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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 310 of 710

Negative / Null Result ReportMedicine

rs6897932 (C>T) and rs987106 (A>T) variants in the <i>IL7RA</i> gene are correlated with the susceptibility and the clinical features of systemic lupus erythematosus.

Sarpeleh F, Ehtesham N, Mirjani R et al. · 2026 · Lupus

ObjectiveThe dysfunction of interleukin-7 receptor alpha (IL-7Rα), which is encoded by the IL7RA gene, has been implicated in the development of systemic lupus erythematosus (SLE). This study aimed to investigate the relationship between…

View details →DOI: 10.1177/09612033261429135
Negative / Null Result ReportOpen accessMedicine

Impact of weekend admission on in-hospital mortality in chronic kidney disease: a nationwide analysis of 184 299 hospitalisations in Poland (2017-2021).

Mazurek A, Jankowski M, Grudziąż-Sękowska J · 2026 · BMC nephrology

BACKGROUND: The weekend effect refers to the observation that patients admitted to the hospital on the weekend experience poorer clinical outcomes than patients admitted during the workweek. This effect has not been previously studied…

View details →DOI: 10.1186/s12882-026-04885-2
Negative / Null Result ReportOpen accessMedicine

Plantar Heel Pain Is Not Associated With Fatty Infiltration of the Abductor Digiti Minimi Muscle on Magnetic Resonance Imaging: A Cross-Sectional Observational Study.

Chen JSC, Osborne JWA, Menz HB et al. · 2026 · Journal of foot and ankle research

Background Fatty infiltration, or fatty atrophy, of the abductor digiti minimi (ADM) muscle of the foot is proposed to be associated with entrapment of the first branch of the lateral plantar nerve (i.e., Baxter's neuropathy) as part of…

View details →DOI: 10.1002/jfa2.70155
Negative / Null Result ReportMedicine

Institutional educational climate and MIR examination outcomes: a multicenter ecological study in Spanish medical schools.

Millán J, Gal B, Esquerda M et al. · 2026 · BMC medical education

Background In Spain, access to specialized medical training is determined through a highly competitive national examination (MIR). While the educational climate of medical schools has been associated with students' learning outcomes and…

View details →DOI: 10.1186/s12909-026-09516-w
Negative / Null Result Report

Fast Food Consumption Habits Knowledge Attitudes and Their Association with Body Mass Index Among Health Sciences Students in Oman

Mahaboob L, Chehade H, Gnanamuthu SS et al. · 2026 · Preprint

Abstract Background Fast-food consumption has become increasingly prevalent among university students, contributing to unhealthy dietary patterns and rising obesity rates. Understanding students' fast-food consumption habits, knowledge,…

View details →DOI: 10.21203/rs.3.rs-9610403/v1
Negative / Null Result ReportMedicine

Relationship between <i>APOE</i> Genotype Status and Imaging Features in Patients with Alzheimer Disease Being Considered for Antiamyloid β Therapy.

Vejdani-Jahromi M, Calle E, Ganem O et al. · 2026 · AJNR. American journal of neuroradiology

Background and purpose Alzheimer disease (AD) is a progressive neurodegenerative disorder that predominantly affects the aging population. Anti-amyloid β (anti-Aβ) therapies, such as lecanemab, have been developed to slow disease…

View details →DOI: 10.3174/ajnr.a9056
Negative / Null Result ReportOpen accessMedicine

Intubation exposure associated with first-pass success - understanding practitioner-related characteristics in South African EMS.

Brown J, Abdullah N, Sobuwa S · 2026 · International journal of emergency medicine

BACKGROUND: Endotracheal intubation is a critical life-saving intervention in prehospital emergency care, yet evidence supporting its safe implementation by prehospital practitioners in lower- to middle-income countries remains limited.…

View details →DOI: 10.1186/s12245-026-01183-4
Negative / Null Result ReportMedicine

Structural-functional dissociation in acute Bell's palsy: a comparative study of high-resolution ultrasound and electrodiagnostic testing.

