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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21665 results · page 34 of 723

Negative / Null Result ReportOpen accessMedicine

Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial

Silvia Fernández-Serrano, Jordi Dorca, Carolina García‐Vidal et al. · 2011 · Critical Care

INTRODUCTION: The benefit of corticosteroids as adjunctive treatment in patients with severe community-acquired pneumonia (CAP) requiring hospital admission remains unclear. This study aimed to evaluate the impact of corticosteroid treatment on outcomes in patients with CAP. METHODS: This was a prospective, double-blind and randomized study. All patients received treatment with ceftriaxone plus levofloxacin and methyl-prednisolone (MPDN) administered randomly and blindly as an initial bolus, followed by a tapering regimen, or placebo. RESULTS: Of the 56 patients included in the study, 28 (50%)

View details →DOI: 10.1186/cc10103Cited by 169
Negative / Null Result ReportEconomics, Econometrics and Finance

HOW DESTRUCTIVE IS CREATIVE DESTRUCTION? EFFECTS OF JOB LOSS ON JOB MOBILITY, WITHDRAWAL AND INCOME

Kristiina Huttunen, Jarle Møen, Kjell G. Salvanes · 2011 · Journal of the European Economic Association

We analyze short and long-term effects of worker displacement. Our sample consists of male workers displaced from Norwegian manufacturing plants. We find that displacement increases the probability of leaving the labor force by 31%. The…

View details →DOI: 10.1111/j.1542-4774.2011.01027.xCited by 169
Negative / Null Result ReportMedicine

Long-term anticonvulsant therapy leads to low bone mineral density — evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells

Joachim Feldkamp, Andréa Becker, Otto W. Witte et al. · 2012 · Experimental and Clinical Endocrinology & Diabetes

Anticonvulsant therapy causes changes in calcium and bone metabolism and may lead to decreased bone mass with the risk of osteoporotic fractures. The two widely used antiepileptic drugs phenytoin and carbamazepine are recognized to have…

View details →DOI: 10.1055/s-0032-1329213Cited by 168
Negative / Null Result ReportOpen accessMedicine

Screening for Adolescent Idiopathic Scoliosis

US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA

Importance: Adolescent idiopathic scoliosis, a lateral curvature of the spine of unknown cause with a Cobb angle of at least 10°, occurs in children and adolescents aged 10 to 18 years. Idiopathic scoliosis is the most common form and…

View details →DOI: 10.1001/jama.2017.19342Cited by 168
Negative / Null Result ReportEconomics, Econometrics and Finance

Housing Wealth and Consumption: A Micro Panel Study

Martin Browning, Mette Gørtz, Søren Leth‐Petersen · 2012 · The Economic Journal

There is strong evidence that house prices and consumption are synchronised. There is, however, disagreement over the causes of this link. This study examines if there is a wealth effect of house prices on consumption. Using a…

View details →DOI: 10.1111/ecoj.12017Cited by 168
Negative / Null Result ReportHealth Professions

What you can and cannot see in TMJ imaging - an overview related to the RDC/TMD diagnostic system

Arne Petersson · 2010 · Journal of Oral Rehabilitation

In the current version (I) of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), imaging of the temporomandibular joint (TMJ) is not required for a diagnosis. Research has shown that radiological findings of the…

View details →DOI: 10.1111/j.1365-2842.2010.02108.xCited by 168
Negative / Null Result ReportOpen accessMedicine

Significant differences in femoral torsion values depending on the CT measurement technique

Peter K. Kaiser, René El Attal, Mark Kammerer et al. · 2016 · Archives of Orthopaedic and Trauma Surgery

INTRODUCTION: This study compared the feasibility of six different CT-based measurement techniques for establishing an indication for derotational osteotomy in the cases of patellar instability or femoral fracture. MATERIALS AND METHODS: CT scans of 52 single human cadaver femora were measured using six different torsion measurement techniques (described by Waidelich, Murphy, and Yoshioka on transverse images and Hernandez, Jarrett, and Yoshioka on oblique images). All measurements were performed by four observers twice to assess intraobserver and interobserver agreement. The intraclass correl

View details →DOI: 10.1007/s00402-016-2536-3Cited by 168
Negative / Null Result ReportOpen accessMedicine

Alterations in White Matter Structure in Young Children With Type 1 Diabetes

Naama Barnea‐Goraly, Mira M. Raman, Paul K. Mazaika et al. · 2013 · Diabetes Care

OBJECTIVE: To investigate whether type 1 diabetes affects white matter (WM) structure in a large sample of young children. RESEARCH DESIGN AND METHODS: Children (ages 4 to <10 years) with type 1 diabetes (n = 127) and age-matched…

View details →DOI: 10.2337/dc13-1388Cited by 167
Negative / Null Result ReportOpen accessPsychology

