Negative / Null Result ReportMedicine
Sukmarova ZN, Simonenko VB · 2025 · Kardiologiia
Despite significant advances in pharmacological, interventional, and surgical treatments for cardiovascular diseases (CVDs) in recent decades, it appeared that the effectiveness of standard treatments has reached a ceiling, and growing…
View details →DOI: 10.18087/cardio.2025.11.n3016 Negative / Null Result ReportMedicine
Zhou J, Jiang X, Liu Q et al. · 2026 · Cancer metastasis reviews
Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six antibodies acting on programmed death ligand 1 or programmed death 1 pathways were approved in 75 cancer indications…
View details →DOI: 10.1007/s10555-026-10314-5 Failed Experiment ReportMedicine
Chichareon P, Suwannanon R, Thungthienthong M et al. · 2026 · British journal of clinical pharmacology
Background Left ventricular hypertrophy (LVH) contributes to a substantial risk of adverse outcomes in patients with coronary artery disease (CAD). Inflammation is one of the mechanisms responsible for LVH progression. The study aimed to…
View details →DOI: 10.1002/bcp.70470 Failed Experiment ReportMedicine
Yerraguntla S, Bakshi B, Chandran K et al. · 2026 · Amyotrophic lateral sclerosis & frontotemporal degeneration
N-acetylcysteine is a thiol-containing compound and a precursor of glutathione, with mechanistic plausibility for ALS, including reducing oxidative stress, regulating neuroinflammation, and mitigating mitochondrial dysfunction. Preclinical…
View details →DOI: 10.1080/21678421.2026.2638590 Negative / Null Result Report
Rourke LM, Byrt CS, Long BM et al. · 2025 · Preprint
Cyanobacteria rely on bicarbonate (HCO 3 - ) as the primary inorganic carbon (Ci) source for photosynthesis in aquatic environments. To use of this Ci source, cyanobacteria employ CO 2 concentrating mechanisms (CCMs) that elevate…
View details →DOI: 10.1101/2025.11.03.686429 Negative / Null Result ReportMedicine
Kakaletsis N, Ntaios G · 2025 · Polish archives of internal medicine
Embolic stroke of undetermined source (ESUS) represents up to one‑sixth of ischemic strokes, and is associated with an annual recurrence risk of 4%-5% despite contemporary secondary prevention. The hypothesis that oral anticoagulation…
View details →DOI: 10.20452/pamw.17139 Negative / Null Result ReportMedicine
Gweon TG, Kim SJ, Myung DS et al. · 2026 · Gastrointestinal endoscopy
Background and aims Insufficient submucosal lifting because of pretreatment with forceps biopsy frequently complicates endoscopic treatment of rectal neuroendocrine tumors (NETs) and potentially affects procedural outcomes. Despite…
View details →DOI: 10.1016/j.gie.2025.11.035 Failed Experiment ReportMedicine
Guin S, Alden KM, Harshbarger E et al. · 2026 · European journal of medicinal chemistry
With millions of cases reported annually, fungal infections represent a growing public health concern. The effectiveness of current treatment options is hindered by the availability of only three antifungal drug classes, rising resistance,…
View details →DOI: 10.1016/j.ejmech.2025.118373 Negative / Null Result ReportOpen accessMedicine
Xu H · 2026 · Nutrition & metabolism
BACKGROUND: Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. METHODS: This review synthesized evidence through a protocol-guided approach, with…
View details →DOI: 10.1186/s12986-026-01108-1 Negative / Null Result ReportOpen accessMedicine
Horsburgh CR Jr, Jenkins HE, Kendall EA et al. · 2026 · IJTLD open
Background Active screening for TB may help address the global TB burden, but the optimal screening strategies are not defined. We have reviewed the effectiveness of community-wide active screening programmes to assess the characteristics…
View details →DOI: 10.5588/ijtldopen.25.0807 Negative / Null Result ReportOpen accessMedicine
Stasinos I, Voulgaris T, Kouimtsidis IA et al. · 2026 · World journal of gastrointestinal pharmacology and therapeutics
