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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21665 results · page 40 of 723

Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Profitability and liquidity on firm value and capital structure as intervening variable

Ida Ayu Gede Dika Martami Sari · 2020 · International Research Journal of Management IT and Social Sciences

This study aims to determine the effect of profitability and liquidity on firm value and determine the role of capital structure in mediating the effect of profitability and liquidity on firm value in the construction and building…

View details →DOI: 10.21744/irjmis.v7n1.828Cited by 141
Replication FailureOpen accessMedicine

Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort

Michelle Luciano, Janie Corley, Simon R. Cox et al. · 2017 · Neurology

OBJECTIVE: To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73-76 years). METHODS: We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline i

View details →DOI: 10.1212/wnl.0000000000003559Cited by 141
Negative / Null Result ReportOpen accessSocial Sciences

Pengaruh Motivasi dan Disiplin Kerja Terhadap Kinerja Karyawan

Salman Farisi, Juli Irnawati, Muhammad Fahmi · 2020 · Jurnal Humaniora Jurnal Ilmu Sosial Ekonomi dan Hukum

To achieve company goals, human resource management which has the potential to affect the performance of employees which will ultimately affect the performance of the company. To be able to show the performance of the employees PT. Perkebunan Nusantara V (Persero) Kebun Tanah Putih at Riau Province, the company is required to uphold the motivation and work discipline of the employees. The purpose of this study was to determine and analyze the influence of motivation and work discipline on the performance of employees of PT. Perkebunan Nusantara V (Persero) Kebun Tanah Putih Provinsi Riau. The

View details →DOI: 10.30601/humaniora.v4i1.420Cited by 141
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Assessment of statistical methods from single cell, bulk RNA-seq, and metagenomics applied to microbiome data

Matteo Calgaro, Chiara Romualdi, Levi Waldron et al. · 2020 · Genome biology

BACKGROUND: The correct identification of differentially abundant microbial taxa between experimental conditions is a methodological and computational challenge. Recent work has produced methods to deal with the high sparsity and compositionality characteristic of microbiome data, but independent benchmarks comparing these to alternatives developed for RNA-seq data analysis are lacking. RESULTS: We compare methods developed for single-cell and bulk RNA-seq, and specifically for microbiome data, in terms of suitability of distributional assumptions, ability to control false discoveries, concord

View details →DOI: 10.1186/s13059-020-02104-1Cited by 141
Negative / Null Result ReportMedicine

Value of Age, Creatinine, and Ejection Fraction (ACEF Score) in Assessing Risk in Patients Undergoing Percutaneous Coronary Interventions in the ‘All-Comers' LEADERS Trial

Joanna J. Wykrzykowska, Scot Garg, Yoshinobu Onuma et al. · 2011 · Circulation Cardiovascular Interventions

BACKGROUND: The age, creatinine, and ejection fraction (ACEF) score (age/left ventricular ejection fraction+1 if creatinine >2.0 mg/dL) has been established as an effective predictor of clinical outcomes in patients undergoing elective…

View details →DOI: 10.1161/circinterventions.110.958389Cited by 141
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

The Patient Simple Clinical Colitis Activity Index (P-SCCAI) can detect ulcerative colitis (UC) disease activity in remission: A comparison of the P-SCCAI with clinician-based SCCAI and biological markers

Floor Bennebroek Evertsz, Pythia T. Nieuwkerk, Pieter Stokkers et al. · 2012 · Journal of Crohn s and Colitis

AIM: To develop a patient-based Simple Clinical Colitis Activity Index (P-SCCAI) of ulcerative colitis (UC) activity and to compare it with the clinician-based SCCAI, C-reactive protein (CRP) and Physician's Global Assessment (PGA) of UC…

View details →DOI: 10.1016/j.crohns.2012.11.007Cited by 140
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Does Socially Responsible Investing Change Firm Behavior?

