and methods: A 1
View details →DOI: 10.5005/jp-journals-10067-0102 