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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21710 results · page 318 of 724

Negative / Null Result ReportMedicine

Effective Coverage of Rehabilitation for Adults with Chronic Primary Low Back Pain in Uganda.

De Groote W, Taremwa Y, Duttine A et al. · 2026 · International journal of environmental research and public health

In Uganda, in 2019, 6.8 million people experienced health conditions that are amenable to rehabilitation. This is largely due to musculoskeletal disorders such as low back pain (LBP). Measuring effective coverage of rehabilitation means…

View details →DOI: 10.3390/ijerph23060693
Negative / Null Result ReportMedicine

National medical occupational radiation dose monitoring in Saudi Arabia.

Aljuaid M, Alsiraj K · 2026 · Annals of the ICRP

This is a national study about the occupational Radiation doses for medical workers in the Kingdom of Saudi Arabia which covers the period since the establishment of the Nuclear and Radiological Regulatory Commission (NRRC). The study aims…

View details →DOI: 10.1177/01466453251411988
Negative / Null Result ReportOpen accessMedicine

Awareness of Effective Communication Skills Among Paediatric Dentists in Turkey.

Büyüksefil M, Çimen Ü, Şimşek Derelioğlu S et al. · 2026 · Oral health & preventive dentistry

Purpose Effective communication with paediatric patients is one of the cornerstones of paediatric dentistry. Strong communication skills play a critical role in reducing dental anxiety, enhancing patient satisfaction, and facilitating the…

View details →DOI: 10.3290/j.ohpd.c_2680
Negative / Null Result ReportMedicine

Comparison of effective phacoemulsification times used in cataract surgery between the Veritas Vision System and the Centurion Vision System.

Choi JY, Song WS, Won YK et al. · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the effective phacoemulsification time used in cataract surgery and postoperative outcomes between the Veritas and the Centurion Vision System. Methods A retrospective analysis was conducted on 90 eyes from 82 patients…

View details →DOI: 10.3341/kjo.2025.0196
Negative / Null Result ReportMedicine

Effective population size and N e /N ratio for two populations of Northern chamois (Rupicapra rupicapra) on the edge of the species' distribution range.

Jacobs S, Edelhoff H, Ebert C et al. · 2026 · BMC ecology and evolution

Effective population size (Ne) is a fundamental parameter in conservation genetics, providing relevant information on the adaptability and long-term viability of populations. In contrast, wildlife management strategies, particularly for…

View details →DOI: 10.1186/s12862-026-02543-7
Negative / Null Result ReportMedicine

Missed Opportunities for Timely Diagnosis and Effective Therapeutic Management of Prolonged Fever: A Case Study of Confirmed Lassa Fever in N'Zérékoré, Guinea, 2022.

Cherif IS, Essis EML, Diallo MA et al. · 2026 · Case reports in infectious diseases

Background Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a…

View details →DOI: 10.1155/crdi/2672939
Methods Dead-EndOpen accessMedicine

Cost utility and cost-effectiveness of the APPLE-Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: economic evaluation embedded within a randomised controlled trial.

Demnitz-King H, Cooper C, Poppe M et al. · 2026 · Age and ageing

Background Previous studies have modelled long-term cost-effectiveness of dementia prevention but seldom within trials. APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build…

View details →DOI: 10.1093/ageing/afag176
Negative / Null Result ReportOpen accessMedicine

Cost-Effectiveness of Anticoagulation Treatment for Subclinical Device-Detected Atrial Fibrillation.

Winstén AK, Langén V, Airaksinen KEJ et al. · 2026 · JAMA network open

Importance Anticoagulation for stroke prevention in subclinical, device-detected atrial fibrillation (AF) remains an area of clinical equipoise, and its cost-effectiveness is unknown. Objective To evaluate the cost-effectiveness of direct…

View details →DOI: 10.1001/jamanetworkopen.2026.17213
Negative / Null Result ReportOpen accessMedicine

Pre-TIPS Liver and Spleen Volumetry Are Not Associated With Liver-Related Outcomes After TIPS Placement for Refractory Ascites.

Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…

View details →DOI: 10.1111/liv.70691
Abandoned HypothesisMedicine

Descriptive oxidative and lipid-related fluorescence observations associated with Esketamine treatment in a high-concentration NMDA-exposed HT-22/C8-D1A co-culture model.

Ni X, Zhou S, He X et al. · 2026 · Toxicology in vitro : an international journal published in association with BIBRA

Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…

View details →DOI: 10.1016/j.tiv.2026.106274
Negative / Null Result ReportMedicine

Early Endoscopic Retrograde Cholangiopancreatography is Associated With Improved Health Care Resource Utilization in Acute Biliary Pancreatitis Without Cholangitis.

Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology

Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…

View details →DOI: 10.1097/mcg.0000000000002341
Negative / Null Result ReportMedicine

Extracellular Vesicles Reflect Thrombo-Inflammatory, Endothelial and Tissue-Remodelling Changes in Cirrhosis.

Campello E, Zanetto A, Ferdinande K et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background and aims Cirrhosis is characterized by progressive immune dysregulation, endothelial dysfunction, and haemostatic imbalance. Circulating extracellular vesicles (EVs) have emerged as potential biomarkers reflecting these…

View details →DOI: 10.1111/liv.70723
Negative / Null Result ReportOpen accessMedicine

Characterizing the spiral: potential mechanisms in AI-associated delusions.

Augustin M, Pollak TA, Morrin H · 2026 · NPP - digital psychiatry and neuroscience

AI-associated delusions represent an emerging phenomenon requiring mechanistic understanding. This review, after summarizing key contributions on AI-associated delusions, proposes the "amplification spiral" framework, wherein three…

View details →DOI: 10.1038/s44277-026-00065-0
Negative / Null Result ReportMedicine

Association of IBS-associated E. coli strains with epithelial inflammatory responses and tight junction dysregulation in Caco-2 cells.

Merzaei Z, Kazemian H, Bamzadeh Z et al. · 2026 · BMC research notes

Objective Irritable bowel syndrome (IBS) presents with symptoms of pain, abdominal discomfort, and altered bowel habits. Changes in the intestinal microbiota, including an increase in Enterobacteriaceae like E. coli, have been associated…

View details →DOI: 10.1186/s13104-026-07924-1
Negative / Null Result ReportOpen accessMedicine

Demographic, birth, parental characteristics, and the risk of early-onset colorectal cancer: A population-based nested case-control study in California.

Siddique S, Wang R, Berardi D et al. · 2026 · Cancer

Background The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50 years, has been increasing. The relationship between demographic, birth, and parental characteristics and risk…

View details →DOI: 10.1002/cncr.70458
Negative / Null Result ReportOpen accessMedicine

Immuno-Proteomic Features Associated to Relapse Risk in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.

Gallaccio G, Müller A, Wang M et al. · 2026 · Neurology(R) neuroimmunology & neuroinflammation

Background and objectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder that overlaps clinically with multiple sclerosis (MS) but immunopathologically distinct. Although…

View details →DOI: 10.1212/nxi.0000000000200615
Negative / Null Result ReportMedicine

Preoperative Factors Associated With Postoperative Delirium in Older Patients With Cancer Undergoing Surgery: Retrospective Cohort Study.

Kumura Y, Maruta M, Yokota H et al. · 2026 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background Post-operative delirium (POD) is a common complication in older patients with cancer undergoing surgery, leading to prolonged hospitalisation and cognitive decline. This study examined the relationship between pre-operative…

View details →DOI: 10.1111/psyg.70179
Negative / Null Result ReportOpen accessMedicine

Barium-associated intestinal ischemia complicated with massive hepatic portal venous gas: A successful survival case report.

Xu P, Zhong S, Peng X · 2026 · The Journal of international medical research

Barium-associated intestinal ischemia is a rare but life-threatening complication following upper gastrointestinal barium contrast examinations, with an incidence of less than 0.01%. Hepatic portal venous gas is a condition secondary to…

View details →DOI: 10.1177/03000605261457776
Negative / Null Result Report

Elevated HbA1c is associated with advanced brain age in severe obesity

Juhasz J, DeFeis B, Britton MK et al. · 2026 · Preprint

ABSTRACT Introduction Brain-predicted age, estimated from structural MRI data, is a machine learning biomarker of biological brain aging. Greater brain age gap (BAG) indicates advanced brain aging and is associated with cognitive decline…

View details →DOI: 10.64898/2026.06.04.26354935
Negative / Null Result ReportMedicine

Diet Quality, Healthy Practices, and Psychosocial Functioning Across School Youth, Students, and Adults in Poland: A Cross-Sectional Online Survey.

Sochacka K, Kotowska A, Lachowicz-Wiśniewska S · 2026 · Nutrients

Background: This study aimed to compare a limited set of predefined diet-, lifestyle-, knowledge-, and psychosocial indicators across school youth, students, and adults in Poland, and to examine their associations with three predefined…

View details →DOI: 10.3390/nu18122022