Negative / Null Result ReportOpen accessMedicine
Liu Z, Cong X, Liu Z et al. · 2026 · Frontiers in immunology
Renal cell carcinoma (RCC) has historically posed a significant therapeutic challenge in the adjuvant setting. Although surgical resection remains the cornerstone of curative-intent treatment for localized disease, a substantial proportion…
View details →DOI: 10.3389/fimmu.2026.1816253 Failed Experiment ReportOpen accessMedicine
Orozco Loaiza G, Alfaro Guerra MJ, Murillo Sotela A et al. · 2026 · Cureus
Geographic atrophy (GA) represents the advanced form of non-neovascular age-related macular degeneration (AMD) and is associated with progressive and irreversible vision loss. Evidence has implicated the dysregulation of the complement…
View details →DOI: 10.7759/cureus.109282 Negative / Null Result ReportMedicine
Marchetti M, Pinzi V, Gemma M et al. · 2025 · International journal of radiation oncology, biology, physics
Purpose During the last decades, in addition to tumor control, hearing preservation has become an important priority in the treatment of vestibular schwannoma (VS). Given that the potential advantages of hypofractionated radiosurgery (hRS)…
View details →DOI: 10.1016/j.ijrobp.2025.03.081 Negative / Null Result ReportOpen accessMedicine
Xu J, Wang H, Chen J et al. · 2025 · International journal of surgery (London, England)
Background Autoimmune rheumatic diseases (ARDs), including rheumatoid arthritis and osteoarthritis, are debilitating conditions with limited curative options. Stem cell therapy offers promising regenerative and immunomodulatory benefits.…
View details →DOI: 10.1097/js9.0000000000003130 Negative / Null Result ReportMedicine
Harris LR, Jörges B, Bury N et al. · 2025 · Experimental brain research
Under the microgravity of the International Space Station, many of the normal processes that determine the perceptual upright on Earth are disrupted. For example, somatosensory cues are absent and an applied physical linear acceleration…
View details →DOI: 10.1007/s00221-025-07023-w Negative / Null Result ReportOpen accessMedicine
Faghihian R, Tofighi MM, Ziaei S et al. · 2025 · European oral research
Purpose A way to reduce the pain of injection is applying of external cold or vibrations with BUZZY, along with spinal cord gate control systems. We aimed to evaluate the effectiveness of this method in reducing children's pain and anxiety…
View details →DOI: 10.26650/eor.20241409206 Negative / Null Result ReportOpen accessMedicine
Costa TE, Lauar JC, Innecchi MLR et al. · 2026 · Journal of the Endocrine Society
Introduction New evidence has emerged linking uric acid levels to Chronic Kidney Disease and Mineral and Bone Disorder (CKD-MBD). However, interventional studies remain scarce. We evaluated the effect of allopurinol on CKD-MBD biomarkers.…
View details →DOI: 10.1210/jendso/bvag118 Negative / Null Result ReportOpen accessMedicine
Ru X, Wu L, Guo Y et al. · 2025 · Medicine
Given that homocysteine (Hey) may be a viable target for intervention and that there is uncertainty regarding the causal relationship between plasma Hcy levels and colorectal cancer (CRC), this study used Mendelian randomization (MR) to…
View details →DOI: 10.1097/md.0000000000045773 Failed Experiment ReportOpen accessMedicine
Jackson AC · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Human rabies has a very high fatality rate and there have only been about 34 well-documented survivors, defined as survival at 6 months after onset of clinical rabies. Many have had serious neurological sequelae. After a young patient…
View details →DOI: 10.1093/cid/ciaf157 Negative / Null Result ReportMedicine
Crespo R, Poudel I, Malheiros DM et al. · 2024 · Journal of Applied Poultry Research.
This study aimed to compare the performance of 2 quantitative ultrasound (QUS) devices and to investigate the possible relationship between bone density, measured by speed of sound (SOS), and the biomechanical properties of bone. The bone…
Negative / Null Result ReportOpen accessMedicine
Aziz YN, Aragon Garcia R, Plummer P et al. · 2026 · Stroke (Hoboken, N.J.)
