Negative / Null Result ReportOpen accessMedicine
Shi J, Li G, Tang W et al. · 2026 · Frontiers in oncology
Adenocarcinoma originating from the anal gland with immunohistochemical expression of GATA3 and TTF-1 (ACAGGT) is a rare entity. This report describes an 80-year-old female patient who detected a perianal mass without an obvious cause 10…
View details →DOI: 10.3389/fonc.2026.1673646 Negative / Null Result ReportMedicine
K K V, P R A, Rao BK et al. · 2024 · Rapid communications in mass spectrometry : RCM
Rationale The exploration of the gut microbiome and related metabolites holds an exciting future in health science. The challenges associated with fecal sample testing are proper sample collection, sterile transportation, optimal transport…
View details →DOI: 10.1002/rcm.9923 Negative / Null Result ReportOpen accessMedicine
Burrows P, Brown RA, Samuelsen A et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE
Objective To assess whether antibiotic duration (AD) and one-year antibiotic-free days (AFD) are associated with key in-hospital and post-discharge outcomes among critically ill adults. Design Prospective observational study. Setting…
View details →DOI: 10.1017/ash.2025.10054 Negative / Null Result ReportOpen accessMedicine
Sun L, Jiang Y, Ma X et al. · 2026 · Frontiers in pharmacology
Background Currently, postoperative nonsteroidal anti-inflammatory drugs-associated kidney damage in hypertensive patients remains undetermined. This study aimed to examine renal safety of short-term post-surgery use of flurbiprofen axetil…
View details →DOI: 10.3389/fphar.2026.1773939 Negative / Null Result ReportOpen accessMedicine
Sachetto ATA, Mackman N · 2024 · Research and practice in thrombosis and haemostasis
Background Tissue factor (TF) is the primary cellular initiator of the blood coagulation cascade. Increased levels of TF expression on circulating monocytes or on extracellular vesicles (EVs) are associated with thrombosis in a variety of…
View details →DOI: 10.1016/j.rpth.2024.102325 Negative / Null Result ReportOpen accessMedicine
De Ryst JE, Bergström S, Mravinacova S et al. · 2026 · Fluids and barriers of the CNS
Background Aquaporin-4 (AQP4) is crucial for brain fluid regulation and glymphatic system function. Idiopathic normal pressure hydrocephalus (INPH) is characterized by impaired CSF flow and is treated with shunt surgery. This study…
View details →DOI: 10.1186/s12987-026-00809-2 Negative / Null Result ReportMedicine
Liu D, Yan Q, Qin X et al. · 2025 · Biochimica et biophysica acta. Bioenergetics
Photosystem I (PSI) is a large membrane photosynthetic complex that harvests sunlight and drives photosynthetic electron transport. In both green algae and higher plants, PSI's ultrafast energy transfer and charge separation kinetics have…
View details →DOI: 10.1016/j.bbabio.2024.149526 Negative / Null Result ReportOpen accessMedicine
S R S, Holla R, Rao M et al. · 2026 · The Indian journal of medical research
Background and objectives The gold standard for diagnosing malaria is peripheral smear. Histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs) are particularly used for P. falciparum (pf) infections. These tests are easily…
View details →DOI: 10.25259/ijmr_2856_2025 Negative / Null Result ReportOpen accessMedicine
N R, Sivamani H, Sivaraman A et al. · 2024 · Cureus
This report presents the case of vaginal foreign body (FB) in a seven-year-old girl with recurrent genitourinary symptoms that went unrecognized for two years. Despite thorough evaluation including MRI, cystourethroscopy, and several…
View details →DOI: 10.7759/cureus.71259 Negative / Null Result ReportOpen accessMedicine
Zehner KM, Salib A, Sanchez JG et al. · 2026 · Journal of hand surgery global online
Purpose Carpal tunnel syndrome may be considered for carpal tunnel injection (CTI). Ultrasound (US) guidance has been proposed to improve CTI accuracy, but the trend across the years, factors associated with utilization, and outcomes are…
