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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21300 results · page 368 of 710

Negative / Null Result ReportMedicine

Evaluation of pharmacy unit inspection utilizing a mobile application with smart glasses.

Abdel-Kerem A, Wei W, Calzado A et al. · 2025 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose This study aimed to evaluate the impact of integrating smart glasses with a pharmacy compliance mobile application on the efficiency of completing medication unit inspections. The goal was to compare traditional inspection methods…

View details →DOI: 10.1093/ajhp/zxaf083
Negative / Null Result ReportMedicine

Provisional Treatment of Volumetric Muscle Loss With Insulin-like Growth Factor 1 Releasing Muscle Void Fillers.

Clark AR, Adams AT, McKinley TO et al. · 2026 · The Journal of surgical research

Introduction Volumetric muscle loss (VML) resulting from severe extremity injuries in combat remains a significant clinical challenge, particularly in austere environments. Current research emphasizes the development and evaluation of…

View details →DOI: 10.1016/j.jss.2025.11.043
Negative / Null Result ReportMedicine

Antigenic Imprinting and Immune Response Dynamics: Neutralization Against Emerging SARS-CoV-2 Omicron Variants Following Breakthrough Infections.

Li J, Wang X, Li J et al. · 2025 · Journal of medical virology

The recently mutated Omicron variant of SARS-CoV-2 exhibits extremely high infectivity and strong evolution and immune escape capabilities. Given the unique epidemic prevention policies of China, we collected 16 sets of sera from…

View details →DOI: 10.1002/jmv.70681
Negative / Null Result ReportMedicine

Assessing the Impact of Visualizations of Quantitative and Qualitative Risk Information on the Comprehension of Hypothetical Risk-Based Breast Cancer Screening Results.

van Strien-Knippenberg IS, Timmermans DRM, Weber M et al. · 2025 · Health communication

This study aimed to assess whether, in the context of communicating risk-based breast cancer screening results, visualizations of risk information consisting of an icon array depicting quantified breast cancer risk and simplified drawings…

View details →DOI: 10.1080/10410236.2025.2582779
Negative / Null Result Report

Vibratory stimulation and not action observation or mirror therapy reduces paralyzed hand spasticity in chronic stroke survivors

Nakano H, Nakagawa K, Ikuno T et al. · 2024 · Preprint

Objective Post-stroke spasticity prevalence increases with time from stroke onset, and negatively impacts the patient’s quality of life. Vibratory stimulation (VS) to the spastic muscles can reduce spasticity, whereas action observation…

View details →DOI: 10.1101/2024.12.03.24318436
Negative / Null Result ReportMedicine

Unveiling the linkage between low-carbon energy and energy sources diversification.

Kuziboev B, Pícha K, Nazif Çatık A et al. · 2025 · Journal of environmental management

This research is the first to investigate the effect of low-carbon energy risk on the diversification of energy sources. To this end, a sample of 64 countries from 2000 to 2018 is analysed. For empirical estimations, we employ the Method…

View details →DOI: 10.1016/j.jenvman.2025.127544
Negative / Null Result Report

Effects of Two Different Intraoperative Fluid Rates on Tissue Oxygenation and Haemodynamic Stability in Anaesthetised Horses

Moura RA, Bisiau A, Freeman D et al. · 2025 · Preprint

Background: Perioperative fluid therapy can influence oxygen delivery and tissue oxygenation, but its effects in horses are poorly understood. Objectives: To compare two intraoperative fluid administration strategies on peripheral tissue…

View details →DOI: 10.22541/au.176131103.35539940/v1
Negative / Null Result Report

Multimodal Approach to Intraventricular Hemorrhage Using Echocardiography, Near-Infrared Spectroscopy, and Electrical Cardiometry in Preterm Infants

Hibner A, Tong MK, Liu L et al. · 2025 · Preprint

Abstract OBJECTIVE: To investigate single versus combination hemodynamic parameters on intraventricular hemorrhage (IVH) or mortality in preterm infants. STUDY DESIGN: Data from 482 infants under 32 weeks gestational age were analyzed,…

View details →DOI: 10.21203/rs.3.rs-7376716/v1
Negative / Null Result Report

Optimizing Biomass and Phycobilin Production in Arthrospira platensis Through Carbon Source Variation and Developing a Cost-Effective Purification Method

Far ZS, Nematollahi MA, Hosseini SV et al. · 2025 · Preprint

Abstract Arthrospira platensis, commonly known as Spirulina , is an industrially cultivated cyanobacterium due to its high content of phycobiliproteins, mainly phycoerythrin, phycocyanin, and allophycocyanin. In this work, a low-cost…

View details →DOI: 10.21203/rs.3.rs-7284160/v1
Negative / Null Result ReportMedicine

Mental Fatigue Impairs Motor Performance but Not Motor Learning in Fatigued or Non-Fatigued Conditions.

