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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 315 of 710

Failed Experiment ReportMedicine

[Study of a fetus with confined placental mosaicism for trisomy 2 in conjunct with fetal uniparental disomy and a literature review].

Liu C, Lyu Y, Jiang Y et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To carry out genetic analysis for a fetus with confined placental mosaicism (CPM) for trisomy 2 (T2) in conjunct with fetal uniparental disomy (UPD). Methods Amniocentesis and chromosomal karyotyping was carried out for a…

View details →DOI: 10.3760/cma.j.cn511374-20220524-00348
Negative / Null Result ReportMedicine

Cognitive behavioral program for the prevention of depression in at-risk adolescents: isolating the effects of dose.

Dickerson JF, Clarke G, Weersing VR et al. · 2025 · American journal of epidemiology

The current study estimated effects of intervention dose (attendance) of a cognitive behavioral prevention (CBP) program on depression-free days (DFDs) in adolescent offspring of parents with a history of depression. As part of secondary…

View details →DOI: 10.1093/aje/kwae131
Negative / Null Result ReportOpen accessMedicine

The Airway, Breathing, Circulation-Plan, Risk, Options (ABC-PRO) Handover Tool in the PICU: Retrospective Evaluation of Pre- Versus Post-Implementation and Occurrence Rate of Cardiac Arrests, 2020-2023.

De Gaudenzi M, Mozun R, Schlapbach LJ et al. · 2026 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives Healthcare improvement studies indicate a potential to reduce cardiac arrests in the PICU through anticipatory care and shared awareness. We developed a structured risk-assessment and anticipation tool (i.e., the Airway,…

View details →DOI: 10.1097/pcc.0000000000003884
Negative / Null Result ReportOpen accessMedicine

Association between maternal serum levels of Alpha-Fetoprotein and eruption timing of the first central deciduous tooth: a cross-sectional study.

Faghihian E, Ghobadi S, Rezaei R et al. · 2025 · The Saudi dental journal

The current study investigated the relationship between the first central deciduous tooth eruption time and serum levels of maternal alpha-fetoprotein and related multiple of the median (MoM). The cross-sectional study was performed on a…

View details →DOI: 10.1007/s44445-025-00089-w
Negative / Null Result ReportOpen accessMedicine

Revisiting the relationship between impulsivity, apathy, and action control: Bayesian inference from a stop-signal task study.

Michel E, Garnier-Allain A, Kaliuzhna M et al. · 2026 · PloS one

Apathy and impulsivity are multidimensional constructs that shape goal-directed behavior. Although the motivational dopaminergic spectrum hypothesis frames them as opposing ends of a single continuum, questionnaire-based studies…

View details →DOI: 10.1371/journal.pone.0352351
Negative / Null Result ReportOpen accessMedicine

Exploring the effects of faecal microbiota transplantation on cognitive function: A review of clinical trials.

Alaeddin S, Chatterjee A, Roberts TL et al. · 2025 · Brain, behavior, & immunity - health

Faecal Microbiota Transplantation (FMT) is a widely used microbiota-modulation technique to treat recurrent Clostridioides difficile infections (rCDI). Rodent studies and clinical trials on probiotic interventions indicate that alterations…

View details →DOI: 10.1016/j.bbih.2025.101049
Negative / Null Result ReportOpen accessMedicine

Consensus Report by the Italian Academy of Osseointegration on the Importance of Peri-Implant Soft Tissues.

Bressan E, Zucchelli G, Tommasato G et al. · 2024 · Medicina (Kaunas, Lithuania)

Background and Objectives : The influence of the quantity and quality of peri-implant soft tissue on implant health and long-term maintenance is controversial. This consensus aimed to assess the importance of peri-implant soft tissue by…

View details →DOI: 10.3390/medicina60091393
Negative / Null Result ReportMedicine

Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke ? Discordance between randomised controlled trials and observational studies.

Scheen AJ · 2023 · Diabetes & metabolism

Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular complication has been less carefully investigated than the risk of cardiovascular mortality, heart failure and renal disease. Some data suggested…

View details →DOI: 10.1016/j.diabet.2023.101474
Negative / Null Result ReportMedicine

Effects of HIV and Adverse Childhood Experiences on Neurocognition.

Inman EM, Inman EM, Ramsammy CW et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)

Background Both HIV and adverse childhood experiences (ACEs) can affect neurocognitive performance. Among youth with perinatal HIV (PHIV), living with a chronic viral infection and experiencing ACEs simultaneously may result in an…

View details →DOI: 10.1097/qai.0000000000003858
Negative / Null Result ReportOpen accessMedicine

Use of alteplase continuous rate infusion, pentoxifylline, and cyproheptadine in association or not, in acute feline aortic thromboembolism: a study of nine cats.

