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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 316 of 710

Negative / Null Result ReportOpen accessMedicine

Ground-Level Ozone as Community-Acquired Pneumonia Risk Factor in Different Population Groups in Summer: The Case of Moscow.

Dudorova N, Belan B, Kotel'nikov S · 2026 · Toxics

A correlation between the near-surface ozone concentration in the urban atmosphere and hospitalizations of community-acquired pneumonia patients has been analyzed based on a long-term (five years) series of observations in the warm season…

View details →DOI: 10.3390/toxics14010083
Negative / Null Result ReportOpen accessMedicine

Transcriptional evidence of pluripotency during development of the leaf gall formed by grape phylloxera (Daktulosphaira vitifoliae).

Schultz JC, Body MJA, Edger PP et al. · 2025 · The New phytologist

Galls are structures formed by plants in response to stimuli by parasitic insects. Because galls require altered gene expression to change cell fates, their initiation requires pluripotent or 'reactive' cells. We used RNA sequencing to…

View details →DOI: 10.1111/nph.70241
Negative / Null Result ReportMedicine

In what ways does user experience design improve printed educational materials?

Kealey MR, Urakami J, Henderson K et al. · 2023 · Applied ergonomics

We report on a series of four studies that investigated how user experience design (UXD) can improve printed educational materials (PEMs). We examined the perceived usability of an existing PEM for breast cancer screening and observed the…

View details →DOI: 10.1016/j.apergo.2023.104081
Negative / Null Result ReportMedicine

Association Between Continuous Kidney Replacement Therapy Clearance and Outcome in Pediatric Patients With Hyperammonemia Not Due to Inborn Error of Metabolism.

Starr MC, Cater DT, Wilson AC et al. · 2022 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To describe a single-center experience of pediatric patients with hyperammonemia not due to inborn errors of metabolism and determine the association between use of continuous kidney replacement therapy (CKRT) treatment and…

View details →DOI: 10.1097/pcc.0000000000002949
Negative / Null Result ReportOpen accessMedicine

Discrete Repetition Effects for Visual Words Compared to Faces and Animals, but No Modulation by Expectation: An Event-Related Potential Study.

Song B, Sommer W, Maurer U · 2025 · The European journal of neuroscience

Repetition suppression (RS) refers to the reduction of neuronal responses to repeated stimuli as compared to nonrepeated stimuli. The predictive coding account of RS proposes that its magnitude is modulated by repetition probability…

View details →DOI: 10.1111/ejn.70047
Negative / Null Result ReportMedicine

Devaluation of NoGo stimuli is both robust and fragile.

Liu H, Holland RW, Blechert J et al. · 2022 · Cognition & emotion

Consistently not responding to stimuli during go/no-go training leads to lower evaluations of these NoGo stimuli. How this NoGo-devaluation-effect can be explained has remained unclear. Here, we ran three experiments to test the hypothesis…

View details →DOI: 10.1080/02699931.2022.2067132
Negative / Null Result ReportOpen accessMedicine

Traumatic birth experiences and maternal caregiving behaviors and attitudes in black and white women.

Kornfield SL, Henry NM, Waller R et al. · 2026 · Archives of women's mental health

PURPOSE: This longitudinal investigation examined the association between traumatic birth experiences (measured via self-report and clinician-report) and caregiving behaviors and attitudes and any race-related differences in these…

View details →DOI: 10.1007/s00737-026-01682-6
Negative / Null Result ReportMedicine

Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re-evaluation of a cohort study with a detailed follow-up.

Zhang Q, Yang G, Xiong Y et al. · 2023 · American journal of reproductive immunology (New York, N.Y. : 1989)

Problem The impact of antibiotic-cured chronic endometritis (CE) on perinatal outcomes of patients conceived with frozen embryo transfer (FET) was unclear. Method This study was to re-evaluate the perinatal outcomes of a cohort of…

View details →DOI: 10.1111/aji.13751
Negative / Null Result ReportOpen accessMedicine

Association between maternal and perinatal outcomes and histological changes in the placenta of patients with Covid-19: A cohort study.

Rocha de Souza L, Ramos Amorim MM, Souza AS et al. · 2024 · Medicine

Although studies evaluated placental involvement in Covid-19 patients, few have assessed its association with clinical repercussions. The study aimed to determine the association between the clinical status and maternal and perinatal…

View details →DOI: 10.1097/md.0000000000038171
Failed Experiment ReportOpen accessMedicine

Fluid Reservoir Characteristics in Established Scleral Lens Wear, Part I-Evaluation of Fluid Reservoir Depth and Midday Fogging.

Fogt JS, Schornack M, Shorter E et al. · 2026 · Eye & contact lens

Objectives Fluid reservoir (FR) depth is an important parameter in the evaluation of scleral lens fitting, yet the range of depths compatible with successful wear, clinicians' ability to estimate depth, and implications of FR depth on…

View details →DOI: 10.1097/icl.0000000000001272
Negative / Null Result ReportOpen accessMedicine

Pregnancy Outcomes Among Young, Middle-Aged, and Older Adolescents in Gadarif, Eastern Sudan: A Case-Control Study.

Munder O, Adam GK, Nasralla K et al. · 2025 · SAGE open nursing

Introduction Adolescent pregnancy is considered a global public health problem that affects both developed and developing countries. While the obstetric and perinatal outcomes of adolescent pregnancies have been extensively studied, there…

View details →DOI: 10.1177/23779608251364596
Failed Experiment ReportOpen accessMedicine

The Influence of Glucagon-like Peptide-1 Receptor Agonists on Outcomes Following Trigger Finger Release.

