Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roisín M. Connolly, Fengmin Zhao, Kathy D. Miller et al. · 2021 · Journal of Clinical Oncology
PURPOSE Endocrine therapy resistance in advanced breast cancer remains a significant clinical problem that may be overcome with the use of histone deacetylase inhibitors such as entinostat. The ENCORE301 phase II study reported improvement…
View details →DOI: 10.1200/jco.21.00944Cited by 119 Negative / Null Result Report
Clive S. Lennox · 2015 · The Accounting Review
ABSTRACT In 2005–2006, the PCAOB imposed restrictions on auditors' tax services in order to strengthen auditor independence and improve audit quality. The restrictions resulted in a significant drop in auditor-provided tax services (APTS).…
View details →DOI: 10.2308/accr-51356Cited by 118 Negative / Null Result ReportOpen accessHealth Professions
Girmay Tsegay Kiross, Catherine Chojenta, Daniel Barker et al. · 2020 · Health Economics Review
INTRODUCTION: Although health expenditure in sub-Saharan African countries is the lowest compared with other regions in the world, most African countries have improved their budget allocations to health care over the past 15 years. The majority of health care sources in sub-Saharan Africa are private and largely involve out-of-pocket expenditure, which may prevent healthcare access. Access to healthcare is a known predictor of infant mortality. Therefore the objective of this study is to determine the impact of health care expenditure on infant mortality in sub-Saharan Africa. METHODS: The stu
View details →DOI: 10.1186/s13561-020-00262-3Cited by 117 Negative / Null Result ReportOpen accessPsychology
Suzanna M. Zick, Benjamin D. Wright, Ananda Sen et al. · 2011 · BMC Complementary and Alternative Medicine
BACKGROUND: Despite being the most commonly used herbal for sleep disorders, chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia is unknown. We examined the preliminary efficacy and safety of chamomile for improving subjective sleep and daytime symptoms in patients with chronic insomnia. METHODS: We performed a randomized, double-blind, placebo-controlled pilot trial in 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6-months. Patients were randomized to 270 mg of chamomile twice daily or placebo for 28-days. The primary outcomes were sle
View details →DOI: 10.1186/1472-6882-11-78Cited by 115 Negative / Null Result ReportOpen accessNursing
Simone Passarelli, Dawit Mekonnen, Elizabeth Bryan et al. · 2018 · Food Security
Interventions that aim to increase water availability for agriculture hold great potential for improving nutrition through increasing food production, generating income, enhancing water access and sanitation and hygiene conditions, and through strengthening women’s empowerment. Yet there is scarce evidence on the linkages between small-scale irrigation and the pathways through which nutrition outcomes can be achieved. Using data from a cross-sectional household survey collected in Ethiopia and Tanzania, we explored the potential for small-scale irrigation to contribute to improved diets, and i
View details →DOI: 10.1007/s12571-018-0812-5Cited by 115 Negative / Null Result ReportOpen accessDecision Sciences
Erick H. Turner, Daniel Knoepflmacher, Lee Shapley · 2012 · PLoS Medicine
BACKGROUND: Publication bias compromises the validity of evidence-based medicine, yet a growing body of research shows that this problem is widespread. Efficacy data from drug regulatory agencies, e.g., the US Food and Drug Administration (FDA), can serve as a benchmark or control against which data in journal articles can be checked. Thus one may determine whether publication bias is present and quantify the extent to which it inflates apparent drug efficacy. METHODS AND FINDINGS: FDA Drug Approval Packages for eight second-generation antipsychotics-aripiprazole, iloperidone, olanzapine, pali
View details →DOI: 10.1371/journal.pmed.1001189Cited by 109 Negative / Null Result ReportMedicine
Daniel S. Thoma, Manuel Sancho‐Puchades, Dominik A. Ettlin et al. · 2011 · Journal Of Clinical Periodontology
AIM: To test whether a collagen matrix (CM) can improve early wound healing and aesthetics, and decrease wound sensitivity compared with spontaneous healing. METHODS: In 15 volunteers, 6-mm punch biopsies were harvested at both palatal…