Godoi Filho JRM, Abreu TFO, Vieira QR et al. · 2026 · Journal of motor behavior

We investigated the influence of mental fatigue on motor performance and learning. Additionally, we examined whether practicing under mental fatigue induces resilience in future performance under similar fatigue conditions. Ninety-two…

View details →DOI: 10.1080/00222895.2025.2585181
Replication FailureMedicine

Back on track: Feasibility and efficacy randomized trial of a two-week online self-guided intervention for cannabis use reduction.

Kroon E, Elsey JWB, Kuhns LN et al. · 2025 · Drug and alcohol dependence

Background and aims Many individuals aiming to reduce or quit cannabis use prefer self-guided interventions over formal treatment. In this pilot and feasibility randomized trial, we tested a two-week self-guided online intervention…

View details →DOI: 10.1016/j.drugalcdep.2025.112943
Negative / Null Result ReportMedicine

Effect of copper and iron on the oxidation of vegetable oil during aging

Randhawa S, Mukherjee T · 2025 · Journal of Food Composition and Analysis.

The research paper investigates how elemental copper and iron, affect the aging process of canola, coconut, groundnut, rice bran, soybean, and sunflower oils. Samples analysed biannually over two years indicate that the addition of copper,…

Negative / Null Result ReportMedicine

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.

Borges CC, Alves da Silva W, de Sá Filho AS et al. · 2026 · International journal of sport nutrition and exercise metabolism

This study aimed to evaluate the effects of short-term oral L-arginine (ARG) supplementation on vascular parameters, nitric oxide (NO) concentration, and muscular performance during upper limb resistance exercise in healthy young men. A…

View details →DOI: 10.1123/ijsnem.2025-0125
Negative / Null Result Report

Metabolic interoceptive rewards shape affect, but not action

Fleming HA, Whines A, Whelehan P et al. · 2025 · Preprint

Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…

View details →DOI: 10.31234/osf.io/px3ub_v1
Negative / Null Result ReportMedicine

Electrocardiographic LVH criteria: Poor diagnostic accuracy even with optimized cutoffs. Insights from MESA study.

de Alencar JN, Felicioni SP · 2025 · Journal of electrocardiology

Background Electrocardiographic (ECG) "left ventricular hypertrophy (LVH) criteria" are widely used as surrogates for increased LV mass but show limited sensitivity. We evaluated their diagnostic performance against cardiac magnetic…

View details →DOI: 10.1016/j.jelectrocard.2025.154138
Negative / Null Result ReportOpen accessMedicine

Biomechanical evaluation of patch augmentation in a rotator cuff repair model using a porcine flexor digitorum profundus tendon: influence of knot tying and time-zero stability.

Rhee SM, Cho CH, Kim M et al. · 2025 · Clinics in shoulder and elbow

Background This study evaluates the biomechanical effects of acellular dermal matrix (ADM) patch augmentation in a rotator cuff repair model and determines the effect of medial knot tying on time-zero stability. Methods A biomechanical…

View details →DOI: 10.5397/cise.2025.00164
Negative / Null Result ReportMedicine

A Simplified and Data-Driven Lung Ultrasound Approach for Predicting Surfactant Need in Preterm Infants: A Pilot Study Using Machine Learning and Rule-Based Models.

Meau-Petit V, Mottez C, Bhojnagarwala B et al. · 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Objectives Six-region lung ultrasound (LUS) scores show good predictive value for predicting surfactant need in preterm infants but rely on a fixed threshold, which may lead to misclassification near the cut-off and lack data-driven…

View details →DOI: 10.1002/jum.70092
Negative / Null Result ReportOpen accessMedicine

Correlation between systemic blood pressure and free flap perfusion: A photoplethysmography study.

Sahu SA, Mishra JK, De M et al. · 2026 · GMS Interdisciplinary plastic and reconstructive surgery DGPW

Background Microvascular tissue transfer is the method of choice for oncological and trauma reconstruction. Successful free tissue transfer requires technical expertise and management of patients and surgery related factors. However,…

View details →DOI: 10.3205/iprs000194
Negative / Null Result ReportMedicine

Does Hypnosis Aid Memory Retrieval?: A Review of Steven Jay Lynn's Research.

Krackow E, Rashed J, Thompson I · 2025 · The International journal of clinical and experimental hypnosis

Steven Jay Lynn was one of the most prolific clinical psychologists who made major contributions to the scientific literature in numerous areas, including in the area of hypnosis and memory. We review this work, limited to studies…

View details →DOI: 10.1080/00207144.2025.2508410
Negative / Null Result ReportMedicine

Regenerative effects of topical insulin on corneal wound healing: From surface restoration to stromal remodeling.

