Negative / Null Result ReportOpen accessMedicine
Matsuoka C, Takatama N, Muraoka T et al. · 2026 · Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to…
View details →DOI: 10.1186/s41021-026-00361-3 Negative / Null Result ReportOpen accessMedicine
Loayza J, Taylor CJL, Renstrom JG et al. · 2026 · eNeuro
Tourette syndrome (TS) has been linked to reduced GABAergic inhibition, the so-called neural disinhibition, in the dorsal striatum. Dorsal striatal neural disinhibition in animal models, caused by local microinfusion of GABA-A receptor…
View details →DOI: 10.1523/eneuro.0068-26.2026 Negative / Null Result ReportMedicine
Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…
View details →DOI: 10.1016/j.cgh.2024.05.017 Failed Experiment ReportOpen accessMedicine
Chihara Y, Takeda T, Goto Y et al. · 2022 · The oncologist
Background Osimertinib is one of the standard first-line treatments for advanced non-small cell lung cancer in patients with epidermal growth factor receptor (EGFR) mutations, because it achieves significantly longer progression-free…
View details →DOI: 10.1093/oncolo/oyac193 Failed Experiment ReportMedicine
Tsimafeyeu I, Goutnik V, Shrainer I et al. · 2023 · American journal of cancer research
About 40% of patients with non-small cell lung cancer (NSCLC) developed pleural effusions at some time during the course of their disease. Preliminary results from our Phase 2 multicentre clinical trial (Cohort 1) demonstrated the safety…
Negative / Null Result ReportOpen accessMedicine
Gathirua-Mwangi W, Martin H, He D et al. · 2025 · The oncologist
Background Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in patients…
View details →DOI: 10.1093/oncolo/oyae274 Failed Experiment ReportMedicine
Paz-Ares L, Goto Y, Wan-Teck Lim D et al. · 2024 · Lung cancer (Amsterdam, Netherlands)
Objectives Canakinumab, an interleukin-1 beta inhibitor, previously showed reduced lung cancer incidence and mortality (CANTOS). Here, we compare the efficacy/safety of canakinumab versus placebo in patients with advanced non-small cell…
View details →DOI: 10.1016/j.lungcan.2023.107451 Negative / Null Result ReportMedicine
Ogasawara F, Minami Y, Chi S et al. · 2026 · International journal of hematology
Mutant TP53 (mTP53) variants are diverse, and residual wild-type p53 function (functional, non-functional), gain-of-function (GOF) mTP53, and the number of mTP53 (single-hit, multi-hit) can affect prognosis. We used next-generation…
View details →DOI: 10.1007/s12185-026-04192-4 Negative / Null Result Report
Galvan M, Fujitani M, Dushime J et al. · 2026 · Preprint
β2-Adrenergic receptor ( Adrβ2 ) is the most abundant form of adrenergic receptors in skeletal muscle. Our previous studies have shown that the ventromedial hypothalamic nucleus (VMH) regulates metabolic benefits of exercise, potentially…
View details →DOI: 10.64898/2026.03.27.714812 Negative / Null Result ReportMedicine
Fattahi Z, Talakesh T, Kheiri S et al. · 2026 · Recent advances in inflammation & allergy drug discovery
Introduction/objective In children affected by allergic proctocolitis, impaired weight gain and developmental failure to thrive can be a prominent manifestation. However, it remains unclear whether the association between White Blood Cell…
View details →DOI: 10.2174/0127722708469650260417115846 Negative / Null Result ReportMedicine
Baillon A, Bleichrodt H, Granic GD · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making
BackgroundHealth state utility measurements are central in health policy and medical decision making. Common methods are the standard gamble (SG) and the time tradeoff (TTO). They typically use hypothetical questions. It is unknown whether…
View details →DOI: 10.1177/0272989x261423884 Negative / Null Result ReportMedicine
Kim DI, Lagravère MO, Almeida F et al. · 2026 · The Angle orthodontist
Objectives To characterize functional changes of the airway while wearing an appliance simulating severe arch constriction using level 3 polysomnography. Materials and methods For this pilot, single-blinded prospective randomized…
View details →DOI: 10.2319/051925-396.1 Negative / Null Result Report
Fröhlich F, Mentesana L, Deimel C et al. · 2026 · Preprint
Capturing and handling wild animals is essential for ecological and evolutionary research, yet their effects on physiology, behaviour, and reproductive success remain poorly understood. We investigated short-and longer-term consequences of…
View details →DOI: 10.64898/2026.03.17.712382 Negative / Null Result Report
Zheng Y, Chen L · 2026 · Preprint
Perceptual processing integrates information from multiple sensory modalities to form a coherent representation of the environment. A classic example of such is the Sound-Induced Flash Illusion (SIFI), where the perceived number of visual…
View details →DOI: 10.64898/2026.02.19.706740 Negative / Null Result ReportMedicine
Nakamura M, Nishioka Y, Akamatsu N et al. · 2026 · Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Biliary cast syndrome (BCS) remains a significant concern that can lead to graft failure and mortality. Data on the etiology and outcomes are limited, particularly with regard to the differences in the risk of occurrence of BCS between…
View details →DOI: 10.1097/lvt.0000000000000872 Negative / Null Result ReportMedicine
Bottura RM, Fassone M, Avanzino L et al. · 2026 · Neuroscience
Previous studies on motor imagery (MI) suggest that the more similar the imagined and actual movement contexts are, the better the imagery quality. Thus, one might hypothesize that for movements performed within a medium, MI is more…