View details →DOI: 10.1016/j.jhsg.2026.100950 Negative / Null Result ReportOpen accessMedicine
Almutairi M, Alalmaee R, Alamer E et al. · 2026 · Journal of clinical tuberculosis and other mycobacterial diseases
Background Tuberculosis (TB) is a major global health issue, particularly among HIV-positive individuals. In Saudi Arabia, the incidence has declined to 8.4 per 100,000 but remains a concern among high-risk groups. Extrapulmonary TB,…
View details →DOI: 10.1016/j.jctube.2026.100603 Negative / Null Result Report
Zheng J, Zhou Y, Fuentes RJ et al. · 2024 · Preprint
The motor protein Prestin found in the outer hair cells (OHCs) of the inner ear is responsible for producing high sensitivity and sharp frequency selectivity for mammalian hearing. Some studies have suggested that Prestin could serve as a…
View details →DOI: 10.20944/preprints202405.0825.v1 Negative / Null Result ReportMedicine
Zhang P, Guo Y, Xu Y et al. · 2025 · Talanta
The identification of natural active compounds is typically a cumbersome and time-intensive process due to the necessity for elaborate sample pretreatment, leading to inefficiencies. Although recent advancements have introduced methods for…
View details →DOI: 10.1016/j.talanta.2024.127163 Negative / Null Result ReportMedicine
Britnell JA, Palme R, Kerley GIH et al. · 2024 · Functional Ecology
Steroid hormones, especially glucocorticoids (GCs), are widely used to assess physiological responses to stressors. As steroid hormones are heavily metabolised prior to excretion, it is essential to validate enzyme immunoassays (EIAs) for…
Negative / Null Result Report
McDaniel CS, Vannette RL, Arroyo-Flores A et al. · 2024 · Preprint
ABSTRACT Fire blight is a devastating disease affecting pome fruit trees that is caused by Erwinia amylovora and leads to substantial annual losses worldwide. While antibiotic-based management approaches like streptomycin can be effective,…
View details →DOI: 10.1101/2024.07.03.601912 Negative / Null Result ReportMedicine
Anez SG, Flail DB, Burkhart EP et al. · 2025 · Journal of natural products
Monotropa uniflora L. ("ghost pipe"), is a North American traditional medicinal plant which has recently seen an increase in consumption nationwide. However, a single 1889 study reported the presence of grayanotoxin I in M. uniflora,…
View details →DOI: 10.1021/acs.jnatprod.5c00805 Negative / Null Result Report
Håkansson G, Grossmann KR, Ådén U et al. · 2024 · Preprint
Aim Neonatal hypoxic-ischemic encephalopathy (HIE) injures the infant brain during the basic formation of the developing functional connectome. This study aimed to investigate long-term changes in the functional connectivity (FC) networks…
View details →DOI: 10.1101/2024.05.31.24308185 Methods Dead-EndMedicine
Psaltis PJ, Nguyen MT, Singh K et al. · 2025 · Cardiovascular research
Aims Low-dose colchicine reduces the risk of cardiovascular events after myocardial infarction (MI). The purpose of this study was to assess the effect of colchicine post-MI on coronary plaque morphology in non-culprit segments by optical…
View details →DOI: 10.1093/cvr/cvae191 Methods Dead-EndOpen accessMedicine
Kardjadj M, Chang TW, Chavez R et al. · 2025 · Microorganisms
Clinical success in treating complicated urinary tract infections (cUTIs) depends on accurate pathogen detection, given the common occurrence of polymicrobial infections and antimicrobial resistance. This multicenter, randomized,…
View details →DOI: 10.3390/microorganisms13040949 Failed Experiment ReportOpen accessMedicine
Sawada A, Yoneta K, Togashi E et al. · 2024 · Journal of physical therapy science
[Purpose] In gastric cancer patients, low muscle mass decreases overall survival and quality of life (QOL). Resistance exercise with leucine-enriched essential amino acid (LEAA) supplementation may prevent muscle mass loss. This study was…
View details →DOI: 10.1589/jpts.36.218 Negative / Null Result ReportMedicine