Girgin Y, Vural GS, Yigit Y et al. · 2026 · Experimental eye research

Aim This study aimed to investigate the regenerative efficacy of topically administered insulin on corneal epithelial and stromal healing in a well-established rabbit model of ocular surface damage induced by chemical injury. Methods A…

View details →DOI: 10.1016/j.exer.2025.110775
Negative / Null Result ReportMedicine

Mechanistic Insights Into Postprandial Insulin-Glucagon Interactions and Their Impact on Glucose Flux After Protein-Glucose Coingestion in Humans.

Dao GM, Shaw CS, Betik AC et al. · 2025 · Diabetes

Despite stimulating glucagon secretion, the mechanisms by which protein ingestion lowers glucose excursions remain unclear. We investigated this using the triple stable isotope glucose tracer technique to measure postprandial glucose…

View details →DOI: 10.2337/db25-0395
Negative / Null Result ReportMedicine

Antibacterial effects of charcoal and fluoride dentifrices in oral biofilms.

Bowers AN, Tonon CC, Yeo S et al. · 2025 · Archives of oral biology

Objectives Charcoal-containing dentifrices are increasingly popular for their whitening claims, but data on antimicrobial effects are limited. This study compared the antibacterial efficacy of charcoal dentifrices versus non-charcoal…

View details →DOI: 10.1016/j.archoralbio.2025.106405
Negative / Null Result Report

Putting the testing effect to the test in the wild: Retrieval enhances real-world memories and promotes their semantic integration while preserving episodic integrity

Homann LA, Jahed M, Barense M · 2025 · Preprint

Retrieval practice—actively recalling information—is an established memory-strengthening technique. However, understanding how retrieval transforms memory requires examining its effects on memories that evolve across multiple episodic and…

View details →DOI: 10.31234/osf.io/923rj_v1
Negative / Null Result Report

Putting the testing effect to the test in the wild: Retrieval enhances real-world memories and promotes their semantic integration while preserving episodic integrity

Homann LA, Jahed M, Barense M · 2025 · Preprint

Retrieval practice—actively recalling information—is an established memory-strengthening technique. However, understanding how retrieval transforms memory requires examining its effects on memories that evolve across multiple episodic and…

View details →DOI: 10.31234/osf.io/923rj_v2
Negative / Null Result ReportMedicine

Effects of Combined Intragastric Administration of Quinine with L-Leucine or L-Isoleucine on the Glycemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Healthy Males.

Sajjad M, Ghorbaninejad P, Bitarafan V et al. · 2026 · The Journal of nutrition

Background The amino acids, L-leucine (Leu) and L-isoleucine (Ile), and the bitter substance, quinine, reduce postprandial glucose, stimulate insulin, and/or slow gastric emptying. Whether combining these stimuli can enhance these effects…

View details →DOI: 10.1016/j.tjnut.2025.101259
Negative / Null Result Report

A New Approach in Pharmacological Research: Measurement of Empathy and Cooperation Behavior in the Rat at a Single Apparatus

Fathollahzadeh I, Hashemi A, Mehan M et al. · 2025 · Preprint

Abstract ​The existence of empathy in rodents and, more broadly, in lower mammals has been hotly debated. Each group has designed its apparatus to address this issue. While well-established methods for measuring cooperation are in the…

View details →DOI: 10.21203/rs.3.rs-6742141/v1
Negative / Null Result ReportMedicine

Antileishmanial Activity of Oseltamivir and Acyclovir: Modulation of Macrophage Phagocytosis and Cytotoxicity Assessment.

Lima Neta PP, Leal PPMS, Passos VHAA et al. · 2025 · Anais da Academia Brasileira de Ciencias

Leishmaniasis is a group of diseases caused by protozoa of the genus Leishmania . Current treatments exhibit high toxicity, high costs, and parasite resistance. Consequently, the search for new drugs is of utmost importance, and drug…

View details →DOI: 10.1590/0001-3765202520250377
Negative / Null Result ReportMedicine

Comparative Analysis of Intrathecal Lidocaine Combined With Guanfacine or Dexmedetomidine on Nociceptive and Motor Blockade in Rats.

Chou AK, Chiu CC, Chen YW et al. · 2025 · Fundamental & clinical pharmacology

The aim of this study was to examine the effects of intrathecal lidocaine combined with guanfacine or dexmedetomidine on nociceptive and motor blockade, in comparison to clonidine. Using a rat model of intrathecal injection, we evaluated…

View details →DOI: 10.1111/fcp.70057
Negative / Null Result Report

Audiovisual interaction between runners: Examining the role of perceptual cues in step synchronization and physiological responses

Furukawa H, Nishikawa Y, Saito A et al. · 2025 · Preprint

Abstract This study aimed to examine the effects of visual and auditory cues on step frequency (SF) and physiological load, measured by heart rate (HR), in runners. The experiment involved two runners—a main runner and a neighboring…

View details →DOI: 10.21203/rs.3.rs-6650523/v1