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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21309 results · page 378 of 711

Negative / Null Result ReportOpen accessMedicine

Postoperative radiotherapy improves overall survival and was not associated with a statistically significant increase in cardiac-specific mortality in thymoma patients: a propensity score-matched analysis of the SEER database.

Wang R, Dai P, Deng X et al. · 2026 · Journal of thoracic disease

Background Thymoma is an uncommon cancer of the thymus and postoperative radiotherapy (PORT) is often considered for selected patients with high-risk or locally advanced thymoma after resection. The effect of PORT on overall survival (OS)…

View details →DOI: 10.21037/jtd-2026-1-0184
Negative / Null Result Report

Exploring the Impact of ResearchEazy, an Online Research Series for Medical Students: The Longitudinal Impact of Perspectives and Knowledge of Research

Au YE, Baskaran R, Li JY et al. · 2026 · Preprint

Abstract Background The ability to appraise and apply research is fundamental to the practice of evidence-based medicine (EBM). Despite the General Medical Council’s (GMC) mandate for United Kingdom (UK) medical graduates to integrate…

View details →DOI: 10.21203/rs.3.rs-8150678/v1
Negative / Null Result ReportOpen accessMedicine

Evaluation of Differences in Imaging Findings on Stress-MRI in Throwing Athletes With and Without a History of Ulnar Collateral Ligament Reconstruction.

Patel M, Schwartz K, Schenk M et al. · 2026 · Orthopaedic journal of sports medicine

Background Ulnar collateral ligament (UCL) reconstruction (UCLR) of the elbow is common in throwing athletes and reliably allows return to play. The literature supports stress imaging of the elbow to evaluate the integrity of the UCL. The…

View details →DOI: 10.1177/23259671261453313
Negative / Null Result ReportOpen accessMedicine

Impact of a Routine Third Trimester Ultrasound Policy on Obstetric, Neonatal and Service Delivery Outcomes in an Australian Tertiary Centre.

Kumar P, Gordon A, Fisher E et al. · 2026 · The Australian & New Zealand journal of obstetrics & gynaecology

Background Routine third trimester ultrasound scans have been introduced in several maternity centres to increase detection of fetal growth disorders and improve perinatal outcomes. Aims To assess changes in obstetric and neonatal outcomes…

View details →DOI: 10.1111/ajo.70139
Negative / Null Result ReportOpen accessMedicine

Photobiomodulation at 830 nm with 5 J/cm<sup>2</sup> does not promote PI3K/AKT/mTOR signalling pathway activation in hyperglycemic wounded cells.

Kasowanjete P, Dhilip Kumar SS, Houreld N · 2026 · Lasers in medical science

The phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), mammalian target of rapamycin (mTOR) (PI3K/AKT/mTOR) pathway regulates cell survival, proliferation, and the synthesis of protein. Photobiomodulation (PBM) stimulates…

View details →DOI: 10.1007/s10103-026-04859-8
Negative / Null Result ReportOpen accessMedicine

The effect of sodium bicarbonate mini-tablets in a carbohydrate hydrogel on prolonged high-intensity cycling performance and metabolism in acute normobaric hypoxia.

Shannon ES, Sparks SA, McNaughton LR et al. · 2026 · European journal of applied physiology

PURPOSE: Hydrogen cation (H+) accumulation is exacerbated in hypoxia. Sodium bicarbonate (NaHCO3) ingestion can reduce fatigue associated with high-intensity exercise performance by counteracting H+ ion accumulation. The present study…

View details →DOI: 10.1007/s00421-025-06069-6
Negative / Null Result Report

Alzheimer’s disease associations with increased Biondi body amyloid in hippocampal-associated choroid plexus epithelial cells and ependymal cells

Shin E, Kim M, Soo TJ et al. · 2026 · Preprint

ABSTRACT To resolve discrepancies in the literature regarding the association between Alzheimer’s disease (AD) and Biondi body (BB) amyloid in choroid plexus epithelial cells (CPECs), we investigated postmortem hippocampal paraffin blocks…

View details →DOI: 10.64898/2026.05.25.727667
Negative / Null Result ReportMedicine

Increased morning cortisol after ketamine treatment for suicidal depression: Exploratory report from a randomized trial.

Choo TH, Galfalvy HC, Keilp JG et al. · 2026 · Journal of affective disorders

Depression and its severe outcomes, suicidal ideation and behavior, are exacerbated by stress. A broad literature links dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) stress response system to depression, suicidal…

View details →DOI: 10.1016/j.jad.2026.122175
Negative / Null Result ReportMedicine

Preoperative volume status in vascular access creation: A despised influence?

Guedes Marques M, Maia P, Martins A et al. · 2026 · The journal of vascular access

Background The most common causes of early primary failures of a vascular access (VA) is related to small caliber vessels. Weight gain between dialyses expands both extracellular and blood volume, which may lead to rises in intravascular…

View details →DOI: 10.1177/11297298261461436
Negative / Null Result ReportMedicine

Hearing Status, Loneliness, and Verbal Fluency in Older Adults: A Latent Growth Curve Modeling Approach.