Davidson Heath, Daniele Macciocchi, Roni Michaely et al. · 2023 · European Finance Review

Abstract Using micro-level data, we examine the behavior of socially responsible investment (SRI) funds. SRI funds select firms with lower pollution, more board diversity, higher employee satisfaction, and better workplace safety. Yet,…

View details →DOI: 10.1093/rof/rfad002Cited by 140
Negative / Null Result ReportOpen accessMedicine

COVID-19 in patients with hematologic malignancy

Petra Langerbeins, Michael Hallek · 2022 · Blood

The coronavirus infectious disease (COVID-19) shows a remarkable symptomatic heterogeneity. Several risk factors including advanced age, previous illnesses, and a compromised immune system contribute to an unfavorable outcome. In patients…

View details →DOI: 10.1182/blood.2021012251Cited by 140
Negative / Null Result ReportOpen accessMedicine

Ten-year follow-up results of a randomized clinical trial comparing left thoracoabdominal and abdominal transhiatal approaches to total gastrectomy for adenocarcinoma of the oesophagogastric junction or gastric cardia

Yukinori Kurokawa, Mitsuru Sasako, Takeshi Sano et al. · 2015 · British journal of surgery

BACKGROUND: The optimal surgical approach for treatment of oesophagogastric junction (OGJ) cancer is controversial. A randomized clinical trial (JCOG9502) comparing transhiatal (TH) and left thoracoabdominal (LTA) approaches was stopped…

View details →DOI: 10.1002/bjs.9764Cited by 140
Failed Experiment ReportOpen accessPhysics and Astronomy

Absence of local moments in the kagome metal KV 3 Sb 5 as determined by muon spin spectroscopy

Eric M Kenney, Brenden R Ortiz, Chennan Wang et al. · 2021 · Journal of Physics Condensed Matter

Abstract We have carried out muon spin relaxation and rotation measurements on the newly discovered kagome metal KV 3 Sb 5 , and find a local field dominated by weak magnetic disorder which we associate with the nuclear moments present,…

View details →DOI: 10.1088/1361-648x/abe8f9Cited by 140
Negative / Null Result ReportMedicine

Efficacy and tolerability of adjunctive brivaracetam in adults with uncontrolled partial‐onset seizures: A phase IIb, randomized, controlled trial

Wim Van Paesschen, Édouard Hirsch, Martin Johnson et al. · 2012 · Epilepsia

PURPOSE: To evaluate the efficacy and tolerability of adjunctive brivaracetam (BRV), a novel high-affinity synaptic vesicle protein 2A ligand that also displays inhibitory activity at neuronal voltage-dependent sodium channels, in adult…

View details →DOI: 10.1111/j.1528-1167.2012.03598.xCited by 140
Negative / Null Result ReportOpen accessMedicine

Effect of Vocimagene Amiretrorepvec in Combination With Flucytosine vs Standard of Care on Survival Following Tumor Resection in Patients With Recurrent High-Grade Glioma

Timothy F. Cloughesy, Kevin Petrecca, Tobias Walbert et al. · 2020 · JAMA Oncology

Importance: New treatments are needed to improve the prognosis of patients with recurrent high-grade glioma. Objective: To compare overall survival for patients receiving tumor resection followed by vocimagene amiretrorepvec (Toca 511)…

View details →DOI: 10.1001/jamaoncol.2020.3161Cited by 140
Negative / Null Result ReportSocial Sciences

Does Grief Transfer across Generations? Bereavements during Pregnancy and Child Outcomes

Sandra E. Black, Paul J. Devereux, Kjell G. Salvanes · 2015 · American Economic Journal Applied Economics

Using population data from Norway, we examine the effects of stress induced by the death of the mother's parent during pregnancy on both the short-run and the long-run outcomes of the infant. Using a variety of empirical strategies to…

View details →DOI: 10.1257/app.20140262Cited by 140
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving

Yuchao Zhang, Atahualpa Castillo-Morales, Min Jiang et al. · 2013 · Molecular Biology and Evolution

In female mammals most X-linked genes are subject to X-inactivation. However, in humans some X-linked genes escape silencing, these escapees being candidates for the phenotypic aberrations seen in polyX karyotypes. These escape genes have…

View details →DOI: 10.1093/molbev/mst148Cited by 140
Negative / Null Result ReportPsychology

The impact of betrayal trauma on the tendency to trust.