Two Failures to Replicate High-Performance-Goal Priming Effects

Christine R. Harris, Noriko Coburn, Doug Rohrer et al. · 2013 · PLoS ONE

Bargh et al. (2001) reported two experiments in which people were exposed to words related to achievement (e.g., strive, attain) or to neutral words, and then performed a demanding cognitive task. Performance on the task was enhanced after exposure to the achievement related words. Bargh and colleagues concluded that better performance was due to the achievement words having activated a "high-performance goal". Because the paper has been cited well over 1100 times, an attempt to replicate its findings would seem warranted. Two direct replication attempts were performed. Results from the first

View details →DOI: 10.1371/journal.pone.0072467Cited by 167
Negative / Null Result ReportOpen accessPsychology

The relationship between well-being and commuting revisited: Does the choice of methodology matter?

Andy Dickerson, Arne Risa Hole, Luke Munford · 2014 · Regional Science and Urban Economics

This paper provides an assessment of a range of alternative estimators for fixed-effects ordered models in the context of estimating the relationship between subjective well-being and commuting behaviour. In contrast to previous papers in the literature we find no evidence that longer commutes are associated with lower levels of subjective well-being, in general. From a methodological point of view our results support earlier findings that linear and ordered fixed-effects models of life satisfaction give similar results. However, we argue that ordered models are more appropriate as they are th

View details →DOI: 10.1016/j.regsciurbeco.2014.09.004Cited by 167
Negative / Null Result ReportOpen accessSocial Sciences

Measuring Learning Effectiveness: A New Look at No-Significant-Difference Findings

Ernest H. Joy, Federico E. Garcia · 2019 · Online Learning

Researchers, instructional designers and consumers of ALNs must be cautious when interpreting results of media comparison studies. Much of the literature purports to have found no significant difference in learning effectiveness between technology-based and conventional delivery media. This research, though, is largely flawed. In this paper, we first outline the philosophical positions of the opposing sides of an intense debate in the literature as to whether delivery media alone influence learning outcomes. We then select at random several representative media comparison studies to illustrate

View details →DOI: 10.24059/olj.v4i1.1909Cited by 166
Negative / Null Result ReportOpen accessPsychology

Sleep Quality, Mental and Physical Health: A Differential Relationship

Violeta Clement‐Carbonell, Irene Portilla, María Rubio‐Aparicio et al. · 2021 · International Journal of Environmental Research and Public Health

This study aimed to explore the association between sleep quality and its components and both dimensions of health-related quality of life (HRQoL) in a sample of young adults. The sample comprised 337 participants with a mean age of 19.6 y (SD = 2.22). Sleep quality and HRQoL were measured through the Pittsburgh Sleep Quality Index and the SF-12, respectively. Regression analyses were used to investigate the association between sleep quality and HRQoL. Our results confirm the significant association between sleep quality and both physical (p = 0.015; β = −0.138; R2 = 0.07) and mental (p &lt; 0

View details →DOI: 10.3390/ijerph18020460Cited by 166
Negative / Null Result ReportHealth Professions

Evidence of collaboration, pooling of resources, learning and role blurring in interprofessional healthcare teams: a realist synthesis

Sarah Sims, Gillian Hewitt, Ruth Harris · 2014 · Journal of Interprofessional Care

Interprofessional teamwork has become an integral feature of healthcare delivery in a wide range of conditions and services in many countries. Many assumptions are made in healthcare literature and policy about how interprofessional teams…

View details →DOI: 10.3109/13561820.2014.939745Cited by 166
Negative / Null Result ReportOpen accessPsychology

Comparing the Performances of Apes (Gorilla gorilla, Pan troglodytes, Pongo pygmaeus) and Human Children (Homo sapiens) in the Floating Peanut Task

Daniel Hanus, Natacha Mendes, Claudio Tennie et al. · 2011 · PLoS ONE

Recently, Mendes et al. [1] described the use of a liquid tool (water) in captive orangutans. Here, we tested chimpanzees and gorillas for the first time with the same "floating peanut task." None of the subjects solved the task. In order to better understand the cognitive demands of the task, we further tested other populations of chimpanzees and orangutans with the variation of the peanut initially floating or not. Twenty percent of the chimpanzees but none of the orangutans were successful. Additional controls revealed that successful subjects added water only if it was necessary to obtain

View details →DOI: 10.1371/journal.pone.0019555Cited by 166
Replication FailureOpen accessComputer Science

Assessing the Effect of Visualizations on Bayesian Reasoning through Crowdsourcing

Luana Micallef, Pierre Dragicevic, Jean‐Daniel Fekete · 2012 · IEEE Transactions on Visualization and Computer Graphics

