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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21290 results · page 308 of 710

Negative / Null Result ReportMedicine

Different effects of guilt and shame on grief among naturally bereaved Chinese adults: A three-wave cross-lagged panel analysis.

Yu X, Huang J, Jiang W et al. · 2026 · Journal of psychiatric research

Background Bereavement, i.e., the death of significant others, generally arouses grief reactions and may be accompanied by feelings of guilt and shame. However, it remains unclear whether guilt and shame can influence grief adaptation…

View details →DOI: 10.1016/j.jpsychires.2025.12.005
Negative / Null Result ReportMedicine

Persistence of pulmonary hypertension in patients with ventricular septal defect after intracardiac repair: insights from a long-term follow-up study.

Wakisaka Y, Inai K, Harada G et al. · 2025 · Cardiology in the young

Background Ventricular septal defect is the most common CHD and is complicated by pulmonary hypertension in about 5% of cases. Although long-term outcomes after repair are generally good, persistent pulmonary hypertension has been…

View details →DOI: 10.1017/s1047951125110159
Negative / Null Result ReportMedicine

The effect of race/ethnicity on systemic chemotherapy in urothelial carcinoma patients exposed to radiotherapy.

de Angelis M, Siech C, Di Bello F et al. · 2025 · World journal of urology

Introduction Based on prospective trials' result, it is unknown whether race/ethnicity affects the magnitude of cancer-specific survival differences after trimodal therapy (TMT) versus external beam radiation therapy alone (EBRT) for…

View details →DOI: 10.1007/s00345-025-05767-2
Negative / Null Result ReportMedicine

Ethnicity and income as predictors of clinical outcomes of a youth-focused personalizable modular treatment.

Cho E, Chorpita BF, Reeder K et al. · 2025 · Journal of consulting and clinical psychology

Objective Personalizable modular treatments may be helpful in addressing the mental health needs of minoritized youths. We used data from five randomized effectiveness trials of the Modular Approach to Therapy for Children, a…

View details →DOI: 10.1037/ccp0000979
Negative / Null Result ReportMedicine

Subjective well-being mediates the longitudinal effect of insomnia symptoms on internalizing symptoms in community-dwelling older adults.

Ying Y, Meng R, Xu J et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences

Objectives The associations between insomnia symptoms and internalizing symptoms are well-established, particularly in older adults; however, the mediating factors remain inconsistent. This study seeks to explore the longitudinal…

View details →DOI: 10.1093/geronb/gbaf221
Negative / Null Result Report

Attention-Deficit/Hyperactivity Disorder across the Menstrual Cycle: Late-Luteal Symptom Exacerbation, Medication Use, and the Role of Sleep Quality and Perceived Stress

Nayman S, Del Din J, Ríos MB et al. · 2025 · Preprint

BackgroundEmerging evidence indicates perimenstrual exacerbation of Attention-Deficit/Hyperactivity Disorder (ADHD) in females and reduced perceived stimulant responsiveness during the luteal phase. Prospective clinical studies jointly…

View details →DOI: 10.31234/osf.io/vjn53_v1
Negative / Null Result ReportMedicine

Clinical impact of TP53 classifications in previously treated advanced driver-negative non-small cell lung cancer: A biomarker analysis of the OAK and POPLAR randomized clinical trials.

Zhou DD, Lord SJ, Lin FP et al. · 2026 · Lung cancer (Amsterdam, Netherlands)

Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…

View details →DOI: 10.1016/j.lungcan.2025.108891
Negative / Null Result ReportMedicine

Computed Tomography Measurement of Optic Nerve Sheath Diameter in Thrombolysis-Treated Ischemic Stroke: Association with Post-Thrombolytic Intracranial Hemorrhage.

Coşkun Yaş S, Üçöz Kocaşaban D, Güler S et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Optic nerve sheath diameter (ONSD) measurement is a non-invasive marker of intracranial pressure. Its role in predicting post-thrombolytic intracranial hemorrhage in acute ischemic stroke patients remains unclear. This study aimed to…

View details →DOI: 10.1016/j.jocn.2025.111754
Negative / Null Result ReportMedicine

Survival implications of computed tomography-derived muscle mass changes in patients with epithelial ovarian cancer undergoing bowel surgery.

Kim J, Lee YY, Kim TJ et al. · 2026 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Objective Sarcopenia is a known adverse prognostic factor in gastrointestinal cancers undergoing bowel resection; however, its prognostic relevance in epithelial ovarian cancer remains unclear. This study aimed to evaluate the prognostic…

View details →DOI: 10.1016/j.ijgc.2025.102838
Negative / Null Result Report

Sleep Benefits to Spatial Source Memory in Older Adults

Kuhlmann BG, Shakoor S, Schicker LA et al. · 2025 · Preprint

While it is well-established that sleep benefits episodic memory, most evidence is on younger adults. The current study examined sleep benefits in older adults and chose spatial source memory as a target measure for which a recent study in…

View details →DOI: 10.31234/osf.io/jfswh_v1
Negative / Null Result ReportMedicine

Postoperative Outcomes in Body Contouring Procedures Following Glucagon-Like Peptide-1 Receptor Agonist Use: A 10-Year Analysis.

Liang J, Pillai T, Chopra S et al. · 2025 · Aesthetic surgery journal

Background Utilization of glucagon-like peptide-1 receptor agonists (GLP-1ras) has increased dramatically in recent years. Although GLP-1ras appear safe to use overall, it remains unclear whether preoperative GLP-1ra use impacts body…

View details →DOI: 10.1093/asj/sjaf029
Negative / Null Result ReportMedicine

Cranioplasty after surgical site infection in brain tumor patients: insights from a 15-year Swedish multicenter study.

