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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21294 results · page 331 of 710

Negative / Null Result ReportMedicine

A new species of hermit crab provisionally assigned to the genus Pagurus Fabricius, 1775 (Crustacea: Anomura: Paguridae) from the Ryukyu Islands, Japan.

Komai T · 2025 · Zootaxa

A new pagurid hermit crab species, Pagurus inflatus sp. nov., has been provisionally assigned to the heterogeneous genus Pagurus Fabricius, 1775. This new species is characteristic in its elongated right cheliped with a noticeably inflated…

View details →DOI: 10.11646/zootaxa.5647.1.3
Negative / Null Result ReportMedicine

Evaluation of passive immunity from dams previously immunized with an inactivated glycoprotein E-deleted infectious bovine rhinotracheitis marker vaccine after challenge infection with wild-type bovine alphaherpesvirus 1 in calves

Petrini S, Martucciello A, Righi C et al. · 2025 · Vaccine: X

Bovine alphaherpesvirus 1 (BoAHV-1) is a major cattle pathogen that causes infectious bovine rhinotracheitis (IBR) and other respiratory and reproductive disorders, resulting in substantial global economic losses to the cattle industry.…

Negative / Null Result ReportMedicine

Comparative population genetic structure of the mitochondrial 16S ribosomal RNA gene of Haemaphysalis flava (Acari: Ixodidae) between Nantong, China, and regions along the East Asia-Australasian Flyway.

Su J, Zhang WB, Sun B et al. · 2025 · Experimental & applied acarology

Haemaphysalis flava Neumann, 1897 is recognized as a vector for Dabie bandavirus (severe fever with thrombocytopenia syndrome virus, SFTSV), which is the etiological agent of severe fever with thrombocytopenia syndrome (SFTS). The tick…

View details →DOI: 10.1007/s10493-025-01051-5
Negative / Null Result ReportOpen accessMedicine

Comparison of Extraction Socket Healing in Patients with Type 2 Diabetes on Oral Hypoglycemics Versus Nondiabetic-Original Research.

Edsor E, Jose M, Sajesh S et al. · 2025 · Journal of pharmacy & bioallied sciences

Background The aim of this study is to assess whether there is a difference in the wound healing process following the extraction of a tooth between type 2 diabetes patients on oral hypoglycemic medications and nondiabetic patients.…

View details →DOI: 10.4103/jpbs.jpbs_1240_25
Failed Experiment ReportMedicine

Pembrolizumab in recurrent or metastatic medullary thyroid cancer.

Del Rivero J, Donahue RN, Marte JL et al. · 2025 · The oncologist

Background It has been hypothesized that sequencing antigen-directed immunotherapy with immune checkpoint inhibitors could prime a tumor for immune response to immune checkpoint inhibitors. Methods This study (NCT03072160) was designed to…

View details →DOI: 10.1093/oncolo/oyaf348
Failed Experiment ReportMedicine

Behavior of Listeria monocytogenes in commercial queso fresco and queso cotija and investigation of salt concentration as a control factor.

Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of dairy science

Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…

View details →DOI: 10.3168/jds.2025-26959
Abandoned HypothesisOpen accessMedicine

Engaging in the Life-planning in Early Alzheimer's and other Dementias advance care planning intervention is associated with perceived advance care planning concordance and interpersonal connectedness.

Bybee SG, Clayton JL, Aruscavage N et al. · 2025 · The Gerontologist

Background and objectives Persons living with dementia often rely upon a care partner as their surrogate medical decision maker, yet little is known about how dementia care dyads achieve advance care planning (ACP) concordance: when a care…

View details →DOI: 10.1093/geront/gnaf179
Negative / Null Result ReportMedicine

<i>N</i>-glycans on SLC26A3 do not significantly alter plasma membrane or lipid raft trafficking, but appear to stabilize interdomain contacts to stimulate transport.