El Habashy HR, Ahmed SM, Al Salmawy DA et al. · 2026 · Neurological research

Background Bell's palsy (BP) is the most common acute peripheral mononeuropathy worldwide. While electrodiagnostic studies are established tools for functional assessment, high-resolution ultrasonography (HRUS) has emerged as a…

View details →DOI: 10.1080/01616412.2026.2680967
Negative / Null Result ReportMedicine

Emotion Perception in Behavioral Variant Frontotemporal Dementia and Alzheimer Disease: The Parahippocampal Conundrum.

Morais RF, Duro D, Pires R et al. · 2026 · Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

Background Emotion perception is the capacity that enables humans to correctly identify the cues that guide interpersonal interactions, forming the basis for social behavior. The parahippocampal cortex may contribute to emotion perception…

View details →DOI: 10.1097/wnn.0000000000000420
Negative / Null Result ReportOpen accessMedicine

Changes in Upper Airway Anatomy and Apnea-Hypopnea Index in Patients with Obstructive Sleep Apnea Undergoing Bariatric Surgery: A Pilot Study.

Nithya M, Titiyal R, Ajayababu A et al. · 2026 · Journal of clinical medicine

Background: Obstructive sleep apnea (OSA) is common in individuals with obesity, largely due to increased soft tissue causing upper airway narrowing. However, mechanisms of OSA improvement following weight loss are incompletely understood,…

View details →DOI: 10.3390/jcm15114038
Negative / Null Result ReportOpen accessMedicine

Assessment of Pulp-Tooth Ratio Based on 3D Segmentation for Age Estimation for Forensic Purposes in a Senegalese Population.

Soumboundou SM, Ndiaye ML, Ndiaye R et al. · 2026 · Cureus

Introduction The advent of 3D imaging has created a significant opportunity to enhance the accuracy of age estimation. By utilizing 3D segmentation, it is now possible to evaluate the three-dimensional pulp volume as an indicator of age.…

View details →DOI: 10.7759/cureus.109325
Negative / Null Result ReportMedicine

Pd-L1 Expression in Oral Cavity Squamous Cell Carcinomas.

Nalwa A, Visakhan A, Elhence PA et al. · 2026 · Indian journal of surgical oncology

Programmed cell death ligand-1 (PD-L1) is involved in T-cell regulation by acting as an immune checkpoint inhibitor, and its expression is being widely studied in various malignancies. The following study was designed to examine the role…

View details →DOI: 10.1007/s13193-026-02565-z
Negative / Null Result ReportOpen accessMedicine

Association Between MRI-Based Cartilage Repair Morphology and Clinical Outcomes After Osteochondral Autograft Transfer of the Talus.

Rizvanoglu İH · 2026 · Foot & ankle orthopaedics

Background Osteochondral lesions of the talus (OLT) represent a challenging ankle pathology that may lead to persistent pain, functional impairment, and progressive joint degeneration. Open transmalleolar osteochondral autograft transfer…

View details →DOI: 10.1177/24730114261445398
Negative / Null Result ReportOpen accessMedicine

Assessment of sleep duration and cortisol levels among selected South African medical students.

Mhlana A, Milanes-Rodriguez G, Olojede SO et al. · 2026 · BMC endocrine disorders

Background Sleep is essential for maintaining the body's balance, particularly in regulating the Hypothalamic-pituitary-adrenal (HPA) axis, which controls cortisol, the main stress hormone. Cortisol follows a daily rhythm, but irregular…

View details →DOI: 10.1186/s12902-026-02266-2
Negative / Null Result Report

Skin Microbiome Profiles in RA, AS, BS and FMF: A Cross-Sectional Study

Doğantekin E, Albayrak F, Doğantekin A et al. · 2026 · Preprint

Introduction: Microbiota refers to all microorganisms colonising the body, whereas microbiome is a broader term covering the genetic material and ecosystem of this population. The skin is the largest organ of the body with a skin…

View details →DOI: 10.20944/preprints202602.1466.v1
Negative / Null Result ReportMedicine

Significant Correlation Between White Matter Hyperintensity Volume and Rare NOTCH3 Variants in the General Japanese Population.

