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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 309 of 710

Negative / Null Result ReportOpen accessMedicine

Children with Dyslexia Benefit from Short Combined Reading and Motor Training: Objective Measures Assessed by Eye Movements and Postural Sway Recordings.

Caldani S, Khoury E, Delorme R et al. · 2025 · Brain sciences

Background/Objectives: Children with dyslexia report poor motor control; several studies have shown poor eye movements control during reading and important body instability in these children. The present study aimed to test in children…

View details →DOI: 10.3390/brainsci15111218
Negative / Null Result ReportMedicine

Sensory Stimulation and Robot-Assisted Arm Training After Stroke: A Randomized Controlled Trial.

Egger M, Bergmann J, Krewer C et al. · 2024 · Journal of neurologic physical therapy : JNPT

Background and purpose Functional recovery after stroke is often limited, despite various treatment methods such as robot-assisted therapy. Repetitive sensory stimulation (RSS) might be a promising add-on therapy that is thought to…

View details →DOI: 10.1097/npt.0000000000000486
Negative / Null Result ReportOpen accessMedicine

Analysing the clinical outcomes between FIGO 2009 and 2023 staging for endometrial cancer-a single institution retrospective study.

Vuppu DP, Rajanbabu A, Nair IR et al. · 2025 · Ecancermedicalscience

The latest International Federation of Gynaecology and Obstetrics (FIGO) staging for endometrial cancer incorporated molecular profiles and histopathological factors into the basic staging framework. This study was done to determine its…

View details →DOI: 10.3332/ecancer.2025.1836
Negative / Null Result ReportOpen accessMedicine

Insulin resistance as a modifiable contributor to breast cancer: mechanisms, biomarkers, and therapeutic implications.

Marouf SP, Meskar Z, Rezaei N · 2026 · Discover oncology

Insulin resistance (IR) has emerged as a metabolically relevant contributor to the development and progression of breast cancer (BC), with a case fatality of nearly 15%. IR mainly shows a relationship with obesity, type 2 diabetes mellitus…

View details →DOI: 10.1007/s12672-026-04828-1
Negative / Null Result ReportMedicine

Development of an evaluation and treatment strategy for olfactory neuroblastoma: a review of evidence from large-scale studies, including population-based and multicenter studies, and meta-analyses.

Ariizumi Y, Asakage T · 2024 · Japanese journal of clinical oncology

Olfactory neuroblastoma is a rare sinonasal malignancy arising from the olfactory epithelium that is characterized by skull base involvement and a modest natural history. Because of its rarity and long course, identification of independent…

View details →DOI: 10.1093/jjco/hyae062
Negative / Null Result ReportMedicine

Alteration of methylation pattern and gene expression of FTO, PPARγ and Slc2a4 on pre-diabetes-induced BALB/c mice.

Listiyani P, Sanjaya R, Nathanael J et al. · 2025 · Molecular and cellular biochemistry

T2DM is a serious global health problem and usually caused by unhealthy diet, such diet with high carbohydrate or monosodium glutamate (MSG). In this study, we used the T2DM mice (BALB/c) model by exposing the mice with foods high in…

View details →DOI: 10.1007/s11010-024-05141-7
Negative / Null Result ReportMedicine

Immunonutrition to improve the quality of life of upper gastrointestinal cancer patients undergoing neoadjuvant treatment prior to surgery (NEOIMMUNE): double-blind randomized controlled multicenter clinical trial.

Markar S, Markar S, Mariette C et al. · 2025 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

Background Malnutrition is common with esophagogastric cancers and is associated with negative outcomes. We aimed to evaluate if immunonutrition during neoadjuvant treatment improves patient's health-related quality of life (HRQOL) and…

View details →DOI: 10.1093/dote/doae113
Negative / Null Result ReportOpen accessMedicine

Is fixation of a single end of flail segment rib fractures enough?

Perugini A, Iandoli J, Pelz N et al. · 2025 · Trauma surgery & acute care open

Background Segmental rib fractures in blunt thoracic trauma present with increased morbidity and mortality with an association of increased pulmonary insult and concomitant injuries. There is a paucity within the literature regarding the…

View details →DOI: 10.1136/tsaco-2024-001707
Negative / Null Result ReportMedicine

Fundus blood flow density changes in the smoking population by artificial intelligence-based optical coherence tomography angiography.

