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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 409 of 724

Negative / Null Result ReportOpen accessMedicine

<i>IL4</i> Gene Variants rs2243250 and rs2243248 and Their Association with Clinical Phenotypes of Severe Asthma in the Mexican Population: In Silico Functional Analysis and Regulatory Implications.

Montoya-Delgado IB, Ochoa-García IV, Escobedo-Salcedo ZL et al. · 2026 · International journal of molecular sciences

Severe asthma (SA) is a chronic respiratory disease characterized by clinical heterogeneity and poor therapeutic response. Variants in the IL4 gene, including rs2243250 and rs2243248, have been associated with asthma susceptibility and…

View details →DOI: 10.3390/ijms27114711
Negative / Null Result ReportOpen accessMedicine

Lack of association between food insecurity, eating disorders, and orthorexia nervosa: findings from a cross-sectional study in Lebanon.

Sacre H, Haddad C, Rizk R et al. · 2025 · Frontiers in public health

Objectives To investigate the association between food insecurity (FI), eating disorders (EDs), and orthorexia nervosa (ON) among Lebanese university students. Methods This cross-sectional study, conducted between 2021 and 2022, enrolled…

View details →DOI: 10.3389/fpubh.2025.1572654
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Sodium Intake and Cytokine Levels.

Wistrand H, Kaartinen NE, Jousilahti P et al. · 2024 · Integrated blood pressure control

Purpose The complex pathogenesis of hypertension, potentially involving inflammatory pathways, remains elusive. This study aimed to evaluate the relationship between 24-hour urinary sodium excretion and inflammatory cytokines alongside…

View details →DOI: 10.2147/ibpc.s483495
Negative / Null Result ReportOpen accessMedicine

Accounting for Time-Varying Confounding in a Self-Controlled Case Series of Fluoroquinolone Treatment for Uncomplicated Urinary Tract Infections and Risk of Collagen-Related Events.

Schultze A, Ju S, Drysdale M et al. · 2025 · Pharmacology research & perspectives

We report findings from three SCCS conducted to quantify the association between fluoroquinolone (FQ) use for the treatment of uncomplicated urinary tract infection (uUTI) and tendon rupture, retinal detachment, and uveitis. Female…

View details →DOI: 10.1002/prp2.70124
Negative / Null Result ReportOpen accessMedicine

Lack of association of ABO and RhD blood groups with COVID-19 mortality: A 2-center cross-sectional study in Saudi Arabia.

Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine

Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…

View details →DOI: 10.1097/md.0000000000039673
Negative / Null Result ReportOpen accessMedicine

Lack of association between prior or concurrent malignancies and overall survival in gastroesophageal cancer: evidence from a large European single-center cohort.

Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…

View details →DOI: 10.1007/s12094-025-04036-3
Negative / Null Result ReportOpen accessMedicine

Impact of Prediabetes on In-Hospital Mortality and Clinical Outcomes in Acute Pancreatitis: Insights from a Nationwide Inpatient Sample.

Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine

Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…

View details →DOI: 10.3390/jcm14124271
Negative / Null Result ReportOpen accessMedicine

Association of Gallstone and Polymorphisms of ABCB11 Gene among the Adult Patients in Iran: A Case Control Study : Gallstone and ABCB11 Gene.

Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal

Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…

View details →DOI: 10.31661/gmj.v14i.4066
Negative / Null Result ReportOpen accessMedicine

Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index.

Huber A, Pasquier T, Demarchi M et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Primary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is…

View details →DOI: 10.1210/clinem/dgaf687
Negative / Null Result ReportOpen accessMedicine

Ejaculate Ejection by Female Fruit Flies Does Not Correlate With Mating Latency or Male Presence, Irrespective of How Ejection Is Measured.

Sanghvi K, Todorova B, Sepil I · 2025 · Ecology and evolution

Sexual selection operates across pre- and post-mating episodes, driven by intra-sexual competition and inter-sexual choice for mates or gametes. While these episodes can act in the same direction, this is not always the case; for example,…

View details →DOI: 10.1002/ece3.72281
Negative / Null Result ReportOpen accessMedicine

Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer.

Al Shboul S, Abu Al Karsaneh O, Alrjoub M et al. · 2025 · International journal of immunopathology and pharmacology

Objective The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introduction Cellular senescence and its secretory phenotype (the SASP) are implicated in…

View details →DOI: 10.1177/03946320251324821
Negative / Null Result ReportOpen accessMedicine

Association of Previne Brasil Program with prenatal care and maternal-child mortality.

Arato CVB, Guerra LM, Probst LF et al. · 2025 · Revista de saude publica

Objective To investigate the impact of prenatal care on the reduction of maternal-child mortality in Brazilian municipalities following the new primary health care financing model, the Previne Brasil program. Methods This study comprised a…

View details →DOI: 10.11606/s1518-8787.2025059006735
Negative / Null Result ReportOpen accessMedicine

Association of p53 Pro72Arg Polymorphism with Hepatocellular Carcinoma Risk in Hepatitis B Across Multiethnic Populations.

Kholili U, Hidayat AA, Bintoro UY et al. · 2026 · Cancers

Introduction Mounting evidence indicates that the p53 Pro72Arg single-nucleotide polymorphisms (SNPs) may play a role in modulating hepatocarcinogenesis in the setting of chronic HBV infection. However, there is currently a lack of studies…

View details →DOI: 10.3390/cancers18030380
Negative / Null Result ReportMedicine

Somatic symptom distress is not related to cardioceptive accuracy.