Medina-Valdebenito D, Espinoza-Palavicino T, Terán-Mendoza O et al. · 2026 · Journal of aging and health

ObjectivesThis study examined the influence of hearing status and loneliness on verbal fluency trajectories in adults aged 60 years and older, assessing their contributions to baseline performance and longitudinal change over…

View details →DOI: 10.1177/08982643261446020
Negative / Null Result ReportMedicine

Multidimensional Predictors of Ranking-Based Competitive Success in National-Level Junior Tennis Players: Evidence for the Dominant Role of Physical Performance.

Géczi R, Géczi G, Tóth L · 2026 · Sports (Basel, Switzerland)

The aim of this study was to examine the relative contribution of physical performance, executive functions, and competitive anxiety to competitive success in junior tennis players. A total of 39 national-level junior athletes (20 males,…

View details →DOI: 10.3390/sports14060253
Negative / Null Result ReportMedicine

Predictive value of aortic propagation velocity for cardiovascular events in asymptomatic individuals with elevated ASCVD risk.

Bigdelu L, Ahmadi M, Shahri B et al. · 2026 · Scientific reports

Prediction of cardiovascular diseases (CVD) is a challenge that cardiologists have always faced all the times. Aortic propagation velocity (APV) is an echocardiography index that can be helpful with this regard; however, few studies have…

View details →DOI: 10.1038/s41598-026-56810-0
Negative / Null Result ReportMedicine

Assessment of the relationship between sustainable and healthy eating behaviours, acceptance of alternative protein sources (plant-based products, mushroom protein, algae, artificial meat, edible insects) and food neophobia in young adults.

Karahan Yılmaz S, Güldüren S · 2026 · Nutricion hospitalaria

Introduction Introduction: a growing world population, constraints on natural resources and changing nutritional preferences all point to the need to find an alternative to traditional animal protein sources however food neophobia can come…

View details →DOI: 10.20960/nh.06309
Negative / Null Result ReportMedicine

Conversion Rates From Initial Consultation to Bariatric Surgery: A Single-Center Community Practice Experience.

McDonough W, Gevorkian J, Wong D et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques

Background As part of the accreditation process for bariatric surgery, patients must go through a preoperative pathway. There will inevitably be patients who are seen in the clinic but never undergo surgery. This rate of attrition is…

View details →DOI: 10.1097/sle.0000000000001443
Negative / Null Result ReportOpen accessMedicine

Pemafibrate therapy increases serum zinc levels in patients with metabolic dysfunction-associated steatohepatitis: a prospective study.

Wakui N, Ogino Y, Nagumo H et al. · 2026 · BMC gastroenterology

Background Zinc deficiency is common in chronic liver disease and is closely associated with the progression of hepatic fibrosis and metabolic dysfunction. Although pemafibrate, a selective peroxisome proliferator-activated receptor alpha…

View details →DOI: 10.1186/s12876-026-04806-5
Negative / Null Result ReportMedicine

Influence of rubbing during etching on surface roughness and interfacial characteristics of intact enamel.

Biedermann M, Sifakakis I, Zinelis S et al. · 2026 · European journal of oral sciences

Rubbing phosphoric acid during etching has been shown to improve surface roughness in prepared enamel. This study aimed to compare intact enamel's surface roughness and resin tag lengths after etching with and without rubbing. Extracted…

View details →DOI: 10.1111/eos.70108
Failed Experiment ReportMedicine

Mavacamten and left ventricular dysfunction in hypertrophic cardiomyopathy with left bundle branch block.

Van Overmeiren T, de Alaiza Ortega SG, Calle S et al. · 2026 · Progress in cardiovascular diseases

Background Mavacamten is a cardiac myosin inhibitor used for patients with obstructive hypertrophic cardiomyopathy (oHCM). The efficacy and safety of this negative inotropic agent in oHCM and concomitant left bundle branch block (LBBB)…

View details →DOI: 10.1016/j.pcad.2026.06.001
Negative / Null Result ReportMedicine

Gestational Diabetes and Hypothyroidism: Do Other Factors Play a Role? A Retrospective Case-Control Study.

Firoozjaei IT, Sabzi Z, Rajabloo M et al. · 2026 · Nursing research and practice

Background During pregnancy, extensive hormonal and metabolic changes can occur. Gestational diabetes can cause maternal and neonatal complications. Follow-ups have shown that women who first develop metabolic diseases during pregnancy…

View details →DOI: 10.1155/nrp/8165809
Negative / Null Result ReportOpen accessMedicine

The effect of a community intervention based on protection motivation theory on brucellosis preventive behaviors in rural residents.

Ebrahimi S, Tehrani H, Ghavami V et al. · 2025 · Journal of education and health promotion

Background Brucellosis is a major bacterial infectious disease common to human beings and animals. It is considered a prevalent infection in developing countries. The present research was carried out to explore the effect of an educational…

View details →DOI: 10.4103/jehp.jehp_1034_24
Negative / Null Result Report

T3 and Curcumin Regulates Collagen-IV and Collagen-VI Expression: Role in Suppression of Amyloid-β via TGFβ1-Sp1 Signaling in Hypothyroid Mice Brain

Sahu SK, Nayak M, Samal A et al. · 2026 · Preprint

Abstract Hypothyroidism has been associated with cognitive disorders and high risk of neurodegenerative disorders like Alzheimer's disease (AD), which is caused by amyloid-β (Aβ) accumulation in brain. The aim of the study is to examine…

View details →DOI: 10.21203/rs.3.rs-9659339/v1