Zhang LY, Li QJ, Zhou Q et al. · 2025 · International journal of ophthalmology

Aim To determine whether chronic smoking affects fundus blood flow density using optical coherence tomography angiography (OCTA) based on artificial intelligence (AI). Methods All participants underwent a comprehensive ophthalmological…

View details →DOI: 10.18240/ijo.2025.09.01
Negative / Null Result ReportOpen accessMedicine

Evaluation of spot urine CA 19 - 9/creatinine ratio in diagnosis and management of hydronephrosis in children: a prospective study.

Kutukoglu MU, Altuntas T, Sekerci CA et al. · 2025 · BMC pediatrics

Background To demonstrate that the CA19-9/creatinine level could be a potential biomarker in children with obstruction by including ureteropelvic junction obstruction (UPJO) patients and comparing them not only with healthy controls but…

View details →DOI: 10.1186/s12887-025-06453-3
Negative / Null Result Report

Multiple solute binding proteins for gamma-aminobutyrate and 5-aminovalerate in Pseudomonas aeruginosa : assessment of their potential role in sensor kinase activation

Vargas JPC, Krell T · 2024 · Preprint

The canonical mode of receptor activation consists in the binding of signals or signal-loaded solute binding proteins (SBPs) to sensor domains. Many sensor histidine kinases (SHK), that are activated by SBP binding, are encoded next to…

View details →DOI: 10.22541/au.171656259.90626428/v1
Negative / Null Result ReportOpen accessMedicine

Neuromuscular and Neurocognitive Performance Associated with ACL Injury Risk in Youth Handball Players: A Prospective Cohort Study.

Sinka GC, Pavlik A, Mayer Á et al. · 2026 · Sports (Basel, Switzerland)

Background Anterior cruciate ligament (ACL) injuries in youth athletes are multifactorial, and the relative contributions of neuromuscular and neurocognitive variables remain inadequately comprehended. Methods In this prospective cohort…

View details →DOI: 10.3390/sports14050185
Negative / Null Result ReportMedicine

Real-World Patient Eligibility and Feasibility of Transcatheter Edge-to-Edge Repair or Replacement Interventions for Tricuspid Regurgitation.

Abushouk A, Layoun H, Harb SC et al. · 2024 · Journal of cardiac failure

Novel transcatheter therapies for tricuspid regurgitation (TR) appear promising, yet their applicability to an all-comer TR population remains unclear. We aimed to assess the feasibility of emerging transcatheter tricuspid therapies in a…

View details →DOI: 10.1016/j.cardfail.2024.07.014
Failed Experiment Report

Effect of fluticasone-impregnated throat packs on postoperative sore throat (POST) and hoarseness of voice: A randomized clinical trial

Talapatra A, Mathew S, Kanakalakshmi ST et al. · 2024 · Preprint

Background Post-operative sore throat (POST) is one of the most common complaints post-endotracheal intubation and can be decreased through various interventions. This study aimed to determine the effect of fluticasone-impregnated versus…

View details →DOI: 10.12688/f1000research.139742.2
Failed Experiment ReportOpen accessMedicine

Sex Differences in the Effects of Etonogestrel on Respiratory Recovery in an In Vivo Rat Model of Central Chemoreflex Impairment.

Cardani S, Janes TA, Asif R et al. · 2026 · Acta physiologica (Oxford, England)

Aim Rhythmic breathing movements driven by the brainstem rely on chemosensory inputs to homeostatically adjust motor output to the prevailing metabolic demand. The central CO 2 chemoreflex is a critical component of this neural circuitry,…

View details →DOI: 10.1111/apha.70194
Negative / Null Result ReportOpen accessMedicine

Ivermectin to reduce malaria transmission- safety and efficacy results from the BOHEMIA cluster randomized trial in Mozambique.

Chaccour C, Nicolas P, Martinho S et al. · 2025 · EClinicalMedicine

Background Endectocides are a novel vector control tool that reduce the survival and fertility of blood sucking arthropods that feed upon treated humans or animals. Ivermectin mass drug administration is under evaluation as a complementary…

View details →DOI: 10.1016/j.eclinm.2025.103632
Negative / Null Result ReportOpen accessMedicine

The terpenes alpha-bisabolol and camphene modulate pruritus via an action on Cav3.2 T-type calcium channels.

Antunes FTT, Gadotti VM, Zamponi GW · 2025 · Molecular brain

Alpha-bisabolol and camphene have demonstrated analgesic effects in inflammatory pain models by blocking Cav3.2 calcium channels. As the pain pathway overlaps with mechanisms for itch, and because Cav3.2 channels have been associated with…

View details →DOI: 10.1186/s13041-025-01196-9
Negative / Null Result ReportMedicine

Long-term prognostic value of CT-based high-risk coronary lesion attributes and radiomic features of pericoronary adipose tissue in diabetic patients.