Ray CC, Wolf J, Guillaumin J · 2025 · Frontiers in veterinary science

Introduction Locomotion improvement without serious complications is the main goal of treatment for feline aortic thromboembolism (FATE). We aimed to describe the survival and functional recovery of cardiogenic FATE treated with tissue…

View details →DOI: 10.3389/fvets.2025.1512649
Negative / Null Result ReportOpen accessMedicine

The effect of intraoperative low-dose ketamine versus dexmedetomidine infusion on postoperative bowel recovery in patients undergoing gastrointestinal malignancy surgeries: Placebo-controlled, randomized trial.

Kumar SK, Misra S, Behera BK et al. · 2025 · Journal of anaesthesiology, clinical pharmacology

Background and aims No studies have compared the effects of ketamine and dexmedetomidine on bowel recovery. We evaluated the effects of intraoperative low-dose ketamine or dexmedetomidine infusion on postoperative bowel recovery in…

View details →DOI: 10.4103/joacp.joacp_322_23
Negative / Null Result ReportMedicine

Extent of Lymphadenectomy for Surgical Management of Right-Sided Colon Cancer: The Randomized Phase III RELARC Trial.

Lu J, Xing J, Zang L et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there is still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The…

View details →DOI: 10.1200/jco.24.00393
Negative / Null Result ReportOpen accessMedicine

The relationship between glaucoma and an electronic frailty index with the cumulative incidence of healthcare encounters for falls and fractures in older adults.

Duy WD, Pajewski NM, Williamson JD et al. · 2025 · The Journal of frailty & aging

Objective To compare the association of glaucoma and glaucoma suspect diagnoses with frailty, quantified via an electronic frailty index (eFI), and to evaluate whether a glaucoma diagnosis moderates the association between frailty and the…

View details →DOI: 10.1016/j.tjfa.2025.100051
Negative / Null Result ReportMedicine

Racial and ethnic disparities in the usage and outcomes of ischemic stroke treatment in the United States.

Metcalf D, Zhang D · 2023 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Objectives This study explores racial and ethnic differences in 1) receiving tissue plasminogen activator (tPA) and endovascular thrombectomy (EVT) as treatment for ischemic stroke and 2) outcomes and quality of care after use of tPA or…

View details →DOI: 10.1016/j.jstrokecerebrovasdis.2023.107393
Negative / Null Result ReportOpen accessMedicine

The Effects of Repeated Finger Flexion Movements on Self-Reported Affect and Reward System Activation Are Weak and Inconsistent.

Vander Missen MR, Giovanetti AK, Fisher JS et al. · 2025 · Journal of clinical psychology

Recent research has called into question the robustness and reliability of using body movements to activate motivational systems like approach-reward. The purpose of the current studies was to test the effect of a repeated flexion movement…

View details →DOI: 10.1002/jclp.70017
Negative / Null Result ReportOpen accessMedicine

What is the effect of alarmist media and radiofrequency electromagnetic field (RF-EMF) exposure on salivary cortisol and non-specific symptoms?

Verrender A, Wallace NK, Loughran SP et al. · 2025 · Applied psychology. Health and well-being

While there is consistent evidence that the symptoms reported by people who experience Idiopathic Environmental Intolerance attributed to Electromagnetic Fields (IEI-EMF) are closely associated with a nocebo effect, and that alarmist media…

View details →DOI: 10.1111/aphw.70044
Negative / Null Result ReportOpen accessMedicine

The Effects of CenteringPregnancy: A Quasi-Experimental Evaluation.

Park CH, Driver N, Richards RC Jr et al. · 2025 · Healthcare (Basel, Switzerland)

Background/Objectives : CenteringPregnancy (CP) is a group prenatal care model that empowers pregnant women through risk assessment, education, and social support. CP participants have more contact time with providers compared to those in…

View details →DOI: 10.3390/healthcare13091052
Negative / Null Result ReportOpen accessMedicine

The association of third molars with mandibular incisor crowding in a group of the Yemeni population in Sana'a city: cone-beam computed tomography.

Aldhorae K, Ishaq R, Alhaidary S et al. · 2025 · BMC oral health

Background Multiple factors contribute to mandibular incisor crowding. However, the role of wisdom teeth in these irregularities remains a controversial issue among clinicians. Therefore, this study aimed to determine the potential…

View details →DOI: 10.1186/s12903-025-05733-9