Background Risk of post colonoscopy colorectal cancer is related to adenoma miss rate (AMR) during colonoscopy. Artificial intelligence (AI) and Endocuff Vision are tools both used to increase adenoma detection rate (ADR). Aim To assess…
View details →DOI: 10.4292/wjgpt.v17.i1.112825 Negative / Null Result ReportOpen accessMedicine
Lengyel B, Armos R, Bojtor B et al. · 2025 · Pharmaceuticals (Basel, Switzerland)
Vitamin D is well established for its skeletal effects, being a cornerstone of several endocrine disorders. In recent years, it has come under investigation as a potential disease-modifying drug in several endocrine disorders through its…
View details →DOI: 10.3390/ph19010054 Negative / Null Result ReportMedicine
Sadoul M, Balança B, Dailler F et al. · 2025 · Neurosurgical review
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with significant morbidity, particularly related to delayed cerebral ischemia (DCI). Hyponatremia, defined as a serum sodium level < 135 mmol/l, is a common complication of aSAH and…
View details →DOI: 10.1007/s10143-025-03825-2 Negative / Null Result ReportMedicine
Klinghammer K, Graeven U, Ivanyi P et al. · 2026 · Oncology research and treatment
Introduction Elderly, frail, or cisplatin-ineligible patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M HNSCC) have a poor prognosis. To date, no standard of care has been defined for this population.…
View details →DOI: 10.1159/000549947 Negative / Null Result ReportMedicine
Ge Y, Wang X, Zhang Y et al. · 2026 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Objectives This study aims to assess the efficacy of total hysterectomy versus radical hysterectomy in the treatment of gastric-type endocervical adenocarcinoma (GEA). Methods Patients diagnosed with GEA from 2001 to 2021 were derived from…
View details →DOI: 10.1016/j.jogc.2025.103156 Negative / Null Result ReportMedicine
Bakakos A, Sotiropoulou Z, Anagnostopoulos N et al. · 2025 · Respiratory medicine
Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality around the globe. Its main characteristics are persistent respiratory symptoms and progressive airflow limitation, both of which are driven by…
View details →DOI: 10.1016/j.rmed.2025.108396 Negative / Null Result ReportMedicine
Bellamy D, Vickery K · 2026 · Infection, disease & health
Background In accordance with AS5369:2023, disinfection processes need to undergo routine performance qualification (PQ) as part of in-field validation. Automated high-level disinfection (HLD) devices therefore need to undergo PQ.…
View details →DOI: 10.1016/j.idh.2025.08.004 Negative / Null Result ReportOpen accessMedicine
Yang Q, Li J, Ding L et al. · 2026 · Cancer management and research
Background Growing research findings highlight the potential of inflammatory markers measured after surgery as prognostic indicators for survival outcomes in rectal carcinoma patients. However, their precise clinical significance remains…
View details →DOI: 10.2147/cmar.s579958 Negative / Null Result ReportOpen accessMedicine
Wong A, Cheah K, Papathanakos G et al. · 2026 · Anaesthesiology intensive therapy
Introduction Fluid management in critically ill patients relies on clinical assessment, fluid balance calculations and, increasingly, point-of-care ultrasound. However, the rela-tionships between these assessment modalities remain poorly…
View details →DOI: 10.5114/ait/217910 Negative / Null Result ReportMedicine
Xu T, Grubbs JB, Kraus SW · 2025 · Addictive behaviors
As sports betting legalization expands across the United States, understanding its effects on problem gambling remains crucial for evidence-based policy development. This longitudinal study tracked 112 American sports bettors over two…
View details →DOI: 10.1016/j.addbeh.2025.108448 Negative / Null Result ReportMedicine
