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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21294 results · page 330 of 710

Negative / Null Result ReportOpen accessMedicine

Comparison of the Bond Strength of Silane-Treated Glass Fiber Posts at Different Solvent Evaporation Times: An In Vitro Study.

Ramos-Ramos V, Dextre-Herrera S, Ramírez-Vargas G et al. · 2026 · Journal of clinical and experimental dentistry

Background Silane is used as a coupling agent on glass fiber posts to enhance chemical interaction at the post-resin cement interface. This in vitro study evaluated the bond strength of silane-treated glass fiber posts at different solvent…

View details →DOI: 10.4317/jced.63939
Negative / Null Result ReportOpen accessMedicine

Association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken.

Hassania Y, Hassanpour S, Zendehdel M et al. · 2026 · Poultry science

This study aimed to detemine association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken. 264 meat-type chicken were included 6 experiments, each containing 4 groups. In experiment 1,…

View details →DOI: 10.1016/j.psj.2026.107042
Negative / Null Result ReportOpen accessMedicine

Association Between Early Childhood Caries and Systemic Inflammatory Profiles: A Retrospective Analysis of Children Undergoing Dental Treatment Under General Anesthesia.

Tez Yaşar BÇ, Çakmak AB, Eberliköse H et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Early childhood caries (ECC) is a chronic inflammatory condition that may impose a systemic burden in pediatric patients. This study aimed to evaluate the association between dental caries severity, classified by dmft…

View details →DOI: 10.3390/children13050691
Negative / Null Result ReportMedicine

Impact of primary tumor SUVmax on PET accuracy in mediastinal lymph node staging of non-small cell lung cancer (NSCLC).

Kużdżał A, Gambuś K, Moszczyński K et al. · 2026 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Background Positron emission tomography (PET) using 18-fluorodeoxyglucose (18-FDG) is the primary imaging modality for mediastinal staging of lung cancer. Higher standardized uptake value (SUVmax) reportedly correlates with more aggressive…

View details →DOI: 10.17219/acem/210368
Negative / Null Result ReportMedicine

Innovative competency-based education approach to radiology residency: integrating modular training in clinical practice and research.

Wan S, Ye L, Yang X et al. · 2026 · Insights into imaging

Objectives This study aimed to design and evaluate a competency-based education (CBE)-oriented modular training model for radiology residents, emphasizing interdisciplinary integration and disease-focused instruction to enhance clinical…

View details →DOI: 10.1186/s13244-026-02335-z
Negative / Null Result ReportMedicine

The Effect of Sleep Environment on Sleep Quality and Behavior in Firefighters: A Cross-Sectional Study.

Zera JN, Esper E, Simonson AP et al. · 2026 · International journal of environmental research and public health

Firefighters face high-stress occupational demands and irregular shift work that negatively impact sleep quality, which is intrinsically linked to long-term physical and psychological health. This cross-sectional study examines how the…

View details →DOI: 10.3390/ijerph23060692
Negative / Null Result ReportOpen accessMedicine

Tinnitus, temporomandibular disorders and muscle activity: what's the connection?

Çoban E, Altay B, Ulucan MÇ et al. · 2026 · Brazilian oral research

This study was aimed at comparatively evaluating the relationship between temporomandibular disorder (TMD) and subjective tinnitus, as well as the effects of TMD treatment on masticatory muscle activity, tinnitus symptoms, and patient…

View details →DOI: 10.1590/1807-3107bor-2026.vol40.037
Negative / Null Result Report

The Impact of Pregnant Women’s Dietary Behavior on the Physiological Adaptation Paradox and Maternal-Fetal Resource Conflict in Conflict Settings: A Predictive Analytical Study

Al-Wesabi MM, Eskander NA · 2026 · Preprint

This scientific study aims to assess the level of awareness, nutritional knowledge, and actual behavioral practices among pregnant women in the Capital District of Sana’a, Republic of Yemen, and to determine their impact on the health and…

View details →DOI: 10.64898/2026.06.17.26355845
Negative / Null Result ReportOpen accessMedicine

Effect of Powder-to-Liquid Ratio on pH, Calcium Ion Release, and Solubility Behaviors of Endodontic Bioceramics: An In Vitro Study.

Aka A, Matsuura T, Yoshimura A · 2026 · Journal of functional biomaterials

This study investigated the physicochemical properties of three endodontic bioceramics: MTA Flow White (F), MTA Repair HP (HP), and Nishika Canal Sealer BG multi (BG). Disc-shaped samples were immersed in deionized water for 28 days to…

View details →DOI: 10.3390/jfb17050220
Negative / Null Result ReportOpen accessMedicine

Association between changes in blood eosinophil levels and alterations in olfactory function in asthma.