Strotzer QD, Nieberle F, Kupke LS et al. · 2024 · Radiology
Background Large language models have already demonstrated potential in medical text processing. GPT-4V, a large vision-language model from OpenAI, has shown potential for medical imaging, yet a quantitative analysis is lacking. Purpose To…
View details →DOI: 10.1148/radiol.240955 Negative / Null Result ReportOpen accessMedicine
Bäumges H, Jelinek S, Lange H et al. · 2025 · Cells
Fucose-containing glycoproteins and glycolipids broadly occur in humans as well as in many other species and are essential for a wide range of physiological processes, such as cell adhesion, fertilization, and tumor development. In humans,…
View details →DOI: 10.3390/cells14171355 Negative / Null Result ReportOpen accessMedicine
Leslie WD, Zarzour F, Binkley N et al. · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Statins are among the most widely prescribed medications in older individuals. Inconsistent data in humans suggest that statin medications may be associated with greater BMD and lower risk for osteoporosis. We identified 22 393 individuals…
View details →DOI: 10.1093/jbmr/zjaf077 Negative / Null Result ReportOpen accessMedicine
Sadiq DR, Mikhael EM · 2024 · Clinical ophthalmology (Auckland, N.Z.)
Background Glaucoma is a chronic progressive eye disorder. It is the primary cause of blindness. To prevent glaucomatous damage and blindness, the intra-ocular pressure (IOP) must be lowered to certain levels, this level is known as "IOP"…
View details →DOI: 10.2147/opth.s478850 Negative / Null Result ReportOpen accessMedicine
Birk JB, Møller MA, Wojtaszewski JFP et al. · 2025 · FEBS letters
It has been proposed that the regulatory Sit4-associated protein subunit 3 (SAPS3) of protein phosphatase 6 (PP6C) acts as an AMP-activated protein kinase (AMPK) inhibitor by recruiting PP6C to dephosphorylate AMPKα-T172. While we confirm…
View details →DOI: 10.1002/1873-3468.70222 Negative / Null Result ReportOpen accessMedicine
Biçengil K, Kurt A, Naralan ME et al. · 2026 · Diagnostics (Basel, Switzerland)
Objectives : To evaluate the diagnostic performance of a YOLOv8x-based deep learning model for detecting approximal, occlusal and buccal caries on paediatric panoramic radiographs and to compare its performance with human observers with…
View details →DOI: 10.3390/diagnostics16081150 Methods Dead-EndOpen accessMedicine
Adhikari S, Eldfors S, Pitkänen E et al. · 2025 · Computational and structural biotechnology journal
Background Acute myeloid leukemia (AML) progresses by the accumulation of somatic mutations and clonal expansion of pre-leukemic cells. Patients may respond to initial therapy, but often relapse, underscoring an evolving disease. Next…
View details →DOI: 10.1016/j.csbj.2025.11.066 Failed Experiment Report
Gill MC, Chuttong B, Davies P et al. · 2024 · Preprint
Tropilaelaps spp. are invasive mites that cause severe disease in Apis mellifera colonies. The UK has deployed an elaborate surveillance system that seeks to detect these mites early in any invasion to allow the best opportunity to…
View details →DOI: 10.1101/2024.03.26.586849 Negative / Null Result ReportMedicine
Airaksinen J, Siimes S, Hartikainen J et al. · 2024 · Pflugers Archiv : European journal of physiology
Arrhythmia detection is essential when assessing the safety of novel drugs and therapies in preclinical studies. Many short-term arrhythmia monitoring methods exist, including non-invasive ECG and Holter. However, there are no reliable,…
View details →DOI: 10.1007/s00424-024-02962-9 Negative / Null Result ReportOpen accessMedicine
Ura H, Hatanaka H, Togi S et al. · 2025 · International journal of molecular sciences
RNA sequencing (RNA-Seq) is a powerful technique for the quantification of transcripts and the analysis of alternative splicing. Previously, our laboratory developed the targeted RNA long-amplicon sequencing (rLAS) method, which has the…
View details →DOI: 10.3390/ijms26073220 