Robyn L. Gobin, Jennifer J. Freyd · 2013 · Psychological Trauma Theory Research Practice and Policy

Early experiences of violation perpetrated by close others, or betrayal traumas, may interfere with developing social capacities, including the ability to make healthy decisions about whom to trust. Betrayal trauma theory posits that…

View details →DOI: 10.1037/a0032452Cited by 140
Negative / Null Result ReportOpen accessPsychology

Facial First Impressions Across Culture: Data-Driven Modeling of Chinese and British Perceivers’ Unconstrained Facial Impressions

Clare Sutherland, Xizi Liu, Lingshan Zhang et al. · 2017 · Personality and Social Psychology Bulletin

People form first impressions from facial appearance rapidly, and these impressions can have considerable social and economic consequences. Three dimensions can explain Western perceivers' impressions of Caucasian faces: approachability,…

View details →DOI: 10.1177/0146167217744194Cited by 140
Negative / Null Result ReportOpen accessImmunology and Microbiology

Re-analysis of health and educational impacts of a school-based deworming programme in western Kenya: a pure replication

Alexander M. Aiken, Calum Davey, James Hargreaves et al. · 2015 · International Journal of Epidemiology

BACKGROUND: Helminth (worm) infections cause morbidity among poor communities worldwide. An influential study conducted in Kenya in 1998-99 reported that a school-based drug-and-educational intervention had benefits regarding worm…

View details →DOI: 10.1093/ije/dyv127Cited by 140
Negative / Null Result ReportOpen accessMedicine

Front of pack labels enhance attention to nutrition information in novel and commercial brands

Mark W. Becker, Nora M. Bello, Raghav Prashant Sundar et al. · 2015 · Food Policy

OBJECTIVES: 1) To assess whether Front-of-Pack (FOP) nutrition labels garner attention more readily than more complete, mandated nutrition information (the Nutrition Facts Panel (NFP), required in the US), and 2) To determine whether label…

View details →DOI: 10.1016/j.foodpol.2015.08.001Cited by 139
Negative / Null Result ReportOpen accessSocial Sciences

The problem with autocracy promotion

Oisín Tansey · 2015 · Democratization

Recent scholarship has increasingly focused on the international dimensions of authoritarian rule, and the idea of autocracy promotion has gained considerable academic currency. While the literature on autocracy promotion has identified…

View details →DOI: 10.1080/13510347.2015.1095736Cited by 139
Negative / Null Result ReportOpen accessMedicine

The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma

Daniel J. Renouf, Jonathan M. Loree, Jennifer J. Knox et al. · 2022 · Nature Communications

Immunotherapy-based monotherapy treatment in metastatic pancreatic ductal adenocarcinoma (mPDAC) has shown limited benefit outside of the mismatch repair deficiency setting, while safety and efficacy of combining dual-checkpoint inhibitor immunotherapy with chemotherapy remains uncertain. Here, we present results from the CCTG PA.7 study (NCT02879318), a randomized phase II trial comparing gemcitabine and nab-paclitaxel with and without immune checkpoint inhibitors durvalumab and tremelimumab in 180 patients with mPDAC. The primary endpoint was overall survival. Secondary endpoints included pr

View details →DOI: 10.1038/s41467-022-32591-8Cited by 139
Negative / Null Result ReportOpen accessMedicine

Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy

Floris Dammeijer, Lysanne A. Lievense, Margaretha E. Kaijen-Lambers et al. · 2017 · Cancer Immunology Research

Abstract New immunotherapeutic strategies are needed to induce effective antitumor immunity in all cancer patients. Malignant mesothelioma is characterized by a poor prognosis and resistance to conventional therapies. Infiltration of…

View details →DOI: 10.1158/2326-6066.cir-16-0309Cited by 139
Negative / Null Result ReportOpen accessPsychology

Group-based treatment for internalized stigma among persons with severe mental illness: Findings from a randomized controlled trial.