Rhyou HI, Bae WY, Nam YH · 2026 · Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

Olfactory dysfunction has been observed in asthma, but its underlying mechanisms are poorly understood. This prospective study assessed olfactory function using the YSK Olfactory Function Test in 30 patients with moderate to severe asthma,…

View details →DOI: 10.1186/s13223-026-01025-1
Negative / Null Result ReportOpen accessMedicine

Comparative accuracy of complete-arch intraoral scans using full-scan and segmental-and-merge strategies.

Shin YJ, Lee KB, Kim SY et al. · 2026 · The journal of advanced prosthodontics

Purpose Full-arch intraoral scanning often suffers from cumulative stitching errors. Segmental scanning using overlapping segments followed by digital merging has been proposed as a potential solution, but quantitative evidence remains…

View details →DOI: 10.4047/jap.2026.18.2.116
Negative / Null Result ReportMedicine

Capsular management in posterolateral total hip arthroplasty: impact on proprioception, balance, functional outcomes, and complications.

Guven S, Veizi E, Nazligul AS et al. · 2026 · Journal of orthopaedic surgery and research

Background The role of capsular management in total hip arthroplasty (THA) performed via the posterolateral approach remains debated, particularly regarding its effects on proprioception, balance, and postoperative stability. While…

View details →DOI: 10.1186/s13018-026-07020-x
Negative / Null Result ReportOpen accessMedicine

Melatonin administration as a strategy to mitigate weaning stress in Lacaune lambs.

Moreno-Manrique M, Ródenas JB, Mínguez C et al. · 2026 · Frontiers in veterinary science

Introduction Weaning from artificial milk feeding represents a critical transition in intensively reared dairy lambs, involving dietary change, relocation, and social reorganization, all of which may compromise welfare, immune status, and…

View details →DOI: 10.3389/fvets.2026.1824547
Negative / Null Result ReportMedicine

Effect of Verbal Working Memory Training on Auditory Processing Abilities, Working Memory, and Listening Effort in Children With Central Auditory Processing Disorders.

Spandita HL, Jain C · 2026 · Language, speech, and hearing services in schools

Purpose The study aimed to assess the effect of verbal working memory (WM) training on auditory processing abilities, WM, and listening effort (LE) in children with central auditory processing disorders ((C)APD). Method The study involved…

View details →DOI: 10.1044/2026_lshss-25-00120
Negative / Null Result ReportOpen accessMedicine

Carotid Plaque Characteristics Evaluation on DUS and MDCTA: Interobserver and Intermodality Agreement in a Single-Center Study.

Mutavdzic P, Kokovic T, Gakovic B et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Carotid artery stenosis has traditionally guided therapeutic decision-making; however, plaque morphology and composition are increasingly recognized as more reliable indicators of cerebrovascular risk than…

View details →DOI: 10.3390/medicina62040724
Negative / Null Result ReportOpen accessMedicine

Longitudinal analysis of lipid mediators in post-tuberculosis lung disease identifies significant differences.

Jackson PD, Helwig M, Bbuye M et al. · 2026 · PLOS global public health

Post-tuberculosis lung disease (PTLD) is a frequent complication after TB cure, affecting millions globally. Yet, its mechanisms, particularly the role of lipid mediators (LMs) in resolution of inflammation are not clear. This study aimed…

View details →DOI: 10.1371/journal.pgph.0006097
Negative / Null Result ReportMedicine

[Comparison between methods to estimate total body fat mass in triathletes: dual X-ray absorptiometry, bioelectrical impedance and anthropometric equations].

Herrera-Torres OA, Flores-Zapata J, Ferreyro-Bravo F · 2026 · Nutricion hospitalaria

Introduction Introduction: the estimation of body fat mass (FM) can be performed using different methods. Although Dual-Energy X-ray Absorptiometry (DXA) is considered the reference technique due to its precision and reproducibility, its…

View details →DOI: 10.20960/nh.06323
Negative / Null Result ReportOpen accessMedicine

Correlations between inflammatory biomarkers and clinicopathological features in surgically resected thymic epithelial tumors: implications for preoperative diagnosis.