Mizuta I, Yamashita F, Sutoh Y et al. · 2026 · Geriatrics & gerontology international

Aim Cerebral small vessel disease (CSVD)-related MRI findings, including white matter hyperintensities (WMHs), are not rare in general elderly populations. The aim of this study was to elucidate the contribution of hereditary CSVD-related…

View details →DOI: 10.1111/ggi.70400
Negative / Null Result ReportMedicine

Evaluation of Circadian Variations of Central Corneal Thickness and Its Correlation With Intraocular Pressures in Healthy Horses.

Iturregui C, Liu CC, Carter RT et al. · 2026 · Veterinary ophthalmology

Justification Circadian variations in central corneal thickness (CCT) and their correlation with intraocular pressure (IOP) have not been reported in horses. This information may be clinically relevant when interpreting IOP readings.…

View details →DOI: 10.1111/vop.70194
Negative / Null Result ReportMedicine

Chondrolabral junction pathology in Femoroacetabular Impingement Syndrome is underestimated by pre-operative MRI and have no significant correlation with baseline outcomes.

Samim M, Jardon M, Vonck C et al. · 2026 · Journal of orthopaedics

Purpose To assess correlation of pre-operative symptoms, labral damage and chondrolabral junction pathology on MRI with intra-operative findings in patients undergoing hip arthroscopy for femoroacetabular impingement (FAI). Methods…

View details →DOI: 10.1016/j.jor.2026.03.010
Negative / Null Result ReportOpen accessMedicine

Exploratory Analysis of the Neutrophil-to-Lymphocyte Ratio (NLR) and Mucositis Severity in Head and Neck Cancer Patients Undergoing Radiotherapy-Based Treatment: A Retrospective Study.

Santo B, Romanello M, De Franco P et al. · 2026 · Journal of clinical medicine

Background/Objectives: The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker reflecting systemic inflammatory status and has been investigated in head and neck cancer (HNC) as a potential prognostic indicator. Its role in relation…

View details →DOI: 10.3390/jcm15103866
Negative / Null Result ReportMedicine

Accuracy and agreement of a wearable device for heart rate and oxygen saturation monitoring in awake dogs.

Melek Ş, Orhun ÖT, Şenocak MG et al. · 2026 · The Journal of small animal practice

Objectives The present study evaluated the accuracy and agreement of heart rate and peripheral oxygen saturation measurements obtained using the Owlet Smart Sock in awake dogs with low activity levels, using a veterinary patient monitor as…

View details →DOI: 10.1111/jsap.70162
Negative / Null Result Report

Electrical Impedance Tomography in Pediatric Acute Respiratory Distress Syndrome: Dynamic Ventilation Monitoring and Clinical Correlation Analysis from Intubation to Extubation

Li C, Liu s · 2026 · Preprint

Abstract Objective: This study aims to investigate the dynamic evolution patterns of regional ventilation parameters monitored by bedside electrical impedance tomography (EIT) in pediatric patients with acute respiratory distress syndrome…

View details →DOI: 10.21203/rs.3.rs-8974424/v1
Negative / Null Result ReportMedicine

Clinical significance of diastolic wall strain in heart failure with preserved ejection fraction: A cross-sectional observational analysis.

Krishnamurthy P, Gnanaraj JP, Ganesan P · 2026 · JRSM cardiovascular disease

Background Diastolic wall strain (DWS) is based on linear elastic theory, which shows that impaired diastolic wall thinning reflects resistance to deformation in diastole and thus, increased diastolic myocardial stiffness. We aim to…

View details →DOI: 10.1177/20480040261418963