People have difficulty understanding statistical information and are unaware of their wrong judgments, particularly in Bayesian reasoning. Psychology studies suggest that the way Bayesian problems are represented can impact comprehension,…

View details →DOI: 10.1109/tvcg.2012.199Cited by 166
Negative / Null Result ReportOpen accessMedicine

A Randomized, Double‐Blind Trial of Abatacept (CTLA‐4Ig) for the Treatment of Takayasu Arteritis

Carol A. Langford, David Cuthbertson, Steven R. Ytterberg et al. · 2017 · Arthritis & Rheumatology

Objective To compare the efficacy of abatacept to that of placebo for the treatment of Takayasu arteritis (TAK). Methods In this multicenter trial, patients with newly diagnosed or relapsing TAK were treated with abatacept 10 mg/kg…

View details →DOI: 10.1002/art.40037Cited by 165
Negative / Null Result ReportOpen accessDecision Sciences

Quantifying the impact of weak, strong, and super ties in scientific careers

Alexander M. Petersen · 2015 · Proceedings of the National Academy of Sciences

Scientists are frequently faced with the important decision to start or terminate a creative partnership. This process can be influenced by strategic motivations, as early career researchers are pursuers, whereas senior researchers are…

View details →DOI: 10.1073/pnas.1501444112Cited by 165
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

The Role of cis Regulatory Evolution in Maize Domestication

Zachary H. Lemmon, Robert Bukowski, Qi Sun et al. · 2014 · PLoS Genetics

Gene expression differences between divergent lineages caused by modification of cis regulatory elements are thought to be important in evolution. We assayed genome-wide cis and trans regulatory differences between maize and its wild progenitor, teosinte, using deep RNA sequencing in F1 hybrid and parent inbred lines for three tissue types (ear, leaf and stem). Pervasive regulatory variation was observed with approximately 70% of ∼17,000 genes showing evidence of regulatory divergence between maize and teosinte. However, many fewer genes (1,079 genes) show consistent cis differences with all s

View details →DOI: 10.1371/journal.pgen.1004745Cited by 165
Negative / Null Result ReportEnvironmental Science

The Environmental Impact of Poverty: Evidence from Firewood Collection in Rural Nepal

Jean‐Marie Baland, Pranab Bardhan, Sanghamitra Das et al. · 2010 · Economic Development and Cultural Change

We investigate determinants of household firewood collection in rural Nepal, using 1995-96 and 2002-3 World Bank Living Standards Measurement Survey (LSMS) data. We incorporate village fixed effects, endogenous censoring, measurement error…

View details →DOI: 10.1086/655455Cited by 165
Negative / Null Result ReportOpen accessMedicine

Advanced Intrahepatic Cholangiocarcinoma: Post Hoc Analysis of the ABC-01, -02, and -03 Clinical Trials

Ángela Lamarca, Paul J. Ross, Harpreet Wasan et al. · 2019 · JNCI Journal of the National Cancer Institute

BACKGROUND: The incidence of intrahepatic cholangiocarcinoma (iCCA) is increasing. The aim of the study was to provide reference survival data for patients with advanced iCCA treated with first-line cisplatin-gemcitabine chemotherapy (current standard of care). METHODS: Individual data from patients with iCCA recruited into the prospective, random assignment Advanced Biliary Tract Cancer (ABC)-01, -02, and -03 studies were retrieved. The prevalence and survival of liver-only iCCA was also assessed. Survival analysis was performed using univariate and multivariable Cox regression. All statistic

View details →DOI: 10.1093/jnci/djz071Cited by 165
Negative / Null Result ReportOpen accessMedicine

Gene Expression Patterns of Th2 Inflammation and Intercellular Communication in Asthmatic Airways

David F. Choy, Barmak Modrek, Alexander R. Abbas et al. · 2010 · The Journal of Immunology

Asthma is canonically thought of as a disorder of excessive Th2-driven inflammation in the airway, although recent studies have described heterogeneity with respect to asthma pathophysiology. We have previously described distinct…

View details →DOI: 10.4049/jimmunol.1002568Cited by 165
Negative / Null Result ReportOpen accessSocial Sciences

Smartphones distract parents from cultivating feelings of connection when spending time with their children

Kostadin Kushlev, Elizabeth W. Dunn · 2018 · Journal of Social and Personal Relationships

In the U.S., 95% of smartphone users admit to having used their smartphones during their latest social gathering. Although smartphones are designed to connect us with others, such smartphone use may create a source of distraction that…

View details →DOI: 10.1177/0265407518769387Cited by 165
Negative / Null Result ReportOpen accessPsychology

The effects of amount of home meditation practice in Mindfulness Based Cognitive Therapy on hazard of relapse to depression in the Staying Well after Depression Trial