Yang W, Ding X, Yu Y et al. · 2024 · Clinical radiology

Aims To investigate the long-term prognostic value of coronary computed tomography angiography (CCTA)-derived high-risk attributes and radiomic features of pericoronary adipose tissue (PCAT) in diabetic patients for predicting major…

View details →DOI: 10.1016/j.crad.2024.08.018
Negative / Null Result ReportMedicine

Chapter 2: Rate Versus Rhythm Control.

Deering TF, Reiffel JA, Solomon AJ et al. · 2023 · The American journal of cardiology

Atrial fibrillation (AF) is a potentially serious health risk, both because of its symptoms and because of its association with an increased risk for heart failure, hospitalization, thromboembolism, and death. Chapter 2 discusses selection…

View details →DOI: 10.1016/j.amjcard.2023.08.022
Negative / Null Result ReportOpen accessMedicine

Prognosis and treatment of plasmablastic lymphoma in the United States: a multicenter retrospective study.

Hamby M, Egleston BL, Frosch ZAK et al. · 2026 · Blood cancer journal

Plasmablastic lymphoma (PBL) is a rare, aggressive AIDS-related lymphoma observed in patients with immunosuppressed states as well as in immunocompetent individuals. We sought to determine survival outcomes, prognostic factors, and optimal…

View details →DOI: 10.1038/s41408-026-01457-3
Negative / Null Result ReportMedicine

The current role of adjuvant radiotherapy in management of medullary thyroid carcinoma: A single institute analysis.

Bhuvana J, Shivhare V, Rath S et al. · 2025 · Journal of cancer research and therapeutics

Objectives Medullary thyroid carcinoma (MTC) accounts for only about 5% of total thyroid cancers. It usually presents as an advanced disease carrying a poor prognosis than well-differentiated thyroid cancers. While the treatment of choice…

View details →DOI: 10.4103/jcrt.jcrt_1174_23
Negative / Null Result ReportOpen accessMedicine

Pharmacological management of agitation in dementia: An evidence-based review with expert consensus.

Cheng CM, Tsai MJ, Tseng CC et al. · 2026 · Journal of the Chinese Medical Association : JCMA

Agitation is a frequently occurring and challenging neuropsychiatric symptom of Alzheimer's disease (AD) that substantially affects quality of life, caregiver burden, and healthcare utilization. Nonpharmacological interventions, especially…

View details →DOI: 10.1097/jcma.0000000000001342
Negative / Null Result ReportMedicine

Real-World Tocilizumab Use in Pediatric Inpatients.

Stitt GA, Hall MW, Diliberto MA et al. · 2025 · The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Objectives Primary objective: to quantify tocilizumab (TCZ) use in pediatric inpatients. Secondary objectives: to explore safety and clinical outcomes. Methods This retrospective cohort study took place in a free-standing, 564-bed…

View details →DOI: 10.5863/jppt-24-00130
Negative / Null Result ReportOpen accessMedicine

Lack of association between the brain penetrance of calcium channel blockers and the incidence of neuropsychiatric outcomes: a retrospective, multidatabase cohort study.

Kern DM, Bohn J, Maher MP et al. · 2026 · BMJ open

Objective To use best practices in pharmacoepidemiology to assess the association between new use of brain-penetrant calcium channel blockers (BP-CCBs) compared with use of non-brain-penetrant CCBs (NP-CCBs) and the incidence of…

View details →DOI: 10.1136/bmjopen-2025-100282
Negative / Null Result ReportMedicine

Correlations between Visual Temporal Resolution and Individual Alpha Peak Frequency: Evidence that Internal and Measurement Noise Drive Null Findings.

Deodato M, Melcher D · 2024 · Journal of cognitive neuroscience

The brain organizes the continuous flow of sensory input by parsing it into discrete events. In the case of two flashes separated by a brief ISI, for example, perception may be of a single flash or two distinct flashes, depending on the…

View details →DOI: 10.1162/jocn_a_01993
Negative / Null Result ReportOpen accessMedicine

Thyroid testing in primary hypothyroidism.

Ambasta A, Grenet G, Otte J et al. · 2025 · African journal of primary health care & family medicine

Thyroid hormones regulate essential metabolic processes and development. The hypothalamic-pituitary-thyroid axis regulates hormone production, with thyroid-stimulating hormone (TSH) levels being a key indicator of thyroid function in…

View details →DOI: 10.4102/phcfm.v17i1.5043