Fu J, Han P, Xu J et al. · 2026 · PeerJ

Objective This study aimed to analyze the correlations between pathological characteristics, risk factors, and inflammatory biomarkers in patients with thymic epithelial tumors (TETs) undergoing surgical resection. Methods A retrospective…

View details →DOI: 10.7717/peerj.21232
Negative / Null Result ReportOpen accessMedicine

Effect of Whey Protein Isolate and Concentrate Shakes on Surface and Optical Properties of 3D-Printed Definitive Resins.

Albayrak HC, Taşın S, İsmatullaev A · 2026 · Polymers

This in vitro study evaluated the effects of whey protein isolate and concentrate on surface roughness, color stainability, and translucency of 3D-printed definitive resins. Five 3D-printed resins were tested: Alias Dental Crown (AC),…

View details →DOI: 10.3390/polym18101166
Negative / Null Result ReportMedicine

The association between a sepsis diagnosis, demographic factors, and health-related quality of life in survivors at 180 days following critical illness.

De Silva S, Charles-Nelson A, McQuilten Z et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Survivors of critical illness often have poor health-related quality of life (HRQoL). However, it is unclear what factors are associated with changes in HRQoL after critical illness. Objectives The aim of this study was to…

View details →DOI: 10.1016/j.aucc.2026.101607
Negative / Null Result ReportMedicine

Effect of common children's beverages on surface properties of single-shade and restorative material: an in vitro study.

Almutairi M, Mousa I, Alqahtani R et al. · 2026 · Scientific reports

Single-shade composite restorations can adapt to the tooth structure, improve esthetics, and reduce reliance on shade selection. The objective of this study was to assess the effect of four different children's beverages on the color…

View details →DOI: 10.1038/s41598-026-55540-7
Negative / Null Result ReportMedicine

Face-To-Face Vs. Online Behavioral Parent Training for Young Children with ADHD: Child and Parent Outcomes.

DuPaul GJ, Kern L, Dever BV et al. · 2026 · Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

Objective Behavioral parent training is a first-line psychosocial intervention for young children with Attention-Deficit/Hyperactivity Disorder. Traditional face-to-face delivery is limited by access to therapists, feasibility, and/or…

View details →DOI: 10.1080/15374416.2026.2687069
Negative / Null Result ReportOpen accessMedicine

The rise and fall of glucocorticoids and immunosuppressants in idiopathic pulmonary fibrosis: a historical paradigm shift driven by mechanistic understanding.

Wen B, Wu X, Ma X et al. · 2026 · Frontiers in immunology

The therapeutic strategy for Idiopathic Pulmonary Fibrosis (IPF) has undergone a fundamental transformation over recent decades. Combination therapy with glucocorticoids and immunosuppressants, particularly the "triple therapy" regimen…

View details →DOI: 10.3389/fimmu.2026.1830573
Negative / Null Result ReportMedicine

[Colchicine in Cardiology Practice. Mechanisms of Influence on the Cardiovascular System, Use in the Treatment of Pericarditis and Ischemic Heart Disease].

Sukmarova ZN, Simonenko VB · 2025 · Kardiologiia

Despite significant advances in pharmacological, interventional, and surgical treatments for cardiovascular diseases (CVDs) in recent decades, it appeared that the effectiveness of standard treatments has reached a ceiling, and growing…

View details →DOI: 10.18087/cardio.2025.11.n3016
Negative / Null Result ReportMedicine

PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results.

Zhou J, Jiang X, Liu Q et al. · 2026 · Cancer metastasis reviews

Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six antibodies acting on programmed death ligand 1 or programmed death 1 pathways were approved in 75 cancer indications…

View details →DOI: 10.1007/s10555-026-10314-5
Failed Experiment ReportMedicine

Efficacy of low dose colchicine on left ventricular hypertrophy in patients with coronary artery disease: A randomized controlled trial.

Chichareon P, Suwannanon R, Thungthienthong M et al. · 2026 · British journal of clinical pharmacology

Background Left ventricular hypertrophy (LVH) contributes to a substantial risk of adverse outcomes in patients with coronary artery disease (CAD). Inflammation is one of the mechanisms responsible for LVH progression. The study aimed to…

View details →DOI: 10.1002/bcp.70470
Failed Experiment ReportMedicine

ALSUntangled #82: N-acetylcysteine.

Yerraguntla S, Bakshi B, Chandran K et al. · 2026 · Amyotrophic lateral sclerosis & frontotemporal degeneration

N-acetylcysteine is a thiol-containing compound and a precursor of glutathione, with mechanistic plausibility for ALS, including reducing oxidative stress, regulating neuroinflammation, and mitigating mitochondrial dysfunction. Preclinical…

View details →DOI: 10.1080/21678421.2026.2638590