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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 318 of 710

Negative / Null Result ReportMedicine

Association of Menopause and Hormone Replacement Therapy with Hearing Loss.

Hsu JZ, Gu K, Nguyen B et al. · 2026 · The Annals of otology, rhinology, and laryngology

Objective Estrogen has been found to impact cochlear blood flow and auditory function, but epidemiological studies on menopause and hearing are inconsistent. This study investigates the associations of menopause, its age at onset,…

View details →DOI: 10.1177/00034894261435259
Negative / Null Result ReportMedicine

The association between mode of delivery and severe intraventricular hemorrhage in very preterm infants.

Keel E, Kalimeris S, Adams M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Background Infants born before 32 weeks of gestation are at high risk of developing intraventricular hemorrhage (IVH), which is associated with significant mortality and morbidity as well as long-term neurodevelopmental impairment. There…

View details →DOI: 10.1080/14767058.2026.2650951
Negative / Null Result ReportMedicine

Perinatal use of targeted synthetic DMARDs and maternal-neonatal outcomes in autoimmune disease: A population-based cohort study.

Cheng V, Sayre EC, Amiri N et al. · 2026 · Journal of autoimmunity

Objectives While targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) have advanced autoimmune disease management, the paucity of perinatal safety data limits evidence-based decision-making in pregnancy. We aimed to…

View details →DOI: 10.1016/j.jaut.2026.103538
Negative / Null Result ReportOpen accessMedicine

Risk of Intraoperative Periprosthetic Femoral Fracture According to Cementless Femoral Stem Geometry: A Cohort Study Based on the Radaelli Classification.

Izquierdo JA, Kerbel J, Apodaca G et al. · 2026 · Cureus

Background Intraoperative periprosthetic femoral fracture is an uncommon but clinically significant complication of total hip arthroplasty (THA) that may compromise implant stability and increase the risk of early revision surgery. Several…

View details →DOI: 10.7759/cureus.106425
Negative / Null Result ReportMedicine

Social inequality and the mental health of Chinese youth.

Wang Y, Zhang Y, Lan Y · 2026 · Scientific reports

The mental health of young people serves as a social barometer, reflecting societal conditions. However, the relationship between social inequality and youth mental health remains a contested issue. This study uses data from the China…

View details →DOI: 10.1038/s41598-026-58041-9
Negative / Null Result ReportMedicine

Steroid with Temporary Stent Versus Steroid Alone for Preventing Stricture After Endoscopic Submucosal Dissection for Early Esophageal Cancer.

Chen Z, Zhang L, Liang Y et al. · 2026 · Digestive diseases and sciences

Background and aims Post-ESD esophageal stricture remains a major complication despite steroid prophylaxis. Temporary stent placement has been proposed as an adjunctive strategy in high-risk cases, yet its independent effect remains…

View details →DOI: 10.1007/s10620-026-09842-5
Negative / Null Result ReportOpen accessMedicine

Association Between Possible Sarcopenia and Fracture Risk Assessment Tool (FRAX)-Estimated Fracture Risk Without Bone Mineral Density in Institutionalized Older Adults: A Cross-Sectional Study.

Yubaitsa CN, Gani KS, Mitchel M et al. · 2026 · Cureus

Background Musculoskeletal problems in the elderly pose a significant challenge for healthcare providers, as they constitute a vulnerable group. Fractures are often undetected, leading to a reduced quality of life due to increased…

View details →DOI: 10.7759/cureus.103678
Negative / Null Result ReportMedicine

FDG PET/CT imaging in recurrent papillary thyroid cancer: does BRAF mutation status matter?

Bastian MB, Kyriakou I, Rosar F et al. · 2026 · The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

Background Papillary thyroid carcinoma (PTC) with a BRAFV600E mutation is linked to more aggressive tumor characteristics, as well as a higher likelihood of recurrence and disease-specific mortality. This study aimed to investigate the…

View details →DOI: 10.23736/s1824-4785.26.03686-1
Negative / Null Result ReportMedicine

Empathy and xenophobic attitudes toward migrants among midwifery students in Türkiye: a cross-sectional study.

Hacıvelioğlu D, Turan Tercan A, Tuna Oran N · 2026 · BMC public health

This study examined xenophobia and empathic tendency among 724 midwifery students from different regions of Turkey. Data were collected online using the Student Information Form, the Empathic Tendency Scale, and the Xenophobia Scale, and…

View details →DOI: 10.1186/s12889-026-27913-0
Negative / Null Result ReportOpen accessMedicine

Integrating Genetic Variants and Expression Profiles of Pharmacogenes to Investigate Resistance to Antidepressant Treatment.