Background Recent randomized trials showed no benefit of mechanical thrombectomy (MT) for ischemic stroke due to distal medium vessel occlusion (DMVO). We sought to understand the use of MT for DMVO stroke treatment before and after the…
View details →DOI: 10.1161/svin.125.001965 Negative / Null Result ReportOpen accessMedicine
Niazi SK · 2024 · International journal of molecular sciences
Although decades of intensive drug discovery efforts to treat neurodegenerative disorders (NDs) have failed, around half a million patients in more than 2000 studies continue being tested, costing over USD 100 billion, despite the…
View details →DOI: 10.3390/ijms251810211 Negative / Null Result ReportOpen accessMedicine
Nutbeam T · 2026 · Scandinavian journal of trauma, resuscitation and emergency medicine
Background Cervical collar application remains prevalent in trauma care despite the absence of evidence of neurological benefit from spinal immobilisation. Clinical behaviour in this area has proven resistant to change, and the persistence…
View details →DOI: 10.1186/s13049-026-01600-w Negative / Null Result ReportMedicine
Struys T, Christiaens V, De Bruyckere T et al. · 2025 · Clinical implant dentistry and related research
Aim To assess the impact of the timing of soft tissue augmentation on soft tissue changes and esthetic outcome following single immediate implant placement (IIP) in the anterior maxilla. Materials and methods Patients with a failing tooth…
View details →DOI: 10.1111/cid.70013 Negative / Null Result ReportOpen accessMedicine
Hedberg F, Lindh JD, Mannheimer B et al. · 2026 · Journal of the Endocrine Society
Context Levothyroxine (LT4) is the primary treatment of hypothyroidism. Despite adequate LT4 substitution some patients experience symptoms and the use of adjunct liothyronine (LT3) has increased. Several trials show no clear advantage of…
View details →DOI: 10.1210/jendso/bvag107 Negative / Null Result ReportOpen accessMedicine
Matera MG, Calzetta L, Rogliani P et al. · 2025 · International journal of chronic obstructive pulmonary disease
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with limited response to standard anti-inflammatory therapies. Biologics targeting specific inflammatory pathways have emerged as potential treatments,…
View details →DOI: 10.2147/copd.s550144 Negative / Null Result ReportOpen accessMedicine
De Pascale G, Cutuli SL, Vargas M et al. · 2026 · Intensive care medicine
Purpose The MICROINHALO trial investigated whether personalized management of endotracheal tube cuff pressure (Pcuff) based on exhaled CO 2 measurement combined with automatic subglottic space drainage (SSD) may prevent tracheal…
View details →DOI: 10.1007/s00134-026-08459-6 Abandoned HypothesisOpen accessMedicine
Xu X, Qin F, Li L et al. · 2025 · BMC pregnancy and childbirth
Objective To present 2 cases of placental rupture at delivery after fetoscopic SOLOMON technique for twin-twin transfusion syndrome. Methods 2 cases diagnosed with TTTS in the second trimester. Fetoscopic SOLOMON procedure was performed…
View details →DOI: 10.1186/s12884-025-07487-2 Negative / Null Result ReportOpen accessMedicine
Bano S, Choudhry N, Numan A et al. · 2026 · Journal of clinical medicine
Background : Circulating cytokines and their soluble receptors in body fluids have been implicated in the pathogenesis of multiple sclerosis (MS). Alterations in serum levels of pro- and anti-inflammatory cytokines and/or their soluble…
View details →DOI: 10.3390/jcm15062397 Negative / Null Result ReportOpen accessMedicine
Wang Y, Niu Y, Qin B et al. · 2025 · Ecology and evolution
Perlidae represents one of the most diverse and ecologically important groups within the order Plecoptera. However, the phylogenetic relationships within Perlidae remain unresolved due to morphological plasticity and the limited…
View details →DOI: 10.1002/ece3.72309 Negative / Null Result ReportOpen accessMedicine