Holmgren K, Fletcher-Sandersjöö A, Sæmundsson B et al. · 2026 · Journal of neurosurgery

Objective Postoperative surgical site infections (SSIs) following brain tumor surgery frequently necessitate wound revision and bone flap removal. However, data on subsequent cranial reconstruction in this context remain limited. The aim…

View details →DOI: 10.3171/2025.7.jns251301
Negative / Null Result ReportMedicine

When the Lights Go Out: Studying Sex Differences in Sleep Latency, Sleep Quality, and Social Behavior in Captive Rhesus Macaques (Macaca mulatta) Over a 24-h Period.

Roach A, Furman S, Hadeed J et al. · 2025 · American journal of primatology

Assessments of nonhuman primate (NHP) affiliation are typically restricted to daytime behavior. There is, however, a growing interest in understanding NHP behavior and welfare over the 24-h period. To assess the sleep quality and sociality…

View details →DOI: 10.1002/ajp.70098
Negative / Null Result ReportMedicine

The MEniscal TeaR Outcome (METRO) study : a prospective cohort study exploring the factors that affect outcomes in patients undergoing treatment for a meniscal tear.

Ahmed I, Dhaif F, Bowes MA et al. · 2025 · The bone & joint journal

Aims The aim of this study was to describe the baseline characteristics of patients with a meniscal tear and explore associations with 12-month outcomes. Methods This prospective, national multicentre cohort study recruited patients aged…

View details →DOI: 10.1302/0301-620x.107b11.bjj-2024-1429.r1
Negative / Null Result ReportMedicine

Longitudinal associations between maternal depression, problematic media use, and parenting efficacy as a time-varying mediator.

Holmgren HG, Densley RL, Coyne SM et al. · 2026 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

Prior research suggests a link between maternal depression and mothers' problematic media use (PMU), defined as compulsive or dysregulated media use that interferes with daily functioning. This study examined whether parenting…

View details →DOI: 10.1037/fam0001474
Negative / Null Result ReportMedicine

Associations between physical literacy and physical activity in adults. A cross-sectional study with self-report and device-based physical activity assessments.

Naylor A, Keegan R, Martin K et al. · 2025 · Journal of sports sciences

Physical literacy has been shown to relate to children's engagement in physical activity. However, it is unclear whether this relationship extends to adults. A two-phase cross-sectional study was conducted to examine whether physical…

View details →DOI: 10.1080/02640414.2025.2468593
Negative / Null Result ReportMedicine

Affective predictors of day-level impaired control over alcohol use.

Waddell JT, DeFalco A, Emery NE · 2026 · Addictive behaviors

Rationale Impaired control over alcohol use is a core aspect of Alcohol Use Disorder symptomatology. However, research regarding how impaired control manifests at the day-level, and what temporally proceeds it in daily life, remains…

View details →DOI: 10.1016/j.addbeh.2025.108506
Negative / Null Result ReportOpen accessMedicine

The effect of using intra-oral camera as an educational aid for oral health promotion in children.

Pratyusha K, Chaitanya P, Vinay C et al. · 2025 · European oral research

Purpose The aim of this study was to evaluate the effect of using an intraoral camera (IOC) as an educational aid for promoting oral health among 7-10-year-old children in India. Materials and methods A randomized trial was conducted…

View details →DOI: 10.26650/eor.20241534830
Negative / Null Result ReportMedicine

Impaired Goal-Directed Planning in Transdiagnostic Compulsivity Is Explained by Uncertainty About Learned Task Structure.

Sookud S, Martin I, Gillan CM et al. · 2026 · Biological psychiatry. Cognitive neuroscience and neuroimaging

Background Diminished use of goal-directed (model-based) decision making is a hallmark of transdiagnostic compulsivity, promoting an overreliance on inflexible and habitual behaviors. However, the origin of this impairment remains unclear.…

View details →DOI: 10.1016/j.bpsc.2025.10.005
Negative / Null Result Report

State but not trait measures of vividness relate to memory accuracy

Duckett W, Simons J · 2025 · Preprint

Vivid mental imagery is often assumed to relate to memory accuracy, but recent empirical findings from studies of aphantasia have found conflicting results regarding this association. The present study investigates the relationship between…

View details →DOI: 10.31234/osf.io/sqydt_v1
Negative / Null Result Report

Consolidating Climate Anxiety Scales Using Rasch Modelling

Gago T, Sargisson RJ, Milfont TL · 2025 · Preprint

Despite being an important mental health consequence of climate change, climate anxiety assessment has been fragmented. Reviews of measures of climate anxiety raise concerns about content and convergent validity. We aimed to select the…

View details →DOI: 10.31234/osf.io/fx3a5_v1
Negative / Null Result ReportMedicine

Predictors and Outcomes Associated with Clinically Significant Improvements in Anxiety and Depression Symptoms Following Cardiac Rehabilitation.

Hernández L, Williamson TM, Campbell T et al. · 2025 · The Canadian journal of cardiology

Background Cardiac rehabilitation (CR) participation improves depressive and anxious symptoms post-coronary catheterization, yet it is unclear to what extent improvements are clinically significant. This study characterized the proportion…

View details →DOI: 10.1016/j.cjca.2025.10.009