View details →DOI: 10.1111/j.1600-051x.2011.01823.xCited by 105 Replication FailureOpen accessMedicine
Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani et al. · 2021 · Scientific Reports
Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters
View details →DOI: 10.1038/s41598-021-89444-5Cited by 104 Negative / Null Result ReportOpen accessMedicine
Patrick J. Leavey, Nadia N. Laack, Mark D. Krailo et al. · 2021 · Journal of Clinical Oncology
PURPOSE The primary aim of this phase III randomized trial was to test whether the addition of vincristine, topotecan, and cyclophosphamide (VTC) to interval compressed chemotherapy improved survival outcomes for patients with previously…
View details →DOI: 10.1200/jco.21.00358Cited by 99 Negative / Null Result ReportOpen accessNeuroscience
Benjamin M. Basile, Gabriel R. Schroeder, Emily Kathryn Brown et al. · 2014 · Journal of Experimental Psychology General
Knowing the extent to which nonhumans and humans share mechanisms for metacognition will advance our understanding of cognitive evolution and will improve selection of model systems for biomedical research. Some nonhuman species avoid…
View details →DOI: 10.1037/xge0000031Cited by 98 Negative / Null Result ReportOpen accessMedicine
Danielle S. Gruen, Joshua B. Brown, Francis X. Guyette et al. · 2020 · JCI Insight
BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomark
View details →DOI: 10.1172/jci.insight.135350Cited by 98 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss et al. · 2019 · The FASEB Journal
While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally…
View details →DOI: 10.1096/fj.201902143rCited by 96 Negative / Null Result ReportOpen accessMedicine
Nancy Kass, Holly A. Taylor, Joseph Ali et al. · 2014 · Clinical Trials
BACKGROUND: Research suggests that participants do not always adequately understand studies. While some consent interventions increase understanding, methodologic challenges have been raised in studying consent outside of actual trial…
View details →DOI: 10.1177/1740774514560831Cited by 93 Negative / Null Result ReportOpen accessEnvironmental Science
Mingshu Wang, Neil Debbage · 2021 · Computers Environment and Urban Systems
Traffic congestion is an ever-increasing issue across urban environments in the US. One potential mitigation strategy is to improve our understanding of how the geographical patterns of urban land use influence congestion. Unfortunately, there is no consensus regarding if more sprawling or dense urban morphologies help mitigate congestion issues. To potentially clarify the conflicting findings of previous studies, we used a detailed spatial metric-based approach and panel regression to quantify the relationships between urban development patterns and congestion in 98 US urban areas from 2001 t
View details →DOI: 10.1016/j.compenvurbsys.2021.101676Cited by 93 Negative / Null Result ReportMedicine
Susanna Wiegand, Dagmar l’Allemand, Hanna Hübel et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: To study whether metformin reduces obesity, homeostasis model assessment for insulin resistance index (HOMA-IR), and the metabolic syndrome (MtS) in obese European adolescents in addition to previous unsuccessful lifestyle…
View details →DOI: 10.1530/eje-10-0570Cited by 92 Negative / Null Result ReportOpen accessNursing
Muhammed A. Usman, Daniel Callo-Concha · 2021 · Agricultural and Food Economics
Abstract Market access influences the dietary diversity and food security for smallholder households in many ways. In Ethiopia, most smallholders are subsistence farmers who have poor access to markets. This study used primary data from a household survey to examine the relationship between market access and the dietary diversity and food security for 324 smallholder households in the Yayu area of southwestern Ethiopia in early 2018. Multivariate regression analysis showed that households located far from market centers consumed not only less diverse foods but also spend less on food consumpti
View details →DOI: 10.1186/s40100-021-00190-8Cited by 92 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Davide Fiore Bavaro, Alessandra Belati, Lucia Diella et al. · 2021 · Antibiotics
Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as “rescue” treatments in immunocompromised or critically ill patients or in patients with post-surgical infections who had failed previous regimens. A total of 13 patients were treated from 1 September 2020 to 31 March 2021. In total, 5/13 (38%) patients were classified as critically ill, due to severe COVID-19 lung failure; 4/13 (31%) patients had post-surgical infections and 4/13 (31%) had severe infections in immunoc
View details →DOI: 10.3390/antibiotics10060652Cited by 92 Replication FailureOpen accessMedicine
Mikkael A. Sekeres, J. E. Lancet, Brent L. Wood et al. · 2012 · Haematologica
Improving outcomes in older adults with acute myeloid leukemia remains a formidable challenge. Lintuzumab (SGN-33; HuM195) is a humanized monoclonal antibody directed against CD33, which is expressed on the majority of myeloblasts in acute…
View details →DOI: 10.3324/haematol.2012.066613Cited by 91 Negative / Null Result ReportOpen accessMedicine
Susan M. Smith, Tom Fahey, John Smucny et al. · 2017 · Cochrane Database of Systematic Reviews
Background The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care. Objectives To assess the effects of antibiotics in improving outcomes and to…
View details →DOI: 10.1002/14651858.cd000245.pub4Cited by 90 Negative / Null Result ReportMedicine
Mark A. Hyde, Michael L. Hadley, Payam Tristani‐Firouzi et al. · 2012 · Archives of Dermatology
OBJECTIVE: To determine if the complete response rates of lentigo maligna (LM) to imiquimod, 5%, cream can be improved by the addition of a topical retinoid. DESIGN: Prospective randomized study of patients treated with imiquimod alone vs…
View details →DOI: 10.1001/archdermatol.2012.270Cited by 89 Negative / Null Result ReportOpen accessMedicine
Raffaele Garofalo, Brody A. Flanagin, Alessandro Castagna et al. · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Complex proximal humeral fractures are very difficult to treat particularly in patients older than 65 years with an osteoporotic bone and tuberosities compromised. The goal of this paper is to evaluate radiological outcomes at mid-term follow-up of proximal humerus fractures treated with reverse shoulder arthroplasty using a dedicated fracture stem. MATERIALS AND METHODS: The study population included 98 patients who underwent reverse shoulder with a dedicated fracture stem for an acute proximal humerus fracture; 87/98 patients were available for analysis. There were 62 female and
View details →DOI: 10.1186/s13018-015-0261-1Cited by 87 Negative / Null Result ReportOpen accessMedicine
Katherine D. LaClair, Kebreten F. Manaye, Dexter L. Lee et al. · 2013 · Molecular Neurodegeneration
BACKGROUND: Though the precise cause(s) of Alzheimer's disease (AD) remain unknown, there is strong evidence that decreased clearance of β-amyloid (Aβ) from the brain can contribute to the disease. Therapeutic strategies to promote natural Aβ clearance mechanisms, such as the protein apolipoprotein-E (APOE), hold promise for the treatment of AD. The amount of APOE in the brain is regulated by nuclear receptors including retinoid X receptors (RXRs). Drugs that activate RXRs, including bexarotene, can increase APOE and ABCA1 production, and have been shown to decrease the Aβ burden and improve c
View details →DOI: 10.1186/1750-1326-8-18Cited by 84 Negative / Null Result ReportOpen accessMedicine
Christopher W. Lewis, Jamiluddin Qazi, Daniel S. Hippe et al. · 2019 · Cancer Medicine
Approximately one-third of Merkel cell carcinoma (MCC) patients eventually develop distant metastatic disease. Little is known about whether the location of the primary lesion is predictive of initial distant metastatic site, or if survival likelihood differs depending on the metastatic site. Such data could inform imaging/surveillance practices and improve prognostic accuracy. Multivariate and competing-risk analyses were performed on a cohort of 215 MCC patients with distant metastases, 31% of whom had two or more initial sites of distant metastasis. At time of initial distant metastasis in
View details →DOI: 10.1002/cam4.2781Cited by 84 Negative / Null Result ReportOpen accessEnvironmental Science