Flores-Prado V, Godoy-Padilla D, Limaymanta-Zavala M et al. · 2025 · Journal of advanced veterinary and animal research
Objective The study assessed the anthelmintic activity of Artemisia absinthium ethanolic extract for controlling gastrointestinal nematodes in goats, both in vitro using infective larvae and in vivo in naturally infected goats under…
View details →DOI: 10.5455/javar.2025.l960 Negative / Null Result ReportMedicine
Feygin MS, Brenner A, Tanweer O · 2025 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Background The management of acute ischemic stroke (AIS) was revolutionized within the last 15 years with the introduction of mechanical thrombectomy (MT) to standard of care. Despite the success of mechanical thrombectomy (MT) in…
View details →DOI: 10.1016/j.jstrokecerebrovasdis.2024.108188 Negative / Null Result Report
Rodgers J, Brothers T · 2024 · Preprint
Abstract Purpose: Blind tunneling of subfascial femoropopliteal bypass grafts may result in inadvertent graft passage through the sartorius. The purpose of this study was to determine whether intramuscular passage of femoropopliteal bypass…
View details →DOI: 10.21203/rs.3.rs-4742653/v1 Negative / Null Result ReportMedicine
Tidadini F, Trilling B, Sage PY et al. · 2024 · Techniques in coloproctology
Background The enhanced recovery after surgery (ERAS) protocol has been introduced over the past three decades for patients undergoing colorectal surgery. However, the effect of this program on long-term survival is poorly studied. We…
View details →DOI: 10.1007/s10151-024-03036-9 Negative / Null Result Report
Rohan T, Turchetta G, Yang S · 2024 · Preprint
Abstract Importance: It is hypothesized that 5α-reductase inhibitors (5aRI) increase aromatase-mediated conversion of testosterone to estrogen, which may facilitate development of estrogen-driven malignancy. Previous studies in male…
View details →DOI: 10.21203/rs.3.rs-4810414/v1 Negative / Null Result ReportMedicine
Matheux A, Collas L, Grisard M et al. · 2024 · Cancer chemotherapy and pharmacology
Objectives The use of plasma uracil measurements to detect dihydropyrimidine dehydrogenase (DPD) deficiency is one of the methods for preventing toxicities associated with fluoropyrimidines, including 5-Fluorouracil (5-FU). Unfortunately,…
View details →DOI: 10.1007/s00280-024-04732-x Negative / Null Result ReportOpen accessMedicine
He W, Ding L, Liu Z et al. · 2025 · JAMA network open
Importance Although insulin is widely used for early lipid lowering in hypertriglyceridemic acute pancreatitis, the clinical benefit of heparin combined with insulin remains unclear. Objective To examine whether low-molecular-weight…
View details →DOI: 10.1001/jamanetworkopen.2025.42124 Negative / Null Result ReportOpen accessMedicine
Kim Y, Salazar-Marioni S, Abdelkhaleq R et al. · 2025 · Scientific reports
The role of intravenous thrombolysis (IVT) in combination with endovascular thrombectomy (EVT) for the treatment of large vessel occlusion acute ischemic stroke has been evaluated exclusively outside the US, in randomized clinical trials…
View details →DOI: 10.1038/s41598-025-03249-4 Negative / Null Result ReportMedicine
Santucci J, Hua C, Chong L et al. · 2025 · ANZ journal of surgery
Background Data on optimal extent of resection for various stages of gallbladder cancer are lacking. This study aims to evaluate disease-free (DFS) and overall survival (OS) after simple (SC) versus radical cholecystectomy (RC) for…
View details →DOI: 10.1111/ans.19300 Failed Experiment ReportOpen accessMedicine
Kinnard KR, Khalid E · 2026 · Case reports in neurological medicine
Myasthenia gravis is an autoimmune disorder characterized by muscle weakness due to impaired neuromuscular transmission. While antibodies against the acetylcholine receptor and muscle-specific kinase are commonly used for diagnosis, a…
View details →DOI: 10.1155/crnm/3092521 