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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21710 results · page 308 of 724

Negative / Null Result ReportMedicine

Presence and potential impact of anthropogenic nesting materials on a colonial breeding waterbird.

Ferreira HRS, Hadden AC, Champagnon J et al. · 2025 · The Science of the total environment

Despite the vital importance of wetlands globally, these habitats have increasingly received anthropogenic materials, such as plastics, which can impact the wildlife these habitats support. Despite commonly found in the nests of Eurasian…

View details →DOI: 10.1016/j.scitotenv.2025.178588
Negative / Null Result ReportOpen accessMedicine

Do ChatGPT and Gemini provide accurate answers to patient questions about glenohumeral arthritis?

Ohlsen SM, Pirkle SB, Yang J et al. · 2026 · JSES reviews, reports, and techniques

Background Machine learning, a subset of artificial intelligence, enables large language models (LLMs) like ChatGPT and Gemini to analyze data, learn from context, and generate responses without explicit programming. While machine learning…

View details →DOI: 10.1016/j.xrrt.2026.100715
Negative / Null Result ReportMedicine

Thrombectomy in Stroke Patients with Large Vessel Occlusion and Mild Symptoms: Insights from a Multicenter Observational Study.

Qiu K, Hang Y, Lv P et al. · 2025 · Translational stroke research

To evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) is more effective than BMM alone in treating mild stroke patients (National Institutes of Health Stroke Scale score pri ) group and the primary…

View details →DOI: 10.1007/s12975-025-01337-1
Negative / Null Result Report

Embryonic exposure to valproic acid and neonicotinoid deteriorates the developmental GABA switch and impairs long-term potentiation in the local circuit of intermediate medial mesopallium of chick telencephalon

Matsushima T, Toji N, Wada K et al. · 2024 · Preprint

Embryonic exposure to valproic acid (VPA) and imidacloprid (IMI, a neonicotinoid insecticide) impairs filial imprinting in hatchlings, and the deteriorating effects of VPA are mitigated by post-hatch injection of bumetanide, a blocker of…

View details →DOI: 10.1101/2024.09.15.613159
Negative / Null Result ReportOpen accessMedicine

Baseline gut microbiome features associated with fecal calprotectin response to exclusive enteral nutrition in pediatric Crohn's disease.

Zheng H, Chen W · 2026 · Frontiers in pediatrics

Background and aims Exclusive enteral nutrition is an established induction therapy for pediatric Crohn's disease, but biochemical response varies across patients. We assessed whether baseline gut microbiome features were associated with…

View details →DOI: 10.3389/fped.2026.1833193
Negative / Null Result ReportMedicine

Is it personality or genes? - A secondary analysis on a randomized controlled trial investigating responsiveness to placebo analgesia.

van Lennep JPA, van Middendorp H, Leong OV et al. · 2025 · Scandinavian journal of pain

Objectives To understand how different individuals respond to placebo effects, it is relevant to disentangle the influence of someone's personality and genetic variations. The aim of this exploratory study was to investigate the role of…

View details →DOI: 10.1515/sjpain-2025-0029
Negative / Null Result ReportMedicine

Association between human telomerase reverse transcriptase (hTERT) MNS16A polymorphism and risk of breast cancer.

Salehi-Reyhani SM, Saadat M · 2024 · Molecular biology reports

Background It is well known that telomerase activity is suppressed in normal human tissues and reactivated in tumors, suggesting that the human telomerase reverse transcriptase (hTERT, MIM: 187270) gene may be involved in carcinogenesis. A…

View details →DOI: 10.1007/s11033-024-09999-0
Negative / Null Result ReportOpen accessMedicine

Bioavailability of and US Infant Exposure to Arsenic, Cadmium, Lead, Mercury, and Per- and Polyfluoroalkyls from Human Milk and Infant Formula: Results from a Series of Systematic Reviews.

O'Connor LE, Thoerig RC, Leta CN et al. · 2026 · Advances in nutrition (Bethesda, Md.)

Infants may be exposed to contaminants from environmental and food sources, including human milk (HM) or infant formula (IF). The objective of this series of systematic reviews (PROSPERO: CRD42024530332, CRD42024530336, CRD42024530339, and…

View details →DOI: 10.1016/j.advnut.2026.100628
Failed Experiment ReportMedicine

Investigation of malondialdehyde as a trait marker associated with familial risk in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives - A longitudinal cohort study.

Coello K, Stanislaus S, Forman JL et al. · 2025 · Free radical biology & medicine

Aims Increased oxidative stress-generated tissue damage seems to play a pivotal role in the pathophysiology and progression of bipolar disorder (BD). Malondialdehyde (MDA), a product of lipid oxidation, may represent a trait marker in BD…

View details →DOI: 10.1016/j.freeradbiomed.2025.03.041
Negative / Null Result ReportOpen accessMedicine

Psoas muscle variables and adjuvant chemotherapy-related and survival outcomes following pancreaticoduodenectomy for periampullary malignancy.