Philip T. Yanos, David Roe, Michelle L. West et al. · 2012 · Psychological Services

Elevated internalized stigma is common and is linked to subjective and objective outcomes for severe mental illness. The authors developed a manualized group-based intervention (Narrative Enhancement/Cognitive Therapy; NECT) to address…

View details →DOI: 10.1037/a0028048Cited by 139
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

How anticipated employee mobility affects acquisition likelihood: Evidence from a natural experiment

Kenneth Younge, Tony W. Tong, Lee Fleming · 2014 · Strategic Management Journal

This study draws on strategic factor market theory and argues that acquirers' decisions regarding whether to bid for a firm reflect their expectations about employee departure from the firm post‐acquisition, suggesting a negative…

View details →DOI: 10.1002/smj.2237Cited by 139
Negative / Null Result ReportOpen accessMedicine

Effects of Cinacalcet on Atherosclerotic and Nonatherosclerotic Cardiovascular Events in Patients Receiving Hemodialysis: The EValuation Of Cinacalcet HCl Therapy to Lower CardioVascular Events (EVOLVE) Trial

David C. Wheeler, Gérard M. London, Patrick S. Parfrey et al. · 2014 · Journal of the American Heart Association

BACKGROUND: Premature cardiovascular disease limits the duration and quality of life on long-term hemodialysis. The objective of this study was to define the frequency of fatal and nonfatal cardiovascular events attributable to…

View details →DOI: 10.1161/jaha.114.001363Cited by 139
Negative / Null Result ReportOpen accessHealth Professions

Changes in Hospital Quality Associated with Hospital Value-Based Purchasing

Andrew M. Ryan, Sam Krinsky, Kristin A. Maurer et al. · 2017 · New England Journal of Medicine

BACKGROUND: Starting in fiscal year 2013, the Hospital Value-Based Purchasing (HVBP) program introduced quality performance-based adjustments of up to 1% to Medicare reimbursements for acute care hospitals. METHODS: We evaluated whether…

View details →DOI: 10.1056/nejmsa1613412Cited by 139
Negative / Null Result ReportOpen accessNeuroscience

Behavioural response of the malaria vector Anopheles gambiae to host plant volatiles and synthetic blends

Vincent O. Nyasembe, Peter E. A. Teal, Wolfgang R Mukabana et al. · 2012 · Parasites & Vectors

BACKGROUND: Sugar feeding is critical for survival of malaria vectors and, although discriminative plant feeding previously has been shown to occur in Anopheles gambiae s.s., little is known about the cues mediating attraction to these plants. In this study, we investigated the role of olfaction in An. gambiae discriminative feeding behaviour. METHODS: Dual choice olfactometer assays were used to study odour discrimination by An. gambiae to three suspected host plants: Parthenium hysterophorus (Asteraceae), Bidens pilosa (Asteraceae) and Ricinus communis (Euphorbiaceae). Sugar content of the t

View details →DOI: 10.1186/1756-3305-5-234Cited by 139
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Employment Protection Legislation, Multinational Firms, and Innovation

Rachel Griffith, Gareth Macartney · 2013 · The Review of Economics and Statistics

Abstract The theoretical effects of labor regulations, such as employment protection legislation (EPL), on innovation is ambiguous. EPL increases job security, and the greater enforceability of job contracts may increase worker investment…

View details →DOI: 10.1162/rest_a_00348Cited by 139
Negative / Null Result ReportOpen accessMedicine

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model

Céline Grégoire, Caroline Ritacco, Muriel Hannon et al. · 2019 · Frontiers in Immunology

Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft-versus-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate their superiority over placebo in the sole phase III trial reported thus far. MSCs from different tissue origins display different characteristics, but their therapeutic benefits have never been directly compared in GVHD. Here, we compared the impact of BM-, umbilical cord (UC-), and adipose-tissue (AT-) derived MSCs on T-cell function in

View details →DOI: 10.3389/fimmu.2019.00619Cited by 139
Negative / Null Result ReportOpen accessMedicine

Exercise, inflammation, and fatigue in cancer survivors

Emily C. LaVoy, Christopher P. Fagundes, Robert Dantzer · 2026 · PubMed

Cancer-related fatigue significantly disrupts normal functioning and quality of life for a substantial portion of cancer survivors, and may persist for years following cancer treatment. While the causes of persistent fatigue among cancer…

View details →DOI: 10.22029/eir.2016.1710Cited by 138