Ke TM, Lin T, Chow WH et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Introduction Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is the standard treatment for esophageal cancer, but the role of adjuvant chemotherapy remains unclear. This study investigates the survival benefits of adjuvant…
View details →DOI: 10.1016/j.ejso.2025.111177 Negative / Null Result ReportMedicine
Schneble CA, Miltenberg B, Jurgensmeier K et al. · 2025 · The American journal of sports medicine
Background Arthrofibrosis is seen in 1.7% to 38% of patients after anterior cruciate ligament reconstruction (ACLR) and has been associated with worse postoperative patient-reported outcomes. There are limited data regarding the optimal…
View details →DOI: 10.1177/03635465251383162 Negative / Null Result ReportOpen accessMedicine
Rowland S, Brummel K, Aatre R et al. · 2026 · Case reports in medicine
Familial dysbetalipoproteinemia (FDB) is a lipid disorder characterized by defective clearance of triglyceride-rich lipoprotein remnants. Definitive diagnosis has relied on genetic markers, lipid profiles, and specialized lipid assays…
View details →DOI: 10.1155/carm/8758502 Negative / Null Result ReportMedicine
Chakraborty S, Gagnon H, McNamara TP et al. · 2026 · IEEE transactions on visualization and computer graphics
Multi-user virtual reality (VR) systems support multiple locomotion methods, but coordination may be challenging when partners use different methods. We studied dyads navigating a shared virtual maze using symmetric (same) or asymmetric…
View details →DOI: 10.1109/tvcg.2026.3679060 Abandoned HypothesisOpen accessMedicine
Sporns PB, Almohammad M, Minnerup J et al. · 2025 · Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
BackgroundWhile endovascular thrombectomy (EVT) is firmly established for large vessel occlusion stroke, recent enthusiasm for extending EVT to distal medium vessel occlusions (DMVOs) has been tempered by the neutral results of three major…
View details →DOI: 10.1177/15910199251365526 Negative / Null Result ReportOpen accessMedicine
Roy S, Gupta N, Bharti SJ et al. · 2026 · Journal of anaesthesiology, clinical pharmacology
Background and aims Managing acute postsurgical pain following midline exploratory laparotomy in colorectal cancer patients involves various approaches, such as central neuraxial blockade, patient-controlled intravenous analgesia with…
View details →DOI: 10.4103/joacp.joacp_293_25 Negative / Null Result ReportMedicine
Singh N, Petrakis I, Pittman B et al. · 2025 · Journal of psychopharmacology (Oxford, England)
Background There is growing interest in developing pharmacological agents to reverse alcohol (ethanol) intoxication, akin to naloxone for opioids. GABAergic modulation offers a potential pathway for reversing alcohol effects, specifically…
View details →DOI: 10.1177/02698811251330746 Negative / Null Result ReportOpen accessMedicine
Li ZY, Peng SY, Li FL et al. · 2026 · World journal of clinical oncology
Pancreatic ductal adenocarcinoma remains largely refractory to current immunotherapies due to a profoundly immunosuppressive tumor microenvironment dominated by regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and…
View details →DOI: 10.5306/wjco.v17.i2.114423 Negative / Null Result ReportOpen accessMedicine
Huang L, He J · 2025 · World journal of clinical oncology
Background Human epidermal growth factor receptor 2 (HER2) plays pivotal roles in cellular proliferation, survival, and differentiation of several malignancies. Upper tract urothelial carcinoma (UTUC) is a relatively rare malignancy. The…
View details →DOI: 10.5306/wjco.v16.i10.110047 Negative / Null Result ReportMedicine
Anzures G, Mildort M, Valenzuela KPM · 2026 · Developmental psychobiology
Despite the early emergence of differences in processing own- and other-race faces, examinations of the corresponding neural correlates prior to adulthood remain limited. The present study examined 5- to 10-year-olds' and adults' P100 and…
View details →DOI: 10.1002/dev.70108 