Pisanu C, Squassina A, Perera-Bel J et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Treatment-resistant depression (TRD) is a major clinical challenge in the management of major depressive disorder (MDD). While pharmacogenetics has been suggested to be clinically useful in guiding…

View details →DOI: 10.3390/medicina62050965
Negative / Null Result ReportOpen accessMedicine

Cephalometric Assessment of Airway-Related Hyoid Position and Velar Morphology Across Skeletal Malocclusions: A Cross-Sectional Study.

Özen GY, Özen AK, Bilge NH · 2026 · Diagnostics (Basel, Switzerland)

Background: The anatomical position of the hyoid bone and the morphological characteristics of the soft palate play a key role in upper airway patency, craniofacial balance, and the coordination of functional structures. These features may…

View details →DOI: 10.3390/diagnostics16060947
Negative / Null Result ReportMedicine

Does ethnicity affect primary palliative care identification and coding? Retrospective cohort study.

Clarke G, Shuweihdi F, Relton SD et al. · 2026 · The British journal of general practice : the journal of the Royal College of General Practitioners

Background Primary palliative care is symptom support and care for people with life-limiting illnesses incorporated within standard primary care. Early identification of needs is best practice. There is limited research concerning…

View details →DOI: 10.3399/bjgp.2025.0602
Negative / Null Result Report

Do Researchers Claim Their Findings Are Applicable to the Real World? An Empirical Study of Social and Personality Psychology Articles

Clarke B, Sajjad A, Moodie N et al. · 2026 · Preprint

The topics and questions that social and personality psychologists study attract a great deal of public interest. The level of evidence required to make an application claim should be high, in our opinion, to avoid misapplying evidence…

View details →DOI: 10.31234/osf.io/zjkcy_v3
Negative / Null Result ReportMedicine

The Moderating Effect of Physical Activity on the Association Between Cognitive Function and Fear of Falling in Low-Income Community-Dwelling Older Adults.

Ojo EO, Xie R, Ng BP et al. · 2026 · Research in gerontological nursing

Purpose The current study aimed to examine the association between cognitive function, fear of falling, and physical activity and assess the moderating effect of physical activity on the association between cognitive function and fear of…

View details →DOI: 10.3928/19404921-20260615-02
Negative / Null Result ReportMedicine

Auditory Perception of Neutral Voices in K-Pop Singers.

Dornelas R, Marins I, Rodrigues TS et al. · 2025 · Journal of voice : official journal of the Voice Foundation

Objective To analyze the auditory perception of Korean pop (K-pop) singers' voices to identify vocal characteristics associated with gender neutrality. Study design This is a cross-sectional observational study. Methods The inclusion…

View details →DOI: 10.1016/j.jvoice.2025.11.010
Negative / Null Result ReportOpen accessMedicine

Correlation Between First-line Immunotherapy and Second-line TKI Outcomes in Metastatic Renal Cell Carcinoma.

Sugimoto K, Minami T, Nukaya T et al. · 2025 · Cancer diagnosis & prognosis

Background/aim Immune checkpoint inhibitors (ICIs) have improved survival in metastatic renal cell carcinoma (mRCC), with nivolumab (NIVO) plus ipilimumab (IPI) showing benefits in intermediate- and poor-risk patients. Despite first-line…

View details →DOI: 10.21873/cdp.10488
Negative / Null Result ReportMedicine

Parallel Liquid Biopsy Analysis of miR-371a-3p and Cell-Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors.

Matouskova L, Kralova R, Parobkova E et al. · 2026 · Andrology

Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR-371a-3p testing has not yet been implemented in routine clinical practice. Cell-free DNA…

View details →DOI: 10.1111/andr.70283
Negative / Null Result ReportOpen accessMedicine

Tampa scale for kinesiophobia in individuals with knee osteoarthritis: a cross-sectional psychometric evaluation using item-level and exploratory factor analyses.

Sakulsriprasert P, Bunprajun T, Hengsomboon N et al. · 2026 · Scientific reports

This study evaluated floor and ceiling (F/C) effects within the Tampa Scale for Kinesiophobia (TSK) and examined item-level correlations with total TSK scores and pain intensity in individuals with knee osteoarthritis (KOA). A…

View details →DOI: 10.1038/s41598-026-46580-0
Failed Experiment ReportMedicine

Mortality among patients with diabetic foot ulcers and its relationship with Wagner classification and glucose regulation.

Düsünen E, Tural E, Yonak AK et al. · 2026 · The National medical journal of India

Background Diabetic foot ulcers are an important problem for people with diabetes mellitus. We aimed to determine the mortality rate in patients with diabetic foot ulcers and assess the relationship between mortality, the Wagner…

View details →DOI: 10.25259/nmji_536_2024