Michael A. Litzow, Mary E. Hunsicker · 2016 · Ecosphere
Abstract Early warning signals ( EWS ) might dramatically improve our ability to manage nonlinear ecological change. However, the degree to which theoretical EWS predictions are supported in empirical systems remains unclear. The goal of this study is to make recommendations for identifying the types of ecological transitions that are expected to show EWS . We conducted a review and meta‐analysis of published studies and comparative analysis of eight northeast Pacific Ocean time series to illustrate the importance of testing for nonlinearity in empirical EWS studies. We found that published st
View details →DOI: 10.1002/ecs2.1614Cited by 82 Negative / Null Result Report
Christina Brock, Christian Stevns Hansen, Jesper Karmisholt et al. · 2019 · British Journal of Clinical Pharmacology
Aims Type 1 diabetes can be complicated with neuropathy that involves immune‐mediated and inflammatory pathways. Glucagon‐like peptide‐1 receptor agonists such as liraglutide, have shown anti‐inflammatory properties, and thus we…
View details →DOI: 10.1111/bcp.14063Cited by 81 Negative / Null Result ReportOpen accessMedicine
Konstantinos A. Toulis, Brian H Willis, Tom Marshall et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism
Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes mellitus (T2DM) and a prior cardiovascular disease (CVD) event. Objectives: To establish whether these benefits can be replicated in a real-world…
View details →DOI: 10.1210/jc.2016-3446Cited by 80 ProtocolOpen accessMedicine
Eric Lim, Liz Darlison, John Edwards et al. · 2020 · BMJ Open
INTRODUCTION: Mesothelioma remains a lethal cancer. To date, systemic therapy with pemetrexed and a platinum drug remains the only licensed standard of care. As the median survival for patients with mesothelioma is 12.1 months, surgery is an important consideration to improve survival and/or quality of life. Currently, only two surgical trials have been performed which found that neither extensive (extra-pleural pneumonectomy) or limited (partial pleurectomy) surgery improved survival (although there was some evidence of improved quality of life). Therefore, clinicians are now looking to evalu
View details →DOI: 10.1136/bmjopen-2020-038892Cited by 80 Failed Experiment ReportOpen accessMedicine
Michael A. Castello, John D. Jeppson, Salvador Soriano · 2014 · BMC Neurology
BACKGROUND: High-profile Phase 3 clinical trials of bapineuzumab and solanezumab, antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. Neither drug improves clinical outcomes in patients with late onset AD, joining a long list of unsuccessful attempts to treat AD with anti-amyloid therapies. DISCUSSION: These therapies are based on the assumption that Aβ accumulation is the primary pathogenic trigger of AD. Current evidence suggests that Aβ may actually accumulate as part of an adaptive response to long-term chronic brain stress stimuli that would make
View details →DOI: 10.1186/s12883-014-0169-0Cited by 80 Negative / Null Result ReportOpen accessMedicine
Boulos Nassar, Mary Vaughan‐Sarrazin, Lan Jiang et al. · 2014 · JAMA Internal Medicine
IMPORTANCE: Intensive care unit (ICU) telemedicine (TM) programs have been promoted as improving access to intensive care specialists and ultimately improving patient outcomes, but data on effectiveness are limited and conflicting.…
View details →DOI: 10.1001/jamainternmed.2014.1503Cited by 79 Negative / Null Result ReportOpen accessPsychology
Adam Oei, Michael D. Patterson · 2015 · Frontiers in Psychology
Despite increasing evidence that shows action video game play improves perceptual and cognitive skills, the mechanisms of transfer are not well-understood. In line with previous work, we suggest that transfer is dependent upon common demands between the game and transfer task. In the current study, participants played one of four action games with varying speed, visual, and attentional demands for 20 h. We examined whether training enhanced performance for attentional blink, selective attention, attending to multiple items, visual search and auditory detection. Non-gamers who played the game (
View details →DOI: 10.3389/fpsyg.2015.00113Cited by 77 