Advanced Intrahepatic Cholangiocarcinoma: Post Hoc Analysis of the ABC-01, -02, and -03 Clinical Trials
Ángela Lamarca; Paul J. Ross; Harpreet Wasan; Richard Hubner; Mairéad G. McNamara; Andre Lopes; Prakash Manoharan; Daniel G. Palmer · 2019 · JNCI Journal of the National Cancer Institute
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The incidence of intrahepatic cholangiocarcinoma (iCCA) is increasing. The aim of the study was to provide reference survival data for patients with advanced iCCA treated with first-line cisplatin-gemcitabine chemotherapy (current standard of care). METHODS: Individual data from patients with iCCA recruited into the prospective, random assignment Advanced Biliary Tract Cancer (ABC)-01, -02, and -03 studies were retrieved. The prevalence and survival of liver-only iCCA was also assessed. Survival analysis was performed using univariate and multivariable Cox regression. All statistic
Abstract by Ángela Lamarca; Paul J. Ross; Harpreet Wasan; Richard Hubner; Mairéad G. McNamara; Andre Lopes; Prakash Manoharan; Daniel G. Palmer, JNCI Journal of the National Cancer Institute (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/jnci/djz071