View details →DOI: 10.1016/j.neuroscience.2026.04.010 Negative / Null Result Report
Ullah S, Subhan G, Shakir L et al. · 2026 · Preprint
Abstract Allelopathy involves the release of bioactive compounds from plants that influence the germination and growth of surrounding species. Limited evidence exists on the allelopathic effects of common weeds on wheat germination. This…
View details →DOI: 10.21203/rs.3.rs-9212354/v1 Negative / Null Result ReportMedicine
Alipour A, Ganjkhanlou M, Zali A et al. · 2026 · Scientific reports
The pre-weaning period is critical because early-life nutrition and management influence growth, metabolic function and Rumen development, thereby affecting subsequent productivity in dairy calves. Zinc (Zn) supplementation plays a key…
View details →DOI: 10.1038/s41598-026-51255-x Negative / Null Result ReportMedicine
Palacios-Duchicela R, Létourneau-Montminy MP, Lizardo R et al. · 2026 · Animal : an international journal of animal bioscience
Feeding strategies such as P and Ca depletion and repletion have been proposed to reduce the use of phosphate or improve P utilisation efficiency in pig diets, thereby contributing to the sustainability of the sector. A total of 48 entire…
View details →DOI: 10.1016/j.animal.2026.101865 Negative / Null Result ReportMedicine
Zerlin RR, Elissetche JC, Avila-Sanchez JS et al. · 2025 · Journal of environmental management
Butterflies are important pollinators worldwide and are often sensitive indicators of ecosystem health. Prescribed fire is used in grassland to mimic historic wildfires, improve forage nutritional value, and increased forb production and…
View details →DOI: 10.1016/j.jenvman.2025.128034 Negative / Null Result ReportMedicine
Sarimehmetoglu N, Simsek H · 2026 · The International journal of prosthodontics
Purpose To evaluate the fracture resistance of primary tooth crowns fabricated at different thicknesses using two different 3D-printing technologies: stereolithography (SLA) and digital light processing (DLP). Materials and methods A…
View details →DOI: 10.11607/ijp.9234 Negative / Null Result ReportMedicine
Sawamoto A, Shiba M, Okuyama S et al. · 2026 · The Journal of pharmacy and pharmacology
Objectives Cynandione A (CA), a major bioactive compound isolated from Cynanchum wilfordii Radix, is a crude drug traditionally used in East Asia. We have previously demonstrated that CA induces a beige adipocyte-like phenotype in vitro.…
View details →DOI: 10.1093/jpp/rgag038 Negative / Null Result ReportMedicine
Stock A, Adaniya C, Gaines M et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Urethral Bulkamid is a U.S. Food and Drug Administration-approved nonsurgical treatment for stress urinary incontinence and stress-predominant mixed urinary incontinence due to intrinsic sphincter deficiency. This procedure is…
View details →DOI: 10.1097/spv.0000000000001828 Negative / Null Result ReportMedicine
Deng SM, Chen YJ, Hung WC et al. · 2026 · Translational psychiatry
Anxiety is a common mental health disorder marked by heightened stress responses and impaired emotional regulation. While the hippocampus and the hypothalamic-pituitary-adrenal (HPA) axis play key roles in regulating anxiety, the molecular…
View details →DOI: 10.1038/s41398-026-04088-1 Negative / Null Result Report
Ching ASM, Kim J, Davis C · 2025 · Preprint
This preregistered study investigated whether linguistic information can influence low-level visual perception. We argue that many previous studies supporting this view have significant shortcomings. Specifically, these studies conflate…
View details →DOI: 10.31234/osf.io/7erj2_v1 Negative / Null Result ReportMedicine
Najafi A, Nosaka K, Javidi M et al. · 2026 · Journal of strength and conditioning research
Abstract Najafi, A, Nosaka, K, Javidi, M, Naddafha, S, Kumagawa, D, Bertochi, GFA, and Latella, C. Acute effects of accentuated eccentric loading in comparison to traditional resistance loading on velocity and other parameters in…
View details →DOI: 10.1519/jsc.0000000000005396 Negative / Null Result ReportMedicine
Goonasekera MA, Malijan GB, Sardell RJ et al. · 2026 · American journal of nephrology
Introduction Sacubitril/valsartan shows benefits in heart failure and may have kidney protective effects. Its impact on kidney tubular health in chronic kidney disease (CKD) remains unclear. We evaluated the effects of sacubitril/valsartan…
View details →DOI: 10.1159/000552348 Negative / Null Result Report
Wang T, Liu Y, Li R et al. · 2026 · Preprint
Middle East respiratory syndrome coronavirus (MERS-CoV) is a global health concern due to a high fatality rate associated with human infections and no approved vaccines or therapeutics. While Syrian hamsters are a value animal model for…
View details →DOI: 10.64898/2026.05.26.725122 Negative / Null Result Report
Chambaro HM, Delhon G, Miraglia MC et al. · 2026 · Preprint
Foot-and-mouth disease (FMD) remains a major burden in endemic regions, where inactivated vaccines are constrained by cost, short duration of immunity, cold-chain dependence, and high-containment manufacturing. Here, we engineered a…
View details →DOI: 10.64898/2026.06.01.729332 Negative / Null Result ReportMedicine
Meisinger BD, Coufal CD, Olson EG et al. · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
Reducing microbial contamination during late-stage incubation is important for hatchery sanitation and early chick microbial exposure. Formaldehyde is commonly applied in commercial hatchers to reduce airborne and eggshell-associated…
View details →DOI: 10.1080/03601234.2026.2677407 