Catherine Crane, Rebecca Crane, Catrin Eames et al. · 2014 · Behaviour Research and Therapy

Few empirical studies have explored the associations between formal and informal mindfulness home practice and outcome in Mindfulness-based Cognitive Therapy (MBCT). In this study ninety-nine participants randomised to MBCT in a multi-centre randomised controlled trial completed self-reported ratings of home practice over 7 treatment weeks. Recurrence of Major Depression was assessed immediately after treatment, and at 3, 6, 9, and 12-months post-treatment. Results identified a significant association between mean daily duration of formal home practice and outcome and additionally indicated th

View details →DOI: 10.1016/j.brat.2014.08.015Cited by 165
Negative / Null Result ReportOpen accessMedicine

Predicting Outcome of Endovascular Treatment for Acute Ischemic Stroke: Potential Value of Machine Learning Algorithms

Hendrikus J. A. van Os, Lucas A. Ramos, Adam Hilbert et al. · 2018 · Frontiers in Neurology

Background: Endovascular treatment (EVT) is effective for stroke patients with a large vessel occlusion (LVO) of the anterior circulation. To further improve personalized stroke care, it is essential to accurately predict outcome after EVT. Machine learning might outperform classical prediction methods as it is capable of addressing complex interactions and non-linear relations between variables. Methods: We included patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) Registry, an observational cohort of LVO

View details →DOI: 10.3389/fneur.2018.00784Cited by 164
Negative / Null Result ReportOpen accessPhysics and Astronomy

Electrical Detection of the Spin Polarization Due to Charge Flow in the Surface State of the Topological Insulator Bi1.5Sb0.5Te1.7Se1.3

Yuichiro Ando, Takahiro Hamasaki, Takayuki Kurokawa et al. · 2014 · Nano Letters

We detected the spin polarization due to charge flow in the spin nondegenerate surface state of a three-dimensional topological insulator by means of an all-electrical method. The charge current in the bulk-insulating topological insulator…

View details →DOI: 10.1021/nl502546cCited by 164
Negative / Null Result ReportOpen accessSocial Sciences

Parents' Relationship Quality and Children's Behavior in Stable Married and Cohabiting Families

Julia S. Goldberg, Marcia J. Carlson · 2014 · Journal of Marriage and the Family

Although an extensive literature has shown that family structure is linked with child well-being, less well understood is how the dynamics within families affect children, in particular the extent to which positive mother-father…

View details →DOI: 10.1111/jomf.12120Cited by 164
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Access To Mental Health Care Increased But Not For Substance Use, While Disparities Remain

Timothy B. Creedon, Benjamin Lê Cook · 2016 · Health Affairs

We assessed whether early implementation of Affordable Care Act (ACA) Medicaid expansion and state health insurance exchanges increased access to mental health and substance use treatment among those in need and whether these changes…

View details →DOI: 10.1377/hlthaff.2016.0098Cited by 164
Negative / Null Result ReportBusiness, Management and Accounting

Voluntary Disclosure to Influence Investor Reactions to Merger Announcements: An Examination of Conference Calls

Michael D. Kimbrough, Henock Louis · 2010 · The Accounting Review

ABSTRACT: We find that bidders are more likely to hold conference calls at merger announcements when the mergers are financed with stock and when the transactions are large. After controlling for endogeneity, we also find that conference…

View details →DOI: 10.2308/accr.00000022Cited by 164
Negative / Null Result ReportOpen accessEnvironmental Science

Ambient Air Pollution and Depressive Symptoms in Older Adults: Results from the MOBILIZE Boston Study

Yi Wang, Melissa Eliot, Petros Koutrakis et al. · 2014 · Environmental Health Perspectives

BACKGROUND: Exposure to ambient air pollution, particularly from traffic, has been associated with adverse cognitive outcomes, but the association with depressive symptoms remains unclear. OBJECTIVES: We investigated the association between exposure to ambient air and traffic pollution and the presence of depressive symptoms among 732 Boston-area adults ≥ 65 years of age (78.1 ± 5.5 years, mean ± SD). METHODS: We assessed depressive symptoms during home interviews using the Revised Center for Epidemiological Studies Depression Scale (CESD-R). We estimated residential distance to the nearest ma

View details →DOI: 10.1289/ehp.1205909Cited by 164
Negative / Null Result ReportComputer Science

Modelling long memory volatility in the Bitcoin market: Evidence of persistence and structural breaks

Elie Bouri, Luis A. Gil‐Alana, Rangan Gupta et al. · 2018 · International Journal of Finance & Economics

Abstract Motivated by the emergence of Bitcoin as a speculative financial investment, the purpose of this paper is to examine the persistence in the level and volatility of Bitcoin price, accounting for the impact of structural breaks.…

View details →DOI: 10.1002/ijfe.1670Cited by 164