Petzke TM, Köteles F, Pohl A et al. · 2024 · Journal of psychosomatic research

Objective (Cardiac) interoception was long considered a key mechanism behind symptom perception in persistent somatic symptoms (PSS). In this study, we aimed to extend earlier findings to clarify this potential interoceptive mechanisms of…

View details →DOI: 10.1016/j.jpsychores.2024.111655
Negative / Null Result ReportMedicine

Efficacy of Low-dose Aspirin in Preventing Hypertensive Disorders of Pregnancy in Women with Systemic Lupus Erythematosus: A Single-Center Retrospective Cohort Study.

Kohno C, Higuchi A, Miyagawa E et al. · 2026 · Modern rheumatology

Objectives Low-dose aspirin (LDA) is widely recommended to prevent hypertensive disorders of pregnancy (HDP). However, the evidence of its effectiveness in pregnancies with systemic lupus erythematosus (SLE) remains limited. This study…

View details →DOI: 10.1093/mr/roag028
Negative / Null Result ReportOpen accessMedicine

Lurasidone

· 2006

Lurasidone is more than 99% bound to plasma proteins, so it is unlikely that the drug would be excreted into milk in sufficient amounts to affect a breastfed infant. Data from one mother-infant pair appears to support the poor excretion…

Negative / Null Result ReportOpen accessMedicine

The Effects of Nitrate on Brown Fat Fraction and Activation in Older Adults With Type 2 Diabetes: A Randomised, Double-Blind and Placebo-Controlled Crossover Trial.

Neal RA, Corbett J, Costello JT et al. · 2026 · European journal of sport science

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterised by chronic hyperglycaemia, whereas obesity is a major risk factor which increases morbidity and mortality. Treatments that alter white adipose tissue to express a…

View details →DOI: 10.1002/ejsc.70117
Negative / Null Result ReportMedicine

Role of Antipsychotic Agents for Adjunct Sedation.

DeGrado J, Devlin JW · 2025 · Critical care clinics

Antipsychotics are an attractive option for adjunctive sedation in critically ill adults given their sedating effects, short duration of action, lack of effect on respiratory drive, and multiple routes of administration but high-quality…

View details →DOI: 10.1016/j.ccc.2025.07.001
Replication FailureMedicine

Impact of Vitamin D Supplementation on IVF Outcomes in Vitamin D-Deficient Poor Responders: a Randomized Controlled Trial.

Mirsharifi MS, Shirdel S, Ghaderi E et al. · 2026 · Reproductive sciences (Thousand Oaks, Calif.)

OBJECTIVE: This study aimed to evaluate the effect of vitamin D supplementation on in vitro fertilization (IVF) outcomes in poor responder women with vitamin D deficiency, focusing on fertilization rates, oocyte quality, and pregnancy…

View details →DOI: 10.1007/s43032-025-02022-2
Replication FailureMedicine

Partial rebreathing is not effective for early treatment of migraine with aura attacks: Results of a double-blind, randomized, controlled trial (PAREMA1).

Gaul C, Ferreira S, Johansen T · 2026 · Headache

Objective Evaluate the efficacy and safety of a novel partial rebreathing device for early treatment of acute attacks of migraine with aura. Background Earlier clinical studies have indicated a potential for CO 2 -enriched gas to be…

View details →DOI: 10.1111/head.15090
Negative / Null Result ReportOpen accessMedicine

Angiogenesis Inhibitors and Arterial Dissection or Aneurysm in Patients With Metastatic Colorectal Cancer.

Singier A, Jarne Munoz A, Maumus-Robert S et al. · 2025 · JAMA network open

Importance Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further…

View details →DOI: 10.1001/jamanetworkopen.2025.46960
Negative / Null Result ReportOpen accessMedicine

Evidence of spontaneous mentalizing in children with Cornelia de Lange and fragile X syndromes, but not autistic children.

Ellis K, Moss J, Dziwisz M et al. · 2025 · Oxford open neuroscience

It has been suggested that mentalizing abilities underlie the distinct profiles of autism characteristics observed between Cornelia de Lange (CdLS) and fragile X syndromes (FXS) and autistic people without a genetic syndrome. However,…

View details →DOI: 10.1093/oons/kvaf003
Negative / Null Result ReportOpen accessMedicine

Assessment of Eating Behavior and Genetic Risk Factors for Metabolic Syndrome.

Turmanbayeva A, Sadykova K, Nuskabayeva G et al. · 2026 · Journal of clinical medicine

Background : Metabolic syndrome (MetS) is influenced by behavioral and genetic factors, yet evidence on eating behavior patterns and related genetic polymorphisms in Central Asian populations remains limited. Aim: The aim of this study was…

View details →DOI: 10.3390/jcm15020739
Negative / Null Result ReportOpen accessMedicine

Visual processing and interference performance influences on knee angular impulse in ACLR individuals: a cognitive-biomechanical analysis of drop-jumps.

Santamaria-Guzman K, Holmes H, Kosek J et al. · 2026 · Archives of orthopaedic and trauma surgery

Introduction Visual processing speed and cognitive interference control are critical for athletic performance and Anterior Cruciate Ligament (ACL) injury risk. However, how these cognitive functions relate to biomechanical performance…

View details →DOI: 10.1007/s00402-026-06353-w