Achilles S, Tomczak JN, Baumann FS et al. · 2025 · American journal of physiology. Gastrointestinal and liver physiology

DRA (Downregulated in adenoma, SLC26A3) is a major apical intestinal Cl - /HCO 3 - exchanger, which is expressed in complex and hybrid N -glycosylated forms. Although the importance of N -glycosylation is evident from the significantly…

View details →DOI: 10.1152/ajpgi.00362.2024
Negative / Null Result ReportMedicine

Effects of a Secondary Cognitive Task on Psychological and Stretch Performance.

Kostrna J, Astudillo A, Perez E · 2025 · Research quarterly for exercise and sport

Extensive research supports the positive effects of stretching on joint flexibility. During stretching, an individual's perceptions of stretch-related discomfort and pain negatively influence affective response. This study examined the…

View details →DOI: 10.1080/02701367.2025.2496765
Negative / Null Result ReportOpen accessMedicine

Piperacillin-tazobactam-associated thrombocytopenia with negative antiplatelet antibody testing: a case report and literature review.

Tian P, Fan M, Huang C · 2026 · Frontiers in medicine

Background Piperacillin-tazobactam is a widely used antibiotic. Although rare, thrombocytopenia related to piperacillin-tazobactam can be clinically significant. Drug-induced immune thrombocytopenia (DIIT) is difficult to distinguish from…

View details →DOI: 10.3389/fmed.2026.1775491
Negative / Null Result ReportMedicine

Body temperature and time perception in morning and evening types.

Erdoğan Ş, Tavat BC · 2025 · Physiology & behavior

Previous studies have suggested that time perception fluctuates throughout the day in relation to daily fluctuations of body temperature, and that there is a negative relationship between body temperature and time perception. The aim of…

View details →DOI: 10.1016/j.physbeh.2025.114943
Negative / Null Result Report

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB

Necker-Brown A, Mostafa MM, Georgescu A et al. · 2025 · Preprint

Transcription factors of the interferon regulatory factor (IRF) family play key roles during viral and bacterial infections. However, IRF regulation by inflammatory cytokines, including interleukin (IL)-1β and tumor necrosis factor (TNF)…

View details →DOI: 10.1101/2025.07.24.665057
Negative / Null Result ReportMedicine

Effect of Radial Lengthening on the Stability of the Distal Radioulnar Joint: A Biomechanical Cadaveric Study.

Yin CY, Vilai P, Thoreson AR et al. · 2026 · The Journal of hand surgery

Purpose Radial lengthening has been clinically proposed as an alternative treatment for distal radioulnar joint (DRUJ) instability associated with distal radius fractures based on the hypothesis that it functions in a manner similar to…

View details →DOI: 10.1016/j.jhsa.2025.06.013
Negative / Null Result ReportMedicine

Three-dimensional Reservoir Modelling and Quantitative Microbial Risk Assessment of Recreational Access to a Drinking Water Reservoir.

Cinque K, Deere D, Veal C et al. · 2025 · Environmental management

The major drinking water reservoirs and catchments supplying many of Australia's capital cities have been protected from significant levels of public access since their construction (up to 140 years ago). In addition to the primary…

View details →DOI: 10.1007/s00267-025-02203-4
Negative / Null Result ReportMedicine

Comparison of Asynchronous Telepsychiatry vs Synchronous Telepsychiatry (CATELEST) in Skilled Nursing Facilities: A Randomized Controlled Noninferiority Clinical Trial.

Xiong GL, Iosif AM, Gonzalez AD et al. · 2025 · Journal of the American Medical Directors Association

Objective Comparison of asynchronous telepsychiatry (ATP) with traditional synchronous telepsychiatry (STP) in skilled nursing facilities (SNFs) in California, United States. Design Patient-level randomized, controlled noninferiority…

View details →DOI: 10.1016/j.jamda.2025.105753
Negative / Null Result ReportOpen accessMedicine

Retraction: miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis.

· 2024 · Journal of cellular and molecular medicine

Xin Li, Hao Xu, Jianfeng Yi, Chunlu Dong, Hui Zhang, Zhengfeng Wang, Long Miao, Wence Zhou. miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT…

View details →DOI: 10.1111/jcmm.18188
Negative / Null Result ReportMedicine

The relationship between smoking and clinical outcome in ischemic stroke patients undergoing reperfusion therapy.