Hajibandeh S, Hajibandeh S, Mckittrick H et al. · 2026 · World journal of gastrointestinal surgery

Background Early skeletal muscle wasting has been demonstrated to be associated with chemotherapy-related toxicity in patients with cancer. Hounsfield unit average calculation (HUAC) or psoas muscle index (PMI) can be used to diagnose…

View details →DOI: 10.4240/wjgs.v18.i2.114743
Negative / Null Result ReportMedicine

Variation in song structure does not predict associative learning performance in zebra finches (Taeniopygia castanotis) raised under controlled cultural conditions.

Derégnaucourt S, Le Maguer L, Geberzahn N · 2026 · Animal cognition

Vocal learning in songbirds requires the integration of auditory perception, sensorimotor learning, and performance monitoring, yet its relationship to general cognitive abilities remains unclear. We tested whether interindividual…

View details →DOI: 10.1007/s10071-026-02077-x
Negative / Null Result ReportMedicine

Predictors and Outcomes of Online Health Information Avoidance in the Context of COVID-19: Application and Extension of the PRIA Model.

Guan M, Yang Q, Carey P et al. · 2026 · Health communication

Despite its significant implications for public health and individual decision-making, research on information avoidance remains limited. In this study, we applied and extended the model of planned risk information avoidance (PRIA) to…

View details →DOI: 10.1080/10410236.2026.2678930
Negative / Null Result ReportMedicine

Prenatal and adolescent exposure to metals/metalloids and telomere dynamics at 14 years: Evidence from the Chitwan birth cohort.

Wai KM, Parajuli RP, Umezaki M · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Telomeres are repetitive non-coding DNA sequences at chromosome ends that progressively shorten with each cell division, serving as markers of cellular aging. Recent studies have suggested that prenatal and postnatal exposure to…

View details →DOI: 10.1016/j.jtemb.2026.127856
Replication Failure

Perspective taking predicts acute psychiatric treatment trajectories

Foley E, Bockhorst JL, Beard C et al. · 2026 · Preprint

Objective: Although perspective taking is a well-established transdiagnostic feature of psychopathology, less is known about its role in treatment outcomes. The present study examined whether perspective taking frequency upon admission to…

View details →DOI: 10.31234/osf.io/5w9g8_v1
Replication FailureMedicine

Eating your emotions: Within-person relations of emotional overeating with lability/negativity and emotion regulation from childhood to young adulthood.

Parisi F, Steinsbekk S, Wichstrøm L et al. · 2026 · Child development

Emotional overeating theories posit that lability/negativity and poor emotion regulation increase emotional overeating risk, yet empirical evidence is limited. This longitudinal study followed 878 Norwegian participants (50.1% girls)…

View details →DOI: 10.1093/chidev/aacag104
Negative / Null Result ReportMedicine

Risk Factors, Biomarkers, and Risk Assessment Models for Prediction of Venous Thromboembolism in Ambulatory Patients with Advanced Lung Cancer.

Ay L, Moik F, Füreder T et al. · 2026 · Hamostaseologie

Summary BACKGROUND: Patients with lung cancer are at high risk of developing venous thromboembolism (VTE). Although several risk assessment models (RAMs) for cancer-associated VTE exist, their performance in advanced lung cancer is…

View details →DOI: 10.1055/a-2882-0557
Negative / Null Result ReportMedicine

Associations among maternal prenatal depression, maternal autism traits, and child autism traits in the Environmental Influences on Child Health Outcome (ECHO) program.

Nutor C, Dunlop AL, Brennan PA · 2026 · Journal of neurodevelopmental disorders

Background Maternal depression during pregnancy has been associated with increased risk of offspring autism spectrum disorder (ASD) - a highly heritable neurodevelopmental disorder. However, no study to date has taken into account maternal…

View details →DOI: 10.1186/s11689-026-09709-w
Negative / Null Result ReportMedicine

A simple clinical risk score can predict frailty in HNSCC patients.

Kunz V, Wald T, Gaenzle M et al. · 2026 · Cancer treatment and research communications

Introduction Frailty is a predictor of adverse outcomes in cancer patients, but its assessment in head and neck squamous cell carcinoma (HNSCC) patients is often limited due to time-consuming questionnaires being required for comprehensive…

View details →DOI: 10.1016/j.ctarc.2026.101253
Negative / Null Result ReportMedicine

Trajectories of physical fitness following paediatric burn injury: A two-year longitudinal and predictive analysis.

Basha MA, Elnaggar RK, Aloraini SM et al. · 2026 · Clinical rehabilitation

ObjectiveTo analyse physical fitness trajectories in paediatric burn survivors from discharge to 2 years post-injury, compare them with an age- and gender-matched control group, and identify baseline demographic and clinical…

View details →DOI: 10.1177/02692155261459618
Negative / Null Result Report

Gendered Interest Structures Exist and Persist Throughout Adolescence: A Latent Profile and Transition Analysis of Academic and Vocational Interests in German Students

Welling J, Ehrtmann L, Malapally A et al. · 2026 · Preprint

Gendered interests are an important driver of gendered academic and vocational decisions and thus contribute to sustaining gender inequalities in the European labor market. Therefore, in order to counteract these inequalities, it is…

View details →DOI: 10.31234/osf.io/zv6yt_v1