Dameron LS, Bank NC, Raghava N et al. · 2026 · Journal of hand surgery global online

Purpose The primary aim was to compare postoperative complications at 90 days and 1 year following trigger finger release (TFR) in patients with versus without glucagon-like peptide-1 receptor agonist (GLP-1 RA) exposure. GLP-1 RAs are…

View details →DOI: 10.1016/j.jhsg.2025.100923
Negative / Null Result ReportOpen accessMedicine

Evaluating the impact of statin therapy on chronic obstructive pulmonary disease outcomes: A retrospective cohort study from a tertiary care hospital in India.

Chari HS, Padukone AM, Magazine R et al. · 2026 · The Journal of international medical research

ObjectiveChronic obstructive pulmonary disease is a common condition marked by significant disability and frequent exacerbations. Statins, owing to their anti-inflammatory and immunomodulatory effects, may offer therapeutic benefits in…

View details →DOI: 10.1177/03000605261417046
Negative / Null Result ReportOpen accessMedicine

Impact of pulsed stimulation on objective and subjective visual acuity measurements in nystagmus.

Quanz EV, Al-Nosairy KO, Stolle FH et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose Quanz et al. (Sci Rep 14:16797, 2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA…

View details →DOI: 10.1007/s10633-025-10060-z
Failed Experiment ReportMedicine

Is physical pain causally related to suicidal behavior: An experimental test.

Park EC, Harris LM, Sigel AN et al. · 2023 · Behaviour research and therapy

Existing evidence suggests a link between physical pain and suicide, but the nature of this relationship remains unknown. To address this critical gap in knowledge, the present study leveraged a validated virtual reality (VR) suicide…

View details →DOI: 10.1016/j.brat.2023.104321
Negative / Null Result ReportOpen accessMedicine

Comparison of effectiveness of common targeting heuristics in repetitive transcranial magnetic stimulation treatment of depression.

Sakreida K, Trapp NT, Kreuzer S et al. · 2025 · BMJ mental health

Background Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective non-pharmacological, non-invasive intervention for depression. However, the optimal strategy for localising…

View details →DOI: 10.1136/bmjment-2025-301598
Negative / Null Result ReportOpen accessMedicine

Clinical Impact of Flow-Adjusted Transprosthetic Pressure Gradient After Aortic Valve Replacement.

Ohmori T, Hiraoka A, Totsugawa T et al. · 2025 · Annals of thoracic surgery short reports

Background It is still controversial whether prosthesis-patient mismatch (PPM) adversely affects long-term outcomes after aortic valve replacement (AVR). The aim of this study was to examine whether flow-adjusted pressure gradient is a…

View details →DOI: 10.1016/j.atssr.2024.07.008
Negative / Null Result ReportOpen accessMedicine

Corneal biomechanics are not exclusively compromised in high myopia.

Yii F, Strang N, Bernabeu MO et al. · 2024 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Research assuming linearity has concluded that corneal biomechanics are compromised in high myopia. We investigated whether this assumption was appropriate and re-examined these associations across different levels of myopia.…

View details →DOI: 10.1111/opo.13313
Failed Experiment ReportMedicine

Morphea after Silicone Implants.

Wollina U, Schönlebe J · 2023 · Acta dermatovenerologica Croatica : ADC

Dear Editor, Silicone is a hydrophobic polymer containing silicon. Silicon is an essential compound of soft tissue proteoglycans. Reports about morphea and other autoimmune connective tissue disorders in association with silicone implants…

Failed Experiment ReportMedicine

Seeing color following gene augmentation therapy in achromatopsia.

McKyton A, Marks Ohana D, Nahmany E et al. · 2023 · Current biology : CB

How will people who spent their visual lives with only rods respond to cone function restoration? Will they be able suddenly see the colors of the rainbow? CNGA3-achromatopsia is a congenital hereditary disease in which cone dysfunction…

View details →DOI: 10.1016/j.cub.2023.06.041
Negative / Null Result ReportMedicine

The distribution of the Lansing Effect across animal species.

Ivimey-Cook ER, Shorr S, Moorad JA · 2023 · Evolution; international journal of organic evolution

Maternal senescence is the reduction in individual performance associated with increased maternal age at conception. When manifested on adult lifespan, this phenomenon is known as the "Lansing Effect." Single-species studies report both…

View details →DOI: 10.1093/evolut/qpac045
Negative / Null Result ReportOpen accessMedicine

An Exploratory Analysis of Essential Tremor and Associated Phenotypes.

Gharibian D, Medeiros M, Dion PA et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)

Essential Tremor (ET) is a highly heterogeneous movement disorder with a strong genetic basis. However, the etiology of ET is unclear, largely due to its clinical heterogeneity and frequently observed comorbidities. We conducted a…

View details →DOI: 10.5334/tohm.1168
Negative / Null Result ReportMedicine

New Morbidities During Critical Illness and Associated Risk of ICU Readmission: Virtual Pediatric Systems Cohort, 2017-2020.

Heneghan JA, Akande MY, Ramgopal S et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To describe change in Functional Status Scale (FSS) associated with critical illness and assess associated development of new morbidities with PICU readmission. Design Retrospective, cross-sectional cohort study using the…

View details →DOI: 10.1097/pcc.0000000000003542