Kömürcü HF, Sever N, Gökdereli NS et al. · 2025 · Neurological research

Background It has been suggested that smokers have higher recanalization rate, lower risk of cerebral hemorrhage and better prognosis than non-smokers (smoking paradox) after reperfusion therapy in patients with acute ischemic stroke (IS).…

View details →DOI: 10.1080/01616412.2024.2448628
Negative / Null Result ReportMedicine

Behavior of Listeria monocytogenes in commercial queso fresco and queso cotija and investigation of salt concentration as a control factor

Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of Dairy Science

Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…

Negative / Null Result ReportOpen accessMedicine

Adolescent Exposure to Nicotine and Ethanol Attenuates Adult Nicotine Reward Sensitivity in Rats.

Toyoshima M, Toyofuku R, Shimoda S et al. · 2026 · Neuropsychopharmacology reports

Adolescence is a sensitive developmental stage in which exposure to addictive substances can produce long-lasting changes in the neural circuits that regulate reward. Nicotine and ethanol are frequently co-used among adolescents, and…

View details →DOI: 10.1002/npr2.70132
Negative / Null Result ReportOpen accessMedicine

An Occurrence of Mass Psychogenic Illness: LeRoy, New York.

McVige J, Masset L, Mechtler L et al. · 2026 · Journal of child neurology

Mass psychogenic illness (MPI), also known as mass sociogenic illness, is a functional neurologic symptom disorder affecting multiple people simultaneously. This study presents a pediatric MPI outbreak involving abrupt-onset tics in LeRoy,…

View details →DOI: 10.1177/08830738251369759
Negative / Null Result ReportMedicine

Presence and potential impact of anthropogenic nesting materials on a colonial breeding waterbird.

Ferreira HRS, Hadden AC, Champagnon J et al. · 2025 · The Science of the total environment

Despite the vital importance of wetlands globally, these habitats have increasingly received anthropogenic materials, such as plastics, which can impact the wildlife these habitats support. Despite commonly found in the nests of Eurasian…

View details →DOI: 10.1016/j.scitotenv.2025.178588
Negative / Null Result ReportOpen accessMedicine

Do ChatGPT and Gemini provide accurate answers to patient questions about glenohumeral arthritis?

Ohlsen SM, Pirkle SB, Yang J et al. · 2026 · JSES reviews, reports, and techniques

Background Machine learning, a subset of artificial intelligence, enables large language models (LLMs) like ChatGPT and Gemini to analyze data, learn from context, and generate responses without explicit programming. While machine learning…

View details →DOI: 10.1016/j.xrrt.2026.100715
Negative / Null Result ReportMedicine

Thrombectomy in Stroke Patients with Large Vessel Occlusion and Mild Symptoms: Insights from a Multicenter Observational Study.

Qiu K, Hang Y, Lv P et al. · 2025 · Translational stroke research

To evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) is more effective than BMM alone in treating mild stroke patients (National Institutes of Health Stroke Scale score pri ) group and the primary…

View details →DOI: 10.1007/s12975-025-01337-1
Negative / Null Result Report

Embryonic exposure to valproic acid and neonicotinoid deteriorates the developmental GABA switch and impairs long-term potentiation in the local circuit of intermediate medial mesopallium of chick telencephalon

Matsushima T, Toji N, Wada K et al. · 2024 · Preprint

Embryonic exposure to valproic acid (VPA) and imidacloprid (IMI, a neonicotinoid insecticide) impairs filial imprinting in hatchlings, and the deteriorating effects of VPA are mitigated by post-hatch injection of bumetanide, a blocker of…

View details →DOI: 10.1101/2024.09.15.613159
Negative / Null Result ReportOpen accessMedicine

Baseline gut microbiome features associated with fecal calprotectin response to exclusive enteral nutrition in pediatric Crohn's disease.

Zheng H, Chen W · 2026 · Frontiers in pediatrics

Background and aims Exclusive enteral nutrition is an established induction therapy for pediatric Crohn's disease, but biochemical response varies across patients. We assessed whether baseline gut microbiome features were associated with…

View details →DOI: 10.3389/fped.2026.1833193